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Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude,...
https://doi.org/10.1111/joim.13149
Journal of Internal Medicine; Rhodes JM, Subramanian S et. al.

Jul 1st, 2020 - SARS-CoV-2 coronavirus infection ranges from asymptomatic through to fatal COVID-19 characterised by a "cytokine storm" and lung failure. Vitamin D deficiency has been postulated as a determinant of severity. To review the evidence relevant to vitamin D and COVID-19 METHODS: Narrative review RESULTS: Regression modelling shows that more northerly countries in the Northern Hemisphere are current...

COVID-19 Fatalities, Latitude, Sunlight, and Vitamin D.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319635
American Journal of Infection Control; Whittemore PB

Jun 30th, 2020 - Since Vitamin D is known to be vital in regulating the immune system, and sunlight UV radiation exposure on the skin produces Vitamin D and UV intensity is highest nearest the equator, a study was done to examine the correlation between the latitude and COVID-19 fatality rates for countries. Eighty-eight countries were selected based on their likelihood of providing reliable data. Using death r...

NICE: 'No Evidence' to Support Vitamin D for COVID-19
https://www.medscape.com/viewarticle/933090

Jun 28th, 2020 - A National Institute for Health and Care Excellence (NICE) rapid evidence review has failed to find data to support using vitamin D supplements to reduce the risk or severity of COVID-19. There was a focus on vitamin D partly due to the additional risks of COVID-19 on black and minority ethnic (BAME) groups in the UK. BAME groups are already advised to take 10 micrograms of vitamin D daily thro...

COVID-19 Update: Stages to Brain Damage, Remdesivir Pricing
https://www.medscape.com/viewarticle/933151

Jun 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Here are the coronavirus stories Medscape's editors around the globe think you need to know about today: Stages to Brain Damage Neurologists propose a three-stage description of COVID-19's impact on the central nervous system in a new review, and they recommend hospitalized COVID-19 patients rec...

UK COVID-19 Update: Vitamin D Review, Leicester Lockdown?
https://www.medscape.com/viewarticle/933089

Jun 28th, 2020 - Editor's note, 29th June 2020: England's Health Secretary Matt Hancock announced to the Commons this evening that non-essential shops will close again in Leicester from tomorrow, schools will close from Thursday, and the lockdown loosening measures due to come into force on Saturday will not apply to the Leicester area. These are the UK coronavirus stories you need to know about today. Leiceste...

Vitamin D and Coronavirus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301098
Geriatric Nursing (New York, N.Y.); Simonson W

Jun 27th, 2020 - Vitamin D and Coronavirus.|2020|Simonson W,|

A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Impl...
https://doi.org/10.1002/rmv.2119
Reviews in Medical Virology REFERENCES; Malek Mahdavi A

Jun 24th, 2020 - The novel coronavirus disease 2019 (COVID-19) is rapidly expanding and causing many deaths all over the world with the World Health Organization (WHO) declaring a pandemic in March 2020. Current therapeutic options are limited and there is no registered and/or definite treatment or vaccine for this disease or the causative infection, severe acute respiratory coronavirus 2 syndrome (SARS-CoV-2)....

Serum calcium as a biomarker of clinical severity and prognosis in patients with corona...
https://doi.org/10.18632/aging.103526
Aging Sun JK, Zhang WH et. al.

Jun 24th, 2020 - The aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. The clinical outcome variables were also recorded. From February 10 to February 28, 2020, 241 patients were enro...

Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation...
https://doi.org/10.1080/22221751.2020.1785336
Emerging Microbes & Infections; Berthelot JM, Drouet L et. al.

Jun 23rd, 2020 - As healthy young adults can die of COVID-19, whereas old COVID-19 patients can have mild symptoms only, genetic variances probably contribute to the severity of this emerging infection. We previously put forward the hypothesis that gain of function variants of TMEM 173, which encodes STING, contribute to COVID-19, since bats are protected from coronaviruses due to loss of function mutations of ...

"Quarantine during COVID-19 outbreak: Changes in diet and physical activity increase th...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260516
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD; Mattioli AV, Sciomer S et. al.

Jun 23rd, 2020 - CoV-19/SARS-CoV-2 is a highly pathogenic virus that is causing a global pandemic with a high number of deaths and infected people. To contain the diffusion of infection, several governments have enforced restrictions on outdoor activities or even collective quarantine on the population. The present commentary briefly analyzes the effects of quarantine on lifestyle, including nutrition and physi...

Ultravıolet and COVID-19 pandemıc.
https://doi.org/10.1111/jocd.13559
Journal of Cosmetic Dermatology; Türsen Ü, Türsen B et. al.

Jun 22nd, 2020 - Coronaviruses cause COVID-19 and it is a extremely infectious viral infection. In this article, we will discuss the potential phototherapy problems and also alternative options for dermatologists, ultraviolet treatment against covid-19 virus, vitamin D-associated problems in these coronavirus days.

Risk and Management of Patients with Mastocytosis and MCAS in the SARS-CoV-2 (COVID-19)...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297685
The Journal of Allergy and Clinical Immunology; Valent P, Akin C et. al.

Jun 20th, 2020 - The COVID-19 (SARS-CoV-2) pandemic has massively distorted our health care systems and caused catastrophic consequences in our affected communities. The number of victims continues to increase and patients at risk can only be protected to a degree, since the virulent state may be asymptomatic. Risk factors concerning COVID-19-induced morbidity and mortality include advanced age, an impaired imm...

Covid-19: Public health agencies review whether vitamin D supplements could reduce risk.
https://doi.org/10.1136/bmj.m2475
BMJ (Clinical Research Ed.); Torjesen I

Jun 20th, 2020 - Covid-19: Public health agencies review whether vitamin D supplements could reduce risk.|2020|Torjesen I,|

Possible role of vitamin D in Covid-19 infection in pediatric population.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299247
Journal of Endocrinological Investigation; Panfili FM, Roversi M et. al.

Jun 19th, 2020 - Covid-19 is a pandemic of unprecedented proportion, whose understanding and management is still under way. In the emergency setting new or available therapies to contrast the spread of COVID-19 are urgently needed. Elderly males, especially those affected by previous diseases or with comorbidities, are more prone to develop interstitial pneumonia that can deteriorate evolving to ARDS (acute res...

Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not ...
https://doi.org/10.1093/pubmed/fdaa095
Journal of Public Health (Oxford, England); Raisi-Estabragh Z, McCracken C et. al.

Jun 18th, 2020 - We examined whether the greater severity of coronavirus disease 2019 (COVID-19) amongst men and Black, Asian and Minority Ethnic (BAME) individuals is explained by cardiometabolic, socio-economic or behavioural factors. We studied 4510 UK Biobank participants tested for COVID-19 (positive, n = 1326). Multivariate logistic regression models including age, sex and ethnicity were used to test whet...

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-1...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289226
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]; Meftahi GH, Jangravi Z et. al.

Jun 12th, 2020 - Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide pandemic. Strangely, ample evidences have been shown that the severity of COVID-19 infections varies widely from children (asymptomatic), adults (mild infection), as well as elderly adults (deadly critical). It has proven that COVID-19 infection i...

People With Rheumatic Diseases Should Pay Extra Attention to Self-Care During COVID-19: Experts
https://www.medscape.com/viewarticle/932138

Jun 11th, 2020 - NEW YORK (Reuters Health) - People with rheumatic diseases should continue their medicines, monitor their health and avoid stress when possible during the current coronavirus pandemic, according to a group of rheumatologists in South Korea. Since rheumatic diseases are linked with chronic inflammation and abnormal immune functions, patients may be at a greater risk for COVID-19 infection, the a...

What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcys...
https://doi.org/10.3949/ccjm.87a.ccc046
Cleveland Clinic Journal of Medicine; Bauer SR, Kapoor A et. al.

Jun 9th, 2020 - Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. The authors outline the biologic plausibility, applicable...

Does vitamin D deficiency increase the severity of COVID-19?
https://doi.org/10.7861/clinmed.2020-0301
Clinical Medicine (London, England); Weir EK, Thenappan T et. al.

Jun 4th, 2020 - The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against uncontrolled inflammation, and against viral infection in general, is provided by T regulatory lymphocytes...

Is COVID-19 Fueling the Fire of Opinion-Based Medicine?
https://www.medscape.com/viewarticle/931608

Jun 3rd, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Is it just me, or have you noticed that the sounds of pseudoscience are getting louder lately? "I heard that vitamin C and zinc boost the immune system against COVID-19, so I take both supplements every day." "I believe vitamin D has important immune-modulatory properties, so I supplement my sun exposure with ...