×
Covid-19: Peak of viral shedding is later with omicron variant, Japanese data suggest.
https://doi.org/10.1136/bmj.o89
BMJ (Clinical Research Ed.); Torjesen I

Jan 15th, 2022 - Covid-19: Peak of viral shedding is later with omicron variant, Japanese data suggest.|2022|Torjesen I,|

Trajectory of Viral RNA Load Among Persons With Incident SARS-CoV-2 G614 Infection (Wuh...
https://doi.org/10.1001/jamanetworkopen.2021.42796
JAMA Network Open; Stankiewicz Karita HC, Dong TQ et. al.

Jan 11th, 2022 - The SARS-CoV-2 viral trajectory has not been well characterized in incident infections. These data are needed to inform natural history, prevention practices, and therapeutic development. To characterize early SARS-CoV-2 viral RNA load (hereafter referred to as viral load) in individuals with incident infections in association with COVID-19 symptom onset and severity. This prospective cohort st...

Protection against avian coronavirus conferred by oral vaccination with live bacteria s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717763
Vaccine Lublin A, Katz C et. al.

Jan 10th, 2022 - The devastating impact of infectious bronchitis (IB) triggered by the IB virus (IBV), on poultry farms is generally curbed by livestock vaccination with live attenuated or inactivated vaccines. Yet, this approach is challenged by continuously emerging variants and by time limitations of vaccine preparation techniques. This work describes the design and evaluation of an anti-IBV vaccine comprise...

Initial findings of universal screening for SARS-CoV-2 in women admitted for delivery i...
https://doi.org/10.1080/01443615.2021.2011179
Journal of Obstetrics and Gynaecology : the Journal of Th... Maraj H, Bhattacharjee D et. al.

Jan 9th, 2022 - We describe the prevalence of overall and asymptomatic SARS-CoV-2 infection in pregnant women admitted for delivery at three maternity units in North Wales. This was a prospective, multicentre cohort study of universal testing for SARS-CoV-2 infection offered to all pregnant women admitted for delivery. Four hundred and seventy-five women were tested by reverse transcription-polymerase chain re...

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SA...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690919
Theranostics Huang KA, Zhou D et. al.

Jan 7th, 2022 - Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has been shown to curtail viral shedding and reduce hospitalization in patients with SARS-CoV-2 infection. However, the structure-function analysis of potent human anti-RBD monoclonal antibodies and its links to the formulation of antibody cocktails remains largely elusive. Methods: Previously, we isol...

Inflammatory but not respiratory symptoms are associated with ongoing upper airway vira...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627385
Diagnostic Microbiology and Infectious Disease; Jacobson KB, Purington N et. al.

Jan 3rd, 2022 - Although the vast majority of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are uncomplicated, our understanding of predictors of symptom resolution and viral shedding cessation remains limited. We characterized symptom trajectories and oropharyngeal viral shedding among 120 outpatients with uncomplicated Coronavirus Disease of 2019 (COVID-19) enrolled in a clinical tr...

Prolonged viral positivity induced recurrent coronavirus disease 2019 (COVID-19) pneumo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718200
Medicine Deveci B, Saba R

Dec 31st, 2021 - The outbreak of novel coronavirus (severe acute respiratory syndrome coronavirus 2), which causes the coronavirus disease 2019 (COVID-19), is the most important current health problem. The number of patients is increasing worldwide. Pneumonia is the most life-threatening complication of the disease. Prolonged viral shedding in hematological patients with COVID-19 has been demonstrated; however,...

Prolonged viral shedding of SARS-CoV-2 and related factors in symptomatic COVID-19 pati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711078
BMC Infectious Diseases; Long H, Zhao J et. al.

Dec 29th, 2021 - The temporal relationship between SARS-CoV-2 and antibody production and clinical progression remained obscure. The aim of this study was to describe the viral kinetics of symptomatic patients with SARS-CoV-2 infection and identify factors that might contribute to prolonged viral shedding. Symptomatic COVID-19 patients were enrolled in two hospitals in Wuhan, China, from whom the respiratory sa...

Are We Testing for Omicron Wrong?
https://www.medpagetoday.com/infectiousdisease/covid19/96385

Dec 27th, 2021 - If confirmed in follow-up research and if the diagnostics industry can pivot quickly enough, findings from a South African study could make COVID-19 testing a lot easier for patients and healthcare workers, as the SARS-CoV-2 Omicron variant becomes the dominant source of infection. In a manuscript posted to the medRxiv preprint server on Friday, researchers from the University of Cape Town repo...

Pathogenicity, infective dose and altered gut microbiota in piglets infected with porci...
https://doi.org/10.1016/j.virol.2021.12.006
Virology Li J, Zhou J et. al.

Dec 25th, 2021 - Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that cause severe diarrhea, resulting in high mortality in neonatal piglets. Little is known regarding the pathogenicity of PDCoV in different infective dose and the dynamic changes in the composition of the gut microbiota in PDCoV-induced diarrhea piglets. In this study, 5-day-old piglets were experimentally inf...

Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755281
The Journal of Infectious Diseases; Nussenblatt V, Roder AE et. al.

Dec 24th, 2021 - B-cell depleting therapies may lead to prolonged disease and viral shedding in individuals infected with SARS-CoV-2 and this viral persistence raises concern for viral evolution. We report on the sequencing of early and late samples from a 335-day infection in an immunocompromised patient. The virus accumulated a unique deletion in the amino-terminal domain of the spike protein, and complete de...

Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids expla...
https://doi.org/10.1080/22221751.2021.2019559
Emerging Microbes & Infections; Te N, Rodon J et. al.

Dec 18th, 2021 - Middle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle East region are subdivided into two clades (A and B), all the contemporary epidemic viruses belong to clade B. Thus, MERS-CoV clade B strains may display adaptive advantages over clade A in humans and/or reservoir hosts. To test this hypothesis in vivo,...

SARS-CoV-2 neutralizing antibody treatment in COVID-19 patients with immunodeficiency d...
https://doi.org/10.1182/bloodadvances.2021006655
Blood Advances; Malin JJ, Di Cristanziano V et. al.

Dec 16th, 2021 - Humoral immunodeficiency is a common finding in patients with B-cell related malignancies such as Non-Hodgkin lymphoma. Failure to induce a sufficient humoral immune response to viral pathogens such as SARS-CoV-2 can result in impaired viral clearance with prolonged viral shedding and symptomatic infections. Here we describe six COVID-19 patients with B-cell Non-Hodgkin lymphoma and impaired hu...

Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664001
Journal of Clinical Immunology; Lang-Meli J, Fuchs J et. al.

Dec 12th, 2021 - Patients with primary antibody deficiency are at risk for severe and in many cases for prolonged COVID-19. Convalescent plasma treatment of immunocompromised individuals could be an option especially in countries with limited access to monoclonal antibody therapies. While studies in immunocompetent COVID19 patients have demonstrated only a limited benefit, evidence for the safety, timing, and e...

Transmission dynamics of the Delta variant of SARS-CoV-2 infections in South Korea.
https://doi.org/10.1093/infdis/jiab586
The Journal of Infectious Diseases; Hwang H, Lim JS et. al.

Dec 6th, 2021 - The Delta variant of SARS-CoV-2 is now the predominant variant worldwide. However, its transmission dynamics remain unclear. We analyzed 405 local case-patients infected with the Delta variant of SARS-CoV-2 and temporal patterns of viral shedding identified between 22 June and 31 July 2021 in Daejeon, South Korea. Overall, 20% were presymptomatic at the time of epidemiological investigation. We...

AIDS patient with severe T cell depletion achieved control but not clearance of SARS-Co...
https://doi.org/10.1002/eji.202149574
European Journal of Immunology; Spinicci M, Mazzoni A et. al.

Nov 26th, 2021 - A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.

Emerging SARS-CoV-2 variants can potentially break set epidemiological barriers in COVI...
https://doi.org/10.1002/jmv.27467
Journal of Medical Virology; Kumar A, Parashar R et. al.

Nov 24th, 2021 - Young age, female sex, absence of comorbidities, and prior infection or vaccination are known epidemiological barriers for contracting the new infection and/or increased disease severity. Demographic trends from the recent coronavirus disease 2019 waves, which are believed to be driven by newer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, indicate that the aforemention...

Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmiss...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610237
PloS One; Zeiss CJ, Asher JL et. al.

Nov 24th, 2021 - At present, global immunity to SARS-CoV-2 resides within a heterogeneous combination of susceptible, naturally infected and vaccinated individuals. The extent to which viral shedding and transmission occurs on re-exposure to SARS-CoV-2 is an important determinant of the rate at which COVID-19 achieves endemic stability. We used Sialodacryoadenitis Virus (SDAV) in rats to model the extent to whi...

SARS-CoV-2 infection and replication in human gastric organoids.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595698
Nature Communications; Giobbe GG, Bonfante F et. al.

Nov 18th, 2021 - COVID-19 typically manifests as a respiratory illness, but several clinical reports have described gastrointestinal symptoms. This is particularly true in children in whom gastrointestinal symptoms are frequent and viral shedding outlasts viral clearance from the respiratory system. These observations raise the question of whether the virus can replicate within the stomach. Here we generate gas...

Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host protea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554394
World Journal of Gastroenterology; Berdowska I, Matusiewicz M

Nov 11th, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seems to employ two routes of entrance to the host cell; via membrane fusion (with the cells expressing both angiotensin converting enzyme 2 (ACE2) and transmembrane peptidase/serine subfamily member 2/4 (TMPRSS2/4)) or via receptor-mediated endocytosis (to the target cells expressing only ACE2). The second mode is associated with cys...