Apr 17th, 2021 - Cognitive impairment has recently attracted researchers as one of the possible neuropsychiatric manifestations of COVID-19, although how the infection perpetuates impairment of cognitive functions is still obscure. We presented a 29-year-old male patient with COVID-19 who developed new-onset transient attention deficit and memory problems following a SARS-CoV-2 infection. Structural neuroimagin...

Apr 17th, 2021 - The "Corona Virus Disease 2019 (COVID-19)", caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), progressed rapidly since its first outbreak, and quickly developed into a pandemic. Although COVID-19 mostly presents with respiratory symptoms, researchers have started reporting neurologic manifestations such as cerebrovascular diseases in patients, with COVID-19 as the pandemic has prog...

Apr 17th, 2021 - Despite neuropsychiatric outcomes of SARS-CoV-2 infection are now under close scrutiny, psychoneuroimmunological characteristics of COVID-19 and precise pathophysiology of neuropsychiatric manifestations of the infection are still obscure. Moreover, there still exists a shortfall in demonstrating specific clinical manifestations of the brain involvement of the virus. Here, we presented a 33-yea...

Apr 17th, 2021 - COVID-19 has greatly impacted surgical specialities throughout the globe leading to a decrease in hospital admissions and referrals. Neurosurgery has seen a great decline in cases including head trauma leading to a negative impact on the development of neurosurgical trainees. The main objective of this study is to the identify changes in neurosurgical referrals, admissions and management during...

Apr 17th, 2021 - Coronavirus disease (COVID-19) has a number of emerging neurological manifestations in addition to pneumonia and respiratory distress. In what follows, we describe a case of a previously healthy young man with severe COVID-19 who subsequently developed an acute flaccid paralysis. Work up revealed a lesion in his cervical spinal cord concerning for spinal infarction or transverse myelitis. He re...

Apr 17th, 2021 - This study investigated the association between COVID-related myalgia experienced by patients at hospital admission and the presence of post-COVID symptoms. A case-control study including patients hospitalised due to COVID-19 between February 20 and May 31, 2020 was conducted. Patients reporting myalgia and patients without myalgia at hospital admission were scheduled for a telephone interview ...

Apr 17th, 2021 - To investigate the short-term effects of COVID-19 pandemic related unintended treatment lapses on neovascular age related macular degeneration (nAMD) patients. In this prospective cross-sectional study, 140 patients who had at least one anti-vascular endothelial growth factor (VEGF) injection for nAMD within 12 months before COVID-19 pandemic and who had at least 3 months of unintended lapse fo...

Apr 17th, 2021 - Previous studies have reported a correlation between coronavirus disease-2019 (COVID-19) and asthma. However, data on whether asthma constitutes a risk factor for COVID-19 and the prevalence of asthma in COVID-19 cases still remains scant. Here, we interrogated and analysed the association between COVID-19 and asthma. In this study, we systematically searched PubMed, Embase, and Web of Science ...

Apr 17th, 2021 - In 2020, a new coronavirus, SARS-CoV-2, quickly spread worldwide within a few months. Although coronaviruses typically infect the upper or lower respiratory tract, the virus RNA can be detected in plasma. The risk of transmitting coronavirus via transfusion of blood products remains. As more asymptomatic infections are identified in COVID-19 cases, blood safety has become particularly important...

Apr 17th, 2021 - COVID-19 pandemic has forced physicians to quickly determine the patient's condition and choose treatment strategies. This study aimed to build and validate a simple tool that can quickly predict the deterioration and survival of COVID-19 patients. A total of 351 COVID-19 patients admitted to the Third People's Hospital of Yichang between 9 January to 25 March 2020 were retrospectively analyzed...

Apr 17th, 2021 - Pregnant women are potentially a high-risk population during infectious disease outbreaks such as COVID-19, because of physiologic immune suppression in pregnancy. However, data on the morbidity and mortality of COVID-19 among pregnant women, compared to nonpregnant women, are sparse and inconclusive. We sought to assess the impact of pregnancy on COVID-19 associated morbidity and mortality, wi...

Apr 17th, 2021 - While the relation between care involvement of informal caregivers and caregiver burden is well-known, the additional psychosocial burden related to care involvement during the COVID-19 pandemic has not yet been investigated. A total of 1000 informal caregivers, recruited offline, participated in a cross-sectional online survey from April 21 to May 2, 2020. Questionnaires were used to assess CO...

Apr 17th, 2021 - During the COVID-19 pandemic, NHS services had to convert face-to-face consultations to remote consultations to facilitate the ongoing provision of healthcare. Many specialties including Oral and Maxillofacial Surgery and Rheumatology have found such virtual clinics effective and appreciated by both patients and clinicians. In Oral Medicine, whilst responses to virtual clinics have been positiv...

Apr 17th, 2021 - To determine the impact of the first COVID-19 surge (March through June 2020) on mental well-being and associated risk factors among intensive care unit nurses. In September 2020, a nationwide cross-sectional survey study among Dutch intensive care nurses was carried out to measure prevalence rates of symptoms of anxiety, depression, posttraumatic stress disorder, and need for recovery (NFR), o...

Apr 17th, 2021 - Cytokine storm-related hypercoagulation may be important in the pathogenesis of stent thrombosis in patients with SARS-CoV-2. Whether stent polymers behave differently under such conditions has never been explored. Fluorinated polymer-nanocoated and uncoated COBRA stents (CeloNova), BioLinx-polymer-coated Resolute Onyx stents (Medtronic), and Synergy stents (Boston Scientific), which are ablumi...

Apr 17th, 2021 - Covid-19: Failed response in Brazil has led to humanitarian catastrophe, says MSF.|2021|Kmietowicz Z,|

Apr 17th, 2021 - Covid-19: US reports low rate of new infections in people already vaccinated.|2021|Dyer O,|

Apr 17th, 2021 - COVID-19 pneumonia and the pulmonary vasculature - a marriage made in hell.|2021|George PM,Desai SR,|

Apr 17th, 2021 - Covid-19: Risk of cerebral blood clots from disease is 10 times that from vaccination, study finds.|2021|Torjesen I,|

Apr 17th, 2021 - Anatomical complexity does not predict outcomes after COVID-19 in adults with congenital heart disease.|2021|Yuan S,Oechslin E,|

Apr 17th, 2021 - Covid-19: NHS will take at least a year and a half to recover, doctors warn.|2021|Rimmer A,|

Apr 17th, 2021 - Covid-19: Irish GP who refused to vaccinate patients is suspended.|2021|Dyer C,|

Apr 17th, 2021 - Faith-based organisations (FBOs) in India provide health services particularly to marginalised communities. We studied their preparedness and delivery of palliative care during COVID-19 as part of a mixed-method study. We present the results of an online questionnaire. All FBOs providing palliative care in India were invited to complete an online questionnaire. Descriptive analysis was undertak...

Apr 17th, 2021 - Resident clinical experience during the pandemic: What has it cost us and what have we gained?|2021|Nguyen B,Barber A,Rassbach CE,|

Apr 17th, 2021 - Pediatric Intern Clinical Exposure During the COVID-19 Pandemic.|2021|Geanacopoulos AT,Sundheim KM,Greco KF,Michelson KA,Parsons CR,|

Apr 17th, 2021 - Can the HIV Commission's recommendation to expand HIV testing regardless of local HIV prevalence be met in a pandemic?|2021|McClure J,Dewsnap C,van Zwanenberg D,Varney C,|

Apr 17th, 2021 - In their discussion paper of November 2020, Cook et al present a draft protocol for navigating circumstances in which emergency services are overwhelmed. Their paper suggests that COVID-related triage decisions should be based on clinical assessment, patient and family consultation, and a range of ethical considerations. In this response, we note that the protocol exhibits an ambiguity that is ...

Apr 17th, 2021 - The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhib...

Apr 17th, 2021 - Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among children or adolescents vaccinated with AS03 adjuvant-supplemented pandemic H1N1 influenza A vaccine, Pandemrix. Here we show that pediatric Pandemrix-associated NT1 patients have enhanced T-cell immu...

Apr 17th, 2021 - Power and powerlessness in a pandemic.|2021|Fine-Goulden MR,|

Apr 17th, 2021 - RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape.|2021|Mullard A,|

Apr 17th, 2021 - Daily briefing: Why the coronavirus death toll in Wuhan, China, has just jumped by 50.|2021|Graham F,|

Apr 17th, 2021 - Daily briefing: Video guide to the science of coronavirus variants.|2021|Graham F,|

Apr 17th, 2021 - Despite progress in clinical care for patients with coronavirus disease 2019 (COVID-19)1, population-wide interventions are still crucial to manage the pandemic, which has been aggravated by the emergence of new, highly transmissible variants. In this study, we combined the SIDARTHE model2, which predicts the spread of SARS-CoV-2 infections, with a new data-based model that projects new cases o...

Apr 17th, 2021 - Commentary on: The Safe Resumption of Elective Plastic Surgery in Accredited Ambulatory Surgery Facilities During the COVID-19 Pandemic.|2021|Teitelbaum S,|

Apr 17th, 2021 - The purpose of this study is to evaluate MAWID mobile application developed by the Ministry of Health, Saudi Arabia, which is used for primary care hospitals appointments management and for tracking and tracing COVID-19. An online questionnaire-based survey was used for collecting data related to three major factors including Ease of Use, Satisfaction, and Benefits of MAWID application among it...

Apr 17th, 2021 - Increasing evidence suggests that SARS-CoV-2 infection may lead to severe and multi-site vascular involvement. Our study aimed at assessing the frequency of vascular and extravascular events' distribution in a retrospective cohort of 42 COVID-19 patients. Patients were evaluated by whole-body CT angiography between March 16 and April 30, 2020. Twenty-three out of the 42 patients evaluated were ...

Apr 17th, 2021 - Ivermectin (IVM) and doxycycline (DOXY) have demonstrated in-vitro activity against SARS-CoV-2, and have a reasonable safety profile. The objective of this systematic review was to explore the evidence in the literature on the safety and efficacy of their use as monotherapy and combination therapy in COVID-19 management. After prospectively registering the study protocol with the Open Science F...

Apr 17th, 2021 - Health-related quality of life (HRQoL) and the delivery of high quality care are ongoing concerns when caring for pregnant women in the COVID-19 pandemic. We compared self-reported HRQoL and hospital quality of care (QoC) among perinatal women with and without COVID-19 infection. This is a prospective cohort study of perinatal women attending a tertiary maternity unit during the pandemic. 18 wo...

Apr 17th, 2021 - Remote dermatology consultations largely superseded face-to-face (FTF) consultations during the peak of the COVID-19 pandemic in the UK. Remote examination of patients with hidradenitis suppurativa (HS) brings particular challenges, given the propensity of HS to affect intimate body parts. To understand the impact of remote consultations on the care of HS patients, a retrospective analysis was ...

Apr 17th, 2021 - The novel coronavirus SARS-CoV-2 (COVID-19) rapidly escalated from its origin in an animal market in Wuhan, China in December 2019 to a global pandemic, and the lungs are the most frequently affected organ. The aim of this study was to investigate the relationship between pulmonary function test parameters and laboratory parameters in COVID-19. A total of 60 patients who were admitted to the ch...

Apr 17th, 2021 - While discussions on the effectiveness of COVID-19 vaccines continue, healthcare professionals' attitudes and their growing fear and anxiety during the pandemic process are not yet fully known. In this study, we aimed to investigate the COVID-19 vaccine acceptance and affecting factors in healthcare professionals. This was a cross-sectional online survey conducted in 1574 healthcare professiona...

Apr 17th, 2021 - Newly intensified use of personal protective equipment (PPE) in emergency departments presents teamwork challenges affecting the quality and safety of care at the frontlines. We conducted a qualitative study to categorize and describe barriers to teamwork posed by PPE and distancing in the emergency setting. We conducted 55 semi-structured interviews between June-August, 2020 with personnel fro...

Apr 17th, 2021 - To inform prevention strategies, we assessed the extent of SARS-CoV-2 transmission and settings in which transmission occurred in a Georgia public school district. During December 1, 2020-January 22, 2021, SARS-CoV-2-infected index cases and their close contacts in schools were identified by school and public health officials. For in-school contacts, we assessed symptoms and offered SARS-CoV-2 ...

Apr 17th, 2021 - Psychiatric problems, such as stress and anxiety disorders, are encountered among healthcare professionals fighting epidemics. Considering that COVID-19 suddenly became a pandemic and healthcare professionals have not had access to sufficient information, it is a fact that healthcare professionals have been affected on a large scale. Heavy workloads, insufficient equipment and anxiety over fami...

Apr 17th, 2021 - Physicians hospitalize the patients with complicated urinary tract infections (cUTIs) when they need intravenous antibiotics and outpatient parenteral antimicrobial therapy (OPAT) is unavailable. Daily inpatient antimicrobial therapy is an alternative to hospitalisation which is similar to OPAT; patients go home after they are administered antibiotics in a separate room in the hospital setting....

Apr 17th, 2021 - The Recovery Coach and Peer Support Initiative (RCPSI) in Indiana focused on implementing peer recovery coaches (PRCs) to engage opioid overdose patients in emergency department (ED) settings and promote entry into recovery services. State workers and researchers organized an informal learning collaborative primarily through teleconference meetings with representatives of 11 health service vend...

Apr 17th, 2021 - Multisystem Inflammatory Syndrome in Children (MIS-C) recently reported in a minority of children affected by SARS-CoV-2, mimics Kawasaki disease (KD), a medium vessel vasculitis of unknown cause. In contrast to acute COVID-19 infection, which is usually mild in children, 68% of patients with MIS-C will need intensive care unit. Myocarditis and coronary artery ectasia/aneurysm are included betw...

Apr 17th, 2021 - An integrated emergency department/hospital at home model in mild COVID-19 pneumonia: feasibility and outcomes after discharge from the emergency department: comment.|2021|Nattino G,Paglia S,|

Apr 17th, 2021 - On March 14, 2020 one of the strictest confinements in Europe was imposed on the citizens of Spain. The online tool for parents, iCygnus, was designed to reduce the psychological impact generated by the pandemic on the child population (2-12 years of age) through automatic recommendations to parents based on individual responses about their parenting styles and their child's characteristics. Th...