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SARS-CoV-2 Infection Rate 16% in Asymptomatic Pregnant Women at Delivery
https://www.medscape.com/viewarticle/931356

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Among women with a planned delivery in a New York City health system during the first half of April, the rate of asymptomatic SARS-CoV-2 infection was 16%, according to a study published in Obstetrics & Gynecology. Among the patients' designated support persons, the asymptomatic carrier rate was...

Whether to Test Laboring Women for Sars-Cov-2 May Hinge on Regional Prevalence
https://www.medscape.com/viewarticle/931357

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Labor & delivery units may need to consider regional prevalence of COVID-19 when deciding whether to test asymptomatic pregnant women for SARS-CoV-2 infection at the time of admission, research published online in Obstetrics & Gynecology suggests. In Los Angeles, researchers stopped universal te...

Features of Enteric Disease from Human Coronaviruses: Implications for COVID-19.
https://doi.org/10.1002/jmv.26066
Journal of Medical Virology; Cimolai N

May 27th, 2020 - Coronaviruses have long been studied in both human and veterinary fields. Whereas the initial detection of endemic human respiratory coronaviruses was problematic, detection of these and newly discovered human coronaviruses has been greatly facilitated with major advances in the laboratory. Nevertheless, technological factors can affect the accuracy and timeliness of virus detection. Many human...

Chloroquine or Hydroxychloroquine for COVID-19: Is Cardiotoxicity a Concern?
https://doi.org/10.1161/JAHA.120.016887
Journal of the American Heart Association; Kamp TJ, Hamdan MH et. al.

May 27th, 2020 - The SARS-Cov-2 viral pandemic causing COVID-19 disease begs for rapid and innovative treatments. In addition to flu-like respiratory symptoms, acute cardiac manifestations include cardiac injury, shock and arrhythmia. Several pharmacological therapies have been suggested including repurposing of existing drugs such as chloroquine and hydroxychloroquine, sometimes co-administered with azithromyc...

Management of Heart Failure Patients with COVID-19. A Joint Position Paper of the Chine...
https://doi.org/10.1002/ejhf.1915
European Journal of Heart Failure; Zhang Y, Stewart Coats AJ et. al.

May 27th, 2020 - The Coronavirus Disease 2019 (COVID-19) pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is causing considerable morbidity and mortality worldwide. Multiple reports have suggested that patients with heart failure (HF) are at a higher risk of severe disease and mortality with COVID-19. Moreover, evaluating and treating HF patients with comorbid COVID-19 represen...

Asymptomatic transmission during the COVID-19 pandemic and implications for public heal...
https://doi.org/10.1093/cid/ciaa654
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Huff HV, Singh A

May 27th, 2020 - SARS-CoV-2 spread rapidly within months despite global public health strategies to curb transmission by testing symptomatic patients and encouraging social distancing. Here, we summarize rapidly emerging evidence highlighting transmission by asymptomatic and pre-symptomatic individuals. Viral load of asymptomatic carriers is comparable to symptomatic patients, viral shedding is highest before s...

COVID-19 Daily: Airborne Transmission, Vaccine Timing Doubt
https://www.medscape.com/viewarticle/931350

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Here are the coronavirus stories Medscape's editors around the globe think you need to know about today:  COVID-19 Is Likely Airborne  Evidence is mounting that the virus that causes COVID-19 is transmitted via aerosol transmission, a researcher at the University of California San Diego reports ...

COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Par...
https://doi.org/10.1186/s13058-020-01293-8
Breast Cancer Research : BCR; Vuagnat P, Frelaut M et. al.

May 27th, 2020 - Cancer patients have been reported to be at higher risk of COVID-19 complications and deaths. We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France). An IRB-approved prospective registry was set up at ICH on March 13, 2020, for all breast cancer patients with COVID-19 symptoms or radiolog...

Assessment of Adequacy of Respiratory Infection Prevention in Hospitals of Inner Mongol...
https://doi.org/10.1080/00325481.2020.1776015
Postgraduate Medicine; Xie Y, McNeil EB et. al.

May 27th, 2020 - Recent respiratory infectious disease (RID) outbreaks of influenza and the novel coronavirus have resulted in global pandemics. RIDs can trigger nosocomial infections if not adequately prevented. The objective of this study was to rate the adequacy of healthcare workers (HCWs) and hospital settings on RID prevention using unannounced standardized patients (USP) in clinical settings of hospital ...

B-cell depleting therapies may affect susceptibility to acute respiratory illness among...
https://doi.org/10.1016/j.msard.2020.102195
Multiple Sclerosis and Related Disorders; Safavi F, Nourbakhsh B et. al.

May 27th, 2020 - To determine whether the course of COVID-19 is more severe in patients with MS and if MS disease-modifying treatments (DMTs) affect the risk of contracting the disease. In a cross-sectional survey, data were collected by sending a questionnaire to 2000 patients with a demyelinating disease through an online portal system. Collected data included the current MS DMT and patient-reported disabilit...

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and ...
https://doi.org/10.1016/j.cyto.2020.155143
Cytokine Noroozi R, Branicki W et. al.

May 27th, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells ...

Estimation of the time-varying reproduction number of COVID-19 outbreak in China.
https://doi.org/10.1016/j.ijheh.2020.113555
International Journal of Hygiene and Environmental Health; You C, Deng Y et. al.

May 27th, 2020 - The 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China has attracted world-wide attention. As of March 31, 2020, a total of 82,631 cases of COVID-19 in China were confirmed by the National Health Commission (NHC) of China. Three approaches, namely Poisson likelihood-based method (ML), exponential growth rate-based method (EGR) and stochastic Susceptible-Infected-Removed dynamic model-ba...

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19...
https://doi.org/10.1159/000508544
Cardiorenal Medicine; Koratala A, Ronco C et. al.

May 27th, 2020 - As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Some present ...

Non-steroidal anti-inflammatory drugs in management of COVID-19; a systematic review on...
https://doi.org/10.1111/ijcp.13557
International Journal of Clinical Practice; Yousefifard M, Zali A et. al.

May 27th, 2020 - Since there is still no definitive conclusion regarding which non-steroidal anti-inflammatory drugs (NSAIDs) are most effective and safe in viral respiratory infections, we decided to evaluate the efficacy and safety of various NSAIDs in viral respiratory infections so that we can reach a conclusion on which NSAID is best choice for COVID-19. A search was performed in Medline (via PubMed), Emba...

Covid-19 in solid organ transplant recipients: A single center experience.
https://doi.org/10.1111/tri.13662
Transplant International : Official Journal of the European Society for Organ Transplantation; Hoek RAS, Manintveld OC et. al.

May 27th, 2020 - Solid organ transplant (SOT) recipients may be at risk for severe COVID-19. Data on the clinical course of COVID-19 in immunosuppressed patients are limited and the effective treatment strategy for these patients is unknown. We describe our institutional experience with COVID-19 in SOT. Demographic, clinical and treatment data were extracted from the electronic patient files. A total of 23 SOT ...

COVID-19 - neurologists stay aware!
https://doi.org/10.1111/ene.14365
European Journal of Neurology; von Oertzen TJ

May 27th, 2020 - In December 2019 an epidemic outbreak of a new virus disease in the Chinese area of Wuhan was reported. The new disease caused primarily symptoms of a respiratory tract infection with cough, shortness of breath, and viral pneumonia. The clinical spectrum showed mostly mild symptoms with some patients developing bilateral pneumonia needing partly intensive care treatment and causing death(1). It...

Digital prosthetic workflow during COVID-19 pandemic to limit infection risk in dental ...
https://doi.org/10.1111/odi.13442
Oral Diseases; Papi P, Di Murro B et. al.

May 27th, 2020 - A novel human coronavirus(SARS-CoV-2) causing a severe acute respiratory syndrome, coronavirus disease 2019 (COVID-19), was reported in Wuhan, China at the end of 2019(Wang, Horby, Hayden, & Gao,2020; Khan, Ali, Siddique, Nabi, 2020).The infectionhas an estimated incubation period of 1-14 days and its clinical manifestations and symptoms include cough, fever and shortness of breath (Zhuet al., ...

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Sy...
https://doi.org/10.7326/M20-2496
Annals of Internal Medicine; Hernandez AV, Roman YM et. al.

May 27th, 2020 - Hydroxychloroquine and chloroquine have antiviral effects in vitro against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19). PubMed (via MEDLINE), EMBASE (via Ovid), Scopus, Web of Science, Cochrane Library, bioRxiv, Preprin...

Prevalence of COVID-19-like symptoms in Italy and Lombardy, March-April 2020, and their...
https://doi.org/10.1097/CEJ.0000000000000604
European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP); Negri E, Scarpino V et. al.

May 27th, 2020 - Two population-based surveys on coronavirus disease-2019 (Covid-19)-like symptoms were conducted by BVA-Doxa on representative samples of the general population from Italy and its largest region, Lombardy, with over 10 million inhabitants and heavily struck by Covid-19, on 27-30 March and 3-7 April, on a total of 2000 individuals - 353 from Lombardy. Overall, 14.2% of Italians - and 19.6% in Lo...

Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (C...
https://doi.org/10.1097/AOG.0000000000003996
Obstetrics and Gynecology; Andrikopoulou M, Madden N et. al.

May 27th, 2020 - To characterize symptoms and disease severity among pregnant women with coronavirus disease 2019 (COVID-19) infection, along with laboratory findings, imaging, and clinical outcomes. Pregnant women with COVID-19 infection were identified at two affiliated hospitals in New York City from March 13 to April 19, 2020, for this case series study. Women were diagnosed with COVID-19 infection based on...