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The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with H...
https://doi.org/10.1016/j.intimp.2021.108187
International Immunopharmacology; Perween R, PraveenKumar M et. al.

Oct 15th, 2021 - Cross-reactivity among the two diverse viruses is believed to originate from the concept of antibodies recognizing similar epitopes on the two viral surfaces. Cross-reactive antibody responses have been seen in previous variants of SARS and SARS-CoV-2, but little is known about the cross reactivity with other similar RNA viruses like HIV-1. In the present study, we examined the reactivity the S...

Optimizing Operating Parameters of Electric Ultra-Low Volume Sprayer with Slightly Acid...
https://doi.org/10.3390/ijerph181910183
International Journal of Environmental Research and Publi... Lee HW, Yoon SR et. al.

Oct 14th, 2021 - Recently, and considering the COVID-19 pandemic, there has been a growing consensus that the disinfection of surfaces contaminated with pathogenic viral particles is essential. Chemical disinfectant sprays are effective at preventing the spread of infectious human noroviruses (Hu-NoVs) in healthcare and public areas. We assessed the virucidal activity of slightly acidic electrolyzed water (SAEW...

Differential roles of interferons in innate responses to mucosal viral infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496891
Trends in Immunology; Walker FC, Sridhar PR et. al.

Oct 12th, 2021 - Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. Inhibition of viral establishment and spread at and from these mucosal sites is paramount for preventing severe disease, while concomitantly limiting pu...

SARS-CoV2 neutralizing activity of ozone on porous and non-porous materials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492887
New Biotechnology; Wolfgruber S, Loibner M et. al.

Oct 10th, 2021 - The COVID-19 pandemic has generated a major need for non-destructive and environmentally friendly disinfection methods. This work presents the development and testing of a disinfection process based on gaseous ozone for SARS-CoV-2-contaminated porous and non-porous surfaces. A newly developed disinfection chamber was used, equipped with a CeraPlas™ cold plasma generator that produces ozone duri...

Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing...
https://doi.org/10.1084/jem.20211003
The Journal of Experimental Medicine; Shinnakasu R, Sakakibara S et. al.

Oct 9th, 2021 - Broadly protective vaccines against SARS-related coronaviruses that may cause future outbreaks are urgently needed. The SARS-CoV-2 spike receptor-binding domain (RBD) comprises two regions, the core-RBD and the receptor-binding motif (RBM); the former is structurally conserved between SARS-CoV-2 and SARS-CoV. Here, in order to elicit humoral responses to the more conserved core-RBD, we introduc...

Recent strategies driving oral biologic administration.
https://doi.org/10.1080/14760584.2021.1990044
Expert Review of Vaccines; Alotaibi BS, Buabeid M et. al.

Oct 7th, 2021 - : High patient compliance, non-invasiveness, and self-administration are the leading features of vaccine delivery through the oral route. The implementation of swift mass vaccination campaigns in pandemic outbreaks fascinates the use of oral vaccination. This approach can elicit both mucosal and systemic immune responses to protect against infection at the surface of the mucosa. : As pathogen e...

Transfer efficiency of an enveloped virus, human coronavirus 229E, from various hard su...
https://doi.org/10.1017/ice.2021.428
Infection Control and Hospital Epidemiology; Gerba CP, Leija BM et. al.

Oct 7th, 2021 - Respiratory viruses can be transmitted by fomite contact, but no data currently exist on the transfer of enveloped viruses. The transfer efficiency of human coronavirus from various hard surfaces ranged from 0.46% to 49.0%. This information can be used to model the fomite transmission of enveloped viruses.

SARS-CoV2 Data: Real‐World Results of Environmental Surface Testing From a Large Tertiary Cancer Center
https://www.onclive.com/view/sars-cov2-data-real-world-results-of-environmental-surface-testing-from-a-large-tertiary-cancer-center

Oct 6th, 2021 - Patients with hematologic malignancies, which include cancers that affect the blood, bone marrow, and lymph nodes, have demonstrated a higher susceptibility to COVID-19 potentially because of inherent and cancer therapy–related immunosuppression1. Current evidence suggests that COVID-19–related morbidity and mortality is higher in patients with underlying co-morbidities, male gender, older age...

Phi 6 recovery from inoculated fingerpads based on elution buffer and methodology.
https://doi.org/10.1016/j.jviromet.2021.114307
Journal of Virological Methods; Baker CA, Gibson KE

Oct 5th, 2021 - Phi 6 (Φ6) bacteriophage is a proposed surrogate to study pathogenic enveloped viruses including SARS-CoV-2-the causative agent of COVID-19-based on structural similarities, BSL-1 status, and ease of use. To determine the role of virus-contaminated hands in disease transmission, an enhanced understanding of buffer and method performance for Φ6 recovery needs to be determined. Four buffer types ...

Cold Viruses Thrived in Kids as Other Viruses Faded in 2020
https://www.medscape.com/viewarticle/960210

Oct 4th, 2021 - The common-cold viruses rhinovirus (RV) and enterovirus (EV) continued to circulate among children during the COVID-19 pandemic while there were sharp declines in influenza, respiratory syncytial virus (RSV), and other respiratory viruses, new data indicate. Researchers used data from the Centers for Disease Control and Prevention's (CDC's) New Vaccine Surveillance Network. The cases involved 3...

FDA In Brief: FDA Warns Consumers of Risk of Exposure to Unsafe Levels of Radiation with Safe-T-Lite UV WAND | FDA
https://www.fda.gov/news-events/press-announcements/fda-brief-fda-warns-consumers-risk-exposure-unsafe-levels-radiation-safe-t-lite-uv-wand

Oct 1st, 2021 - For Immediate Release: September 29, 2021 The following quote is attributed to Thalia Mills, Ph.D., director, Division of Radiological Health, Office of In Vitro Diagnostics and Radiological Health, FDA’s Center for Devices and Radiological Health Español “The FDA is warning consumers that using the Safe-T-Lite UV WAND, a handheld ultraviolet-C (UV-C) germicidal wand intended for sanitization, ...

Evaluation of electrostatic sprayers and foggers for the application of disinfectants i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483385
PloS One; Wood JP, Magnuson M et. al.

Oct 1st, 2021 - Although research has shown that the COVID-19 disease is most likely caused by airborne transmission of the SARS-CoV-2 virus, disinfection of potentially contaminated surfaces is also recommended to limit the spread of the disease. Use of electrostatic sprayers (ESS) and foggers to rapidly apply disinfectants over large areas or to complex surfaces has emerged with the COVID-19 pandemic. ESSs a...

YouTube Bans Anti-Vaxxers; UV Disinfection Danger; Beijing's Olympics Rules
https://www.medpagetoday.com/infectiousdisease/covid19/94782

Sep 30th, 2021 - Note that some links may require registration or subscription. Anti-vaccine videos will no longer have a home on YouTube. (Washington Post) EHR data suggested that long COVID affected one in three people who had been infected, and lingering symptoms varied across age and sex. (CNN) As of Thursday at 8:00 a.m. EDT, the unofficial U.S. COVID-19 toll reached 43,350,990 cases and 695,123 deaths, up...

Insights in ChAdOx1 nCov-19 Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483989
Blood Greinacher A, Selleng K et. al.

Sep 30th, 2021 - SARS-CoV-2 vaccine ChAdOx1 nCov-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models and analysis of VITT patient samples we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with plate...

Concern About New Recommendations to Relax COVID-19 Prevention Measures
https://www.medscape.com/viewarticle/958850

Sep 30th, 2021 - An expert in microbiology has expressed concern about the new UK Health Security Agency (UKHSA) recommendations on COVID-19 infection prevention and control (IPC) around elective procedures. The recommendations include three interventions which relate to social distancing and testing in NHS and Social Care elective care services, and a removal of enhanced cleaning practices. The new recommendat...

Occupational Dermatoses Related to Personal Protective Equipment Used During the COVID-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165076
Dermatologic Clinics; Abdali S, Yu J

Sep 25th, 2021 - The recent coronavirus disease 2019 (COVID-19) pandemic has led to the dramatic increase in use of personal protective equipment (PPE) among health care providers and the general public. Herein the authors discuss the various occupational dermatoses including allergic and irritant contact dermatitis, acne, seborrheic dermatitis, and rosacea related to frequent handwashing, disinfecting of surfa...

Sotrovimab - sotrovimab injection, solution, concentrate-GlaxoSmithKline LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aa5cca2e-4351-4f81-b0e5-3303ac0b2474

Sep 23rd, 2021 - SPL UNCLASSIFIED SECTION The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved product sotrovimab for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing...

A case-control study of airborne dissemination of bacteria during CT colonography.
https://doi.org/10.1259/bjr.20210607
The British Journal of Radiology; Taylor A, Williams C et. al.

Sep 21st, 2021 - The COVID-19 pandemic has highlighted the importance of aerosol spread of infection. We have conducted a study to detect bacterial contamination of room surfaces and room air during CT colonography and confirm the efficacy of room disinfection procedures carried out between examinations. Systematic sampling of the CT examination couch and horizontal surfaces 1 m and 3 m from the couch was perfo...

Prevention of SARS-CoV-2 (COVID-19) transmission in residential aged care using ultravi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446719
BMC Infectious Diseases; Brass A, Shoubridge AP et. al.

Sep 19th, 2021 - SARS-CoV-2 poses a considerable threat to those living in residential aged care facilities (RACF). RACF COVID-19 outbreaks have been characterised by the rapid spread of infection and high rates of severe disease and associated mortality. Despite a growing body of evidence supporting airborne transmission of SARS-CoV-2, current infection control measures in RACF including hand hygiene, social d...

Transmission of SARS-CoV-2 considering shared chairs in outpatient dialysis: a real-wor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444531
BMC Nephrology; Thadhani R, Willetts J et. al.

Sep 18th, 2021 - SARS-CoV-2 can remain transiently viable on surfaces. We examined if use of shared chairs in outpatient hemodialysis associates with a risk for indirect patient-to-patient transmission of SARS-CoV-2. We used data from adults treated at 2,600 hemodialysis facilities in United States between February 1st and June 8th, 2020. We performed a retrospective case-control study matching each SARS-CoV-2 ...