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Rapid incidence estimation from SARS-CoV-2 genomes reveals decreased case detection in ...
https://doi.org/10.1038/s41467-021-26267-y 10.1056/NEJMoa2035389 10.1056/NEJMoa2034577 10.1016/S0140-6736(21)00306-8 10.1126/science.abe9728 10.1016/S2214-109X(20)30467-8 10.1080/21645515.2020.1830683 10.1016/S0140-6736(21)00183-5 10.1038/d41586-021-00396-2 10.1126/science.abb5793 10.1126/science.abd7343 10.1186/s13063-020-04976-x 10.1038/s41579-020-00441-3 10.1038/s41598-021-81333-1 10.2196/19421 10.1016/j.scitotenv.2020.139631 10.1038/s41587-020-0684-z 10.1002/gch2.1018 10.2807/1560-7917.ES.2017.22.13.30494 10.1136/bmjopen-2020-040263 10.1093/molbev/msz081 10.1073/pnas.1207965110 10.1371/journal.pcbi.1003537 10.1093/aje/kwh255 10.1093/molbev/msz106 10.1093/molbev/msaa136 10.1016/S1473-3099(20)30314-5 10.15252/emmm.202013296 10.1093/ve/veab041 10.1093/aje/kwp375 10.1038/hdy.2016.43 10.1093/genetics/98.3.625 10.1098/rstb.2010.0060 10.1371/journal.pcbi.1002947 10.1016/j.meegid.2011.08.005 10.1534/genetics.110.125260 10.1534/genetics.109.106021 10.1097/QAI.0000000000001122 10.1038/s41586-021-03677-y 10.1001/jamanetworkopen.2020.33706 10.7326/M20-3012 10.1093/bioinformatics/bty191 10.1371/journal.pgen.1009175 10.1371/journal.pone.0018204 10.1016/j.cub.2020.06.031 10.1186/1472-6947-12-147 10.1038/s41564-020-0770-5 10.1093/ve/veab064 10.1093/nar/gks1195 10.1093/molbev/mst010 10.1093/sysbio/syy032 10.1093/bioinformatics/bty633 10.1093/nar/gkv1189 10.1093/bioinformatics/bts480
Nature Communications; Smith MR, Trofimova M et. al.

Oct 16th, 2021 - By October 2021, 230 million SARS-CoV-2 diagnoses have been reported. Yet, a considerable proportion of cases remains undetected. Here, we propose GInPipe, a method that rapidly reconstructs SARS-CoV-2 incidence profiles solely from publicly available, time-stamped viral genomes. We validate GInPipe against simulated outbreaks and elaborate phylodynamic analyses. Using available sequence data, ...

Neuropsychological profiles and cerebral glucose metabolism in neurocognitive Long COVI...
https://doi.org/10.2967/jnumed.121.262677
Journal of Nuclear Medicine : Official Publication, Socie... Dressing A, Bormann T et. al.

Oct 16th, 2021 - During the Corona Virus Disease 2019 (COVID-19) pandemic, Long COVID-syndrome, which impairs patients through cognitive deficits, fatigue, and exhaustion, has become increasingly relevant. Its underlying pathophysiology, however, is unknown. In this study, we assessed cognitive profiles and regional cerebral glucose metabolism as a biomarker of neuronal function in outpatients suffering from lo...

Coronavirus (COVID-19) Update: 10/15/21 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-101521

Oct 15th, 2021 - For Immediate Release: October 15, 2021 The U.S. Food and Drug Administration (FDA) continued to take action in the ongoing response to the COVID-19 pandemic: On Oct. 12, the FDA posted information about an assessment of the Emergency Use Authorization (EUA) process that the FDA’s Center for Devices and Radiological Health (CDRH) implemented to help authorize COVID-19 tests during the public he...

OncLive® Honors 14 Cancer Care Pioneers
https://www.onclive.com/view/onclive-honors-14-cancer-care-pioneers

Oct 15th, 2021 - OncLive® is honored to announce the 2021 Giants of the Cancer Care® inductees. The 14 winners are innovators of change whose invaluable contributions to the field have changed the trajectory of care across tumor types and improved the quality of life for countless patients. Breast Cancer Nancy E. Davidson, MD, Fred Hutchinson Cancer Research Center/ University of Washington School of Medici...

Bill Clinton Hospitalized; Califf to Again Lead FDA? Global TB Deaths Rise Again
https://www.medpagetoday.com/infectiousdisease/covid19/95064

Oct 15th, 2021 - Note that some links may require registration or subscription. Former President Bill Clinton was admitted to the ICU at the University of California Irvine Medical Center for a urinary tract infection that developed into sepsis, but is reportedly "on the mend." (CNN) Robert Califf, the FDA commissioner in 2016-2017 under President Obama, is President Biden's top choice to lead the agency, accor...

Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio COVID-1...
https://doi.org/10.1136/bmjopen-2020-048206
BMJ Open; Winkel B, Schram E et. al.

Oct 15th, 2021 - Antigen-based point-of-care tests for identification of SARS-CoV-2 may markedly enhance effectiveness of population-based controlling strategies. Previous studies have demonstrated >70% sensitivity and high specificity compared with reverse transcriptase real-time PCR (RT-PCR) in symptomatic individuals, but test performance for asymptomatic individuals is unknown. Test performance of the Panbi...

Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for...
https://doi.org/10.1136/jclinpath-2021-207776
Journal of Clinical Pathology; Holland D, Heald AH et. al.

Oct 15th, 2021 - The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrogate, across six UK centres. Using routinely collected laboratory data, we estimated the number of missed HbA1c tests for 'diagnostic'/'screening'/'manage...

Preeclampsia-like syndrome in a pregnant patient with Coronavirus Disease 2019 (COVID-19).
https://doi.org/10.1016/j.jogc.2021.09.015
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Naeh A, Berezowsky A et. al.

Oct 15th, 2021 - Hypertension, proteinuria, and hepatic dysfunction have been described as manifestations of coronavirus disease 2019 (COVID-19) and are generally accepted as poor prognostic factors. However, these same findings can also occur in pregnant women with preeclampsia, thus creating a diagnostic challenge. We report a case of COVID-19 infection in an otherwise healthy pregnant patient with secondary ...

Protective Immunity after Natural Infection with Severe Acute Respiratory Syndrome Coro...
https://doi.org/10.1016/j.ijid.2021.10.010
International Journal of Infectious Diseases : IJID : Off... Spicer KB, Glick C et. al.

Oct 15th, 2021 - As vaccine supply and access remain limited in many parts of the world, understanding the duration of protection from reinfection after natural infection is important. Distinct individuals testing positive and negative for SARS-CoV-2 between March 6, 2020, and August 31, 2020, in Kentucky, USA, were identified using the Kentucky National Electronic Disease Surveillance System. Individuals were ...

The association between early country-level COVID-19 testing capacity and later COVID-1...
https://doi.org/10.1111/irv.12906
Influenza and Other Respiratory Viruses; Kannoth S, Kandula S et. al.

Oct 15th, 2021 - The COVID-19 pandemic has overrun hospital systems while exacerbating economic hardship and food insecurity on a global scale. In an effort to understand how early action to find and control the virus is associated with cumulative outcomes, we explored how country-level testing capacity affects later COVID-19 mortality. We used the Our World in Data database to explore testing and mortality rec...

Prediction of in-hospital mortality with machine learning for COVID-19 patients treated...
https://doi.org/10.1002/jmv.27393
Journal of Medical Virology; Kuno T, Sahashi Y et. al.

Oct 15th, 2021 - We aimed to create the prediction model of in-hospital mortality using machine learning methods for patients with COVID-19 treated with steroid and remdesivir. We reviewed 1,571 hospitalized patients with laboratory confirmed COVID-19 from the Mount Sinai Health System treated with both steroid and remdesivir. The important variables associated with in-hospital mortality were identified using L...

Building Capacity of Community Health Centers to Overcome Data Challenges with the Deve...
https://doi.org/10.1093/jamia/ocab233
Journal of the American Medical Informatics Association :... Romero L, Carneiro PB et. al.

Oct 15th, 2021 - During the COVID-19 pandemic, federally qualified health centers rapidly mobilized to provide SARS-CoV-2 testing, COVID-19 care, and vaccination to populations at increased risk for COVID-19 morbidity and mortality. We describe the development of a reusable public health data analytics system for reuse of clinical data to evaluate the health burden, disparities, and impact of COVID-19 on popula...

Availability and use of fetal fibronectin testing and transvaginal ultrasound for prete...
https://doi.org/10.1080/14767058.2021.1989403
The Journal of Maternal-fetal & Neonatal Medicine : the O... Ruma MS, Banker WM

Oct 15th, 2021 - Measure availability and use of fetal fibronectin (fFN) testing and transvaginal ultrasound to measure cervical length (TVCL) for symptomatic preterm labor (PTL) patients. Additionally, assess the presence and impact of PTL triage protocols. Cross-sectional online survey among clinicians from 255 unique hospitals regarding prior 12-month practices (pre-COVID-19). fFN testing was always availabl...

Prediction of viral symptoms using wearable technology and artificial intelligence: A p...
https://doi.org/10.1371/journal.pone.0257997
PloS One; D'Haese PF, Finomore V et. al.

Oct 15th, 2021 - Conventional testing and diagnostic methods for infections like SARS-CoV-2 have limitations for population health management and public policy. We hypothesize that daily changes in autonomic activity, measured through off-the-shelf technologies together with app-based cognitive assessments, may be used to forecast the onset of symptoms consistent with a viral illness. We describe our strategy u...

Clinical and epidemiological characteristics of patients seeking COVID-19 testing in a ...
https://doi.org/10.1371/journal.pone.0258671
PloS One; Chow YP, Chin BHZ et. al.

Oct 15th, 2021 - This cross-sectional observational study summarized the baseline characteristics of subjects who underwent COVID-19 molecular testing in a private medical centre located in the state of Selangor in Malaysia between 1 Oct 2020 and 31 Jan 2021. We compared the baseline characteristics between subjects who were tested positive and negative of SARS-CoV-2 infection, and identified risk factors which...

Detection of SARS-CoV-2 infection in asymptomatic populations using the DiaSorin molecu...
https://doi.org/10.1016/j.diagmicrobio.2021.115513
Diagnostic Microbiology and Infectious Disease; Antonara S, Ozbolt P et. al.

Oct 15th, 2021 - Identification of asymptomatic patients is necessary to control the COVID-19 pandemic and testing is one of the measures to detect this population. We evaluated the clinical correlation of the DiaSorin Molecular Simplexa COVID-19 Direct (DiaSorin Molecular) and Roche Cobas 6800 SARS-CoV-2 (Roche) assays using 253 oropharyngeal (OP) swab specimens collected from asymptomatic patients. Agreement ...

Sociodemographic and clinical features predictive of SARS-CoV-2 test positivity across ...
https://doi.org/10.1371/journal.pone.0258339
PloS One; Phuong J, Hyland SL et. al.

Oct 15th, 2021 - Despite increased testing efforts and the deployment of vaccines, COVID-19 cases and death toll continue to rise at record rates. Health systems routinely collect clinical and non-clinical information in electronic health records (EHR), yet little is known about how the minimal or intermediate spectra of EHR data can be leveraged to characterize patient SARS-CoV-2 pretest probability in support...

Experience from five Asia-Pacific countries during the first wave of the COVID-19 pande...
https://doi.org/10.1016/j.tmaid.2021.102171
Travel Medicine and Infectious Disease; El Guerche-Séblain C, Chakir L et. al.

Oct 15th, 2021 - With no vaccines or specific treatments, non-pharmaceutical interventions are the only tools for controlling the human-to-human transmission of the COVID-19 disease, which appeared in Wuhan, China last December and has spread globally since. Here we describe and compare the first-wave mitigation strategies and epidemiology of five Asia-Pacific countries that responded rapidly to the epidemic. F...

Polyethylene glycol and polysorbate testing in twelve patients prior to or after COVID-...
https://doi.org/10.1016/j.anai.2021.10.009
Annals of Allergy, Asthma & Immunology : Official Publica... Carpenter T, Konig J et. al.

Oct 15th, 2021 - Polyethylene glycol and polysorbate testing in twelve patients prior to or after COVID-19 vaccine administration.|2021|Carpenter T,Konig J,Hochfelder J,Siegel S,Gans M,|

Timing of venous thromboembolism diagnosis in hospitalized and non-hospitalized patient...
https://doi.org/10.1016/j.thromres.2021.09.021
Thrombosis Research; Pasha AK, McBane RD et. al.

Oct 15th, 2021 - The reported incidence of venous thromboembolism (VTE) in COVID-19 patients varies widely depending on patient populations sampled and has been predominately studied in hospitalized patients. The goal of this study was to assess the evolving burden of COVID-19 and the timing of associated VTE events in a systems-wide cohort. COVID-19 PCR positive hospitalized and non-hospitalized patients ≥18 y...