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UNRAVELING THE THREAD OF UNCONTROLLED IMMUNE RESPONSE IN COVID-19 AND STEMI: AN EMERGIN...
https://doi.org/10.1152/ajpheart.00934.2020
American Journal of Physiology. Heart and Circulatory Phy... Rios-Navarro C, de Dios E et. al.

Apr 12th, 2021 - The outbreak of severe acute respiratory syndrome coronavirus 2 that first emerged in Wuhan in December 2019 has resulted in the devastating pandemic of coronavirus disease 2019, creating an emerging need for knowledge sharing. Meanwhile, myocardial infarction is and will probably remain the foremost cause of death in the western world throughout the coming decades. Severe deregulation of the i...

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxeti...
https://doi.org/10.1111/bph.15418
British Journal of Pharmacology; Schloer S, Brunotte L et. al.

Apr 7th, 2021 - The SARS-COV-2 pandemic and the global spread of coronavirus disease 2019 (COVID-19) urgently call for efficient and safe antiviral treatment strategies. A straightforward approach to speed up drug development at lower costs is drug repurposing. Here, we investigated the therapeutic potential of targeting the interface of SARS CoV-2 with the host via repurposing of clinically licensed drugs and...

A reduction of the number of assays and turnaround time by optimizing polymerase chain ...
https://doi.org/10.1002/jmv.26972
Journal of Medical Virology; Perivolaropoulos C, Vlacha V

Mar 30th, 2021 - Early detection of the severe acute respiratory syndrome coronavirus 2 infection can decrease the spread of the disease and provide therapeutic options promptly in affected individuals. However, the diagnosis by reverse-transcription polymerase chain reaction is costly and time-consuming. Several methods of group testing have been developed to overcome this problem. The proposed strategy offers...

Strategies for the Delay of Surgery in the Management of Resectable Hepatobiliary Malig...
https://doi.org/10.3747/co.27.6785
Current Oncology (Toronto, Ont.); Bennett S, Søreide K et. al.

Mar 11th, 2021 - Objective: We aimed to review data about delaying strategies for the management of hepatobiliary cancers requiring surgery during the covid-19 pandemic. Background: Given the covid-19 pandemic, many jurisdictions, to spare resources, have limited access to operating rooms for elective surgical activity, including cancer, thus forcing deferral or cancellation of cancer surgeries. Surgery for hep...

Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929896
European Journal of Clinical Pharmacology; von Hentig N

Mar 4th, 2021 - SARS-CoV-2 is a single-stranded RNA virus which is part of the ß-coronavirus family (like SARS 2002 and MERS 2012). The high prevalence of hospitalization and mortality, in addition to the lack of vaccines and therapeutics, forces scientists and clinicians around the world to evaluate new therapeutic options. One strategy is the repositioning of already known drugs, which were approved drugs fo...

Experience in Nutrition Management of Diabetes-Affected COVID-19 Patients.
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Advances in Experimental Medicine and Biology; Abiri B, Guest PC et. al.

Mar 3rd, 2021 - When diabetic patients are ill, their bodies react by releasing hormones to combat the illness. These hormones can be triggered by some states, such as infections. Some illnesses that most likely have an influence on blood glucose levels include common cold or flu, COVID-19, bronchitis, or chest infections. So, it is important for diabetic patients affected by COVID-19 to eat a healthy balanced...

Emerging Technologies for the Treatment of COVID-19.
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Advances in Experimental Medicine and Biology; Aghamollaei H, Sarvestani R et. al.

Mar 3rd, 2021 - The new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), turned into a pandemic affecting more than 200 countries. Due to the high rate of transmission and mortality, finding specific and effective treatment options for this infection is currently of urgent importance. Emerging technologies have created a promising platform for developing novel treatment options ...

COVID-19: Immunology, Immunopathogenesis and Potential Therapies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919479
International Reviews of Immunology; Bhardwaj A, Sapra L et. al.

Mar 1st, 2021 - The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and affected millions of people around the globe. As of January 2021, 100 million confirmed cases of COVID-19 along with more than 2 million deaths were reported worldwide. SARS-CoV-2 infection causes excessive production of pro-inflammatory cytokines thereby leading to the development of "Cytokine Storm Syndrome." This con...

Sex-based differences in severity and mortality in COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014761
Reviews in Medical Virology; Alwani M, Yassin A et. al.

Mar 1st, 2021 - The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differen...

Zinc deficiency as a possible risk factor for increased susceptibility and severe progr...
https://doi.org/10.1017/S0007114521000738
The British Journal of Nutrition; Wessels I, Rolles B et. al.

Mar 1st, 2021 - The importance of Zn for human health becomes obvious during Zn deficiency. Even mild insufficiencies of Zn cause alterations in haematopoiesis and immune functions, resulting in a proinflammatory phenotype and a disturbed redox metabolism. Although immune system malfunction has the most obvious effect, the functions of several tissue cell types are disturbed if Zn supply is limiting. Adhesion ...

Two patients with rituximab associated low gammaglobulin levels and relapsed covid-19 i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894088
Transfusion and Apheresis Science : Official Journal of T... Ormazabal Vélez I, Induráin Bermejo J et. al.

Feb 27th, 2021 - Patients with haematological malignancies are considered to be a risk group for developing severe Coronavirus disease (Covid-19). Because of the limitations of therapeutic options, the development of new treatment strategies is mandatory, such as convalescent plasma (CP). Herein we report the use of CP therapy as an off-label indication in two lymphoma patients with relapsed COVID-19 in the set...

Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with ...
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Journal of Virology; Yang F, Pang B et. al.

Feb 25th, 2021 - Influenza A viruses (IAVs) continue to pose an imminent threat to humans due to annual influenza epidemic outbreaks and episodic pandemics with high mortality rates. In this context, the suboptimal vaccine coverage and efficacy, coupled with recurrent events of viral resistance against a very limited antiviral portfolio, emphasize an urgent need for new additional prophylactic and therapeutic o...

T Helper 17 Response to Severe Acute Respiratory Syndrome Coronavirus 2: A Type of Immu...
https://doi.org/10.1089/vim.2020.0177
Viral Immunology; Sarmiento-Monroy JC, Parra-Medina R et. al.

Feb 24th, 2021 - The initial immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) includes an interferon-dependent antiviral response. A late and uncontrolled inflammatory response characterized by high activity of proinflammatory cytokines and the recruitment of neutrophils and macrophages develops in predisposed individuals and is potentially harmful in some cases. Interleukin (IL)-...

Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with...
https://doi.org/10.21037/apm-20-2134
Annals of Palliative Medicine; Li J, Rong L et. al.

Feb 22nd, 2021 - Biomarkers to prognosticate the outcomes and guide the treatment of patients with severe coronavirus disease 2019 (COVID-19) are currently required. We aimed to investigate whether the dynamic variation of cytokines was associated with the survival of patients admitted to the intensive care unit (ICU). A retrospective study was performed on 40 patients with COVID-19 admitted to the ICU in Wuhan...

Guidelines Have a Key Role in Driving HCV Elimination by Advocating for Simple HCV Care...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884205
Advances in Therapy; Mangia A, Albanese AP et. al.

Feb 16th, 2021 - The availability of pangenotypic direct-acting antivirals for treatment of hepatitis C (HCV) has provided an opportunity to simplify patient pathways. Recent clinical practice guidelines have recognised the need for simplification to ensure that elimination of HCV as a public health concern remains a priority. Despite the move towards simplified treatment algorithms, there remains some complexi...

Efficacy and safety of convalescent plasma therapy in severe COVID-19 patients with acu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709614
International Immunopharmacology; Allahyari A, Seddigh-Shamsi M et. al.

Feb 14th, 2021 - Since SARS-CoV-2 infection is rapidly spreading all around the world, affecting many people and exhausting health care resources, therapeutic options must be quickly investigated in order to develop a safe and effective treatment. The present study was designed to evaluate the safety and efficacy of convalescent plasma (CP) for treating severe cases of COVID-19 who developed acute respiratory d...

Potential drug targets of SARS-CoV-2: From genomics to therapeutics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871800
International Journal of Biological Macromolecules; Shamsi A, Mohammad T et. al.

Feb 12th, 2021 - The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from China has become a global threat due to the continuous rise in cases of Coronavirus disease 2019 (COVID-19). The problem with COVID-19 therapeutics is due to complexity of the mechanism of the pathogenesis of this virus. In this review, an extensive analysis of genome architecture and mode of pathogenesis of SARS...

SARS-CoV-2: An Update on Genomics, Risk Assessment, Potential Therapeutics and Vaccine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915969
International Journal of Environmental Research and Publi... Mehmood I, Ijaz M et. al.

Feb 11th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great threat to public health, being a causative pathogen of a deadly coronavirus disease (COVID-19). It has spread to more than 200 countries and infected millions of individuals globally. Although SARS-CoV-2 has structural/genomic similarities with the previously reported SARS-CoV and MERS-CoV, the specific mutations in its gen...

COVID Virus–Specific T Cells: Potential Treatment of Severe COVID-19 Infection Under Study
https://ascopost.com/issues/february-10-2021/covid-virus-specific-t-cells-potential-treatment-of-severe-covid-19-infection-under-study/

Feb 9th, 2021 - It may be possible to exploit T cells from healthy volunteers who have recovered from COVID-19 as a treatment for this viral infection. Researchers at the Center for Cell and Gene Therapy at Baylor College of Medicine have designed an off-the-shelf COVID virus–specific T-cell product (called ALVR109) and are now testing it in the clinical setting, according to a presentation at the 2020 America...

Genetic variants are identified to increase risk of COVID-19 related mortality from UK ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856608
Human Genomics; Hu J, Li C et. al.

Feb 4th, 2021 - The severity of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies have reported that males and some ethnic groups are at increased risk of death from COVID-19, which implies that individual risk of death might be influenced by host genetic factors. In this project, we consider the mortality as the trai...