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Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection.
https://doi.org/10.1186/s12916-021-02228-6 10.1038/d41586-021-00055-6 10.1016/S0140-6736(20)30183-5 10.1016/S1473-3099(20)30120-1 10.1001/jama.2020.12603 10.1016/S0140-6736(20)32656-8 10.1001/jamanetworkopen.2020.36142 10.1016/j.jinf.2020.12.022 10.1016/j.jinf.2021.01.004 10.1016/S1473-3099(20)30701-5 10.1136/thoraxjnl-2020-215818 10.1136/thoraxjnl-2020-216086 10.1136/thoraxjnl-2020-216377 10.1016/S1473-3099(15)70152-0 10.1111/j.1440-1843.2010.01720.x 10.1172/JCI140491 10.7554/eLife.64909 10.1038/s41421-020-0168-9 10.1016/j.cell.2021.10.023 10.1038/s41392-020-00457-4 10.1016/j.immuni.2021.05.010 10.2807/1560-7917.ES.2020.25.3.2000045 10.1126/science.abd0826 10.1038/s41591-020-0913-5 10.1093/bioinformatics/btw354 10.1093/bioinformatics/btu170 10.1038/nmeth.3317 10.1093/bioinformatics/btt656 10.1093/bioinformatics/btp616 10.1093/nar/gku864 10.1038/ni.2789 10.1186/1471-2105-14-7 10.1038/s41591-021-01283-z 10.1126/science.abf4063 10.1016/j.cell.2020.09.037 10.1038/s41586-020-2456-9 10.1038/s41423-020-0412-0 10.1182/blood-2011-11-392324 10.1002/eji.201948094 10.1111/imr.12028 10.1172/JCI40202 10.1016/j.chom.2012.09.006 10.1101/cshperspect.a033001 10.1038/s41594-020-0511-8 10.1371/journal.ppat.1002433 10.7554/eLife.49551 10.1136/jclinpath-2020-206933 10.1016/j.bbadis.2009.04.003 10.1038/s41598-020-78551-4 10.1038/srep17794 10.4049/jimmunol.1900940 10.1158/0008-5472.CAN-12-2850 10.1007/s42399-020-00521-8 10.1016/S2352-3026(20)30175-7 10.1111/bjh.16850 10.3109/09537104.2013.815342 10.2174/092986706779026129 10.1038/s41586-021-03553-9 10.1016/j.xcrm.2021.100208 10.1084/jem.20210582 10.1111/all.14647 10.1016/j.celrep.2021.109518 10.1126/sciimmunol.abk1741 10.1038/s41467-021-22034-1 10.1016/j.immuni.2021.01.008 10.1038/s41467-021-21444-5 10.1126/scitranslmed.abf7517 10.1016/j.xcrm.2021.100253 10.1016/j.celrep.2021.108790 10.1016/j.xcrm.2021.100329 10.1038/s41598-021-84840-3 10.1038/s41591-021-01329-2 10.1016/j.celrep.2021.109320 10.1073/pnas.2111315118 10.1126/sciimmunol.aaz9631 10.1126/sciimmunol.aan8664 10.1038/s41467-017-01728-5 10.1038/nm.2425 10.1126/science.1155209 10.1038/s41591-020-0995-0 10.1016/j.cell.2020.08.025 10.1016/j.cels.2020.10.003 10.1186/s13073-020-00823-5 10.1182/blood.2020007214 10.1161/CIRCRESAHA.121.319117 10.1086/518614 10.1038/s41556-021-00681-2 10.1016/j.xcrm.2021.100204 10.1016/j.cell.2020.08.017
BMC Medicine; Ryan FJ, Hope CM et. al.

Jan 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as "long COVID", post-acute sequelae of ...

COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow T...
https://doi.org/10.1038/s41409-021-01561-x 10.1016/S0140-6736(20)30183-5 10.1056/NEJMcp2009249 10.1016/S0140-6736(20)30566-3 10.1056/NEJMoa2002032 10.1001/jama.2020.6775 10.1016/j.chest.2020.04.010 10.1001/jamanetworkopen.2020.5619 10.1038/s41409-020-0919-0 10.1016/j.bbmt.2020.07.021 10.46765/2675-374X.2020v1n1p67-72 10.1017/PHN20062005 10.1016/S1473-3099(20)30198-5 10.1097/00000421-198212000-00014 10.2217/fon-2020-0414 10.1002/lt.25756 10.1016/j.clim.2020.108588 10.1016/S2214-109X(20)30285-0 10.1016/j.htct.2020.08.004 10.1172/JCI141777 10.46765/2675-374X.2020v2n1p63-68
Bone Marrow Transplantation; Daudt LE, Corso MCM et. al.

Jan 15th, 2022 - In the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children...

Efficacy of the use of mefenamic acid combined with standard medical care vs. standard ...
https://doi.org/10.3892/ijmm.2022.5084
International Journal of Molecular Medicine; Guzman-Esquivel J, Galvan-Salazar HR et. al.

Jan 15th, 2022 - Mefenamic acid is a non‑steroidal anti‑inflammatory drug exhibiting a wide range of anti‑inflammatory, antipyretic, analgesic and probable antiviral activities. The present study evaluated the efficacy of treatment with mefenamic acid combined with standard medical care vs. standard medical care plus a placebo in ambulatory patients with coronavirus disease 2019 (COVID‑19; nasal/oropharyngeal s...

DKA and new-onset type 1 diabetes in Brazilian children and adolescents during the COVI...
https://doi.org/10.20945/2359-3997000000433
Archives of Endocrinology and Metabolism; Luciano TM, Halah MP et. al.

Jan 15th, 2022 - We assess the severity and frequency of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus (T1D) patients and in patients with previous diagnosis of T1D in a referral Brazilian university hospital in the first five months of the COVID-19 pandemic. We also compare the data with data from pre-pandemic periods. Forty-three new-onset T1D patients were diagnosed between April and Augu...

Validation of the Brazilian Portuguese version of the Quick Inventory of Depressive Sym...
https://doi.org/10.47626/2237-6089-2021-0381
Trends in Psychiatry and Psychotherapy; Bandinelli L, Schäfer JL et. al.

Jan 15th, 2022 - The aim of this study was to evaluate the psychometric properties of the Quick Inventory of Depressive Symptomatology (QID-SR16), a self-report instrument based on the DSM-IV criteria that assesses the severity of depression symptoms, in the Brazilian population. Participants were 4.400 Brazilians over 15 years old recruited from an online survey assessing depressive symptoms during the early p...

The Prevalence and Predictors of Depressive, Anxiety, and Stress Symptoms Among Tepi To...
https://doi.org/10.1007/s40615-021-01195-1
Journal of Racial and Ethnic Health Disparities; Tareke SA, Lelisho ME et. al.

Jan 15th, 2022 - As a result of the coronavirus disease 2019 (COVID-19) outbreak, many countries have imposed movement restrictions and implemented lockdowns. However, evidence from a variety of nations showed that the COVID-19 outbreak and its associated quarantine measures triggered a wide range of psychological problems, such as anxiety, depression, and stress in the general population. As a result, the purp...

Acupuncture for nasal congestion in COVID-19: A protocol for systematic review and meta...
https://doi.org/10.1097/MD.0000000000028600
Medicine Dong Z, Guo J et. al.

Jan 15th, 2022 - From the end of 2019 to now, coronavirus disease 2019 (COVID-19) has put enormous strain on the world's health systems, causing significant deaths and economic losses worldwide. Nasal congestion, one of the symptoms of COVID-19, poses considerable problems for patients. In China, acupuncture has been widely used to treat nasal congestion caused by COVID-19, but there is still a lack of evidence...

SARS-CoV-2 Gastrointestinal Shedding in Hospitalized Children.
https://doi.org/10.1542/hpeds.2021-006304
Hospital Pediatrics; Tam I, McNamara C et. al.

Jan 15th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that can cause gastrointestinal (GI) symptoms, with studies demonstrating detection of stool viral RNA weeks after respiratory tract clearance. It is unknown if children who test negative for SARS-CoV-2 on a nasopharyngeal (NP) swab may be shedding the virus in their stool. To measure the prevalence of SARS-CoV-...

Coronavirus Disease 2019 (COVID-19)
http://emedicine.medscape.com/article/2500114-overview

Jan 14th, 2022 - Practice Essentials Coronavirus disease 2019 (COVID-19) is defined as illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV), which was first identified amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China. [1] It was initially reported to the WHO on December 31, 2019. On January 30, 2020...

Coronavirus Disease 2019 (COVID-19) Treatment & Management
https://emedicine.medscape.com/article/2500114-treatment

Jan 14th, 2022 - Approach Considerations Utilization of programs established by the FDA to allow clinicians to gain access to investigational therapies during the pandemic has been essential. The expanded access (EA) and emergency use authorization (EUA) programs allowed for rapid deployment of potential therapies for investigation and investigational therapies with emerging evidence. A review by Rizk et al des...

Respiratory tract infections and gut microbiome modifications: A systematic review.
https://doi.org/10.1371/journal.pone.0262057
PloS One; Woodall CA, McGeoch LJ et. al.

Jan 14th, 2022 - Respiratory tract infections (RTIs) are extremely common and can cause gastrointestinal tract symptoms and changes to the gut microbiota, yet these effects are poorly understood. We conducted a systematic review to evaluate the reported evidence of gut microbiome alterations in patients with a RTI compared to healthy controls (PROSPERO: CRD42019138853). We systematically searched Medline, Embas...

Emotion-related impulsivity predicts increased anxiety and depression during the COVID-...
https://doi.org/10.1016/j.jad.2022.01.037
Journal of Affective Disorders; Johnson SL, Porter P et. al.

Jan 14th, 2022 - Emotion-related impulsivity, defined by poor constraint in the face of emotion, is related to internalizing symptoms, cross-sectionally and longitudinally. Internalizing symptoms, though, are profoundly tied to stress reactivity, and little is known about how emotion-related impulsivity relates to stress reactivity. Taking advantage of a sample that had completed measures of depression, anxiety...

Subacute thyroiditis during the COVID-19 pandemic: a prospective study.
https://doi.org/10.1007/s40618-021-01718-x 10.1016/j.cell.2020.02.052 10.1210/endocr/bqaa108 10.1007/s40618-020-01436-w 10.1186/s40249-020-00662-x 10.1007/s12020-021-02807-w 10.1038/s41577-021-00536-9 10.1016/j.autrev.2020.102524 10.2174/1573397116666201029155856 10.1007/s40618-020-01366-7 10.1016/S2666-5247(20)30115-4 10.1016/j.humpath.2006.06.011 10.1007/s40618-021-01554-z 10.1186/1743-422X-6-5 10.1210/clinem/dgaa276 10.1210/clinem/dgaa537 10.1016/j.rce.2021.01.002 10.1007/s40618-020-01312-7 10.1007/s40618-020-01316-3 10.1210/jendso/bvab048.1954 10.1016/j.metop.2021.100136 10.3389/fmed.2021.737142 10.1016/j.amjoto.2021.103211 10.1111/cen.14555 10.3389/fimmu.2020.617089 10.15585/mmwr.mm7029a1 10.1016/S2213-8587(20)30266-7 10.1007/s12020-021-02841-8 10.1210/jendso/bvab130 10.1210/jc.2002-021799 10.1016/S0140-6736(20)30183-5 10.1038/s41467-020-19741-6 10.1093/humupd/dmi008 10.3389/fendo.2021.707726 10.1080/21645515.2015.1117716 10.1016/j.beem.2020.101412 10.1038/s41541-021-00369-6 10.1055/a-1148-2260
Journal of Endocrinological Investigation; Bahçecioğlu AB, Karahan ZC et. al.

Jan 14th, 2022 - Subacute thyroiditis(SAT) is a destructive thyroiditis associated with viral infections. Several SAT cases associated with SARS-CoV-2 infection/vaccination were recently reported. We aimed to evaluate prospectively all cases applied to our tertiary center and their relationship with SARS-CoV-2 during 16 months of the pandemic. Cases during similar pre-pandemic period were recorded for numeric c...

Incidence of SARS-CoV-2 infection among COVID-19 vaccinated and unvaccinated healthcare...
https://doi.org/10.1111/irv.12956
Influenza and Other Respiratory Viruses; Naleway AL, Grant L et. al.

Jan 14th, 2022 - We sought to evaluate the impact of changes in estimates of COVID-19 vaccine effectiveness on the incidence of laboratory-confirmed infection among frontline workers at high risk for SARS-CoV-2. We analyzed data from a prospective frontline worker cohort to estimate the incidence of COVID-19 by month as well as the association of COVID-19 vaccination, occupation, demographics, physical distanci...

Central Retinal Vein Occlusion Following BNT162b2 (Pfizer-BioNTech) COVID-19 Messenger ...
https://doi.org/10.1097/ICB.0000000000001214
Retinal Cases & Brief Reports; Shah PP, Gelnick S et. al.

Jan 14th, 2022 - Coronavirus disease 2019 (COVID-19) has had a wide-ranging public health impact, contributing to at least 5 million deaths globally at the time of this report. Although thromboembolic events following COVID-19 vaccination have been an ongoing concern, only a limited number of ophthalmic manifestations have been reported to date. We obtained a detailed history, hypercoagulable workup, best-corre...

Intrauterine fetal demise in the third trimester of pregnancy associated with mild infe...
https://doi.org/10.1093/infdis/jiac007
The Journal of Infectious Diseases; Guan M, Johannesen E et. al.

Jan 14th, 2022 - SARS-CoV-2 has a higher infection rate in pregnant women than age-matched adults. With increased infectivity and transmissibility, the Delta variant is predominant worldwide. Here, we describe intrauterine fetal demise in an unvaccinated women with mild symptoms of SARS-CoV-2 Delta variant infection. Histology and elevated proinflammatory responses of the placenta suggest that fetal demise was ...

Alterations in 18F-FDG PET/MRI and 15O-Water PET Brain Findings in Patients With Neurol...
https://doi.org/10.1097/RLU.0000000000004041
Clinical Nuclear Medicine; Siripongsatian D, Kunawudhi A et. al.

Jan 14th, 2022 - This study aimed to investigate functional abnormalities in the brain of patients with neurological adverse effects following COVID-19 (coronavirus disease 2019) vaccination using 18F-FDG PET/MRI and 15O-water PET. Eight patients (1 man and 7 women, aged 26-47 years [median age, 36.5 years]) who experienced neurological symptoms after the first COVID-19 vaccination underwent CT, MRI, 18F-FDG PE...

Quarantine-related traumatic stress, views, and experiences during the first wave of Co...
https://doi.org/10.1371/journal.pone.0261967
PloS One; Bin Helayel H, Ahmed A et. al.

Jan 14th, 2022 - Mental health is a significant problem following exposure to a traumatic event. This study aimed to examine quarantine-related experiences, traumatic stress, and coping strategies among adults quarantined in Saudi Arabia due to coronavirus disease 2019 (COVID-19) exposure or travel history. Individuals aged ≥ 18 years who were quarantined in Saudi Arabia due to COVID-19 exposure or travel histo...

Baseline procalcitonin as a predictor of bacterial infection and clinical outcomes in C...
https://doi.org/10.1371/journal.pone.0262342
PloS One; Atallah NJ, Warren HM et. al.

Jan 14th, 2022 - Coronavirus disease-2019 (COVID-19) is associated with a wide spectrum of clinical symptoms including acute respiratory failure. Biomarkers that can predict outcomes in patients with COVID-19 can assist with patient management. The aim of this study is to evaluate whether procalcitonin (PCT) can predict clinical outcome and bacterial superinfection in patients infected with severe acute respira...