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Differences in the clinical characteristics and outcomes of COVID-19 patients in the ep...
https://doi.org/10.1186/s12879-020-05728-7 10.46234/ccdcw2020.017 10.1016/S0140-6736(20)30183-5 10.1016/S0140-6736(20)30211-7 10.1016/S0140-6736(20)30460-8 10.1056/NEJMe2002387 10.1136/bmj.m606 10.1136/heartjnl-2020-317007 10.1016/0021-9681(87)90171-8 10.1002/jmv.25701 10.1016/S1473-3099(20)30230-9 10.1056/NEJMc2007942 10.1016/S0140-6736(20)30566-3 10.1001/jama.2020.6775 10.1001/jama.2020.5394 10.1016/S1473-3099(20)30232-2 10.1016/S0140-6736(20)30462-1 10.1038/s41586-020-2196-x 10.1093/cid/ciaa351 10.1371/journal.pcbi.1008269 10.1016/j.jmb.2020.07.009 10.1016/j.cell.2020.06.043
BMC Infectious Diseases; Wang G, Luo FM et. al.

Feb 25th, 2021 - There is limited information on the difference in epidemiology, clinical characteristics and outcomes of the initial outbreak of the coronavirus disease (COVID-19) in Wuhan (the epicenter) and Sichuan (the peripheral area) in the early phase of the COVID-19 pandemic. This study was conducted to investigate the differences in the epidemiological and clinical characteristics of patients with COVI...

Case Report: Prolonged Viral Shedding in Six COVID-19 Patients.
https://doi.org/10.4269/ajtmh.20-0933
The American Journal of Tropical Medicine and Hygiene; Alsaud AE, Nair AP et. al.

Feb 24th, 2021 - COVID-19 has surfaced as a multi-organ disease predominantly affecting the respiratory system. Detection of the viral RNA through reverse transcriptase-PCR (RT-PCR) from a nasopharyngeal or throat sample is the preferred method of diagnosis. Recent evidence has suggested that COVID-19 patients can shed the SARS-CoV-2 for several weeks. Herein, we report six cases of COVID-19 who had persistentl...

SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for f...
https://doi.org/10.1371/journal.pone.0247367
PloS One; Yuan C, Wang H et. al.

Feb 22nd, 2021 - This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing to promote diagnostic efficiency. All SARS-CoV-2-infected patients with a laboratory-confirmed diagnosis in Zhoushan City were followed up for viral shedding in respiratory tract specimens and faecal samples. Positivity was...

Dynamics of SARS-CoV-2 shedding in the respiratory depends on the severity of disease i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898160
The European Respiratory Journal; Munker D, Osterman A et. al.

Feb 19th, 2021 - A fraction of COVID-19 patients progress to a severe disease manifestation with respiratory failure and the necessity of mechanical ventilation. Identifying patients at risk is critical for optimized care and early therapeutic interventions. We investigated the dynamics of SARS-CoV-2 shedding relative to disease severity.We analyzed nasopharyngeal and tracheal shedding of SARS-CoV-2 in 92 patie...

Viral load of SARS-CoV-2 in adults during the first and second wave of COVID-19 pandemi...
https://doi.org/10.1093/infdis/jiab097
The Journal of Infectious Diseases; Avadhanula V, Nicholson EG et. al.

Feb 15th, 2021 - During the COVID-19 pandemic, a minority of index cases are associated with a majority of secondary cases suggesting that super-spreaders could drive the pandemic. We identified a phenotype in individuals with extremely high viral load who could act as super-spreaders. Data were analyzed from individuals tested for SARS-CoV-2 from March 18 through August 15, 2020. Outcomes were compared using c...

Factors associated with delayed viral shedding in COVID-19 infected patients: A retrosp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866845
Respiratory Medicine; Cao HR, Zhu XY et. al.

Feb 15th, 2021 - The outbreak of COVID-19 has caused ever-increasing attention and public panic all over the world. Until now, data are limited about the risk factors to virus shedding in COVID-19 infected patients. In this retrospective study, data were collected from 87 patients hospitalized with COVID-19 infection in Suzhou. Using Cox proportional hazards regression and Kaplan-Meier survival analysis, the ri...

Epidemiological characterization of symptomatic and asymptomatic COVID-19 cases and pos...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880695
PloS One; Al-Rifai RH, Acuna J et. al.

Feb 12th, 2021 - The coronavirus disease 2019 (COVID-19) cases could be symptomatic or asymptomatic. We (1) characterized and analyzed data collected from the first cohort of reverse transcriptase polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases reported in the Emirate of Abu Dhabi, United Arab Emirates, according to the symptomatic state, and (2) identified factors associated with the symptomatic st...

Symptoms and laboratory manifestations of mild COVID-19 in a repatriated cruise ship co...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900670
Epidemiology and Infection; Bailie CR, Franklin L et. al.

Feb 10th, 2021 - Much of our current understanding about novel coronavirus disease 2019 (COVID-19) comes from hospitalised patients. However, the spectrum of mild and subclinical disease has implications for population-level screening and control. Forty-nine participants were recruited from a group of 99 adults repatriated from a cruise ship with a high incidence of COVID-19. Respiratory and rectal swabs were t...

Dysentery as the only presentation of COVID-19 in a child: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870123
Journal of Medical Case Reports; Tariverdi M, Farahbakhsh N et. al.

Feb 9th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic has caused irreparable damage to society, and the damage continues. Pediatricians are confronted with COVID-19 in a variety of presentations, which may lead to delayed diagnosis and treatment. Early diagnosis of the disease plays an important role in preventing transmission of the virus in the community. Here we report a 27-month-old previously h...

COVID-19: Peginterferon Lambda May Prevent Clinical Deterioration, Shorten Viral Shedding
https://www.medscape.com/viewarticle/945617

Feb 9th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In outpatients with COVID-19, peginterferon lambda has the potential to prevent clinical deterioration and shorten the duration of viral shedding, according to results of a double-blind, placebo-controlled trial (NCT04354259). The investigators pointed out that the difference in viral load decli...

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo...
https://doi.org/10.1016/S2213-2600(20)30566-X
The Lancet. Respiratory Medicine; Feld JJ, Kandel C et. al.

Feb 8th, 2021 - To date, only monoclonal antibodies have been shown to be effective for outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate antiviral responses with activity against respiratory pathogens. We aimed to investigate the safety and efficacy of peginterferon lambda in the treatment of outpatients with mild-to-moderate COVID-19. In this double-blind, placebo-con...

Clinical characteristics and potential factors for recurrence of positive SARS-CoV-2 RN...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860998
Clinical and Experimental Medicine; Ao Z, Li Y et. al.

Feb 5th, 2021 - The recurrence of positive SARS-CoV-2 RT-PCR is frequently found in discharged COVID-19 patients but its clinical significance remains unclear. The potential cause, clinical characteristics and infectiousness of the recurrent positive RT-PCR patients need to be answered. A single-centered, retrospective study of 51 discharged COVID-19 patients was carried out at a designated hospital for COVID-...

A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or int...
https://doi.org/10.1136/bcr-2020-240531
BMJ Case Reports; Tuan J, Spichler-Moffarah A et. al.

Feb 5th, 2021 - We present a case of a patient who had a history of severe coronavirus disease (COVID-19) 4 months prior to this current presentation and, after a long asymptomatic period, subsequently tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by a RNA PCR assay, after several interval negative SARS-CoV-2 RNA tests. We present this potential case of SARS-CoV-2 reinfection...

Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853502
PloS One; Johnston SC, Ricks KM et. al.

Feb 2nd, 2021 - Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to det...

Gastroenterology manifestations and COVID-19 outcomes: A meta-analysis of 25,252 cohort...
https://doi.org/10.1002/jmv.26836
Journal of Medical Virology; Elshazli RM, Kline A et. al.

Feb 2nd, 2021 - A meta-analysis was performed to identify patients with coronavirus disease 2019 (COVID-19) presenting with gastrointestinal (GI) symptoms during the first and second pandemic waves and investigate their association with the disease outcomes. A systematic search in PubMed, Scopus, Web of Science, ScienceDirect, and EMBASE was performed up to July 25, 2020. The pooled prevalence of the GI presen...

The impact of SARS-CoV-2 and COVID-19 on male reproduction and men's health.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775791
Fertility and Sterility; Patel DP, Punjani N et. al.

Jan 29th, 2021 - Many couples initially deferred attempts at pregnancy or delayed fertility care due to concerns about coronavirus disease 2019 (COVID-19). One significant fear during the COVID-19 pandemic was the possibility of sexual transmission. Many couples have since resumed fertility care while accepting the various uncertainties associated with severe acute respiratory syndrome coronavirus 2, including ...

High SARS-CoV-2 load in the nasopharynx of patients with a mild form of COVID-19 is ass...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846025
PloS One; Komissarov A, Molodtsov I et. al.

Jan 29th, 2021 - Because of the constantly growing numbers of COVID-19 infections and deaths, attempts were undertaken to find drugs with anti-SARS-CoV-2 activity among ones already approved for other pathologies. In the framework of such attempts, in a number of in vitro, as well as in vivo, models it was shown that hydroxychloroquine (HCQ) has an effect against SARS-CoV-2. While there were not enough clinical...

First Reported Nosocomial Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 i...
https://doi.org/10.1093/cid/ciaa491
Clinical Infectious Diseases : an Official Publication Of... Schwierzeck V, König JC et. al.

Jan 27th, 2021 - Coronavirus disease 2019 (COVID-19) is a life-threatening respiratory condition caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was initially detected in China in December 2019. Currently, in Germany >140 000 cases of COVID-19 are confirmed. Here we report a nosocomial outbreak of SARS-CoV-2 infections in the pediatric dialysis unit of the University Hospital Münster ...

Home quarantine in COVID-19: A study on 50 consecutive patients in Austria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850183
Clinical Medicine (London, England); Gietl S, Schönegger CM et. al.

Jan 22nd, 2021 - A cohort of the first 50 COVID-19 patients in East Tyrol, a region in the southwest of Austria, were monitored in home quarantine. Specific viral ribonucleic acid was detected in throat swabs and stool samples. Analysis indicated a median virus shedding duration of 13 days; however, statistical outliers highlight the importance of consequent testing. This underlines the need of negative throat ...

An environmental study of tracheostomy on eight COVID-19 patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812555
Journal of Otolaryngology - Head & Neck Surgery = Le Jour... Xu K, Zhang XH et. al.

Jan 19th, 2021 - Tracheostomy, as an aerosol-generating procedure, is considered as a high-risk surgery for health care workers (HCWs) during the coronavirus disease (COVID-19) pandemic. Current recommendations are to perform tracheostomy after a period of intubation of > 14 days, with two consecutive negative throat swab tests, to lower the risk of contamination to HCWs. However, specific data for this recomme...