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Clinical characteristics and predictors of the duration of SARS-CoV-2 viral shedding in...
https://doi.org/10.1111/joim.13160
Journal of Internal Medicine References; Liu W, Liu Y et. al.

Sep 22nd, 2020 - Epidemiological and clinical features of patients with COVID-19 have been reported, but none of them focused on medical staff, and few predictors of the duration of viral shedding have been reported. It is urgent to help healthcare workers prevent and recover quickly from the coronavirus disease 2019 (COVID-19). We enrolled 140 medical workers with COVID-19 in Wuhan. Epidemiological, demographi...

Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Lefl...
https://doi.org/10.1093/cid/ciaa1417
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Wang M, Zhao Y et. al.

Sep 21st, 2020 - To evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, to treat COVID-19 patients with prolonged post-symptomatic viral shedding. We conducted a prospective, randomized, controlled, open-label trial involving hospitalized adult COVID-19 patients with prolonged PCR positivity. Patients were randomly assigned to receive either leflunomide (50 mg, q...

Prolonged RNA shedding of the 2019 novel coronavirus in an asymptomatic patient with a ...
https://doi.org/10.1136/bcr-2020-237720
BMJ Case Reports; El-Baba F, Gabe D et. al.

Sep 15th, 2020 - A 33-year-old man with paranoid schizophrenia and a ventriculoperitoneal (VP) shunt was sent to our institution from an inpatient psychiatric facility due to concerns for the 2019 novel coronavirus (COVID-19). Per the facility, the patient had a fever and non-productive cough. On admission, the patient was afebrile and lacked subjective symptoms. A RNA reverse transcriptase PCR (RNA RT-PCR) tes...

Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cer...
https://doi.org/10.1136/bcr-2020-238597
BMJ Case Reports; Essajee F, Solomons R et. al.

Sep 15th, 2020 - We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinog...

Detection of coronavirus in tear samples of hospitalized patients with confirmed SARS-C...
https://doi.org/10.1097/ICO.0000000000002562
Cornea Dutescu RM, Banasik P et. al.

Sep 8th, 2020 - This study was designed to detect CoV-RNA in the tears of PCR confirmed SARS-CoV-2 positive patients. We performed a prospective case-series study of hospitalized patients that have been confirmed SARS-CoV-2 positive by oropharyngeal swab within the previous 5 days. Tear samples obtained with a laboratory capillary and oropharyngeal swabs were analyzed by RT-PCR using the Altona SARS-CoV-2-Assa...

Sustained responses of neutralizing antibodies against MERS-CoV in recovered patients a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499518
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Kim YS, Aigerim A et. al.

Sep 8th, 2020 - Zoonotic coronaviruses have emerged as a global threat by causing fatal respiratory infections. Given the lack of specific antiviral therapies, application of human convalescent plasma retaining neutralizing activity could be a viable therapeutic option that can bridge this gap. We traced antibody responses and memory B cells in peripheral blood collected from 70 recovered MERS-CoV patients for...

Are the steroids a blanket solution for COVID-19? a systematic review and meta-analysis.
https://doi.org/10.1002/jmv.26483
Journal of Medical Virology; Sarkar S, Khanna P et. al.

Sep 3rd, 2020 - Steroids may play a critical role in the current pandemic of coronavirus disease (COVID-19), given the dearth of specific therapeutic options. This review was conducted to evaluate the impact of glucocorticoid therapy in COVID-19 patients based on the publications reported to date. A comprehensive screening was conducted using electronic databases up to 19th August 2020. The randomized controll...

Short-term inhibition of SARS-CoV-2 by hydrogen peroxide in persistent nasopharyngeal c...
https://doi.org/10.1002/jmv.26485
Journal of Medical Virology; Capetti AF, Borgonovo F et. al.

Sep 3rd, 2020 - Asymptomatic and convalescent COVID-19 subjects may carry SARS-CoV-2 for months in their upper respiratory ways. Desiring to permanently clean the mucosal surfaces we investigated chemical agents fit to rapidly degrade the virus. Among these, hydrogen peroxide, initially tested by two of us for tolerability, showed both good performance and acceptable side effects (burning sensation for 15 - 20...

Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower res...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459254
Endocrine Buetti N, Trimboli P et. al.

Sep 1st, 2020 - The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze clini...

Incidence, clinical course and risk factor for recurrent PCR positivity in discharged C...
https://doi.org/10.1371/journal.pntd.0008648
PLoS Neglected Tropical Diseases; Zheng J, Zhou R et. al.

Aug 31st, 2020 - The phenomenon of COVID-19 patients tested positive for SARS-CoV-2 after discharge (redetectable as positive, RP) emerged globally. The data of incidence rate and risk factors for RP event and the clinical features of RP patients may provide recommendations for virus containment and cases management for COVID-19. We prospectively collected and analyzed the epidemiological, clinical and virologi...

Symptomatic and Asymptomatic Viral Shedding in Pediatric Patients Infected With Severe ...
https://doi.org/10.1001/jamapediatrics.2020.3996
JAMA Pediatrics; DeBiasi RL, Delaney M

Aug 27th, 2020 - Symptomatic and Asymptomatic Viral Shedding in Pediatric Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Under the Surface.|2020|DeBiasi RL,Delaney M,|

Systematic review with meta-analysis: SARS-CoV-2 stool testing and the potential for fa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461227
Alimentary Pharmacology & Therapeutics; van Doorn AS, Meijer B et. al.

Aug 27th, 2020 - Since the start of the COVID-19 pandemic, there have been many scientific reports regarding gastrointestinal manifestations. Several reports indicate the possibility of viral shedding via faeces and the possibility of faecal-oral transmission. To critically assess the clinical relevance of testing stool samples and anal swabs and provide an overview of the potential faecal-oral transmission of ...

COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirme...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499500
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; To KK, Hung IF et. al.

Aug 25th, 2020 - Waning immunity occurs in patients who have recovered from COVID-19. However, it remains unclear whether true re-infection occurs. Whole genome sequencing was performed directly on respiratory specimens collected during two episodes of COVID-19 in a patient. Comparative genome analysis was conducted to differentiate re-infection from persistent viral shedding. Laboratory results, including RT-P...

Clinical characteristics, therapeutic management, and prognostic factors of adult COVID...
https://doi.org/10.1080/10428194.2020.1808204
Leukemia & Lymphoma; Wu Y, Chen W et. al.

Aug 24th, 2020 - Patients with hematological malignancies with immunodeficiency are at high risk for SARS-CoV-2 infection. We retrospective summarized clinical characteristics of coronavirus disease 2019 (COVID-19) inpatients with hematological malignancies, shared treatment experiences, and analysis prognostic factors. Fourteen patients were enrolled. The median duration of viral shedding was 27.5 days in surv...

Epidemiological, virological and serological features of COVID-19 cases in people livin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454403
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Huang J, Xie N et. al.

Aug 17th, 2020 - We aimed to describe the epidemiological, virological and serological features of coronavirus disease 2019 (COVID-19) cases in people living with HIV (PLWH). This population-based cohort study identified all COVID-19 cases among the whole PLWH in Wuhan city, China, by April 16, 2020. The epidemiological, virological and serological features were analyzed based on the demographic data, temporal ...

Telemedicine in the Care of Kidney Transplant Recipients With Coronavirus Disease 2019:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365092
Transplantation Proceedings; Abuzeineh M, Muzaale AD et. al.

Aug 16th, 2020 - Kidney transplant recipients who develop symptoms consistent with coronavirus disease 2019 (COVID-19) are bringing unique challenges to health care professionals. Telemedicine has surged dramatically since the pandemic in effort to maintain patient care and reduce the risk of COVID-19 exposure to patients, health care workers, and the public. Herein we present reports of 3 kidney transplant rec...

Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patient...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411944
JAMA Internal Medicine; Lee S, Kim T et. al.

Aug 11th, 2020 - There is limited information about the clinical course and viral load in asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To quantitatively describe SARS-CoV-2 molecular viral shedding in asymptomatic and symptomatic patients. A retrospective evaluation was conducted for a cohort of 303 symptomatic and asymptomatic patients with SARS-CoV-2 infect...

Inactivated pandemic 2009 H1N1 influenza A virus human vaccines have different efficacy...
https://doi.org/10.1111/irv.12784
Influenza and Other Respiratory Viruses REFERENCES; Vidaña B, Brookes SM et. al.

Aug 10th, 2020 - The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate the efficacy of two licensed A(H1N1)pdm09 inactivated vaccines (AS03B adjuvanted split ...

Convalescent plasma is a clutch at straws in COVID-19 management! A systematic review a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436491
Journal of Medical Virology REFERENCES; Sarkar S, Soni KD et. al.

Aug 10th, 2020 - In the absence of definitive therapy for coronavirus disease (COVID-19), convalescent plasma therapy (CPT) may be a critical therapeutic option. This review was conducted to evaluate the impact of CPT in COVID-19 patients based on the publications reported to date. A robust screening of electronic databases was conducted up to 10th July 2020. Randomized controlled trials (RCTs), cohort studies,...

In-depth virological assessment of kidney transplant recipients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436721
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons References; Benotmane I, Gautier-Vargas G et. al.

Aug 10th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via reverse transcription-polymerase chain reaction and SARS-CoV-2 serology via enzyme-li...