×
Treatment of Multiple Sclerosis.
https://doi.org/10.1212/CON.0000000000001170
Continuum (Minneapolis, Minn.); Cross A, Riley C

Aug 9th, 2022 - Given the expansion of options for the treatment of relapsing multiple sclerosis, this review outlines the framework for developing a treatment strategy, with consideration of when to switch or discontinue therapies, and a comprehensive elaboration of the mechanisms of action, efficacy, and safety considerations for each of the therapeutic classes. The armamentarium of immunotherapies has grown...

Complement activation in COVID-19 and targeted therapeutic options: A scoping review.
https://doi.org/10.1016/j.blre.2022.100995
Blood Reviews; Lim EHT, van Amstel RBE et. al.

Aug 8th, 2022 - Increasing evidence suggests that activation of the complement system plays a key role in the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a systematic approach to create an overview of complement activation in COVID-19 based on histopathological, preclinical, multiomics, observational and clinical interventional studies. A total of 1801 articles from PubMed...

Update on pathomechanisms and treatments in allergic rhinitis.
https://doi.org/10.1111/all.15454
Allergy Zhang Y, Lan F et. al.

Jul 28th, 2022 - Allergic rhinitis (AR) is a global health problem with increasing prevalence and association with an enormous medical and socioeconomic burden. New recognition of immune cells such as type 2 innate lymphocytes (ILC2s), T helper (Th2) 2 cells, follicular helper T cells, follicular regulatory T cells, regulatory T cells, B cells, dendritic cells, and epithelial cells in AR pathogenesis has been u...

Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms i...
https://doi.org/10.1093/cvr/cvac115
Cardiovascular Research; Gyöngyösi M, Alcaide P et. al.

Jul 26th, 2022 - Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multi-organ symptoms that endure for weeks or months after SARS-CoV-2 infection has already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID. In addition to chronic fatigue, which is a commo...

Navigating the unknown: the coronavirus disease 2019 pandemic and solid organ transplan...
https://doi.org/10.1097/QCO.0000000000000852
Current Opinion in Infectious Diseases; Safa K, Kotton CN

Jul 19th, 2022 - This review summarizes the impact of coronavirus disease 2019 (COVID-19) on solid organ transplantation and the most recent data pertinent to disease course and outcomes in this patient population. The COVID-19 pandemic negatively impacted solid organ transplantation with decreased transplant rates in 2020 but improved in 2021, albeit not entirely to prepandemic levels. Mortality rates of COVID...

A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272596
Journal of Hematology & Oncology; García-Gutiérrez V, Breccia M et. al.

Jul 12th, 2022 - Tyrosine kinase inhibitors (TKIs) have vastly improved long-term outcomes for patients with chronic myeloid leukemia (CML). After imatinib (a first-generation TKI), second- and third-generation TKIs were developed. With five TKIs (imatinib, dasatinib, bosutinib, nilotinib, and ponatinib) targeting BCR::ABL approved in most countries, and with the recent approval of asciminib in the USA, treatme...

The Deltacron conundrum: Its origin and potential health risks.
https://doi.org/10.1002/jmv.27990
Journal of Medical Virology; Farheen S, Araf Y et. al.

Jul 12th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since its outbreak in December 2019, has been capable of continuing the pandemic by mutating itself into different variants. Mass vaccinations, antibiotic treatment therapy, herd immunity, and preventive measures have reduced the disease's severity from the emerging variants. However, the virus is undergoing recombination among the c...

Comparison of the characteristics, morbidity and mortality of COVID-19 between first an...
https://doi.org/10.1007/s11739-022-03034-5
Internal and Emergency Medicine; Leidi F, Boari GEM et. al.

Jul 10th, 2022 - Coronavirus disease 2019 (COVID-19) represents a major health problem in terms of deaths and long-term sequelae. We conducted a retrospective cohort study at Montichiari Hospital (Brescia, Italy) to better understand the determinants of outcome in two different COVID-19 outbreaks. A total of 634 unvaccinated patients admitted from local emergency room to the Internal Medicine ward with a confir...

Global research on vitamin D and coronavirus disease 2019: A bibliometric and visualize...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258968
Medicine Shah MW, Ahmad T et. al.

Jul 9th, 2022 - Vitamin D play a substantial role in immune function, but little is known about its prevention in coronavirus disease 2019 (COVID-19). A detail bibliometric analysis of the published scientific literature indexed in Web of Science on vitamin D as a therapeutic option for the COVID-19 patients' treatment is lacking. Thus, the current study was conducted to determine the key bibliometric indices ...

Progress in pediatric obesity: new and advanced therapies.
https://doi.org/10.1097/MOP.0000000000001150
Current Opinion in Pediatrics; Cuda S, Censani M

Jul 8th, 2022 - In this review, we discuss new medical and surgical options for the treatment of children and adolescents with obesity. We review the impact of COVID-19 on this vulnerable population. We also discuss the recent availability of screening tests for rare genetic causes of obesity. COVID-19 increased the prevalence of obesity among children and adolescents. This population is at increased risk for ...

Lung Transplant as a Treatment for Patients with End-Stage Respiratory Failure Due to C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995202
Transplantation Proceedings; Urlik M, Stącel T et. al.

Jun 21st, 2022 - COVID-19 may lead to development of irreversible acute respiratory distress syndrome. Some patients sustain severe respiratory failure after infection subsides. They may require lung transplant as a last resort treatment. The aim of the study is to assess the effect and feasibility of lung transplant as a treatment for patients with severe irreversible respiratory failure due to COVID-19. This ...

Early combination therapy with immunoglobulin and steroids is associated with shorter I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347960
Pharmacotherapy Harthan AA, Nadiger M et. al.

Jun 7th, 2022 - Suggested therapeutic options for Multisystem Inflammatory Syndrome in Children (MIS-C) include intravenous immunoglobulins (IVIG) and steroids. Prior studies have shown the benefit of combination therapy with both agents on fever control or the resolution of organ dysfunction. The primary objective of this study was to analyze the impact of IVIG and steroids on hospital and ICU length of stay ...

Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeut...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347534
Journal of Medical Virology; Saied AA, Nascimento MSL et. al.

Jun 3rd, 2022 - Historically, passive immunotherapy is an approved approach for protecting and treating humans against various diseases when other alternative therapeutic options are unavailable. Human polyclonal antibodies (hpAbs) can be made from convalescent human donor serum, although it is considered limited due to pandemics and the urgent requirement. Additionally, polyclonal antibodies (pAbs) could be g...

COVID-19 in the Critically Ill Patient.
https://doi.org/10.1016/j.idc.2022.02.005
Infectious Disease Clinics of North America; Bell TD

Jun 1st, 2022 - The COVID-19 pandemic has led to significant mortality in the United States with more than 800,000 deaths in 2020 and 2021. The proportion of patients with COVID-19 who develop severe disease varies but is decreasing over time with growing population immunity and improved therapeutic options. Patients who are 65 years and older represent the largest proportion of deaths from COVID-19. Additiona...

The role of cytokines and their antagonists in the treatment of COVID-19 patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347599
Reviews in Medical Virology; Mohseni Afshar Z, Barary M et. al.

May 28th, 2022 - The coronavirus disease 2019 (COVID-19) has various presentations, of which immune dysregulation or the so-called cytokine storm syndrome (COVID-CSS) is prominent. Even though cytokines are vital regulators of body immunoinflammatory responses, their exaggerated release can be harmful. This hyperinflammatory response is more commonly observed during severe COVID-19 infections, caused by the exc...

Neuropsychiatry's Role in the Postacute Sequelae of COVID-19: Report From the American ...
https://doi.org/10.1176/appi.neuropsych.21080209
The Journal of Neuropsychiatry and Clinical Neurosciences; Baslet G, Aybek S et. al.

May 18th, 2022 - The postacute sequelae of COVID-19 infection (PASC), also known as post-COVID condition or "long COVID," refers to symptoms that persist after the initial acute phase of the infection. PASC symptoms may occur in patients who had mild acute disease. On the basis of current data, commonly reported neurological and psychiatric symptoms in PASC include sleep problems, fatigue, cognitive impairment,...

Analysis of the Virus SARS-CoV-2 as a Potential Bioweapon in Light of International Lit...
https://doi.org/10.1093/milmed/usac123
Military Medicine; Farkas CB, Dudás G et. al.

May 16th, 2022 - As of early 2022, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic still represents a worldwide medical emergency situation. The ongoing vaccination programs can slow down the spread of the virus; however, from time to time, the newly emerging variants of concern and antivaccination movements carry the possibility for the disease to remain in our daily lives. After the ...

Long-term cardio-vascular risk assessment in chronic kidney disease and kidney transpla...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077937
BMC Nephrology; Tapoi L, Apetrii M et. al.

May 7th, 2022 - The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a pandemic since March 2020 by affecting more than 243 million people with more than 5 million deaths globally. SARS-CoV-2 infection is produced by binding to angiotensin-converting enzyme, which among other sites is highly expressed in the endothelial cells of the blood vessel...

COVID-19 Infection Has More Than 50 Long-Term Effects
https://www.medscape.com/viewarticle/973598

May 6th, 2022 - MADRID, Spain — Clinical experiences in approaching COVID-19 from different perspectives, results obtained by various therapeutic options and, above all, the challenges posed by a new healthcare reality — long COVID — were all the focus of a recent discussion at the 7th International Congress of the Spanish Society of Precision Health. In this forum, titled Precision Health: A COVID-19 Professi...

Recent Advances and Future Prospects of Treatment of Pulmonary Hypertension.
https://doi.org/10.1016/j.cpcardiol.2022.101236
Current Problems in Cardiology; Hajra A, Safiriyu I et. al.

May 3rd, 2022 - Pulmonary hypertension is one of the difficult situations to treat. Complex pathophysiology, association of the multiple comorbidities make clinical scenario challenging. Recently it is being shown that patients who had recovered from coronavirus disease infection, are at risk of developing pulmonary hypertension. Studies on animals have been going on to find out newer treatment options. There ...