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COVID-19 Reinfections
https://emedicine.medscape.com/article/2500144-overview

Aug 12th, 2022 - Practice Essentials The definition of COVID-19 reinfection has evolved since early 2021. Fundamentally, it describes an infected individual who has been fully vaccinated, with or without a booster or boosters, and who becomes infected with COVID-19 again. The CDC more precisely defines it as COVID-19 infection of a given person with 2 different viral strains occurring at least 45 days apart. Al...

COVID-19 Reinfections
http://emedicine.medscape.com/article/2500144-overview

Aug 12th, 2022 - Practice Essentials The definition of COVID-19 reinfection has evolved since early 2021. Fundamentally, it describes an infected individual who has been fully vaccinated, with or without a booster or boosters, and who becomes infected with COVID-19 again. The CDC more precisely defines it as COVID-19 infection of a given person with 2 different viral strains occurring at least 45 days apart. Al...

COVID-19 Reinfections
https://emedicine.medscape.com/article/2500144-print

Aug 12th, 2022 - The definition of COVID-19 reinfection has evolved since early 2021. Fundamentally, it describes an infected individual who has been fully vaccinated, with or without a booster or boosters, and who becomes infected with COVID-19 again. The CDC more precisely defines it as COVID-19 infection of a given person with 2 different viral strains occurring at least 45 days apart. Alternately, it may re...

Environmental detection of SARS-CoV-2 in hospital rooms in different wards of an Univer...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356633
The Journal of Hospital Infection; Barrigah-Benissan K, Ory J et. al.

Aug 10th, 2022 - Transmission of SARS-CoV-2 can occur through direct, indirect, or close contact with infected people. However, the extent of environmental contamination is unknown. The nature of the relation between patients' symptoms and SARS-CoV-2 environmental shedding remains unclear. The aim of this study was to assess the relationship between patient covid-19 status and environmental contamination. Betwe...

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349033
EBioMedicine Hawman DW, Meade-White K et. al.

Aug 7th, 2022 - In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodies. Within weeks of the first report of B.1.1.529, this VoC has rapidly spread throughout the world, replacing previously circulating strains of SARS-CoV-2 and leading ...

Geriatric risk and protective factors for serious COVID-19 outcomes among older adults ...
https://doi.org/10.1080/22221751.2022.2109517
Emerging Microbes & Infections; Lu G, Zhang Y et. al.

Aug 5th, 2022 - Omicron variant was featured with high transmissibility and striking antibody evasion. Shanghai has been experiencing Omicron wave since March 2022. Though several studies have evaluated the risk factors of severe infections, the analyses of BA.2 infection risk and protective factors among geriatric people was much limited. This multicenter cohort study described clinical characteristics of ger...

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus M...
https://doi.org/10.1128/jvi.00728-22
Journal of Virology; Chan M, Tiwary M et. al.

Aug 5th, 2022 - The 1918 H1N1 influenza pandemic was among the most severe in history, taking the lives of approximately 50 million people worldwide, and novel prophylactic vaccines are urgently needed to prevent another pandemic. Given that macaques are physiologically relevant preclinical models of human immunology that have advanced the clinical treatment of infectious diseases, a lethal pandemic influenza ...

Impact of Variant of Concern and Vaccination Status on COVID-19 Infection Virological D...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353295
Nephrology (Carlton, Vic.); Koh T, Ooi XY et. al.

Jul 30th, 2022 - It is unclear if variant of concern and vaccination status impact COVID-19 infection virological dynamics in haemodialysis patients and affect de-isolation protocol for dialysis centres. We performed a retrospective observational cohort study between February 2020 to September 2021, to examine the virological kinetics of vaccinated and unvaccinated haemodialysis patients with polymerase chain r...

Association of nirmatrelvir/ritonavir treatment on upper respiratory SARS-CoV-2 RT-PCR ...
https://doi.org/10.1093/cid/ciac600
Clinical Infectious Diseases : an Official Publication Of... Li H, Gao M et. al.

Jul 24th, 2022 - Acceleration of negative respiratory conversion of SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19) might reduce viral transmission. Nirmatrelvir/ritonavir is a new antiviral agent recently approved for treatment of COVID-19 that has the potential to facilitate negative conversion. A cohort of hospitalized adult patients with mild-to-moderate COVID-19 who had a high-risk for prog...

Duration of infectious shedding of SARS-CoV-2 omicron variant and its relation with sym...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287585
Clinical Microbiology and Infection : the Official Public... Keske Ş, Esken GG et. al.

Jul 20th, 2022 - SARS CoV-2 infections with omicron variants have a high capability of human-to-human transmission. Nevertheless, the duration of isolation for mild cases was shortened to 5-7 days. We aimed to detect the duration of viral shedding among healthcare workers (HCWs) with omicron by using viral culture. We prospectively included newly diagnosed non-severe, symptomatic SARS CoV-2 positive HCWs. Nasop...

Long and persistent COVID-19 in patients with hematologic malignancies: from bench to b...
https://doi.org/10.1097/QCO.0000000000000841
Current Opinion in Infectious Diseases; Laracy JC, Kamboj M et. al.

Jul 19th, 2022 - Cancer patients, especially those with hematologic malignancies, are at increased risk for coronavirus disease 2019 (COVID-19)-related complications and mortality. We describe the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 infection in patients with hematologic malignancies. The syndrome of persistent COVID-19 in patients with hematologic malignancies...

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) va...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295819
Emerging Microbes & Infections; Rissmann M, Noack D et. al.

Jul 6th, 2022 - The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous i...

Long-term SARS-CoV-2 Asymptomatic Carriage in an Immunocompromised Host: Clinical, Immu...
https://doi.org/10.1007/s10875-022-01313-6
Journal of Clinical Immunology; Spinicci M, Mazzoni A et. al.

Jul 3rd, 2022 - SARS-CoV-2 infection in immunocompromised hosts is challenging, and prolonged viral shedding can be a common complication in these patients. We describe the clinical, immunological, and virological course of a patient with eosinophilic granulomatosis with polyangiitis, who developed the status of long-term asymptomatic SARS-CoV-2 carrier for more than 7 months. Over the study period, the patien...

Early treatment of high-risk hospitalized COVID-19 patients with a combination of inter...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278225
Clinical Infectious Diseases : an Official Publication Of... Tam AR, Zhang RR et. al.

Jun 29th, 2022 - Early antiviral therapy was effective in the treatment of COVID-19. We assessed the efficacy and safety of combined interferon beta-1b and remdesivir treatment in hospitalized COVID-19 patients. We conducted a multicentre, prospective open-label, randomized-controlled trial involving high-risk adults hospitalized for COVID-19. Patients were randomly assigned to a 5-day interferon beta-1b 16 mil...

Modeling the effectiveness of healthcare personnel reactive testing and screening for t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278243
Clinical Infectious Diseases : an Official Publication Of... Zipfel CM, Paul P et. al.

Jun 21st, 2022 - The SARS-CoV-2 Omicron variant has been hypothesized to exhibit faster clearance (time from peak viral concentration to clearance of acute infection), decreased sensitivity of antigen tests, and increased immune escape (the ability of the variant to evade immunity conferred by past infection or vaccination) compared to prior variants. These factors necessitate re-evaluation of prevention and co...

Viral Shedding Kinetics and Transmission of Emerging SARS-CoV-2 Variants-Critical Compo...
https://doi.org/10.1001/jamanetworkopen.2022.13614
JAMA Network Open; Gowler CD, Paul P et. al.

May 25th, 2022 - Viral Shedding Kinetics and Transmission of Emerging SARS-CoV-2 Variants-Critical Components of Study Design.|2022|Gowler CD,Paul P,Reddy SC,|genetics,

Transmission and Infectious SARS-CoV-2 Shedding Kinetics in Vaccinated and Unvaccinated...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131744
JAMA Network Open; Jung J, Kim JY et. al.

May 25th, 2022 - Data are limited on whether patients with breakthrough COVID-19 infection have the potential to significantly contribute to the spread of SARS-CoV-2. To compare the secondary attack rate and infectious viral shedding kinetics of SARS-CoV-2 between fully vaccinated individuals (breakthrough infection group) and partially or unvaccinated individuals (nonbreakthrough infection group). This cohort ...

Air Surveillance for Viral Contamination with SARS-CoV-2 RNA at a Healthcare Facility.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129059
Food and Environmental Virology; Zahedi A, Seif F et. al.

May 25th, 2022 - The transmission pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 also called COVID-19 disease) in indoor environments are the main area of contention between health systems and scientists. In this context, little has been investigated about the collection of airborne viral shedding. Here, we collected air samples from 24 locations inside the sole COVID-19 patient care cen...

Prolonged severe acute respiratory coronavirus virus 2 (SARS-CoV-2) viral shedding in l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300976
Infection Control and Hospital Epidemiology; Brailita DM, Cushman-Vokoun AM et. al.

May 25th, 2022 - Prolonged severe acute respiratory coronavirus virus 2 (SARS-CoV-2) viral shedding in lower-respiratory specimens of critically ill patients does not correlate with nasopharyngeal swab results.|2022|Brailita DM,Cushman-Vokoun AM,Wood MG,Crowley AM,Rapp SA,|

Similar duration of viral shedding of the severe acute respiratory coronavirus virus 2 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237490
Infection Control and Hospital Epidemiology; Kandel CE, Banete A et. al.

May 23rd, 2022 - Among outpatients with coronavirus disease 2019 (COVID-19) due to the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) δ (delta) variant who did and did not receive 2 vaccine doses at 7 days after symptom onset, there was no difference in viral shedding (cycle threshold difference 0.59, 95% CI, -4.68 to 3.50; P = .77) with SARS-CoV-2 cultured from 2 (7%) of 28 and 1 (4%) of 26 outpatie...