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Structural biology of SARS-CoV-2 and implications for therapeutic development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447893
Nature Reviews. Microbiology; Yang H, Rao Z

Sep 19th, 2021 - The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach for treating COVID-19. Belonging to the subfamily Orthocoronavirinae with the largest RNA geno...

Effect of mortality from COVID-19 on inpatient outcomes.
https://doi.org/10.1002/jmv.27332
Journal of Medical Virology; Phillips MC, Sarff L et. al.

Sep 14th, 2021 - When hospitals first encountered coronavirus disease 2019 (COVID-19), there was a dearth of therapeutic options and nearly 1 in 3 patients died from the disease. By the summer of 2020, as deaths from the disease declined nationally, multiple single-center studies began to report declining mortality of patients with COVID-19. To evaluate the effect of COVID-19 on hospital-based mortality, we sea...

Post-COVID syndrome. A case series and comprehensive review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428988
Autoimmunity Reviews; Anaya JM, Rojas M et. al.

Sep 13th, 2021 - The existence of a variety of symptoms with a duration beyond the acute phase of COVID-19, is referred to as post-COVID syndrome (PCS). We aimed to report a series of patients with PCS attending a Post-COVID Unit and offer a comprehensive review on the topic. Adult patients with previously confirmed SARS-CoV-2 infection and PCS were systematically assessed through a semi-structured and validate...

Antibody Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442988
International Reviews of Immunology; Mallano A, Ascione A et. al.

Sep 9th, 2021 - Many recent studies have reported the onset of a robust antibody response to SARS-CoV-2 infection and highlighted produced antibodies' specific qualitative and quantitative aspects, relevant for developing antibody-based diagnostic and therapeutic options. In this review, firstly we will report main information acquired so far regarding the humoral response to COVID-19; we will concentrate, in ...

Hospital transfusion service operations during the SARS-CoV-2 pandemic: Lessons learned...
https://doi.org/10.1111/trf.16643
Transfusion Rajbhandary S, Shmookler A et. al.

Sep 2nd, 2021 - The SARS-CoV-2 pandemic disrupted hospital operations, affected the blood supply, and challenged the health care system to develop new therapeutic options, including convalescent plasma (CCP). The aim of this study is to describe and analyze blood supply fluctuations and the use of convalescent plasma in 2020. AABB distributed a weekly and biweekly questionnaire through email to hospital-based ...

Celiac disease: clinical update.
https://doi.org/10.1097/MOG.0000000000000785
Current Opinion in Gastroenterology; Uche-Anya E, Lebwohl B

Aug 31st, 2021 - This review highlights literature from the past year and explores the impact on current understanding of celiac disease pathogenesis, diagnosis, and management. In contrast to earlier clinical trials, recent data suggests that early gluten introduction may protect against the development of celiac disease. Celiac disease is underdiagnosed, associated with high burden of disease and linked to ex...

Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19.
https://doi.org/10.1136/thoraxjnl-2021-217561
Thorax Bridges JP, Vladar EK et. al.

Aug 19th, 2021 - COVID-19 has different clinical stages, and effective therapy depends on the location and extent of the infection. The purpose of this review is to provide a background for understanding the progression of the disease throughout the pulmonary epithelium and discuss therapeutic options. The prime sites for infection that will be contrasted in this review are the conducting airways and the gas ex...

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry...
https://doi.org/10.1128/JVI.00975-21
Journal of Virology; Kreutzberger AJB, Sanyal A et. al.

Aug 19th, 2021 - Repurposing FDA-approved inhibitors able to prevent infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could provide a rapid path to establish new therapeutic options to mitigate the effects of coronavirus disease 2019 (COVID-19). Proteolytic cleavages of the spike S protein of SARS-CoV-2, mediated by the host cell proteases cathepsin and TMPRSS2, alone or in combination,...

Candidate Psychotropics against SARS - CoV - 2: A Narrative Review.
https://doi.org/10.1055/a-1551-3756
Pharmacopsychiatry Khosravi M

Aug 17th, 2021 - Since few therapeutic options are clinically accessible for coronavirus disease 2019 (COVID-19), effective, safe, and globally available pharmaceuticals need to be urgently developed to prevent severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and alleviate the severity of COVID-19. In this regard, the present paper is intended to provide an extensive review of the clinical a...

Is There a Role for Cellular Therapy in Chronic Lymphocytic Leukemia?
https://doi.org/10.1097/PPO.0000000000000532
Cancer Journal (Sudbury, Mass.); Dreger P

Aug 17th, 2021 - Despite multiple advances in the treatment landscape of chronic lymphocytic leukemia (CLL) during recent years, cellular therapies, such as allogeneic hematopoietic cell transplantation and chimeric antigen-engineered T cells, represent valuable therapeutic options for patients with multiply relapsed or poor-risk disease. This brief overview will summarize current results of cellular therapies ...

The information needs of patients with atrial fibrillation: A scoping review.
https://doi.org/10.1111/jocn.15993
Journal of Clinical Nursing; Woo BFY, Bulto LN et. al.

Aug 15th, 2021 - To identify the atrial fibrillation (AF)-specific information needs of patients with AF. Patients' understanding of AF is pertinent to optimising treatment and outcomes, thus highlighting the need for effective patient education. The information required to deliver effective AF-specific patient education is less examined. Guided by Arksey and O'Malley's framework, a scoping review was conducted...

Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317455
International Journal of Infectious Diseases : IJID : Off... Palomba E, Carrabba M et. al.

Aug 1st, 2021 - During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case report discusses the treatment of disease relapse with remdesivir and monoclonal antibodies in an adult patient with X-linked agammaglobulinae...

The Evolving Phenotypes of Cardiovascular Disease during COVID-19 Pandemic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322635
Cardiovascular Drugs and Therapy; Correale M, Croella F et. al.

Jul 31st, 2021 - COVID-19 pandemic has negatively impacted the management of patients with acute and chronic cardiovascular disease: acute coronary syndrome patients were often not timely reperfused, heart failure patients not adequately followed up and titrated, atrial arrhythmias not efficaciously treated and became chronic. New phenotypes of cardiovascular patients were more and more frequent during COVID-19...

In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SAR...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319699
Interdisciplinary Sciences, Computational Life Sciences; Khan A, Umbreen S et. al.

Jul 30th, 2021 - The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world after December 2019, jeopardize the prevailing health system in the world and has raised serious concerns about human safety. Multi-directional efforts are made to design small molecule inhibitors, and vaccines and many other therapeutic options ar...

Early but not late convalescent plasma is associated with better survival in moderate-t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318280
PloS One; Briggs N, Gormally MV et. al.

Jul 29th, 2021 - Limited therapeutic options exist for coronavirus disease 2019 (COVID-19). COVID-19 convalescent plasma (CCP) is a potential therapeutic, but there is limited data for patients with moderate-to-severe disease. What are outcomes associated with administration of CCP in patients with moderate-to-severe COVID-19 infection? We conducted a propensity score-matched analysis of patients with moderate-...

Current Treatments and Therapeutic Options for COVID-19 Patients: A Systematic Review.
https://doi.org/10.2174/1871526521666210726150435
Infectious Disorders Drug Targets; Mehraeen E, Najafi Z et. al.

Jul 28th, 2021 - COVID-19 is the third rising epidemic in the 21st century that quickly turned into a worldwide pandemic. Many clinical studies have been achieved to investigate treatments to confrontation of COVID-19. Therefore, we conducted a systematic reviewto describe the recent treatment strategies to treat COVID-19 patients. A systematic search was performed in the databases of PubMed, Scopus, Embase, Sc...

Long covid-mechanisms, risk factors, and management.
https://doi.org/10.1136/bmj.n1648
BMJ (Clinical Research Ed.); Crook H, Raza S et. al.

Jul 28th, 2021 - Since its emergence in Wuhan, China, covid-19 has spread and had a profound effect on the lives and health of people around the globe. As of 4 July 2021, more than 183 million confirmed cases of covid-19 had been recorded worldwide, and 3.97 million deaths. Recent evidence has shown that a range of persistent symptoms can remain long after the acute SARS-CoV-2 infection, and this condition is n...

From COVID-19 adversity comes opportunity: teaching an online integrative medicine course.
https://doi.org/10.1136/bmjspcare-2020-002713
BMJ Supportive & Palliative Care; Ben-Arye E, Keshet Y et. al.

Jul 17th, 2021 - We examine the impact of a 5-day online elective course in integrative medicine (IM) taking place during the COVID-19 pandemic, attended by 18 medical students from two faculties of medicine in Israel. The course curriculum addressed effectiveness and safety of IM practices highlighting supportive and palliative care, demonstrated the work of integrative physicians (IPs) in designing patient-ta...

Animal models of SARS-CoV-2 transmission.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238653
Current Opinion in Virology; de Vries RD, Rockx B et. al.

Jul 14th, 2021 - SARS-CoV-2 emerged in China as a zoonotic virus in December 2019. The virus proved to be human-to-human transmissible and its global spread resulted in the ongoing COVID-19 pandemic, associated with high morbidity and mortality. Vaccines were developed at an unprecedented speed and proved to be efficacious in preventing disease, but it remains to be determined if vaccines are able to interrupt ...

Sequential dosing of convalescent COVID-19 plasma with significant temporal clinical im...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173591
Transfusion and Apheresis Science : Official Journal of T... Mirihagalle N, Parajuli P et. al.

Jul 13th, 2021 - The current global pandemic, SARS-CoV-2 infection, is still extending across the world affecting millions of lives to the date. While new successful vaccines are available with promising outcomes to minimize the spread and to reduce the severity of the disease, optimal therapeutic options still remain elusive. COVID-19 convalescent plasma (CCP) is an investigational treatment option which studi...