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Utility of Ct values in differentiating COVID-19 reinfection versus prolonged viral she...
https://doi.org/10.1136/bcr-2021-243692
BMJ Case Reports; Julian K, Shah N et. al.

Jul 29th, 2021 - We describe the case of a 26-year-old man who presented to an outside hospital with concerns of blurred vision. He subsequently tested positive for COVID-19 and his lab work suggested acute leukaemia. The patient was admitted to our hospital and completed a course of remdesivir. He eventually tested negative for COVID-19 before initiating chemotherapy. Two days after starting chemotherapy, he d...

Operational challenges in the COVID era: Asymptomatic infections and vaccination timing.
https://doi.org/10.1111/ctr.14437
Clinical Transplantation; Axelrod DA, Ince D et. al.

Jul 24th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has created unprecedented challenges for solid organ transplant programs. While transplant activity has largely recovered, appropriate management of deceased donor candidates who are asymptomatic but have positive nucleic acid test (NAT) for COVID-19 is unclear as this may reflect active infection or prolonged viral shedding. Furthermore, candida...

Re-infection with different SARS-CoV-2 clade and prolonged viral shedding in a patient ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286546
International Journal of Infectious Diseases : IJID : Off... Alshukairi AN, El-Kafrawy SA et. al.

Jul 22nd, 2021 - Re-infection with different SARS-CoV-2 clade and prolonged viral shedding in a patient with hematopoietic stem cell transplantation: SARS-CoV-2 Re-infection with different clade.|2021|Alshukairi AN,El-Kafrawy SA,Dada A,Yasir M,Yamani AH,|

The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-cente...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282451
Contemporary Clinical Trials; Bunning B, Hedlin H et. al.

Jul 19th, 2021 - More than 3000 clinical trials related to COVID-19 have been registered through clinicaltrials.gov. With so many trials, there is a risk that many will be inconclusive due to being underpowered or due to an inability to recruit patients. At academic medical centers, multiple trials are competing for the same resources; the success of one may come at the expense of another. The COVID-19 Outpatie...

Recurrent COVID-19 infection in a health care worker: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273561
Journal of Medical Case Reports; Garg J, Agarwal J et. al.

Jul 14th, 2021 - Recurrent coronavirus disease 2019 (COVID-19) infection is an emerging problem and may prove to be one of the greatest problems in controlling the pandemic in the future. Recurrent infections can be due to reactivation of dormant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or reinfection with similar or different strains of SARS-CoV-2. Here we present an interesting case of a h...

Clinical features and predictors for patients with severe SARS-CoV-2 pneumonia at the s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266160
BMC Infectious Diseases; Cao C, He L et. al.

Jul 10th, 2021 - This study was performed to investigate clinical features of patients with severe SARS-CoV-2 pneumonia and identify risk factors for converting to severe cases in those who had mild to moderate diseases at the start of the pandemic in China. In this retrospective, multicenter cohort study, patients with mild to moderate SARS-CoV-2 pneumonia were included. Demographic data, symptoms, laboratory ...

Persistence of SARS-CoV-2 RNA in the nasopharyngeal, blood, urine, and stool samples of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248752
Virology Journal; Joukar F, Yaghubi Kalurazi T et. al.

Jul 3rd, 2021 - The persistence of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) RNA in the body fluids of patients with the novel coronavirus disease 2019 (COVID-19) may increase the potential risk of viral transmission. There is still uncertainty on whether the recommended quarantine duration is sufficient to reduce the risk of transmission. This study aimed to investigate the persistence of S...

Course of illness and outcomes in older COVID-19 patients treated with HFNC: a retrospe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266360
Aging Deng L, Lei S et. al.

Jun 29th, 2021 - Coronavirus disease-2019 (COVID-19) has rapidly spread worldwide and causes high mortality of elderly patients. High-flow nasal cannula therapy (HFNC) is an oxygen delivery method for severely ill patients. We retrospectively analyzed the course of illness and outcomes in 110 elderly COVID-19 patients (≥65 years) treated with HFNC from 6 hospitals. 38 patients received HFNC (200 mmHg < PaO2/FiO...

Duration of SARS-CoV-2 shedding: A population-based, Canadian study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211234
PloS One; Phillips SP, Wei X et. al.

Jun 18th, 2021 - There is an evidence gap regarding the duration of SARS-CoV-2 shedding and of its variability across different care settings and by age, sex, income, and co-morbidities. Such evidence is part of understanding of infectivity and reinfection. We examine direct measures of viral shedding using a linked population-based health administrative dataset. Laboratory and sociodemographic databases for On...

Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190301
Nature Communications; Yang B, Fan J et. al.

Jun 11th, 2021 - The characteristics of COVID-19 patients with persistent SARS-CoV-2 infection are not yet well described. Here, we compare the clinical and molecular features of patients with long duration of viral shedding (LDs) with those from patients with short duration patients (SDs), and healthy donors (HDs). We find that several cytokines and chemokines, such as interleukin (IL)-2, tumor necrosis factor...

Repositive RT-PCR test in discharged COVID-19 patients during medical isolation observa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176169
International Journal of Medical Sciences; Huang K, Liu W et. al.

Jun 10th, 2021 - Objectives: The epidemiological and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) have been researched. However, the prevalence of repositivity by real-time PCR for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Methods: A retrospective study was conducted involving 599 discharged patients with COVID-19 in a single medical centre. T...

COVID-19 in a premature infant.
https://doi.org/10.1136/bcr-2021-243783
BMJ Case Reports; Ng DC, Chin L et. al.

Jun 2nd, 2021 - We report a case of COVID-19 in a 29-week preterm infant. This child is the youngest reported case of SARS-CoV-2 infection in Malaysia, and to the best of our knowledge, one of the youngest documented cases of established vertical transmission of SARS-CoV-2 reported in literature. Our report highlights the clinical course, timelines of viral shedding by real-time reverse transcription-PCR and a...

H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced...
https://doi.org/10.1080/22221751.2021.1938241
Emerging Microbes & Infections; Li H, Zhao X et. al.

Jun 2nd, 2021 - ABSTRACTThe risk of secondary infection with SARS-CoV-2 and influenza A virus is becoming a practical problem that must be addressed as the flu season merges with the COVID-19 pandemic. As SARS-CoV-2 and IAV have been found in patients, understanding the in vivo characteristics of the secondary infection between these two viruses is a high priority. Here, hACE2 transgenic mice were challenged w...

Modeling the early temporal dynamics of viral load in respiratory tract specimens of CO...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161782
International Journal of Infectious Diseases : IJID : Off... Lim AY, Cheong HK et. al.

Jun 1st, 2021 - To investigate the duration and peak of severe acute respiratory syndrome coronavirus 2 shedding as infectivity markers for determining the isolation period. A total of 2,558 upper respiratory tract (URT) and lower respiratory tract (LRT) specimens from 138 patients with laboratory-confirmed coronavirus disease were analyzed. Measurements of sequential viral loads were aggregated using the cubi...

Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to seru...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159068
BMC Infectious Diseases; Glans H, Gredmark-Russ S et. al.

May 29th, 2021 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic. The understanding of the transmission and the duration of viral shedding in SARS-CoV-2 infection is still limited. To assess the timeframe and potential risk of SARS-CoV-2 transmission from hospitalized COVID-19 patients in relation to antibody response. We performe...

Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135187
International Journal of Infectious Diseases : IJID : Off... Camici M, Zuppi P et. al.

May 24th, 2021 - To investigate the association between sex hormones and the severity of coronavirus disease 2019 (COVID-19). Furthermore, associations between sex hormones and systemic inflammation markers, viral shedding and length of hospital stay were studied. This case-control study included a total of 48 male patients with COVID-19 admitted to an Italian reference hospital. The 24 cases were patients with...

Test-based de-isolation in COVID-19 immunocompromised patients: Cycle threshold value v...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123529
International Journal of Infectious Diseases : IJID : Off... Alshukairi AN, Tolah AM et. al.

May 19th, 2021 - Immunocompromised patients with coronavirus disease 2019 (COVID-19) have prolonged infectious viral shedding for more than 20 days. A test-based approach is suggested for de-isolation of these patients. The strategy was evaluated by comparing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (cycle threshold (Ct) values) and viral culture at the time of hospital discharge ...

A case of laparoscopic hepatectomy for a primary hepatic neuroendocrine tumor.
https://doi.org/10.1007/s12328-021-01403-9 10.1186/s12907-018-0070-7 10.1097/MD.0000000000012408 10.1007/s00261-018-1653-6 10.3748/wjg.15.2418 10.1590/S1679-45082014RC2745 10.1016/S0140-6736(98)02286-7 10.1002/1097-0142(197508)36:2<560::AID-CNCR2820360235>3.0.CO;2-4 10.1097/MD.0000000000011764 10.1111/his.13975 10.1016/j.ejso.2005.11.017 10.12998/wjcc.v4.i8.243 10.5604/01.3001.0010.0313 10.1245/ASO.2003.04.533 10.4174/astr.2019.97.4.176 10.1016/j.jceh.2019.08.002
Clinical Journal of Gastroenterology; Sakamoto Y, Shimada S et. al.

May 16th, 2021 - We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the western United States. Named B.1.427/B.1.429 to denote its two lineages, the variant emerged in May 2020 and increased from 0% to >50% of sequenced cases from September 2020 to Ja...

The Full Spectrum of COVID-19 Development and Recovery Among Kidney Transplant Recipients.
https://doi.org/10.1097/TP.0000000000003751 10.1093/cid/ciaa1097
Transplantation Cristelli MP, Viana LA et. al.

May 15th, 2021 - Coronavirus disease 2019 (COVID-19) fatality rate is high among kidney transplant recipients. Among survivors, kidney outcomes, seroconversion, and persistence of viral shedding are unexplored. Single-center prospective cohort study including data from kidney transplant recipients with confirmed COVID-19 between March 20, 2020 and July 31, 2020. Outcomes were adjudicated until August 31, 2020 o...

Coronavirus disease 2019 severity in obesity: Metabolic dysfunction-associated fatty li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072197
World Journal of Gastroenterology; Vasques-Monteiro IML, Souza-Mello V

May 11th, 2021 - The coronavirus disease 2019 (COVID-19) outbreak has drawn the scientific community's attention to pre-existing metabolic conditions that could aggravate the infection, causing extended viral shedding, prolonged hospitalization, and high death rates. Metabolic dysfunction-associated fatty liver disease (MAFLD) emerges as a surrogate for COVID-19 severity due to the constellation of metabolic al...