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Clinical perspectives, assessment, and mechanisms of metabolic-associated fatty liver d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433612
World Journal of Gastroenterology; Campos-Murguía A, Román-Calleja BM et. al.

Oct 1st, 2021 - Metabolic diseases are highly prevalent worldwide and have been associated with adverse clinical outcomes, including mortality, in patients developing coronavirus disease (COVID-19). Because of the close relationship between metabolic diseases such as type 2 diabetes mellitus and obesity and the presence of metabolic-associated fatty liver disease (MAFLD), a high number of cases of patients aff...

Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476038
PloS One; Cheng HM, Zhao X et. al.

Sep 28th, 2021 - Mildly symptomatic cases of Covid-19 in previously-well individuals form the majority of infections and also serve as potent vectors of transmission. The factors affecting the duration of SARS-CoV-2 RNA viral shedding (DVS) in these patients remain largely unknown. To perform a systematic analysis of the clinical, radiologic, laboratory investigations in patients with few comorbidities infected...

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus...
https://doi.org/10.1093/cid/ciab817
Clinical Infectious Diseases : an Official Publication Of... Chan JF, Poon VK et. al.

Sep 19th, 2021 - The effect of low environmental temperature on viral shedding and disease severity of COVID-19 is uncertain. We investigated the virological, clinical, pathological, and immunological changes in hamsters housed at room (21 oC), low (12-15 oC), and high (30-33 oC) temperature after challenge by 10 5 plaque-forming units of SARS-CoV-2. The nasal turbinate, trachea, and lung viral load and live vi...

Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort stud...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443913
BMC Infectious Diseases; Abdella S, Tessema M et. al.

Sep 18th, 2021 - The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) and became pandemic after emerging in Wuhan, China, in December 2019. Several studies have been conducted to understand the key features of COVID-19 and its public health impact. However, the prognostic factors of COVID-19 are not well studied in the African setting. In this study, we...

Liver and/or Kidney Transplantation After SARS-CoV-2 Infection: Prevalence, Short-Term ...
https://doi.org/10.1097/TP.0000000000003955
Transplantation Verbeek J, Vrij C et. al.

Sep 18th, 2021 - There is paucity of data on the prevalence, adequate timing and outcome of solid organ transplantation after SARS-CoV-2 infection and the kinetics of IgG antibodies in these patients. SARS-CoV-2 anti-nucleocapsid (N) IgG and PCR via nasopharyngeal swab were analyzed in all patients within 24h before liver and/or kidney transplantation. Kinetics of IgG antibodies were analysed and compared with ...

Prolonged SARS-Cov-2 shedding with rapid IgG antibody decay in a COVID-19 patient: A ca...
https://doi.org/10.1002/jcla.24002
Journal of Clinical Laboratory Analysis; Huang J, Lan C et. al.

Sep 17th, 2021 - The coronavirus disease 2019 (COVID-19) epidemic is still spreading rapidly around the world. Recent cases with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA detection have been successively reported, and the phenomenon of false-negative real-time polymerase chain reaction (RT-PCR) results of SARS-CoV-2 RNA or "repositive" was also described in COVID-19 patients. We...

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457559
Aging Bourgin M, Derosa L et. al.

Sep 14th, 2021 - Cancer patients are particularly susceptible to the development of severe Covid-19, prompting us to investigate the serum metabolome of 204 cancer patients enrolled in the ONCOVID trial. We previously described that the immunosuppressive tryptophan/kynurenine metabolite anthranilic acid correlates with poor prognosis in non-cancer patients. In cancer patients, we observed an elevation of anthra...

Late reinfection with a different severe acute respiratory syndrome coronavirus-2 clade...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419670
Journal of Medical Case Reports; García-Abellán J, Galiana A et. al.

Sep 8th, 2021 - Differentiating between persistent infection with intermittent viral shedding and reinfection with severe acute respiratory syndrome coronavirus 2 remains challenging. Although a small number of cases with genomic evidence of second infection have been reported, limited information exists on frequency and determinants of reinfection, time between infections, and duration of immunity after the p...

Evaluation of six commercial SARS-CoV-2 rapid antigen tests in nasopharyngeal swabs: Be...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376530
Journal of Clinical Virology : the Official Publication O... Andreani J, Lupo J et. al.

Sep 8th, 2021 - Robust antigen point-of-care SARS-CoV-2 tests have been proposed as an efficient tool to address the COVID-19 pandemic. This requirement was raised after acknowledging the constraints that are brought by molecular biology. However, worldwide markets have been flooded with cheap and potentially underperforming lateral flow assays. Herein we retrospectively compared the overall performance of fiv...

Longitudinal Assessment of Antisevere Acute Respiratory Syndrome Coronavirus 2 Immune R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989218
The Journal of Infectious Diseases; Noh JY, Kwak JE et. al.

Sep 2nd, 2021 - There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/nonpneumonic (n = 42), and...

Development of the RealTime SARS-CoV-2 quantitative Laboratory Developed Test and corre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367731
Journal of Clinical Virology : the Official Publication O... Berg MG, Zhen W et. al.

Aug 28th, 2021 - While diagnosis of COVID-19 relies on qualitative molecular testing for the absence or presence of SARS-CoV-2 RNA, quantitative viral load determination for SARS-CoV-2 has many potential applications in antiviral therapy and vaccine trials as well as implications for public health and quarantine guidance. To date, no quantitative SARS-CoV-2 viral load tests have been authorized for clinical use...

Variable duration of viral shedding in cancer patients with coronavirus disease 2019 (C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458847
Infection Control and Hospital Epidemiology; Babady NE, Cohen B et. al.

Aug 28th, 2021 - In this retrospective study of 105 severe acute respiratory coronavirus virus 2 (SARS-CoV-2)-infected cancer patients with longitudinal nasopharyngeal sampling, the duration of viral shedding and time to attain cycle threshold >30 was longer in patients with hematologic malignancy than in those with solid tumors. These findings have important public health implications.

Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective co...
https://doi.org/10.1093/cid/ciab721
Clinical Infectious Diseases : an Official Publication Of... Ong SWX, Chiew CJ et. al.

Aug 24th, 2021 - he impact of SARS-CoV-2 variants of concern (VOCs) on disease severity is unclear. In this retrospective study, we compared outcomes of patients infected with B.1.1.7, B.1.351, and B.1.617.2 with those with wild-type strains from early 2020. National surveillance data from 1-January-2021 to 22-May-2021 were obtained from the Ministry of Health, and outcomes in relation to VOC were explored. Det...

Deficient DNA mismatch repair and persistence of SARS-CoV-2 RNA shedding: a case report...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380012
BMC Infectious Diseases; Haque F, Lillie P et. al.

Aug 23rd, 2021 - Several independent risk factors have been reported to influence viral shedding following COVID-19 infection, but the influence of host-related molecular factors has not yet been described. We report a case of a cancer patient with Lynch syndrome (hereditary nonpolyposis colorectal cancer, HNPCC) who manifested SARS-CoV-2 PCR (polymerase chain reaction) positivity for at least 54 days after con...

Impact of coronavirus disease 2019 on respiratory surveillance and explanation of high ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446939
Influenza and Other Respiratory Viruses; Kim HM, Lee EJ et. al.

Aug 19th, 2021 - After the detection of the first case of coronavirus disease 2019 (COVID-19) in South Korea on January 20, 2019, it has triggered three major outbreaks. To decrease the disease burden of COVID-19, social distancing and active mask wearing were encouraged, reducing the number of patients with influenza-like illness and altering the detection rate of influenza and respiratory viruses in the Korea...

Dynamic changes in liver function parameters in patients with coronavirus disease 2019:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365287
BMC Infectious Diseases; Zeng QL, Yu ZJ et. al.

Aug 18th, 2021 - Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this multicentre, retrospective study, the parameters of liver function tests in COVID-19 inpatients were compared between various time-points in reference to SARS-CoV-2 shedding, and ...

Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418473
Journal of Clinical Laboratory Analysis; Zhang S, Zhu H et. al.

Aug 15th, 2021 - The dynamic alteration and comparative study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding pattern during treatment are limited. This study explores the potential risk factors influencing prolonged viral shedding in COVID-19. A total of 126 COVID-19 patients were enrolled in this retrospective longitudinal study. A multivariate logistic regression analysis was car...

Upper respiratory tract SARS-CoV-2 RNA loads in symptomatic and asymptomatic children a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349738
Clinical Microbiology and Infection : the Official Public... Costa R, Bueno F et. al.

Aug 14th, 2021 - Studies comparing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA load in the upper respiratory tract (URT) between children and adults-who either presented with coronavirus disease 2019 (COVID-19) or were asymptomatic-have yielded inconsistent results. Here, we conducted a retrospective, single-centre study to address this issue. Included were 1184 consecutive subjects (256 ch...

Design of the healthcare worker exposure response and outcomes (HERO) research platform.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349387
Contemporary Clinical Trials; Friedland A, Hernandez AF et. al.

Aug 10th, 2021 - The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and prevention. An online research platform was created to support a registry community of healthcare workers (HCWs) to understand their experiences and conduct clin...

Myasthenic Crisis After Recurrent COVID-19 Infection
https://www.mdedge.com/fedprac/article/244023/coronavirus-updates/myasthenic-crisis-after-recurrent-covid-19-infection/page/0/1?channel=45

Aug 9th, 2021 - Discussion Reinfection with the COVID-19 has been continuously debated with alternative explanations suggested for a positive test after a previous negative PCR test in the setting of symptom resolution. 1,2 Proposed causes include dynamic PCR results due to prolonged viral shedding and inaccurate or poorly sensitive tests.