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Lopinavir/ritonavir is associated with pneumonia resolution in COVID-19 patients with i...
https://doi.org/10.1002/jmv.26260
Journal of Medical Virology; Yu C, Zhang Z et. al.

Jul 3rd, 2020 - During the early stages of the pandemic, some coronavirus disease (COVID-19)patients were misdiagnosed as having influenza, which aroused the concern that some deaths attributed to influenza were actually COVID-19-related. Howerver, little is known about whether coinfection with influenza contributes to severity of COVID-19 pneumonia, and the optimal therapeutic strategy for these patients. We ...

Clinical characteristics of COVID-19 patients in three consecutive generations of sprea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316043
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases; Yao Y, Chen W et. al.

Jun 30th, 2020 - To determine the clinical characteristics of COVID-19 patients as the SARS-CoV-2 virus continues to circulate in the population. This is a retrospective, multi-center cohort study. Adult COVID-19 cases from four hospitals in Zhejiang were enrolled and clustered into 3 groups based on epidemiological history. First-generation patients had a travel history to Hubei within 14 days before disease o...

Active Surveillance for Acute Respiratory Infections among Pediatric Long-Term Care Fac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316056
American Journal of Infection Control; Wilmont S, Neu N et. al.

Jun 30th, 2020 - Transmission of respiratory viruses between staff and residents of pediatric long-term care facilities (pLTCFs) can occur. We assessed the feasibility of using text or email messages to perform surveillance for acute respiratory infections (ARIs) among staff. From December 7, 2016 to May 7, 2017, 50 staff participants from two pLTCFs received weekly text or email requests to report the presence...

Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and ot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163
Travel Medicine and Infectious Disease; Lagier JC, Million M et. al.

Jun 30th, 2020 - In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases. We retrospectively report the clinical management of 3,737 screened patients, including 3,119 (83.5%) treated with HCQ-AZ (200 mg of oral HCQ, three time...

Duration of Respiratory and Gastrointestinal Viral Shedding in Children With SARS-CoV-2...
https://doi.org/10.1097/INF.0000000000002814
The Pediatric Infectious Disease Journal; Xu CLH, Raval M et. al.

Jun 29th, 2020 - Children with coronavirus disease 2019 (COVID-19) are more likely to have mild or no symptoms compared to adults and may represent important vectors for transmitting the virus. Little is known about the duration of respiratory and gastrointestinal viral shedding in children with COVID-19. To determine the average shedding times of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via...

High-dose but not low-dose corticosteroids potentially delay viral shedding of patients...
https://doi.org/10.1093/cid/ciaa829
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Li S, Hu Z et. al.

Jun 25th, 2020 - High-dose but not low-dose corticosteroids potentially delay viral shedding of patients with COVID-19.|2020|Li S,Hu Z,Song X,|

Comparable Disease Severity by Influenza Virus Subtype in the Acute Respiratory Infecti...
https://doi.org/10.1093/milmed/usaa120
Military Medicine; Schofield C, Colombo RE et. al.

Jun 25th, 2020 - Since the influenza A/H1N1 pandemic of 2009 to 2010, numerous studies have described the clinical course and outcome of the different subtypes of influenza (A/H1N1, A/H3N2, and B). A recent systematic literature review concluded that there were no appreciable differences in either clinical presentation or disease severity among these subtypes, but study parameters limit the applicability of the...

Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody ...
https://doi.org/10.4049/jimmunol.2000429
Journal of Immunology (Baltimore, Md. : 1950); McNee A, Smith TRF et. al.

Jun 25th, 2020 - mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus infection. However, questions remain whether small animal models accurately predict efficacy in humans. We have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing mAbs. We show that a strongly neutralizing mAb (2-12C) aga...

Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding dur...
https://doi.org/10.1017/S0950268820001399
Epidemiology and Infection; Han J, Shi LX et. al.

Jun 25th, 2020 - The clinical characteristics of patients with COVID-19 were analysed to determine the factors influencing the prognosis and virus shedding time to facilitate early detection of disease progression. Logistic regression analysis was used to explore the relationships among prognosis, clinical characteristics and laboratory indexes. The predictive value of this model was assessed with receiver oper...

Epidemiology and clinical course of COVID-19 in Shanghai, China.
https://doi.org/10.1080/22221751.2020.1787103
Emerging Microbes & Infections; Shen Y, Zheng F et. al.

Jun 22nd, 2020 - Background Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in a large urban center to inform prevention and treatment of imported epidemics. Methods We retrospectively analyzed data collected at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results Among 325 cases admitted...

A Comparison Between Chinese Children Infected with COVID-19 and with SARS.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301144
The Journal of Pediatrics; Xiong X, Chua GT et. al.

Jun 22nd, 2020 - To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. This is a cross-sectional study reviewing paediatric patients with SARS (n = 43) and COVID-19 (n=244) who were admitted to the Princess Margaret Hospital in Hong...

Persistence of SARS-CoV-2 in the environment and COVID-19 transmission risk from enviro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280109
Environmental Pollution (Barking, Essex : 1987); Carraturo F, Del Giudice C et. al.

Jun 22nd, 2020 - The Coronavirus disease 2019 (COVID-19) is spreading around the world, representing a global pandemic, counting, as of June 5th, 2020, over 6,600,000 confirmed cases and more than 390,000 deaths, with exponentially increasing numbers. In the first half of 2020, because of the widespread of the COVID-19, researches were focused on the monitoring of SARS-CoV-2 in water, wastewater, sludge, air, a...

Differences of SARS-CoV-2 Shedding Duration in Sputum and Nasopharyngeal Swab Specimens...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305751
Chest Wang K, Zhang X et. al.

Jun 22nd, 2020 - The viral shedding duration of SARS-CoV-2 has not been fully defined. Consecutive detection of SARS-CoV-2 RNA from respiratory tract specimens is essential for determining duration of virus shedding and providing evidence to optimize the clinical management of COVID-19. What are the shedding durations of SARS-CoV-2 RNA in upper and lower respiratory tract specimens respectively? What are their ...

Probable causes and risk factors for positive SARS-CoV-2 test in recovered patients: Ev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323238
Journal of Medical Virology; Wong J, Koh WC et. al.

Jun 19th, 2020 - Case reports of COVID-19 patients who have been discharged and subsequently report positive RT-PCR again (hereafter referred as 're-positive') do not fully describe the magnitude and significance of this issue. In order to determine the re-positive rate (proportion) and review probable causes and outcomes, we conduct a retrospective study of all 119 discharged patients in Brunei Darussalam up t...

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections.
https://doi.org/10.1038/s41591-020-0965-6
Nature Medicine; Long QX, Tang XJ et. al.

Jun 17th, 2020 - The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. As...

SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292581
The Lancet. Infectious Diseases; Hung IF, Cheng VC et. al.

Jun 16th, 2020 - A cruise ship is a closed-off environment that simulates the basic functioning of a city in terms of living conditions and interpersonal interactions. Thus, the Diamond Princess cruise ship, which was quarantined because of an onboard outbreak of COVID-19 in February, 2020, provides an opportunity to define the shedding pattern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and...

Epidemiological features and viral shedding in children with SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323101
Journal of Medical Virology; Hua CZ, Miao ZP et. al.

Jun 16th, 2020 - A pandemic of SARS-CoV-2 infection broke out all over the world, however, epidemiological data and viral shedding in pediatric patients are limited. We conducted a retrospective, multi-center study, and followed up with all children from the families with SARS-CoV-2 infected members in Zhejiang Province, China. All infections were confirmed by testing the SARS-CoV-2 RNA with RT-PCR method, and ...

Four in 10 Patients With Coronavirus Infection Shed Virus in Stool
https://www.medscape.com/viewarticle/932374

Jun 15th, 2020 - (Reuters Health) - While just 12% of patients with confirmed SARS-Cov-2 infection experience gastrointestinal symptoms, 40.5% have viral RNA in their stool, a new study suggests. In a meta-analysis of 29 studies that included more than 4,800 patients, researchers found that gastrointestinal symptoms are common and fecal shedding may present an important transmission risk, according to the repor...

Duration of viral shedding in asymptomatic or mild cases of novel coronavirus disease 2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289725
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases; Miyamae Y, Hayashi T et. al.

Jun 14th, 2020 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of novel coronavirus disease 2019 (COVID-19) first reported in Wuhan, China, has spread across the world, and has been characterized as a global pandemic. The propagation from asymptomatic polymerase chain reaction (PCR)-positive individuals represents a complicating factor in the efforts to control the COVID-19 pa...

Persistent viral RNA shedding after COVID-19 symptom resolution in older convalescent p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323103
Transfusion Hartman WR, Hess AS et. al.

Jun 13th, 2020 - The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for a worldwide pandemic. While the medical community understands the mode of viral transmission, less is known about how long viral shedding occurs once viral symptoms have resolved. Our objective was to determine how long the SARS-CoV-2 remains detectable following self-reporting of viral sympt...