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Hemoadsorption cartridge and coronavirus disease 2019 infections: A case report and bri...
https://doi.org/10.1111/aor.13846
Artificial Organs; Melegari G, Bertellini E et. al.

Oct 21st, 2020 - The cytokine storm has been frequently reported to occur in patients with severe coronavirus disease 2019 (COVID-19). Data from the literature suggest that elevated levels of inflammatory mediators, such as interleukin (IL)-6, IL-8, and tumor necrosis factor, indicate a severe course or the fatality of the disease. Several therapeutic options have been employed to treat critically ill patients,...

Angiotensin enzyme inhibitors and angiotensin receptor blockers as protective factors i...
https://doi.org/10.1007/s11739-020-02523-9
Internal and Emergency Medicine; Yahyavi A, Hemmati N et. al.

Oct 21st, 2020 - Targeting the renin-angiotensin system is proposed to affect mortality due to coronavirus disease 2019 (COVID-19). We aimed to compare the mortality rates in COVID-19 patients who received angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs) and those who did not. In this retrospective cohort study, mortality was considered as the main outcome measure. All unde...

COVID-19-Associated Coagulopathy and Inflammatory Response: What Do We Know Already and...
https://doi.org/10.1213/ANE.0000000000005147
Anesthesia and Analgesia; Görlinger K, Dirkmann D et. al.

Oct 20th, 2020 - Patients with coronavirus disease 2019 (COVID-19) frequently experience a coagulopathy associated with a high incidence of thrombotic events leading to poor outcomes. Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6), and immunity (such as lymphocyte count) as well as clinical scoring systems (such as sequential organ failure ass...

Primary Palliative Care for Patients with Advanced Hematologic Malignancies: A Pilot Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543863
Journal of Palliative Medicine; Resick JM, Sefcik C et. al.

Oct 19th, 2020 - As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. Among options for accelerated development is the evaluation of drug combinations in the absence of prior monotherapy data. This approach is appealing for a number of reasons. First, combining two or more...

Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic.
https://doi.org/10.1080/21645515.2020.1824497
Human Vaccines & Immunotherapeutics; Siddique R, Bai Q et. al.

Oct 16th, 2020 - A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), while the disease was named COVID-19 (Coronavirus Diseas...

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves v...
https://doi.org/10.1038/s41564-020-00802-x
Nature Microbiology; Yuan S, Wang R et. al.

Oct 8th, 2020 - SARS-CoV-2 is causing a pandemic of COVID-19, with high infectivity and significant mortality1. Currently, therapeutic options for COVID-19 are limited. Historically, metal compounds have found use as antimicrobial agents, but their antiviral activities have rarely been explored. Here, we test a set of metallodrugs and related compounds, and identify ranitidine bismuth citrate, a commonly used ...

Therapeutic Options for Treatment of COVID-19: A Review from Repur-posed Drugs to New D...
https://doi.org/10.2174/1389450121999201006193329
Current Drug Targets; Akhtar B, Muhammad F et. al.

Oct 7th, 2020 - A new virus pandemic, COVID-19, has instigated substantial damage to human wellness in terms of death and ailment, economic compromises along with restriction of daily routine life. There is a profound increase in the number of victims and causalities day by day. Thus far, there is no available treatment and vaccination for COVID-19. Under the rapid pace of clinical research work, scientists ha...

COVID-19: Between Past and Present.
https://doi.org/10.1089/vim.2020.0102
Viral Immunology; Assaf AM, Haddadin RN et. al.

Oct 5th, 2020 - Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This article attempts to provide a timely and comprehensive review of the coronavi...

The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513802
Virology Seyed Hosseini E, Riahi Kashani N et. al.

Oct 3rd, 2020 - Novel coronavirus SARS-CoV-2, designated as COVID-19 by the World Health Organization (WHO) on the February 11, 2020, is one of the highly pathogenic β-coronaviruses which infects human. Early diagnosis of COVID-19 is the most critical step to treat infection. The diagnostic tools are generally molecular methods, serology and viral culture. Recently CRISPR-based method has been investigated to ...

Repurposing existing drugs for COVID-19: an endocrinology perspective.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523486
BMC Endocrine Disorders; Cadegiani FA

Sep 30th, 2020 - Coronavirus Disease 2019 (COVID-19) is a multi-systemic infection caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that has become a pandemic. Although its prevailing symptoms include anosmia, ageusia, dry couch, fever, shortness of brief, arthralgia, myalgia, and fatigue, regional and methodological assessments vary, leading to heterogeneous clinical descriptio...

Nicotine' actions on energy balance: Friend or foe?
https://doi.org/10.1016/j.pharmthera.2020.107693
Pharmacology & Therapeutics; Seoane-Collazo P, Diéguez C et. al.

Sep 28th, 2020 - Obesity has reached pandemic proportions and is associated with severe comorbidities, such as type 2 diabetes mellitus, hepatic and cardiovascular diseases, and certain cancer types. However, the therapeutic options to treat obesity are limited. Extensive epidemiological studies have shown a strong relationship between smoking and body weight, with non-smokers weighing more than smokers at any ...

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional...
https://doi.org/10.1080/22221751.2020.1829082
Emerging Microbes & Infections; Schloer S, Brunotte L et. al.

Sep 25th, 2020 - The Coronavirus Disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Related Coronavirus 2 (SARS-CoV-2) is a global health emergency. As only very limited therapeutic options are clinically available, there is an urgent need for the rapid development of safe, effective, and globally available pharmaceuticals that inhibit SARS-CoV-2 entry and ameliorate COVID-19 sever...

Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform fo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537153
Stem Cells Translational Medicine; Esmail S, Danter WR

Sep 22nd, 2020 - Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we were not prepared. Several clinical trials using previously approved drugs and drug combinations are urgently underway to improve our current situation. Unfortunately, a vaccine option is optimistically at least a year away. It is imperative that for future viral pandemic preparedness, we have a rapid screenin...

Kawasaki-like disease in children with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492688
Rheumatology International; Akca UK, Kesici S et. al.

Sep 16th, 2020 - Children with Coronavirus disease 2019 (COVID-19) are being reported to have manifestations of hyperinflammatory states and/or Kawasaki-like disease. In this study, we investigated children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19. We have reported four children with Kawasaki-like disease probably associated with COVID-19. The clinical features were ...

Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfuncti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488591
The Journal of Allergy and Clinical Immunology; Sims JT, Krishnan V et. al.

Sep 13th, 2020 - Physicians treating patients with coronavirus disease 2019 (COVID-19) increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm. The circulating biomarkers seen across the spectrum of COVID-19 have not been characterized compared with healthy controls, but such analyses are likely to yield insights into the pursuit of interventions that adequately reduc...

Potential statin drug interactions in elderly patients: a review.
https://doi.org/10.1080/17425255.2020.1822324
Expert Opinion on Drug Metabolism & Toxicology; Damiani I, Corsini A et. al.

Sep 10th, 2020 - Persons aged more than 65 years may be more prone to suffer from chronic diseases and comorbidities (as demonstrated by the recent COVID-19 pandemics) and are treated with multiple concomitant medications. This may result in drug-drug interactions (DDIs) that are often overlooked in clinical practice. Elderly patients are more affected by comorbidities increasing the risk of DDIs and adverse dr...

The efficacy of colchicine in the management of coronavirus disease 2019: A protocol fo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478773
Medicine Elshafei MN, Khalil A et. al.

Sep 9th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infection is a recently emerged viral infection causing predominantly mild upper respiratory symptoms. However, in some instances, it might result in acute respiratory distress syndrome (ARDS) that poses a significant mortality risk. ARDS is postulated to be mediated by a surge of pro-inflammatory cytokines and chemokines, leading to a...

The potential similarities of COVID-19 and autoimmune disease pathogenesis and therapeu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471540
Clinical Rheumatology; Najafi S, Rajaei E et. al.

Sep 4th, 2020 - Cytokine pathways and their signaling disorders can be the cause of onset and pathogenesis of many diseases such as autoimmune diseases and COVID-19 infection. Autoimmune patients may be at higher risk of developing infection due to the impaired immune responses, the use of immunosuppressive drugs, and damage to various organs. Increased secretion of inflammatory cytokines and intolerance of th...

Convalescent plasma therapy for coronavirus infection: experience from MERS and applica...
https://doi.org/10.1080/21645515.2020.1793712
Human Vaccines & Immunotherapeutics; Al-Tawfiq JA, Arabi Y

Sep 3rd, 2020 - The emergence of the COVID-19 pandemic has resulted in a very large number of infections and high number of mortality. There is no specific therapeutic options that are approved for clinical use. Administration of convalescent plasma as a possible therapy was used in the case of viral pneumonia including SARS and influenza. There have been multiple studies of COVID-19 patients utilizing convale...

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464065
Annals of Clinical Microbiology and Antimicrobials; Rabaan AA, Al-Ahmed SH et. al.

Sep 3rd, 2020 - A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 210 countries while affecting more than 25 million people and causing more than 843,000 human deaths, i...