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Placental Injury Reported in Women With COVID-19
https://www.medscape.com/viewarticle/931355

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Maternal vascular malperfusion and intervillous thrombi were more common in the placentas of women infected with SARS-CoV-2, compared with historic controls, report researchers who conducted the first-of-its-kind case series in the English literature. Nevertheless, the neonates in the report app...

SARS-CoV-2 Infection Rate 16% in Asymptomatic Pregnant Women at Delivery
https://www.medscape.com/viewarticle/931356

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Among women with a planned delivery in a New York City health system during the first half of April, the rate of asymptomatic SARS-CoV-2 infection was 16%, according to a study published in Obstetrics & Gynecology. Among the patients' designated support persons, the asymptomatic carrier rate was...

Whether to Test Laboring Women for Sars-Cov-2 May Hinge on Regional Prevalence
https://www.medscape.com/viewarticle/931357

May 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Labor & delivery units may need to consider regional prevalence of COVID-19 when deciding whether to test asymptomatic pregnant women for SARS-CoV-2 infection at the time of admission, research published online in Obstetrics & Gynecology suggests. In Los Angeles, researchers stopped universal te...

Coronavirus Map: Tracking the Global Outbreak
https://www.nytimes.com/interactive/2020/world/coronavirus-maps.html
New York Times;

May 28th, 2020 - The coronavirus pandemic has sickened more than 5,810,200 people, according to official counts. As of Friday morning, at least 360,400 people have died, and the virus has been detected in nearly every country, as these maps show.

Coronavirus (COVID-19) Update: Daily Roundup May 28, 2020 | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-daily-roundup-may-28-2020

May 28th, 2020 - For Immediate Release: May 28, 2020 The U.S. Food and Drug Administration today announced the following actions taken in its ongoing response effort to the COVID-19 pandemic: The FDA issued an Emergency Use Authorization for the Stryker Sustainability Solutions (SSS) VHP N95 Respirator Decontamination System (RDS). This product uses vapor hydrogen peroxide (VHP) to decontaminate compatible N95 ...

Any unique image biomarkers associated with COVID-19?
https://doi.org/10.1007/s00330-020-06956-w
European Radiology; Pu J, Leader J et. al.

May 27th, 2020 - To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. We retrospectively collected chest CT exams including n = 498 on 151 unique patients RT-PCR positive for COVID-19 and n = 497 unique patients with community-acquired pneumonia (CAP). Both COVID-19 and CAP image sets were partitioned into three groups for ...

Guidance for Resumption of Routine Electrodiagnostic Testing during the COVID-19 Pandemic.
https://doi.org/10.1002/mus.26990
Muscle & Nerve; Desai U, Kassardjian CD et. al.

May 27th, 2020 - As the world accommodates to the COVID-19 pandemic, routine in-person medical services are resuming. The resumption of non-urgent electrodiagnostic (EDX) testing faces unique challenges due to the long duration of the procedure and direct close contact with patients, including studies with risk of exposure to oropharyngeal secretions. We provide consensus guidance for resumption of EDX testing,...

Features of Enteric Disease from Human Coronaviruses: Implications for COVID-19.
https://doi.org/10.1002/jmv.26066
Journal of Medical Virology; Cimolai N

May 27th, 2020 - Coronaviruses have long been studied in both human and veterinary fields. Whereas the initial detection of endemic human respiratory coronaviruses was problematic, detection of these and newly discovered human coronaviruses has been greatly facilitated with major advances in the laboratory. Nevertheless, technological factors can affect the accuracy and timeliness of virus detection. Many human...

The COVID-19 epidemic of manuscripts.
https://doi.org/10.1111/jan.14437
Journal of Advanced Nursing; Watson R, Mark M

May 27th, 2020 - In the midst of the novel coronavirus pandemic-referred to as COVID-19-there has been much uncertainty. We remain uncertain about its precise origin, its structure and composition, how best to test for it, or for resulting immunity, whether or not exposure leads to immunity, whether or not disposable surgical masks are effective, why men and some ethnic minorities are more susceptible and just ...

Clinical features, isolation, and complete genome sequence of severe acute respiratory ...
https://doi.org/10.1002/jmv.26075
Journal of Medical Virology; Phan LT, Nguyen TV et. al.

May 27th, 2020 - In January 2020, we identified two SARS-CoV-2 infections in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of...

COVID-19: Consider IL6 receptor antagonist for the therapy of cytokine storm syndrome i...
https://doi.org/10.1002/jmv.26078
Journal of Medical Virology; Chakraborty C, Sharma AR et. al.

May 27th, 2020 - COVID-19 leads to mortality of several patients and the cytokine storm is reportedly critical in the patients. In order to reduce the cytokine storm, we would like to propose the IL6 receptor antagonist therapy for the COVID-19 patients. Two humanized monoclonal antibodies are in clinical trial following IL6R antagonist therapies namely tocilizumab and sarilumab. However, researchers and physic...

Practical Guide for Pediatric Pulmonologists on Imaging Management of Pediatric Patient...
https://doi.org/10.1002/ppul.24870
Pediatric Pulmonology; Foust AM, McAdam AJ et. al.

May 27th, 2020 - Understanding of coronavirus disease 2019 is rapidly evolving with new articles on the subject daily. This flood of articles can be overwhelming for busy practicing clinicians looking for key pieces of information that can be applied in daily practice. This review article synthesizes the reported imaging findings in pediatric COVID-19 across the literature, offers imaging differential diagnosti...

The Diagnosis of SARS-CoV2 Pneumonia: A Review of Laboratory and Radiological Testing R...
https://doi.org/10.1002/jmv.26081
Journal of Medical Virology; Zheng Z, Yao Z et. al.

May 27th, 2020 - The rapid emergence of COVID-19 (coronavirus disease 2019) has necessitated the implementation of diverse pandemic control strategies throughout the world. In order to effectively control the spread of this disease, it is essential that it be diagnosed at an early stage so that patients can be reliably quarantined such that disease spread will be slowed. At present, the diagnosis of this infect...

Impact of COVID-19 on the mental health of surgeons and coping strategies.
https://doi.org/10.1002/hed.26291
Head & Neck REFERENCES; Balasubramanian A, Paleri V et. al.

May 27th, 2020 - Unprecedented times call for extraordinary measures. While surgeons across the globe try to comprehend the evolving facade of the COVID-19 pandemic and improvise surgical practice to the best of their ability, the psychological impact of the stress on their own mental health and well-being has been underestimated. This paper aims to review the indirect and overt factors that may affect the ment...

Psychosocial Stress Contagion in Children and Families During the COVID-19 Pandemic.
https://doi.org/10.1177/0009922820927044
Clinical Pediatrics; Liu CH, Doan SN

May 27th, 2020 - Psychosocial Stress Contagion in Children and Families During the COVID-19 Pandemic.|2020|Liu CH,Doan SN,|

Why have nanotechnologies been underutilized in the global uprising against the coronav...
https://doi.org/10.2217/nnm-2020-0163
Nanomedicine (London, England); Uskoković V

May 27th, 2020 - Prior research on nanotechnologies in diagnostics, prevention and treatment of coronavirus infections is reviewed. Gold nanoparticles and semiconductor quantum dots in colorimetric and immunochromatographic assays, silica nanoparticles in a polymerase chain reaction and spike protein nanospheres as antigen carriers and adjuvants in vaccine formulations present notable examples in diagnostics an...

The COVID-19 Pandemic: A Challenge for the Cardiovascular Health.
https://doi.org/10.2174/1573403X1602200519115447
Current Cardiology Reviews; Crisafulli A, Pagliaro P

May 27th, 2020 - The COVID-19 Pandemic: A Challenge for the Cardiovascular Health.|2020|Crisafulli A,Pagliaro P,|

Exposure to DPP-4 inhibitors and COVID-19 among people with type 2 diabetes. A case-con...
https://doi.org/10.1111/dom.14097
Diabetes, Obesity & Metabolism; Fadini GP, Morieri ML et. al.

May 27th, 2020 - Because other coronaviruses enter the cells by binding to dipeptidyl-peptidase-4 (DPP-4), it has been speculated that DPP-4 inhibitors (DPP-4i) may exert an activity against SARS-CoV-2. In the absence of clinical trial results, we analyzed epidemiological data to support or discard such hypothesis. We retrieved information on exposure to DPP-4i among patients with type 2 diabetes (T2D) hospital...

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations...
https://doi.org/10.1021/acsinfecdis.0c00288
ACS Infectious Diseases; Polonikov A

May 27th, 2020 - Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative str...

Heightened risk of child maltreatment amid the COVID-19 pandemic can exacerbate mental ...
https://doi.org/10.1037/tra0000597
Psychological Trauma : Theory, Research, Practice and Policy; Cuartas J

May 27th, 2020 - The spread of the COVID-19 disrupted ecological systems in which children develop, exacerbating threats to their safety and increasing their vulnerability to future psychopathology. Supports to reduce sources of stress for caregivers and protect children from threats to their safety are warranted. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Stress and cognitive functioning during a pandemic: Thoughts from stress researchers.
https://doi.org/10.1037/tra0000716
Psychological Trauma : Theory, Research, Practice and Policy; Boals A, Banks JB

May 27th, 2020 - In this commentary we discuss a downstream consequence of increases in stress and anxiety during the COVID-19 pandemic. Stress and anxiety can lead to mind wandering, which in turn competes for limited cognitive resources. We encourage researchers to be understanding and patient concerning the inevitable cognitive impact of the pandemic and subsequent reduced productivity levels from our studen...

Shattered social identity and moral injuries: Work-related conditions in health care pr...
https://doi.org/10.1037/tra0000715
Psychological Trauma : Theory, Research, Practice and Policy; Kröger C

May 27th, 2020 - The present article assesses the effects of shattered social identity and moral injuries experienced by health care professionals (HCPs) due to the COVID-19 pandemic. Professional expertise and emotional-cognitive demands as key aspects of HCPs' social identity are introduced, and the effects of moral injuries-in terms of violation of medical-ethical and social-ethical norms-on the mental healt...

Raising awareness of disabled lives and health care rationing during the COVID-19 pande...
https://doi.org/10.1037/tra0000673
Psychological Trauma : Theory, Research, Practice and Policy; Lund EM, Ayers KB

May 27th, 2020 - Discriminatory and ableist health care rationing policies have raised serious concern in the disability community during the novel coronavirus pandemic. These concerns reflect the long-standing devaluation of disabled lives and place considerable weight on the disability community during this already stressful time. Nondisabled psychologists should work to advocate for the rights of people with...

Social representations, identity threat, and coping amid COVID-19.
https://doi.org/10.1037/tra0000773
Psychological Trauma : Theory, Research, Practice and Policy; Jaspal R, Nerlich B

May 27th, 2020 - This article describes an integrative social psychological framework within which human reactions to COVID-19 can be understood and predicted. It is argued that social representations of COVID-19 (and its mitigation strategies) must resonate among diverse communities, not be too threatening, and provide clear pathways for action and engagement. (PsycInfo Database Record (c) 2020 APA, all rights...

When chaos is the norm: How some veterans with PTSD are continuing to engage in trauma-...
https://doi.org/10.1037/tra0000718
Psychological Trauma : Theory, Research, Practice and Policy; Sciarrino NA, Myers US et. al.

May 27th, 2020 - The COVID-19 pandemic has caused many Veterans Healthcare Administration providers working with veterans diagnosed with posttraumatic stress disorder to question the feasibility and appropriateness of continuing to provide trauma-focused treatment during this crisis. The Veterans Healthcare Administration is in a unique position to continue to provide trauma-informed care because of its capacit...

Chloroquine or Hydroxychloroquine for COVID-19: Is Cardiotoxicity a Concern?
https://doi.org/10.1161/JAHA.120.016887
Journal of the American Heart Association; Kamp TJ, Hamdan MH et. al.

May 27th, 2020 - The SARS-Cov-2 viral pandemic causing COVID-19 disease begs for rapid and innovative treatments. In addition to flu-like respiratory symptoms, acute cardiac manifestations include cardiac injury, shock and arrhythmia. Several pharmacological therapies have been suggested including repurposing of existing drugs such as chloroquine and hydroxychloroquine, sometimes co-administered with azithromyc...

Experience with Hydroxychloroquine and Azithromycin in the COVID-19 Pandemic: Implicati...
https://doi.org/10.1161/JAHA.120.017144
Journal of the American Heart Association; Ramireddy A, Chugh H et. al.

May 27th, 2020 - Background Despite a lack of clinical evidence, hydroxychloroquine and azithromycin are being administered widely to patients with verified or suspected COVID-19. Both drugs may increase risk of lethal arrhythmias associated with QT interval prolongation. Methods and Results We performed a case series of COVID-19 positive/suspected patients admitted between 2/1/2020 and 4/4/2020 who were treate...

Conducting Clinical Research During the COVID-19 Pandemic: Protecting Scientific Integr...
https://doi.org/10.1001/jama.2020.9286
JAMA Fleming TR, Labriola D et. al.

May 27th, 2020 - Conducting Clinical Research During the COVID-19 Pandemic: Protecting Scientific Integrity.|2020|Fleming TR,Labriola D,Wittes J,|

Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic.
https://doi.org/10.1001/jama.2020.8573
JAMA Starr P

May 27th, 2020 - Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic.|2020|Starr P,|

Metatranscriptomic Characterization of COVID-19 Identified A Host Transcriptional Class...
https://doi.org/10.1093/cid/ciaa663
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Zhang H, Ai JW et. al.

May 27th, 2020 - The recent identification of a novel coronavirus, also known as SARS-CoV-2, has caused a global outbreak of respiratory illnesses. The rapidly developing pandemic has posed great challenges to diagnosis of this novel infection. However, little is known about the metatranscriptomic characteristics of patients with Coronavirus Disease 2019 (COVID-19). We analyzed metatranscriptomics in 187 patien...

Positive impact of measures against COVID-19 on reducing influenza in the Northern Hemi...
https://doi.org/10.1093/jtm/taaa087
Journal of Travel Medicine; Chan CP, Wong NS et. al.

May 27th, 2020 - Positive impact of measures against COVID-19 on reducing influenza in the Northern Hemisphere.|2020|Chan CP,Wong NS,Leung CC,Lee SS,|

Alterations in smell or taste - Classic COVID-19?
https://doi.org/10.1093/cid/ciaa655
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Trubiano JA, Vogrin S et. al.

May 27th, 2020 - Alterations in smell or taste - Classic COVID-19?|2020|Trubiano JA,Vogrin S,Kwong JC,Homes N,|

Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the ...
https://doi.org/10.1001/jama.2020.9184
JAMA Vaduganathan M, van Meijgaard J et. al.

May 27th, 2020 - Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States.|2020|Vaduganathan M,van Meijgaard J,Mehra MR,Joseph J,O'Donnell CJ,|

Treating the SARS-CoV-2-positive patient with cancer: A proposal for a pragmatic and tr...
https://doi.org/10.1002/cncr.32962
Cancer References; Perni S, Milligan MG et. al.

May 27th, 2020 - The treatment of patients with cancer who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses unique challenges. In this commentary, the authors describe the ethical rationale and implementation details for the creation of a novel, multidisciplinary treatment prioritization committee, including physicians, frontline staff, an ethicist, and an infectious disease ...

The AORN Community Displays its Resiliency Amidst Pandemic Crisis.
https://doi.org/10.1002/aorn.13062
AORN Journal; Groah LK

May 27th, 2020 - The AORN Community Displays its Resiliency Amidst Pandemic Crisis.|2020|Groah LK,|

Screen time for children and adolescents during the COVID-19 pandemic.
https://doi.org/10.1002/oby.22917
Obesity (Silver Spring, Md.); Nagata JM, Abdel Magid HS et. al.

May 27th, 2020 - The coronavirus 2019 (COVID-19) pandemic has led to laws and policies including national school closures, lockdown or shelter in place laws, and social distancing recommendations that may translate to higher overall screen time among children and adolescents for the duration of these laws and policies. These policies may need to be periodically re-instated to control future COVID-19 recurrences...

Management of Heart Failure Patients with COVID-19. A Joint Position Paper of the Chine...
https://doi.org/10.1002/ejhf.1915
European Journal of Heart Failure; Zhang Y, Stewart Coats AJ et. al.

May 27th, 2020 - The Coronavirus Disease 2019 (COVID-19) pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is causing considerable morbidity and mortality worldwide. Multiple reports have suggested that patients with heart failure (HF) are at a higher risk of severe disease and mortality with COVID-19. Moreover, evaluating and treating HF patients with comorbid COVID-19 represen...

Obesity and COVID-19: an Italian snapshot.
https://doi.org/10.1002/oby.22918
Obesity (Silver Spring, Md.); Busetto L, Bettini S et. al.

May 27th, 2020 - The clinical manifestations of COVID-19 run from asymptomatic disease to severe acute respiratory syndrome. Older age and comorbidities are associated to more severe disease. A role of obesity is suspected. We enrolled patients hospitalized in the medical COVID-19 ward with SARS-CoV-2 related pneumonia. Primary outcome of the study was to assess the relationship between the severity of COVID-19...

Possible Role of Adipose Tissue and Endocannabinoid System in COVID-19 Pathogenesis: Ca...
https://doi.org/10.1002/oby.22916
Obesity (Silver Spring, Md.); Briand-Mésange F, Trudel S et. al.

May 27th, 2020 - This is the main conclusion of a recent study describing a strong relationship between the degree of obesity and the severity of COVID-19 infection. Obesity has various negative consequences relative to the course of COVID-19, including adverse effects on lung physiology, and induces comorbidities such as type II diabetes or hypertension. However, additional mechanisms involving the low-grade i...

Global perspectives on Covid-19 from the editorial board.
https://doi.org/10.1111/tct.13167
The Clinical Teacher References; Thistlethwaite J, Locke R et. al.

May 27th, 2020 - Global perspectives on Covid-19 from the editorial board.|2020|Thistlethwaite J,Locke R,Buckley S,Chandratilake M,Jensen G,|

How medical education can help in a COVID-19 crisis.
https://doi.org/10.1111/tct.13183
The Clinical Teacher References; Roberts C

May 27th, 2020 - How medical education can help in a COVID-19 crisis.|2020|Roberts C,|

COVID-19: opportunities for professional development and disruptive innovation.
https://doi.org/10.1111/tct.13175
The Clinical Teacher References; McMaster D, Veremu M et. al.

May 27th, 2020 - COVID-19: opportunities for professional development and disruptive innovation.|2020|McMaster D,Veremu M,Santucci C,|

COVID-19 and the need to prioritize health equity and social determinants of health.
https://doi.org/10.1007/s00038-020-01398-z
International Journal of Public Health; Takian A, Kiani MM et. al.

May 27th, 2020 - COVID-19 and the need to prioritize health equity and social determinants of health.|2020|Takian A,Kiani MM,Khanjankhani K,|

Viewpoint: Impact of the Covid-19 Outbreak on the Clinical and Research Activities of M...
https://doi.org/10.14283/jpad.2020.17
The Journal of Prevention of Alzheimer's Disease; Ousset PJ, Vellas B

May 27th, 2020 - Viewpoint: Impact of the Covid-19 Outbreak on the Clinical and Research Activities of Memory Clinics: An Alzheimer's Disease Center Facing the Covid-19 Crisis.|2020|Ousset PJ,Vellas B,|

Asymptomatic transmission during the COVID-19 pandemic and implications for public heal...
https://doi.org/10.1093/cid/ciaa654
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Huff HV, Singh A

May 27th, 2020 - SARS-CoV-2 spread rapidly within months despite global public health strategies to curb transmission by testing symptomatic patients and encouraging social distancing. Here, we summarize rapidly emerging evidence highlighting transmission by asymptomatic and pre-symptomatic individuals. Viral load of asymptomatic carriers is comparable to symptomatic patients, viral shedding is highest before s...

The Urgent Need for Medicare Reimbursement for Home Infusion Antibiotics amidst a Pande...
https://doi.org/10.1093/cid/ciaa658
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Streifel AC, Sikka MK

May 27th, 2020 - The Centers for Medicare and Medicaid Services should immediately update current policies to include reimbursement for Medicare patients receiving intravenous antibiotics at home. The majority of these patients are over the age of 65 and at increased risk for severe illness due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Requiring them to travel to an infusion center, stay ...

Letter: Using Continuous Intracranial Electroencephalography Monitoring to Manage Epile...
https://doi.org/10.1093/neuros/nyaa244
Neurosurgery Mirro EA, Halpern CH

May 27th, 2020 - Letter: Using Continuous Intracranial Electroencephalography Monitoring to Manage Epilepsy Patients During COVID-19.|2020|Mirro EA,Halpern CH,|

Clinical Utility of Buccal Swabs for Sars-Cov-2 Detection in Covid-19-Infected Children.
https://doi.org/10.1093/jpids/piaa068
Journal of the Pediatric Infectious Diseases Society; Kam KQ, Yung CF et. al.

May 27th, 2020 - SARS-CoV-2 was detected from at least 1 buccal specimen in 9 out of 11 COVID-19-infected children (81.8%). The viral loads in buccal specimens were substantially lower than those in nasopharyngeal specimens. Buccal swabs for SARS-CoV-2 are not good as screening specimens for COVID-19 in children.

Detecting Early Signals of COVID-19 Global Pandemic from Network Density.
https://doi.org/10.1093/jtm/taaa084
Journal of Travel Medicine; Chu AMY, Tiwari A et. al.

May 27th, 2020 - A novel use of network analysis in public health Developing a quantitative assessment method for the COVID-19 pandemic risk Exploring the time series of network density for early warning signals of pandemic risk Tracking the evolution of pandemic risk through the degree of connectedness.

Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series.
https://doi.org/10.1093/jpids/piaa069
Journal of the Pediatric Infectious Diseases Society; Chiotos K, Bassiri H et. al.

May 27th, 2020 - We present a series of six critically ill children with Multisystem Inflammatory Syndrome in Children (MIS-C). Key findings of this syndrome include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes.

COVID-19 Immunity Passport to Ease Travel Restrictions?
https://doi.org/10.1093/jtm/taaa085
Journal of Travel Medicine; Chen LH, Freedman DO et. al.

May 27th, 2020 - COVID-19 Immunity Passport to Ease Travel Restrictions?|2020|Chen LH,Freedman DO,Visser LG,|

The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population.
https://doi.org/10.1007/s11912-020-00945-4
Current Oncology Reports; Asokan I, Rabadia SV et. al.

May 27th, 2020 - The novel Coronavirus (2019-nCoV, COVID-19) is historically one of the most severe acute respiratory syndromes and pandemics to affect the globe in the twenty-first century. Originating in Wuhan, the virus rapidly spread and impacted subsets of populations with initial unclear risk factors contributing to worsening morbidity and mortality. Patients with diagnosis of cancer and undergoing treatm...

USMLE Step 2 CS Suspended for at Least 1 More Year
https://www.medscape.com/viewarticle/931259

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Sponsors of the US Medical Licensing Exam (USMLE) announced on Tuesday that they will continue to suspend administering Step 2 Clinical Skills (CS) for the next 12 to 18 months in light of the COVID-19 pandemic. "Due to the complexity of technical and psychometric work required, we have determin...

How a Small Oncology Practice Has Adapted to COVID-19
https://www.medscape.com/viewarticle/930971

May 27th, 2020 - This interview was originally published as part of MDedge's Blood & Cancer Podcast series. In this episode, podcast host David H. Henry, MD, of Pennsylvania Hospital, Philadelphia, spoke with Matthew Lonergan, MD, chief medical officer at Willamette Valley Cancer Institute and Research Center in Eugene, Oregon, about the myriad ways in which COVID-19 is reshaping inpatient care, clinical trials...

Reconstructing a Knee One Day, Working on COVID-19 the Next
https://www.medscape.com/viewarticle/931265

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. When New York Governor Andrew Cuomo called for licensed healthcare workers to help hospitals overwhelmed with COVID-19 patients, orthopedic surgeon Haydée Brown, MD, answered his appeal. Brown volunteered, as part of the New York City Medical Reserve Corps, at Lincoln Hospital, which is located ...

COVID-19 Test & Trace Goes Live
https://www.medscape.com/viewarticle/931290

May 27th, 2020 - A programme to test new COVID-19 cases and trace their contacts began today in England. Prime Minister Boris Johnson predicted that it would "change people's lives". NHS Test and Trace would form a central part of the Government's coronavirus recovery strategy and "help return life more to normal", the Government said. However, the service went live without a contact tracing app, which had been...

Gaps in Malpractice Insurance Pose Risk for Frontline Physicians, Nurses; More
https://www.medscape.com/viewarticle/931272

May 27th, 2020 - Limited Coverage Working Outside Specialty or State Many doctors and nurses working on the front lines of the coronavirus emergency face an increased malpractice risk without adequate liability coverage,coverage, according to Reuters. While both the federal and state governments have made efforts to limit providers' underlying risk — Washington in the form of the Coronavirus Aid, Relief, and Ec...

Seek Safe Strategies to Diagnose Gestational Diabetes During Pandemic
https://www.medscape.com/viewarticle/931287

May 27th, 2020 - Clinicians and pregnant women are less likely to prescribe and undergo the oral glucose tolerance test (OGTT) to diagnose gestational diabetes in the context of the COVID-19 pandemic, according to a review by H. David McIntyre, MD, of the University of Queensland, Brisbane, Australia, and Robert G. Moses, MD, of Wollongong (Australia) Hospital. National and international discussions of whether ...

Pandemic-Induced Surgery Delays Could Worsen Cancer Survival
https://www.medscape.com/viewarticle/931173

May 27th, 2020 - NEW YORK (Reuters Health) - Delays in cancer surgery related to the COVID-19 pandemic could substantially worsen survival outcomes, according to a model study. "Lockdown and redeployment due to the COVID-19 pandemic are causing significant disruption to cancer diagnosis and management," Dr. Clare Turnbull of the Institute of Cancer Research, in London, told Reuters Health by email. "A 3-month d...

Complete Fibrinolysis Shutdown Seen in Severe COVID-19
https://www.medscape.com/viewarticle/931316

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. COVID-19 causes not only hypercoagulability, but also "fibrinolysis shutdown," which is associated with venous thromboembolism (VTE), stroke, and renal failure, clinicians from Colorado have observed. They have found that the complete lack of clot lysis at 30 minutes on a thromboelastogram (TEG)...

COVID-19 Data Dives: Why Don't We Have a Vaccine for SARS or MERS?
https://www.medscape.com/viewarticle/931226

May 27th, 2020 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Medscape has asked top experts to weigh in on the most pressing scientific questions about COVID-19. Check back frequently for more COVID-19 Data Dives. Natalie E. Dean, PhD It is easy to point to the fact that we don't have licensed vaccines for severe acute respiratory syndrome (SARS), Middle East respirator...

Research Finds Concerning Drop in US Colorectal Cancer Screenings and Surgeries
https://www.medscape.com/viewarticle/931172

May 27th, 2020 - (Reuters) - New diagnoses of one of the deadliest cancers fell by one-third in March and April as U.S. physicians and patients halted appointments and screenings during the COVID-19 outbreak. Research by the health data firm Komodo Health and exclusively shared with Reuters found new colorectal cancer diagnoses declined more than 32%, while the number of performed colonoscopies and biopsies fel...

Concerns About Delayed, Deferred Acute CV Care Substantiated
https://www.medscape.com/viewarticle/931321

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Admissions for primary acute cardiovascular conditions tumbled in the first weeks of the US COVID-19 pandemic and were paralleled by higher in-hospital mortality among those admitted, a multicenter study shows. After examining acute cardiovascular (CV) hospitalizations from January 2019 through ...

Scientific Doubt Tempers COVID-19 Vaccine Optimism
https://www.medscape.com/viewarticle/931330

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. US government and industry projections that a COVID-19 vaccine will be ready by this fall or even January would take compressing what usually takes at least a decade into months, with little room for error or safety surprises. "If all the cards fall into the right place and all the stars are ali...

COVID-19 Daily: Airborne Transmission, Vaccine Timing Doubt
https://www.medscape.com/viewarticle/931350

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Here are the coronavirus stories Medscape's editors around the globe think you need to know about today:  COVID-19 Is Likely Airborne  Evidence is mounting that the virus that causes COVID-19 is transmitted via aerosol transmission, a researcher at the University of California San Diego reports ...

Fast Five Quiz: Kawasaki Disease
https://www.medscape.com/viewarticle/930972

May 27th, 2020 - This article was last updated on May 28, 2020. (Disclaimer: The information in this quiz may not be updated regularly. Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.) Kawasaki disease, also known as "mucocutaneous lymph node syndrome" and "Kawasaki syndrome," is an acute febrile illness seen in children that is characterized by vasculitis of the medium-siz...

Targeted Tx Improves Outcomes in High-Risk Pediatric Cancers
https://www.medscape.com/viewarticle/931326

May 27th, 2020 - Unlike adult cancers, in which targeted therapies have improved outcomes for some patients, the same has not been true for pediatric cancers. Pediatric oncology is really lagging behind, said Cornelis van Tilburg, MD, PhD, from the Hopp Children's Cancer Center, Heidelberg, Germany. But new data suggest that children can also benefit from this approach. Results from the INFORM (Individualized T...

Moving on Up: Maintenance Therapy Extends OS in Bladder Cancer
https://www.medscape.com/viewarticle/931319

May 27th, 2020 - Is maintenance therapy with an immune checkpoint inhibitor a good idea for patients with advanced bladder cancer who do not progress after initial chemotherapy? Yes, and furthermore this approach offers "a new first-line standard of care for advanced urothelial cancer," said Thomas Powles, MD, professor of genitourinary oncology and director of the Barts Cancer Centre in London, UK. Powles was ...

Half of Gastroenterologists Feel Fairly Compensated
https://www.medscape.com/viewarticle/931351

May 27th, 2020 - Just more than half of all gastroenterologists (52%) reported they feel fairly compensated in the Medscape Gastroenterologist Compensation Report 2020. By comparison, oncologists were the specialists most likely to say they were fairly paid (67%) and nephrologists were the least likely to say they were (44%). For gastroenterologists, pay was up only slightly from $417,000 last year to $419,000,...

UK COVID-19 Update: More Lockdown Loosening
https://www.medscape.com/viewarticle/931291

May 27th, 2020 - These are the UK coronavirus stories you need to know about today. More Lockdown Loosening in England Next Week Prime Minister Boris Johnson said the Government's five tests, including protecting the NHS, had been met, meaning more changes could be made to England's lockdown on Monday. He confirmed primary schools will partially reopen on Monday. Two weeks later secondary schools will provide s...

COVID-19 Is Likely Airborne, Aerosol Scientist Says
https://www.medscape.com/viewarticle/931320

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Something has been bothering Kimberly Prather, PhD: everything she reads about COVID-19 points to a pathogen that travels through the air. Kimberly Prather, PhD There's how quickly it has spread around the world, studies showing how it spreads through restaurants (maybe by the air conditioning s...

End-of-Life Care Disrupted in COVID-19 Crisis
https://www.medscape.com/viewarticle/931324

May 27th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. An elderly man with congestive heart failure was getting worse, but fear of going to the emergency department during the COVID-19 public health crisis kept him at home. Fred Rubin, MD, the man's geriatrician, talked with him and his wife on a video call, and together they decided that instead of...

For Mothers With Coronavirus, Baby's First Coo Is Over the Phone
https://www.medscape.com/viewarticle/931202

May 27th, 2020 - MOSCOW (Reuters) - "It's a girl and she is fine, we all are fine," said Rayhona, 23. "They have shown her to me on a smartphone." More than 150 babies have been born to mothers with suspected coronavirus infections at Moscow's City Clinical Hospital Number 15, and the hospital says not a single newborn caught the infection. But to achieve that, the babies are separated from their mothers at bir...

'Bold Action' Urged on Outpatient Dialysis for Undocumented US Patients
https://www.medscape.com/viewarticle/931177

May 27th, 2020 - NEW YORK (Reuters Health) - During the COVID-19 era, all 50 U.S. states should cover standard outpatient dialysis for undocumented immigrant patients with kidney failure, many of whom now rely on emergency-only dialysis, according to new recommendations. "Emergency-only hemodialysis utilizes a number of resources and would increase exposure for both providers and the patient undergoing emergenc...

COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Par...
https://doi.org/10.1186/s13058-020-01293-8
Breast Cancer Research : BCR; Vuagnat P, Frelaut M et. al.

May 27th, 2020 - Cancer patients have been reported to be at higher risk of COVID-19 complications and deaths. We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France). An IRB-approved prospective registry was set up at ICH on March 13, 2020, for all breast cancer patients with COVID-19 symptoms or radiolog...

Importance of Pediatric Inclusion in COVID-19 Therapeutic Trials.
https://doi.org/10.1093/cid/ciaa656
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Raabe VN, Lighter J et. al.

May 27th, 2020 - Pediatric patients are excluded from most COVID-19 therapeutic trials. We outline a rationale for the inclusion of children in COVID-19 therapeutic trials with enabled us to include children of all ages in a therapeutic COVID-19 trial at our institution.

Hospitalized patients with COVID-19 and HIV: a case series.
https://doi.org/10.1093/cid/ciaa657
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Childs K, Post FA et. al.

May 27th, 2020 - Hospitalized patients with COVID-19 and HIV: a case series.|2020|Childs K,Post FA,Norcross C,Ottaway Z,Hamlyn E,|

Tobacco Use Patterns in five countries during the COVID-19 Lockdown.
https://doi.org/10.1093/ntr/ntaa097
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco; Yach D

May 27th, 2020 - Tobacco Use Patterns in five countries during the COVID-19 Lockdown.|2020|Yach D,|

Stress-induced cardiac arrest with mitral annulus disjunction in a physician amid the C...
https://doi.org/10.1093/eurheartj/ehaa450
European Heart Journal; Marona M, Celinska-Spodar M et. al.

May 27th, 2020 - Stress-induced cardiac arrest with mitral annulus disjunction in a physician amid the COVID-19 pandemic fight.|2020|Marona M,Celinska-Spodar M,Spiewak M,Konopka A,|

Hospitalization and Mortality among Black Patients and White Patients with Covid-19.
https://doi.org/10.1056/NEJMsa2011686
The New England Journal of Medicine; Price-Haywood EG, Burton J et. al.

May 27th, 2020 - Many reports on coronavirus disease 2019 (Covid-19) have highlighted age- and sex-related differences in health outcomes. More information is needed about racial and ethnic differences in outcomes from Covid-19. In this retrospective cohort study, we analyzed data from patients seen within an integrated-delivery health system (Ochsner Health) in Louisiana between March 1 and April 11, 2020, who...

Long-Term Care Policy after Covid-19 - Solving the Nursing Home Crisis.
https://doi.org/10.1056/NEJMp2014811
The New England Journal of Medicine; Werner RM, Hoffman AK et. al.

May 27th, 2020 - Long-Term Care Policy after Covid-19 - Solving the Nursing Home Crisis.|2020|Werner RM,Hoffman AK,Coe NB,|

Audio Interview: New Data on Remdesivir in Covid-19.
https://doi.org/10.1056/NEJMe2019975
The New England Journal of Medicine; Rubin EJ, Baden LR et. al.

May 27th, 2020 - Audio Interview: New Data on Remdesivir in Covid-19.|2020|Rubin EJ,Baden LR,Morrissey S,|

Assessment of Adequacy of Respiratory Infection Prevention in Hospitals of Inner Mongol...
https://doi.org/10.1080/00325481.2020.1776015
Postgraduate Medicine; Xie Y, McNeil EB et. al.

May 27th, 2020 - Recent respiratory infectious disease (RID) outbreaks of influenza and the novel coronavirus have resulted in global pandemics. RIDs can trigger nosocomial infections if not adequately prevented. The objective of this study was to rate the adequacy of healthcare workers (HCWs) and hospital settings on RID prevention using unannounced standardized patients (USP) in clinical settings of hospital ...

SARS-CoV-2 Phylogenetic Analysis, Lazio Region, Italy, February-March 2020.
https://doi.org/10.3201/eid2608.201525
Emerging Infectious Diseases; Bartolini B, Rueca M et. al.

May 27th, 2020 - We report phylogenetic and mutational analysis of severe acute respiratory syndrome coronavirus 2 virus strains from the Lazio region of Italy and provide information about the dynamics of virus spread. Data suggest effective containment of clade V strains, but subsequently, multiple waves of clade G strains were circulating widely in Europe.

Teleneurology during the COVID-19 pandemic: A step forward in modernizing medical care.
https://doi.org/10.1016/j.jns.2020.116930
Journal of the Neurological Sciences; Roy B, Nowak RJ et. al.

May 27th, 2020 - The COVID-19 pandemic mandated rapid transition from face-to-face encounters to teleneurology visits. While teleneurology is regularly used in acute stroke care, its application in other branches of neurology was limited. Here we review how the recent pandemic has created a paradigm shift in caring for patients with chronic neurological disorders and how academic institutions have responded to ...

B-cell depleting therapies may affect susceptibility to acute respiratory illness among...
https://doi.org/10.1016/j.msard.2020.102195
Multiple Sclerosis and Related Disorders; Safavi F, Nourbakhsh B et. al.

May 27th, 2020 - To determine whether the course of COVID-19 is more severe in patients with MS and if MS disease-modifying treatments (DMTs) affect the risk of contracting the disease. In a cross-sectional survey, data were collected by sending a questionnaire to 2000 patients with a demyelinating disease through an online portal system. Collected data included the current MS DMT and patient-reported disabilit...

Considerations for interactions of drugs used for the treatment of COVID-19 with anti-c...
https://doi.org/10.1016/j.critrevonc.2020.102982
Critical Reviews in Oncology/hematology; Jafari A, Dadkhahfar S et. al.

May 27th, 2020 - SARS-CoV2 infection is an emerging issue worldwide. Cancer patient are at increased risk of infection compared to general population. On the other hand, these patients are at major risk of drug interactions caused by renal and hepatic impairment background. Because of the long-term use of chemotherapy drugs, drug interactions are important in these patients especially with SARS-CoV2 treatments ...

Altered cytokine levels and immune responses in patients with SARS-CoV-2 infection and ...
https://doi.org/10.1016/j.cyto.2020.155143
Cytokine Noroozi R, Branicki W et. al.

May 27th, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells ...

Evidence and possible mechanisms of rare maternal-fetal transmission of SARS-CoV-2.
https://doi.org/10.1016/j.jcv.2020.104447
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology; Egloff C, Vauloup-Fellous C et. al.

May 27th, 2020 - While SARS-CoV-2 infection has spread rapidly worldwide, data remains scarce about the natural history of infection in pregnant women and the risk of mother-to-fetal transmission. Current data indicates that viral RNA levels in maternal blood are low and there is no evidence of placental infection with SARS-CoV-2. Published reports to date suggest that perinatal transmission of SARSCoV- 2 can o...

Clinical evaluation of AusDiagnostics SARS-CoV-2 multiplex tandem PCR assay.
https://doi.org/10.1016/j.jcv.2020.104448
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology; Attwood LO, Francis MJ et. al.

May 27th, 2020 - In the context of the pandemic, the rapid emergency use authorisation of diagnostic assays for SARS-CoV-2 has meant there are few peer-reviewed published studies of clinical performance of commercial assays. To evaluate the clinical performance of AusDiagnostics respiratory multiplex tandem PCR assay including SARS-CoV-2. We reviewed the results following implementation of AusDiagnostics respir...

Projected increases in suicide in Canada as a consequence of COVID-19.
https://doi.org/10.1016/j.psychres.2020.113104
Psychiatry Research; McIntyre RS, Lee Y

May 27th, 2020 - Macroeconomic indicators, notably unemployment, are significant moderators of suicide. We projected the number of excess suicides in Canada as a consequence of the impact of COVID-19 on unemployment. Annual suicide mortality (2000-2018) and unemployment (2000-2019) data were derived from Statistics Canada. Time-trend regression models were used to evaluate and predict the number of excess suici...

Clinically significant fear and anxiety of COVID-19: A psychometric examination of the ...
https://doi.org/10.1016/j.psychres.2020.113112
Psychiatry Research; Lee SA, Mathis AA et. al.

May 27th, 2020 - The present study examined the psychometric properties of the Coronavirus Anxiety Scale (CAS) using an online survey of 398 adult Amazon MTurk workers in the U.S. Confirmatory factor analyses demonstrated that the CAS measures a reliable (α = 0.92), unidimensional construct with a structure that was shown to be invariant across gender, race, and age. Construct validity was demonstrated with cor...

Chest-X-ray is a mainstay for follow-up in critically ill patients with covid-19 induce...
https://doi.org/10.1016/j.ejrad.2020.109075
European Journal of Radiology; de Barry O, Obadia I et. al.

May 27th, 2020 - Chest-X-ray is a mainstay for follow-up in critically ill patients with covid-19 induced pneumonia.|2020|de Barry O,Obadia I,El Hajjam M,Carlier RY,Obadia I,|

Estimation of the time-varying reproduction number of COVID-19 outbreak in China.
https://doi.org/10.1016/j.ijheh.2020.113555
International Journal of Hygiene and Environmental Health; You C, Deng Y et. al.

May 27th, 2020 - The 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China has attracted world-wide attention. As of March 31, 2020, a total of 82,631 cases of COVID-19 in China were confirmed by the National Health Commission (NHC) of China. Three approaches, namely Poisson likelihood-based method (ML), exponential growth rate-based method (EGR) and stochastic Susceptible-Infected-Removed dynamic model-ba...

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19...
https://doi.org/10.1159/000508544
Cardiorenal Medicine; Koratala A, Ronco C et. al.

May 27th, 2020 - As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Some present ...

Coronavirus misinformation needs researchers to respond.
https://doi.org/10.1038/d41586-020-01550-y
Nature

May 27th, 2020 - Coronavirus misinformation needs researchers to respond.|2020||

The epic battle against coronavirus misinformation and conspiracy theories.
https://doi.org/10.1038/d41586-020-01452-z
Nature Ball P, Maxmen A

May 27th, 2020 - The epic battle against coronavirus misinformation and conspiracy theories.|2020|Ball P,Maxmen A,|

Airway management team for patients with COVID-19: A new role for emergency medicine ph...
https://doi.org/10.1093/ajhp/zxaa129
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists; Faine BA, Carroll E et. al.

May 27th, 2020 - Airway management team for patients with COVID-19: A new role for emergency medicine pharmacists.|2020|Faine BA,Carroll E,Decleene J,Zepeski A,|

Clinical Evaluation and Utilization of Multiple Molecular In Vitro Diagnostic Assays fo...
https://doi.org/10.1093/ajcp/aqaa097
American Journal of Clinical Pathology; Cradic K, Lockhart M et. al.

May 27th, 2020 - To evaluate the clinical performance of 3 molecular assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used 184 nasopharyngeal swab specimens to compare Abbott ID NOW COVID-19 (Abbott ID NOW), DiaSorin Molecular Simplexa COVID-19 Direct (DiaSorin Simplexa), and Roche cobas 6800 SARS-CoV-2 (Roche cobas) assays. In a separate analysis, 3 specimens (nasopharyngeal, orophar...

Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China.
https://doi.org/10.1111/imm.13223
Immunology Tan M, Liu Y et. al.

May 27th, 2020 - Coronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious SARS-CoV-2. The immunopathological characteristics of COVID-19 patients, either systemic or local, have not been thoroughly studied. In the present study, we analyzed both the changes in the number of various immune cell types as well as cytokines important for immune reactions and inflammation. Our da...