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SARS-CoV-2 Infection Rate 16% in Asymptomatic Pregnant Women at Delivery
https://www.medscape.com/viewarticle/931356

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Among women with a planned delivery in a New York City health system during the first half of April, the rate of asymptomatic SARS-CoV-2 infection was 16%, according to a study published in Obstetrics & Gynecology. Among the patients' designated support persons, the asymptomatic carrier rate was...

Whether to Test Laboring Women for Sars-Cov-2 May Hinge on Regional Prevalence
https://www.medscape.com/viewarticle/931357

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Labor & delivery units may need to consider regional prevalence of COVID-19 when deciding whether to test asymptomatic pregnant women for SARS-CoV-2 infection at the time of admission, research published online in Obstetrics & Gynecology suggests. In Los Angeles, researchers stopped universal te...

Coronavirus (COVID-19) Update: Daily Roundup May 28, 2020 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-28-2020

May 28th, 2020 - For Immediate Release: May 28, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: The FDA issued an Emergency Use Authorization for the Stryker Sustainability Solutions (SSS) VHP N95 Respirator Decontamination System (RDS). This product uses vapor hydrogen peroxide (VHP) to decontaminate compatible N95 ...

Any unique image biomarkers associated with COVID-19?
https://doi.org/10.1007/s00330-020-06956-w
European Radiology; Pu J, Leader J et. al.

May 27th, 2020 - To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. We retrospectively collected chest CT exams including n = 498 on 151 unique patients RT-PCR positive for COVID-19 and n = 497 unique patients with community-acquired pneumonia (CAP). Both COVID-19 and CAP image sets were partitioned into three groups for ...

Guidance for Resumption of Routine Electrodiagnostic Testing during the COVID-19 Pandemic.
https://doi.org/10.1002/mus.26990
Muscle & Nerve; Desai U, Kassardjian CD et. al.

May 27th, 2020 - As the world accommodates to the COVID-19 pandemic, routine in-person medical services are resuming. The resumption of non-urgent electrodiagnostic (EDX) testing faces unique challenges due to the long duration of the procedure and direct close contact with patients, including studies with risk of exposure to oropharyngeal secretions. We provide consensus guidance for resumption of EDX testing,...

The Diagnosis of SARS-CoV2 Pneumonia: A Review of Laboratory and Radiological Testing R...
https://doi.org/10.1002/jmv.26081
Journal of Medical Virology; Zheng Z, Yao Z et. al.

May 27th, 2020 - The rapid emergence of COVID-19 (coronavirus disease 2019) has necessitated the implementation of diverse pandemic control strategies throughout the world. In order to effectively control the spread of this disease, it is essential that it be diagnosed at an early stage so that patients can be reliably quarantined such that disease spread will be slowed. At present, the diagnosis of this infect...

Asymptomatic transmission during the COVID-19 pandemic and implications for public heal...
https://doi.org/10.1093/cid/ciaa654
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Huff HV, Singh A

May 27th, 2020 - SARS-CoV-2 spread rapidly within months despite global public health strategies to curb transmission by testing symptomatic patients and encouraging social distancing. Here, we summarize rapidly emerging evidence highlighting transmission by asymptomatic and pre-symptomatic individuals. Viral load of asymptomatic carriers is comparable to symptomatic patients, viral shedding is highest before s...

USMLE Step 2 CS Suspended for at Least 1 More Year
https://www.medscape.com/viewarticle/931259

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Sponsors of the US Medical Licensing Exam (USMLE) announced on Tuesday that they will continue to suspend administering Step 2 Clinical Skills (CS) for the next 12 to 18 months in light of the COVID-19 pandemic. "Due to the complexity of technical and psychometric work required, we have determin...

Reconstructing a Knee One Day, Working on COVID-19 the Next
https://www.medscape.com/viewarticle/931265

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. When New York Governor Andrew Cuomo called for licensed healthcare workers to help hospitals overwhelmed with COVID-19 patients, orthopedic surgeon Haydée Brown, MD, answered his appeal. Brown volunteered, as part of the New York City Medical Reserve Corps, at Lincoln Hospital, which is located ...

COVID-19 Test & Trace Goes Live
https://www.medscape.com/viewarticle/931290

May 27th, 2020 - A programme to test new COVID-19 cases and trace their contacts began today in England. Prime Minister Boris Johnson predicted that it would "change people's lives". NHS Test and Trace would form a central part of the Government's coronavirus recovery strategy and "help return life more to normal", the Government said. However, the service went live without a contact tracing app, which had been...

Seek Safe Strategies to Diagnose Gestational Diabetes During Pandemic
https://www.medscape.com/viewarticle/931287

May 27th, 2020 - Clinicians and pregnant women are less likely to prescribe and undergo the oral glucose tolerance test (OGTT) to diagnose gestational diabetes in the context of the COVID-19 pandemic, according to a review by H. David McIntyre, MD, of the University of Queensland, Brisbane, Australia, and Robert G. Moses, MD, of Wollongong (Australia) Hospital. National and international discussions of whether ...

Complete Fibrinolysis Shutdown Seen in Severe COVID-19
https://www.medscape.com/viewarticle/931316

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. COVID-19 causes not only hypercoagulability, but also "fibrinolysis shutdown," which is associated with venous thromboembolism (VTE), stroke, and renal failure, clinicians from Colorado have observed. They have found that the complete lack of clot lysis at 30 minutes on a thromboelastogram (TEG)...

COVID-19 Data Dives: Why Don't We Have a Vaccine for SARS or MERS?
https://www.medscape.com/viewarticle/931226

May 27th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Medscape has asked top experts to weigh in on the most pressing scientific questions about COVID-19. Check back frequently for more COVID-19 Data Dives. Natalie E. Dean, PhD It is easy to point to the fact that we don't have licensed vaccines for severe acute respiratory syndrome (SARS), Middle East respirator...

Targeted Tx Improves Outcomes in High-Risk Pediatric Cancers
https://www.medscape.com/viewarticle/931326

May 27th, 2020 - Unlike adult cancers, in which targeted therapies have improved outcomes for some patients, the same has not been true for pediatric cancers. Pediatric oncology is really lagging behind, said Cornelis van Tilburg, MD, PhD, from the Hopp Children's Cancer Center, Heidelberg, Germany. But new data suggest that children can also benefit from this approach. Results from the INFORM (Individualized T...

COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Par...
https://doi.org/10.1186/s13058-020-01293-8
Breast Cancer Research : BCR; Vuagnat P, Frelaut M et. al.

May 27th, 2020 - Cancer patients have been reported to be at higher risk of COVID-19 complications and deaths. We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France). An IRB-approved prospective registry was set up at ICH on March 13, 2020, for all breast cancer patients with COVID-19 symptoms or radiolog...

Clinical evaluation of AusDiagnostics SARS-CoV-2 multiplex tandem PCR assay.
https://doi.org/10.1016/j.jcv.2020.104448
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology; Attwood LO, Francis MJ et. al.

May 27th, 2020 - In the context of the pandemic, the rapid emergency use authorisation of diagnostic assays for SARS-CoV-2 has meant there are few peer-reviewed published studies of clinical performance of commercial assays. To evaluate the clinical performance of AusDiagnostics respiratory multiplex tandem PCR assay including SARS-CoV-2. We reviewed the results following implementation of AusDiagnostics respir...

Clinical Evaluation and Utilization of Multiple Molecular In Vitro Diagnostic Assays fo...
https://doi.org/10.1093/ajcp/aqaa097
American Journal of Clinical Pathology; Cradic K, Lockhart M et. al.

May 27th, 2020 - To evaluate the clinical performance of 3 molecular assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used 184 nasopharyngeal swab specimens to compare Abbott ID NOW COVID-19 (Abbott ID NOW), DiaSorin Molecular Simplexa COVID-19 Direct (DiaSorin Simplexa), and Roche cobas 6800 SARS-CoV-2 (Roche cobas) assays. In a separate analysis, 3 specimens (nasopharyngeal, orophar...

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Sy...
https://doi.org/10.7326/M20-2496
Annals of Internal Medicine; Hernandez AV, Roman YM et. al.

May 27th, 2020 - Hydroxychloroquine and chloroquine have antiviral effects in vitro against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19). PubMed (via MEDLINE), EMBASE (via Ovid), Scopus, Web of Science, Cochrane Library, bioRxiv, Preprin...

Symptoms and Critical Illness Among Obstetric Patients With Coronavirus Disease 2019 (C...
https://doi.org/10.1097/AOG.0000000000003996
Obstetrics and Gynecology; Andrikopoulou M, Madden N et. al.

May 27th, 2020 - To characterize symptoms and disease severity among pregnant women with coronavirus disease 2019 (COVID-19) infection, along with laboratory findings, imaging, and clinical outcomes. Pregnant women with COVID-19 infection were identified at two affiliated hospitals in New York City from March 13 to April 19, 2020, for this case series study. Women were diagnosed with COVID-19 infection based on...

Severe Disease Not Uncommon in Kids Hospitalized With COVID-19
https://www.medscape.com/viewarticle/931167

May 26th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Children with COVID-19 are more likely to develop severe illness and require intensive care than previously realized, data from a single-center study suggest. Jerry Y. Chao, MD, from the Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York City, ...