Nocardia spp. infection should remain on the differential diagnosis of pneumonia in immunocompromised hosts, regardless of co-infections.

Online Report — Global Veterinary Diagnostic Laboratory Equipment Management and Sustainability and Implications for Pandemic Preparedness Priorities

Mar 29th, 2023 - Cardiovascular events were not more likely for recipients of the Pfizer-BioNTech COVID-19 mRNA bivalent booster compared with the original monovalent booster, according to French researchers. Their population-based study found no evidence of an increased risk of cardiovascular events at 21 days among the recipients of the bivalent vaccine versus recipients of the monovalent vaccine, including: ...

Mar 29th, 2023 - Transcatheter arterialization of the deep veins in patients with chronic limb-threatening ischemia appeared safe and led to limb salvage and wound healing in most cases, the PROMISE II study showed. The procedure to turn a vein into an artery for no-option patients was successful in all but one of the 105 trial participants (99.0%), with a 66.1% rate of amputation-free survival at 6 months, whi...

Mar 29th, 2023 - In certain groups of men, glucose-6-phosphate dehydrogenase (G6PD) deficiency was linked with an increased likelihood of severe COVID-19, a Veterans Affairs cohort study found. In Black men under 65, for example, those with the common enzyme deficiency had a roughly 1.5-fold higher risk for severe illness (OR 1.47, 95% CI 1.03-2.09), reported Lavannya Pandit, MD, MS, of the Michael E. DeBakey V...

Mar 29th, 2023 - Plasma exchange successfully improved symptoms of immunoglobulin A vasculitis in an adult female patient who developed the condition after infection with COVID-19, according to a case report published in Cureus. Immunoglobulin A (IgA) vasculitis can affect all ages, but is relatively rare in adults, and the etiology remains unclear, wrote Hassan Alwafi, MD, of Umm Al-Qura University, Makkah, Sa.

Mar 29th, 2023 - Note that some links may require subscriptions. A Florida woman wanted to talk to the hospital about her 4-year-old son's bill, but hospital officials said they couldn't speak with her because the bill was in her son's name. (NPR) The FDA approved the first over-the-counter naloxone (Narcan) product for reversing opioid overdoses. While over-the-counter naloxone could be lifesaving, some advoca...

Mar 28th, 2023 - Two groups of long COVID patients -- those hospitalized for acute COVID, and those with mild SARS-CoV-2 infection who weren't hospitalized -- had different neurologic manifestations, prospective data showed. Long COVID patients who were hospitalized with acute infection more frequently had an abnormal neurologic exam (62% vs 37%, P<0.0001) and performed worse on processing speed, attention, and...

Mar 28th, 2023 - An umbrella review of meta-analyses showed a positive overall effect of exercise on cognition, but the underlying studies had substantial limitations. (Nature Human Behaviour) SARS-CoV-2 infection during pregnancy was associated with a higher risk of neurodevelopmental disorders in male offspring. (JAMA Network Open) The FDA will hold an advisory committee meeting to discuss the investigational...

Mar 28th, 2023 - COVID-19 infection in the 60 days prior to surgery was not associated with risk of adverse postoperative outcomes, a cohort study among veterans showed. Of more than 29,000 veterans who underwent surgery, adverse postoperative outcomes occurred among 4.7% of those in the group without a recent COVID infection, 7.6% of those with a recent infection (1 to 30 day prior), and 3.2% of those with a s...

Mar 28th, 2023 - Nearly half of medical groups continue to require masking even as local public health officials have dropped mask mandates, according to a recent poll from the Medical Group Management Association (MGMA). Of 859 respondents, 49% said their office still has a mask requirement in place, while 51% said they do not. Among the medical groups that reported not having a mask requirement, nearly three-...

Mar 28th, 2023 - Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-COV-2 in the immediate post-transplant period.|2023|Melere MU,Soares CS,Nader L,Farina M,Kalil AN,|

Mar 28th, 2023 - Coronavirus disease 2019 (COVID-19) has been proposed as triggering autoimmunity. The aim of this study was to evaluate the presence and clinical significance of autoantibodies in patients with COVID-19. We retrospectively collected data from 245 patients who were hospitalized for COVID-19. All patients were tested for the presence of antinuclear antibody (ANA), rheumatoid factor (RF), anti-cit...

Mar 28th, 2023 - Testing and contact tracing (CT) can interrupt transmission chains SARS-CoV-2. Whole genome sequencing (WGS) can potentially strengthen these investigations and provide insights on transmission. We included all laboratory-confirmed COVID-19 cases diagnosed between June 4 to July 26, 2021, in a Swiss canton. We defined CT clusters based on epidemiological links reported in the CT data and genomi...

Mar 28th, 2023 - Convalescent plasma (CP) treatment of COVID-19 has shown significant therapeutic effect when administered early (e.g. Argentinian trial showing reduced hospitalisation) but has in general been ineffective (e.g. REMAP-CAP trial without improvement during hospitalisation). To investigate whether the differences in CP used could explain the different outcomes, we compared neutralising antibodies, ...

Mar 28th, 2023 - Saudi Arabia (SA) reported its first case of COVID-19 on 2 March 2020. Mortality varied nationwide; by April 14, 2020, Medina had 16% of SA's total COVID-19 cases and 40% of all COVID-19 deaths. A team of epidemiologists investigated to identify factors impacting survival. We reviewed medical records from two hospitals: Hospital A in Medina and Hospital B in Dammam. All patients with a register...

Mar 28th, 2023 - It is impossible to address the many complex needs of respiratory virus surveillance with a single system. Therefore, multiple surveillance systems and complementary studies must fit together as tiles in a "mosaic" to provide a complete picture of the risk, transmission, severity, and impact of respiratory viruses of epidemic and pandemic potential. Below we present a framework (WHO Mosaic Resp...

Mar 28th, 2023 - Although there has been an effective seasonal influenza vaccine available for more than 60 years, influenza continues to circulate and cause illness. The Eastern Mediterranean Region (EMR) is very diverse in health systems capacities, capabilities, and efficiencies, which affect the performance of services, especially vaccination, including seasonal influenza vaccination. The aim of this study ...

Mar 28th, 2023 - Human coronaviruses (HCoVs) 229E, OC43, HKU1, and NL63 are common viruses that continuously circulate in the human population. Previous studies showed the circulation of HCoVs during the cold months in Iran. We studied the circulation of HCoVs during coronavirus disease 2019 (COVID-19) pandemic to find the impact of pandemic on the circulation of these viruses. As a cross-sectional survey condu...

Mar 28th, 2023 - Respiratory syncytial virus (RSV) seasonality is dependent on the local climate. We assessed the stability of RSV seasonality prior to the SARS-CoV-2 pandemic in Western Australia (WA), a state spanning temperate and tropical regions. RSV laboratory testing data were collected from January 2012 to December 2019. WA was divided into three regions determined by population density and climate: Met...

Mar 28th, 2023 - The influenza A(H1N1)pdm09 pandemic highlighted the need for reliable disease burden estimation from low- and middle-income countries like Pakistan. We designed retrospective age-stratified estimation of influenza-related severe acute respiratory infections (SARIs) incidence in Islamabad Pakistan 2017-2019. The catchment area was mapped on SARI data from one designated influenza sentinel site a...

Mar 28th, 2023 - EMARIS Conference 2023: Convergence of science, policy, and practice on acute respiratory infections in post COVID-19 Eastern Mediterranean Region.|2023|Assiri A,Moen A,Brennan R,Abubakar A,Khan W,|

Mar 28th, 2023 - Despite recommendation by the World Health Organization (WHO), influenza vaccination coverage among high-risk groups remains suboptimal in Afghanistan. This study aims to document the knowledge, attitudes, and practices of seasonal influenza vaccine uptake among two priority groups, pregnant women (PWs) and healthcare workers (HCWs). This cross-sectional study enrolled PWs and HCWs in Kabul, Af...

Mar 28th, 2023 - Social psychological scholarship has emphasized the importance of effective leadership during the COVID-19 pandemic. However, the wider material contexts of these dynamics have often remained understudied. Through a critical discursive lens, this paper investigates differences in the social constructions used by leaders of richer and poorer nations during the COVID-19 pandemic. We identify a sh...

Mar 28th, 2023 - The growing demand for palliative care has been accelerated due to the COVID-19 pandemic. However, providing community-based palliative care was also more difficult to do safely and faced several challenges. The goal of this integrative review was to identify, describe, and synthesize previous studies on the challenges for health professionals delivering palliative care in the community during ...

Mar 28th, 2023 - Vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have had a transformative impact on morbidity and mortality. However, the long-term impact of vaccination on patients with genitourinary cancers is currently unknown. This study aimed to assess seroconversion rates in patients with genitourinary cancers receiving COVID-19 vaccination. Patients with prostate cancer...

Mar 28th, 2023 - This is an updated version of the original Cochrane Review published in Issue 2, 2018. Diagnoses of endometrial cancer are increasing secondary to the rising prevalence of obesity. Obesity plays an important role in promoting the development of endometrial cancer, by inducing a state of unopposed oestrogen excess, insulin resistance and inflammation. It also affects treatment, increasing the ri...

Mar 28th, 2023 - The COVID-19 pandemic has significantly impacted peoples' ability to buy, sell, and obtain items that they use in their daily lives. It may have had a particularly negative effect on the ability of people who use illicit opioids to obtain them since the networks they rely upon are illicit and not a part of the formal economy. Our objective in this research was to examine if, and how, disruption...

Mar 28th, 2023 - Since November 2019, Ireland has restricted alcohol advertising at the cinema and outdoors (e.g., near schools), and banned alcohol advertising on public transport. Although awareness of such advertising had decreased one year after the restrictions, measures to limit COVID-19 transmission complicated interpretation. We examine: (1) changes in awareness two years post-restrictions, when COVID-1...

Mar 28th, 2023 - Sources of bias in observational studies of covid-19 vaccine effectiveness.|2023|Fung K,Jones M,Doshi P,|

Mar 28th, 2023 - Guidance for Cardiopulmonary Resuscitation of Children With Suspected or Confirmed COVID-19.|2023||

Mar 28th, 2023 - To investigate determinants of willingness to adopt telerehabilitation, willingness of technology use, core affect regarding using telerehabilitation, and digital competencies in rehabilitation professionals in Austria and Germany before and during the COVID-19 pandemic. A cross-sectional paper-based and online survey was conducted before and during COVID-19, respectively, with three cohorts of...

Mar 28th, 2023 - Nurses experienced intense ethical and moral challenges during the COVID-19 pandemic. Our 2020 qualitative parent study of frontline nurses' experiences during the COVID-19 pandemic identified ethics as a cross-cutting theme with six subthemes: moral dilemmas, moral uncertainty, moral distress, moral injury, moral outrage, and moral courage. We re-analyzed ethics-related findings in light of re...

Mar 28th, 2023 - Independent prescribing by nurses, pharmacists and allied health professionals is diversifying into a variety of healthcare settings as pressures mount on existing resources. Primary care was an early adopter of prescribing by non-medical professionals with resulting improvements in accessibility and flexibility of services but also noted barriers. Exploring existing prescribing activity within...

Mar 28th, 2023 - The impact of the COVID-19 pandemic on analytic training and the delivery of educational content is explored here. The proliferation of Zoom therapy and teaching is creating a post-human platform to which nearly everyone in contemporary society has had to adapt. Looking at the possible meanings of the pandemic, a psychoid factor (the virus) engaging the imagination has come to the fore as a res...

Mar 28th, 2023 - The aim of this study was to describe online prelicensure nursing students' experiences of incivility during COVID-19. Qualitative descriptive. Five optional open-ended questions were presented to nursing students to share their experiences with incivility during the pandemic. Data were collected from September to October 2020 as a part of a larger multimethod study on stress, resilience and in...

Mar 28th, 2023 - Black, Indigenous, and People of Color have borne a disproportionate incidence of COVID-19 cases in the United States. However, few studies have documented the completeness of race and ethnicity reporting in national COVID-19 surveillance data. The objective of this study was to describe the completeness of race and ethnicity ascertainment in person-level data received by the Centers for Diseas...

Mar 28th, 2023 - Disaggregated data on the mental health of Asian/Asian American people are needed to inform public health interventions related to reports of racism during the COVID-19 pandemic. We describe the prevalence of psychological distress and unmet mental health needs among Asian/Asian American adults during the COVID-19 pandemic across various sociodemographic subgroups. We used cross-sectional, weig...

Mar 28th, 2023 - Limited studies are available on how decisions and perceptions on SARS-CoV-2 vaccination have changed since the start of vaccination availability. We performed a qualitative study to identify factors critical to SARS-CoV-2 vaccination decision making and how perspectives evolved among African American/Black, Native American, and Hispanic communities disproportionately affected by COVID-19 and s...

Mar 28th, 2023 - Impact of COVID-19 on Neuro-Ophthalmology in the United States: A National Survey.|2023|Waisberg E,Ong J,Zaman N,Kamran SA,Tavakkoli A,|

Mar 28th, 2023 - Studies have suggested intrapulmonary shunts may contribute to hypoxemia in COVID-19 acute respiratory distress syndrome (ARDS) with worse associated outcomes. We evaluated the presence of right-to-left (R-L) shunts in COVID-19 and non-COVID ARDS patients using a comprehensive hypoxemia workup for shunt etiology and associations with mortality. Prospective, observational cohort study. Four tert...

Mar 28th, 2023 - Melioidosis, caused by Burkholderia pseudomallei, may be considered a neglected tropical disease which remains underdiagnosed in many geographical areas. Travelers can act as sentinels of disease activity and data from imported cases may help complete the global map of melioidosis. A literature search for imported melioidosis for the period 2016-2022 was performed in PubMed and Google Scholar. ...

Mar 28th, 2023 - To explore the moral emotions that frontline nurses navigated in endeavouring to ensure a 'good death' for hospital patients and care home residents during the first wave of the COVID-19 pandemic. Under normal circumstances, frontline staff are focused on clinical ethics, which foreground what is best for individuals and families. Public health crises such as a pandemic require staff to adapt r...

Mar 28th, 2023 - Tetherin prevents viral cross-species transmission by inhibiting the release of multiple enveloped viruses from infected cells. With the evolution of simian immunodeficiency virus of chimpanzees (SIVcpz), a pandemic human immunodeficiency virus type 1 (HIV-1) precursor, its Vpu protein can antagonize human tetherin (hTetherin). Macaca leonina (northern pig-tailed macaque [NPM]) is susceptible t...

Mar 28th, 2023 - Quick access to substance use treatment is associated with better outcomes, but little is known about COVID-19's impact on access and retention. This study examined the relationship between COVID-19-related practice changes and quick access fidelity outcomes of the Sobriety Treatment and Recovery Teams (START) program, which serves families with co-occurring substance use and child abuse/neglec...

Mar 28th, 2023 - Government alcohol sales data were used to investigate associations between estimates of per capita age 15+ alcohol consumption, policy restrictiveness, and area-level deprivation. We analysed weekly consumption data (expressed as per capita age 15+ Canadian standard drinks [13.45g of pure ethanol]), collected from all 89 Local Health Areas in British Columbia, Canada, between April 2017 and Ap...

Mar 28th, 2023 - There has been concern regarding increased substance use during the COVID-19 pandemic, particularly among young adults, but much of this concern stemmed from cross-sectional or short-term data collected early in the pandemic. This study followed a young adult community cohort throughout the first year and a half of the pandemic to examine longer-term trends/trajectories in alcohol and cannabis ...

Mar 28th, 2023 - This study explores international faculty members' resilience and the active challenges to establishing coping mechanisms while facing a mental health crisis provoked by the Delta and Omicron lockdowns in China. Grounded in a qualitative approach, this study used a transcendental phenomenological methodology to examine 16 international faculty members affiliated with higher education institutio...

Mar 28th, 2023 - The prevalence of burnout in intensive care unit (ICU) professionals is difficult to establish due to the variety of survey instruments used, the heterogeneity of the targeted population, the design of the studies, and the differences among countries regarding ICU organization. We performed a systematic review and meta-analysis examining the prevalence of high-level burnout in physicians and nu...

Mar 28th, 2023 - The ongoing COVID-19 pandemic has revealed gender-specific differences between general practitioners in adapting to the posed challenges. As primary care workforce is becoming increasingly female, in many countries, it is essential to take a closer look at gender-specific influences when the global health care system is confronted with a crisis. To explore gender-specific differences in the per...

Mar 28th, 2023 - COVID-19 has affected many communities across the world prompting different strategies of containing it. The strategies to contain COVID-19 included restrictive environments such as self-isolation and quarantine. This research study was set to explore the experiences of quarantined individuals arriving in the United Kingdom (UK) from red listed countries in Southern Africa. This research study ...

Mar 28th, 2023 - Acute Kidney Injury (AKI) complicates a substantial part of patients with COVID-19. Direct viral penetration of renal cells through the Angiotensin Converting Enzyme 2 receptor, and indirect damage by the aberrant inflammatory response characteristic of COVID-19 are likely mechanisms. Nevertheless, other common respiratory viruses such as Influenza and Respiratory Syncytial Virus (RSV) are also...

Mar 28th, 2023 - Neutropenic Fever-Associated Admissions Among Patients With Solid Tumors Receiving Chemotherapy During the COVID-19 Pandemic.|2023|Baus CJ,Kelley B,Dow-Hillgartner E,Kyriakopoulos CE,Schulz LT,|

Mar 28th, 2023 - Uptake of vaccination against COVID-19 is strongly affected by concerns about adverse effects. Research on nocebo effects suggests that these concerns can amplify symptom burden. To investigate whether positive and negative expectations prior to COVID-19 vaccination are associated with systemic adverse effects. This prospective cohort study analyzed the association of expected benefits and risk...

Mar 28th, 2023 - Poor disease outcomes and lethality are directly related to endothelial dysfunction in betacoronavirus infections. Here, we investigated the mechanisms underlying the vascular dysfunction caused by the betacoronaviruses MHV-3 and SARS-CoV-2. Wild-type C57BL/6 (WT) and knockout mice for inducible nitric oxide synthase (iNOS-/-) or TNF receptor 1 (TNFR1-/-) were infected with MHV-3, and K18-hACE2...

Mar 28th, 2023 - The use of alcohol-based sanitizers has been recommended as an effective alternative to clean hands, especially in the case when hand washing is not doable. This is especially critical with the COVID-19 pandemic, where personal hygiene is an important factor to deter the spread of the virus. This study assesses and evaluates the differences in antibacterial efficacy and functionalities of five ...

Mar 28th, 2023 - Stay-at-home strategies taken during the COVID-19 pandemic changed our lifestyle drastically. Although marital status and household size are important social determinants of health that affect lifestyle, their impacts on lifestyle during the pandemic are still unclear. We aimed to evaluate the association between marital status, household size, and lifestyle changes during the first pandemic in...

Mar 28th, 2023 - COVID-19 is associated with cardiac dysfunction. This study tested the relative prognostic role of left (LV), right and bi- (BiV) ventricular dysfunction on mortality in a large multicenter cohort of patients during and after acute COVID-19 hospitalization. All hospitalized COVID-19 patients who underwent clinically indicated transthoracic echocardiography within 30 days of admission at four NY...

Mar 28th, 2023 - Covid-19 response: a perspective from Pakistan.|2023|Mirza Z,|

Mar 28th, 2023 - Throughout the COVID-19 pandemic, policy makers have tried to balance the effectiveness of lockdowns (i.e., stay-at-home orders) with their potential mental health costs. Yet, several years into the pandemic, policy makers lack solid evidence about the toll of lockdowns on daily emotional functioning. Using data from two intensive longitudinal studies conducted in Australia in 2021, we compared...

Mar 28th, 2023 - Common psychosocial health problems (PHPs) have become more prevalent among adolescents globally during the COVID-19 pandemic. However, the psychosocial health of school-going adolescents has remained unexplored in Bangladesh due to limited research during the pandemic. The present study aimed to estimate the prevalence of PHPs (i.e., depression and anxiety) and assess associated lifestyle and ...

Mar 28th, 2023 - This study investigated the implementation of a curricular unit of instruction designed to immerse rising ninth-grade students socioscientific issues via data collection and analysis of the relationships between health, wealth, educational attainment, and the impact of the COVID-19 Pandemic on their communities. Twenty-six (n = 26) rising ninth-grade students (14-15 years old; 16 girls, 10 boys...

Mar 28th, 2023 - Tuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a large proportion of genetic risk for adult pulmonary TB, and even fewer have examined genetic factors underlying TB severity, an intermediate trait impacting disease experience, quality of life, and risk of mortality. No prior severity ana...

Mar 28th, 2023 - Mutations continue to accumulate within the SARS-CoV-2 genome, and the ongoing epidemic has shown no signs of ending. It is critical to predict problematic mutations that may arise in clinical environments and assess their properties in advance to quickly implement countermeasures against future variant infections. In this study, we identified mutations resistant to remdesivir, which is widely ...

Mar 27th, 2023 - Refugees left in limbo by online permit system Scant access to costly internet adds extra stress No documents - no work, no welfare JOHANNESBURG, March 27 (Thomson Reuters Foundation) - As if life weren’t hard enough for refugees trying to forge a new life in South Africa, the online system set up to help them has thrown a big, new barrier their way. Experts say that government technology is no...

Mar 27th, 2023 - There is growing concern that Coronavirus Disease 2019 (COVID-19) vaccine fatigue will be a major obstacle in maintaining immunity in the general population. In this study, we assessed vaccine acceptance in future scenarios in two conjoint experiments, investigating determinants such as new vaccines, communication, costs/incentives and legal rules.

Mar 27th, 2023 - This study examined differences in mental health in older adult women before versus during the COVID-19 pandemic. Participants who were community dwelling (N = 227) included n = 67 women aged 60-94 in the pre-pandemic group and n = 160 women aged 60-85 in the peri-pandemic group who completed self-report measures assessing mental health and quality of life (QOL). We compared mental health and Q...

Mar 27th, 2023 - To characterize neurologic manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients. Prospective study of the first 100 consecutive PNP and 500 NNP patients evaluated at a Neuro-COVID-19 clinic between 5/2020 and 8/2021. PNP were older than NNP patients (mean 53.9 vs 44.9 y; p < 0.0001) with a higher prevalence of pre-existing comorbidities. An aver...

Mar 27th, 2023 - Background Colonoscopy is a commonly performed procedure but most patients will not actually be found with colorectal cancer. Subsequent face-to-face consultations to explain post-colonoscopy findings are common despite the time and cost-saving benefits of teleconsultation, especially in a post-COVID-19 era. This exploratory retrospective study examined the proportion of post-colonoscopy follow...

Mar 27th, 2023 - The consequences of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can range from asymptomatic to fatal disease. Variations in epithelial susceptibility to SARS-CoV-2 infection depend on the anatomical location from the proximal to distal respiratory tract. However, the cellular biology underlying these variations is not completely understood. Thus, air-liquid inter...

Mar 27th, 2023 - Human Herpes Virus-6 (HHV-6) is a ubiquitous virus but can lead to deleterious clinical manifestations due to its predilection for the pediatric central nervous system. Despite significant literature describing its common clinical course, it is rarely considered as a causative agent in CSF pleocytosis in the setting of craniotomy and external ventricular drainage device. Identification of a pri...

Mar 27th, 2023 - Kidney transplant recipients (KTRs) show poorer response to SARS-CoV-2 mRNA vaccination, yet response patterns and mechanistic drivers following third doses are ill-defined. We administered third monovalent mRNA vaccines to n=81 KTRs with negative or low-titer anti-receptor binding domain (RBD) antibody (n=39 anti-RBDNEG; n=42 anti-RBDLO), compared to healthy controls (HC, n=19), measuring anti...

Mar 27th, 2023 - As the COVID-19 pandemic progressed, so too did the proportion of cases admitted to critical care in Ireland who were fully vaccinated. Reporting of this observation has public health implications as incorrect interpretation may affect public confidence in COVID-19 vaccines. A potential explanation is the reduced ability of those who are immunocompromised to produce an adequate, sustained immun...

Mar 27th, 2023 - Protein subunit vaccines have been widely used to combat infectious diseases, including the current COVID-19 pandemic. Adjuvants play the key role in shaping the quality and magnitude of the immune response to protein and inactivated vaccines. We previously developed a protein subunit COVID-19 vaccine, termed ZF2001, based on an aluminium hydroxide-adjuvanted tandem-repeat dimeric receptor-bind...

Mar 27th, 2023 - The COVID-19 pandemic highlighted the fragmented nature of governmental policy decisions in Europe. However, the extent to which COVID-19 vaccination policies differed between European countries remains unclear. Here, we mapped the COVID-19 vaccination policies that were in effect in January 2022 as well as booster regulations in April 2022 in Austria, Denmark, England, France, Germany, Ireland...

Mar 27th, 2023 - Patients with hematologic malignancies are considered at high risk for COVID-19 infection either from the disease or the treatment. Hematopoietic stem cell transplantation, one of the approved therapies for hematologic malignancies, was performed worldwide during the COVID-19 era with some regulations, such as COVID-19 testing, before proceeding with transplantation or cellular therapy. To the ...

Mar 27th, 2023 - The current world is plagued by unpredictability as a result of various COVID-19 variants. The current variants of concern (VOCs) are B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617/B.1.617.2(Delta). WHO classified two variants, delta (B.1.617.2) and omicron (B.1.1.529), as having highly mutable strikes. The WHO predicted that it would be more dangerous than previous variants due to it...

Mar 27th, 2023 - Over the past year, the leadership of the Clinician Investigator Trainee Association of Canada (CITAC), alongside our MD+ trainees, had the opportunity to further develop and implement our strategic plan in response to the evolving medical landscape. We have dedicated our efforts to the progression towards a post-pandemic environment, have taken advantage of the lessons learned during the coron...

Mar 27th, 2023 - The USA struggled in responding to the COVID-19 pandemic, but not all states struggled equally. Identifying the factors associated with cross-state variation in infection and mortality rates could help to improve responses to this and future pandemics. We sought to answer five key policy-relevant questions regarding the following: 1) what roles social, economic, and racial inequities had in int...

Mar 27th, 2023 - Single-cell 'omics methodology has yielded unprecedented insights based largely on data-centric informatics for reducing, and thus interpreting, massive datasets. In parallel, parsimonious mathematical modeling based on abstractions of pathobiology has also yielded major insights into inflammation and immunity, with these models being extended to describe multi-organ disease pathophysiology as ...

Mar 27th, 2023 - The prevalence of hypothyroidism among older patients hospitalized for COVID-19 and its association with mortality is unclear. This study aims to investigate the prevalence of hypothyroidism in older COVID-19 inpatients and verify if this comorbidity is associated with a specific pattern of onset symptoms and a worse prognosis. COVID-19 inpatients aged ≥ 60 years, participating in the GeroCovid...

Mar 27th, 2023 - Currently, there are no data available on SARS-CoV-2 vaccine responses in pediatric-onset multiple sclerosis (POMS), and little is known about the course of SARS-CoV-2 infection in this age group. We therefore investigated humoral immune responses after COVID-19 vaccination and/or infection in POMS. We retrospectively analyzed seroconversion rates and SARS-CoV-2-specific antibody levels in 30 P...

Mar 27th, 2023 - Mechanisms contributing to COVID-19 severity in people with HIV (PWH) are poorly understood. We evaluated temporal changes in plasma proteins following SARS-CoV-2 infection and identified pre-infection proteomic markers associated with future COVID-19. We leveraged data from the global Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). Antiretroviral therapy (ART)-treated PWH with c...

Mar 27th, 2023 - COVID-19 can cause psychological problems including loss of smell and taste, long-lasting memory, speech, and language impairments, and psychosis. Here, we provide the first report of prosopagnosia following symptoms consistent with COVID-19. Annie is a 28-year-old woman who had normal face recognition prior to contracting COVID-19 in March 2020. Two months later, she noticed face recognition d...

Mar 27th, 2023 - Thromboembolic complications including cerebrovascular accidents, pulmonary embolism, myocardial infarction, deep vein thrombosis and disseminating intravascular coagulopathy are serious encounters in sever coronavirus disease 2019 (COVID-19) infected patients. This worsens the prognosis and may lead to death or life long morbidities. The laboratory finding of the disturbed haemostasias and the...

Mar 27th, 2023 - To examine the extent of long-term functional deficits experienced by individuals hospitalized for COVID-19. Specific objectives were to: 1. describe changes in perceived global health, mobility, participation in daily activities, and employment status from pre-COVID-19 to ≥2 months following infection; and 2. evaluate factors associated with change in function. We conducted a telephone survey ...

Mar 27th, 2023 - The COVID-19 pandemic led to millions of deaths worldwide following its emergence in 2020. The SARS-CoV-2 virus primarily affects respiratory function, but immune dysregulation leading to systemic inflammation, endothelial dysfunction, and coagulopathy can predispose to systemic complications including hematologic and vascular complications. Treatment strategies for patients with COVID-19 have ...

Mar 27th, 2023 - To evaluate the impact of early implementation of public health and social measures (PHSMs) on contact rates over time. And explore contact behavior of asymptomatic versus symptomatic cases. We used the so far largest contact tracing data in China to estimate mean contacts over time by age groups and contact settings. We used bootstrap with replacement to quantify the uncertainty of contact mat...

Mar 27th, 2023 - We aimed to estimate the rate of myocarditis following the mRNA COVID-19 booster vaccination by vaccine type, age, and sex. We used data from the BC COVID-19 Cohort (BCC19C), a population-based cohort surveillance platform. The exposure was a booster dose of an mRNA vaccine. The outcome was diagnosis of myocarditis during hospitalization, or an emergency department visit within 7 and 21 days of...

Mar 26th, 2023 - Vaccine hesitancy is gaining attention due to the increasing spread of the COVID-19 pandemic in Malaysia. Malaysia is a majority Muslim country and religion has a significant influence on the acceptance or rejection of vaccines. This is clearly seen through the disagreement over the  halal status of vaccines. Social media has become a platform for discussion and dissemination of information and...

Mar 26th, 2023 - Although there are numerous brief odor identification tests available for quantifying the ability to smell, none are available in multiple parallel forms that can be longitudinally administered without potential confounding from knowledge of prior test items. Moreover, empirical algorithms for establishing optimal test lengths have not been generally applied. In this study, we employed and comp...

Mar 26th, 2023 - During the pandemic, there was a dramatic shift to telemedicine for opioid use disorder (OUD) treatment. Little is known about how clinician attitudes about telemedicine use for OUD treatment are evolving or their preferences for future use. To understand OUD clinician views of and preferences regarding telemedicine. Longitudinal survey (wave 1, December 2020; wave 2, March 2022). National samp...

Mar 26th, 2023 - Although literature states that individual, relational, and contextual factors contribute to adolescents' sense of agency, more research is needed to clarify and understand how adolescents develop this belief over time. The current study examined the stability/change trajectories of the sense of agency during adolescence, specifically across high school, analyzing whether attachment to parents ...

Mar 26th, 2023 - At the beginning of the COVID-19 pandemic, the role of extracorporeal membrane oxygenation (ECMO) was uncertain and the outcomes of ECMO-treated patients were unfavorable. During the pandemic, medical community realized that carefully selected patients may benefit from ECMO support. The goal of the study was to present the outcomes of ECMO-treated patients with severe COVID-19 ARDS referred to ...

Mar 26th, 2023 - Many studies report about risk factors associated with adverse changes in mental health during the COVID-19 pandemic while few studies report about protective and buffering factors, especially in older adults. We present an observational study to assess protective and buffering factors against COVID-19 related adverse mental health changes in older adults. 899 older adults (55 +) in the Netherl...

Mar 26th, 2023 - Metabolic physiology plays a key role in maintaining our health and resilience. Metabolic disorders can lead to serious illnesses, including obesity. The pathogenesis of the new long COVID syndrome in individuals with long-term recovery after SARS-Co-2 infection is still incomplete. Thus there is growing attention in the study of adipose tissue activities, especially brown adipose tissue (BAT) ...

Mar 26th, 2023 - The previous acute respiratory diseases caused by viruses originating from China or the middle east (e.g., SARS, MERS) remained fast developing short diseases without major sequalae or any long-lasting complications. The new COVID-19, on the other hand, not only that it rapidly spread over the world, but some patients never fully recovered or even if they did, a few weeks later started to compl...

Mar 26th, 2023 - Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens. Older patients, a...

Mar 26th, 2023 - Road traffic accidents are a real pandemic and incur expenses amounting to 1-2% of every country's GDP. AESLEME (Association for the Study of Spinal Cord Injuries) has celebrated its 30th anniversary here in Spain. AESLEME's instructors are health workers and people with spinal cord injuries caused by road accidents: their presentations-teaching road safety and sharing information on irreversib...

Mar 26th, 2023 - The aim of our study was to explore the impact of the COVID-19 pandemic on reported cancer cases in Bavaria, Germany, by comparing pre-pandemic (March 2019 to February 2020) and pandemic period (March 2020 to February 2021). Data on incident cases were retrieved from the Bavarian Cancer Registry (until 22nd April 2022). We included patients with malignant and in situ neoplasms reported by patho...