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Spatial Variability in COVID-19 Mortality.
https://doi.org/10.3390/ijerph18115892
International Journal of Environmental Research and Publi... Bossak BH, Turk CA

Jun 2nd, 2021 - COVID-19 emerged as a global pandemic in the spring of 2020. Since that time, the disease has resulted in approximately 150 million cases and 3 million deaths worldwide. However, there is significant spatial variation in the rate of mortality from COVID-19. Here, we briefly explore spatial variations in COVID-19 mortality by country groupings and propose possible explanations for the difference...

High Vitamin D Levels May Not Protect Against COVID-19
https://www.medscape.com/viewarticle/952339

Jun 2nd, 2021 - (Reuters) - Low levels of vitamin D have been tied to higher risks for COVID-19 and more severe illness, although no studies have proved that vitamin D deficiency is actually to blame. A study published on Tuesday in PLoS Medicine suggests that boosting vitamin D levels with supplements would not help. Researchers studied more than 1.2 million people of European ancestry from 11 countries, some...

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initia...
https://doi.org/10.1371/journal.pmed.1003605
PLoS Medicine; Butler-Laporte G, Nakanishi T et. al.

Jun 1st, 2021 - Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro, observational, and ecological studies. However, vitamin D levels are associated with many confounding variables, and thus associations described to date may not be causal. Vitamin D Mendelian randomization (MR) studies have provided results tha...

The Vitamin D–COVID Question: Is the Answer in Our Genes?
https://www.medscape.com/viewarticle/952170

Jun 1st, 2021 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine. This week, we're going to dive into the lion's den once again with this study appearing in PLOS Medicine, which failed to show a c...

Potential benefit of vitamin d supplementation in people with respiratory illnesses, du...
https://doi.org/10.1111/cts.13044
Clinical and Translational Science; Chetty VV, Chetty M

May 31st, 2021 - This review describes the evidence for the potential benefit of Vitamin D supplementation in people with respiratory diseases who may have a higher susceptibility to Covid-19 infection and its consequences. Clinical evidence indicates that vitamin D may reduce the risk of both upper and lower respiratory tract infections and offers benefit particularly in people with Vitamin D deficiency. Some ...

Association between vitamin D supplementation or serum vitamin D level and susceptibili...
https://doi.org/10.1136/bmjopen-2020-043737
BMJ Open; Grove A, Osokogu O et. al.

May 29th, 2021 - To systemically review and critically appraise published studies of the association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19, including clinical course, morbidity and mortality outcomes. Systematic review. MEDLINE (OVID), Embase (OVID), Cochrane Central Register of Controlled Trials, MedRxiv and BioRxiv preprint databases....

Racial differences in dietary choices and their relationship to inflammatory potential ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143979
Nutrition Research (New York, N.Y.); Piyathilake CJ, Badiga S et. al.

May 28th, 2021 - Since the ongoing coronavirus disease 2019 (COVID-19) pandemic is linked to chronic inflammation, people with initial lower inflammatory status could have better outcomes from exposure to this disease. Because dietary habits are one of the most important modifiable risk factors for inflammation, identification of dietary components associated with inflammation could play a significant role in c...

Integrative omics provide biological and clinical insights into acute respiratory distr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144871
Intensive Care Medicine; Du M, Garcia JGN et. al.

May 25th, 2021 - Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional immune-inflammatory response following lung injury, including during coronavirus disease 2019 (COVID-19). Limited causal biomarkers exist for ARDS development. We sought to identify novel genetic susceptibility targets for ARDS to focus further investigation on their biological mechanism and therapeutic potential. Meta...

Reasons to avoid vitamin D deficiency during COVID-19 pandemic.
https://doi.org/10.20945/2359-3997000000291
Archives of Endocrinology and Metabolism; Dos Santos RN, Maeda SS et. al.

May 25th, 2021 - The effects of vitamin D on the musculoskeletal system are well established. Its deficiency causes osteomalacia, secondary hyperparathyroidism, and an increased risk for fractures and falls. However, clinical and experimental evidence points to extra-skeletal actions of vitamin D, including on immune and respiratory systems. Thus, during this COVID-19 pandemic, a possible deleterious role of vi...

Vitamin D supplementation for the treatment of COVID-19: a living systematic review.
https://doi.org/10.1002/14651858.CD015043
The Cochrane Database of Systematic Reviews; Stroehlein JK, Wallqvist J et. al.

May 24th, 2021 - The role of vitamin D supplementation as a treatment for COVID-19 has been a subject of considerable discussion. A thorough understanding of the current evidence regarding the effectiveness and safety of vitamin D supplementation for COVID-19 based on randomised controlled trials is required. To assess whether vitamin D supplementation is effective and safe for the treatment of COVID-19 in comp...

Maternal nutrients and effects of gestational COVID-19 infection on fetal brain develop...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144544
Clinical Nutrition ESPEN; Hoffman MC, Freedman R et. al.

May 24th, 2021 - Maternal gestational infection is a well-characterized risk factor for offsprings' development of mental disorders including schizophrenia, autism, and attention deficit disorder. The inflammatory response elicited by the infection is partly directed against the placenta and fetus and is the putative pathogenic mechanism for fetal brain developmental abnormalities. Fetal brain abnormalities are...

Can an anti-inflammatory diet be effective in preventing or treating viral respiratory ...
https://doi.org/10.1016/j.clnesp.2021.04.009
Clinical Nutrition ESPEN; Vahid F, Rahmani D

May 24th, 2021 - Respiratory Viruses infections (RVI) such as rhinovirus, coronavirus, influenza virus, and adenovirus affect the respiratory and the immune systems. The role of nutrition in the respiratory and immune systems has been studied in some studies, and its importance is undeniable. In addition, one of the key findings in this disease is high inflammation that affects almost all patients. This systema...

Serum vitamin D, calcium, and zinc levels in patients with COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053215
Clinical Nutrition ESPEN; Elham AS, Azam K et. al.

May 24th, 2021 - COVID-19 is a global public health concern. As no standard treatment has been found for it yet, several minerals and vitamins with antioxidants, immunomodulators, and antimicrobials roles can be sufficient for the immune response against the disease. The present study evaluates the serum vitamin D, calcium, and Zinc levels in patients with COVID-19. This research is a case-control study perform...

Influence of vitamin D status on hospital length of stay and prognosis in hospitalized ...
https://doi.org/10.1093/ajcn/nqab151
The American Journal of Clinical Nutrition; Reis BZ, Fernandes AL et. al.

May 21st, 2021 - Vitamin D acts as a mediator in the immune system regulating antiviral mechanisms and inflammatory processes. Vitamin D insufficiency has been suggested as a potential risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, although its impact on the prognosis of hospitalized patients with coronavirus disease 2019 (COVID-19) remains unclear. This multicenter pros...

Lack of association between vitamin D insufficiency and clinical outcomes of patients w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130780
BMC Infectious Diseases; Davoudi A, Najafi N et. al.

May 19th, 2021 - A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Ira...

Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135000
JAMA Network Open; Li Y, Tong CH et. al.

May 19th, 2021 - Low vitamin D levels have been reported to be associated with increased risk of SARS-CoV-2 infection. Independent, well-powered studies could further our understanding of this association. To examine whether low levels of vitamin D are associated with SARS-CoV-2 seropositivity, an indicator of previous infection. This is a cohort study of employees and spouses who elected to be tested for SARS-...

Vitamin D in the Covid-19 era: a review with recommendations from a G.I.O.S.E.G. expert...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127472
Endocrine Ulivieri FM, Banfi G et. al.

May 17th, 2021 - Vitamin D (VITD) is a key hormone for bone health and has relevant extra-skeletal effects that might play a role in the prevention and treatment of COronaVIrus Disease 19 (COVID-19). Literature regarding this scenario is voluminous but controversial. Glucocorticoid Induced Osteoporosis Skeletal Endocrinology Group (G.I.O.S.E.G) has been present in the scientific debate about the use of VITD and...

Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity.
https://doi.org/10.1002/jmv.27075
Journal of Medical Virology; Getachew B, Tizabi Y

May 15th, 2021 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, disproportionally targets older people, particularly men, ethnic minorities, and individuals with underlying diseases such as compromised immune system, cardiovascular disease, and diabetes. The discrepancy in COVID-19 incidence and severity is multifaceted and likely involves biol...

Coronavirus disease 2019, vitamin D and kidney function.
https://doi.org/10.1097/MNH.0000000000000723
Current Opinion in Nephrology and Hypertension; Szeto B, Fan L et. al.

May 15th, 2021 - The purpose of this review is to summarize the emerging studies analyzing the association between vitamin D and risk of COVID-19 infection and severity, as well as the early interventional studies investigating the protective effect of vitamin D supplementation against COVID-19. Studies investigating the association between vitamin D levels and risk of COVID-19 infection and risk of severe dise...

Low Circulating Vitamin D in Intensive Care Unit-Admitted COVID-19 Patients as a Predic...
https://doi.org/10.1093/jn/nxab107
The Journal of Nutrition; Bychinin MV, Klypa TV et. al.

May 13th, 2021 - Vitamin D deficiency has been associated with an increased risk of respiratory infections. The study aimed to evaluate the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients admitted to the intensive care unit (ICU) as a predictor of coronavirus disease 2019 (COVID-19) mortality. A single-center retrospective observational study was conducted. Forty adult patients (50% men) with conf...