Jan 20th, 2022 - Rapid antigen testing using a nasal swab with the BinaxNOW test was able to detect the Omicron variant at an urban community testing site, whereas other swabbing routes did not perform as well, researchers found. Sensitivity of the BinaxNOW assay for detecting PCR-positive cases within a cycle threshold (Ct) of <30, indicating a higher viral load, was 74% (95% CI 53.7-88.9%) using a throat swab...

Jan 20th, 2022 - Americans keep hearing that it is important to test frequently for COVID-19 at home. But just try to find an “at-home” rapid COVID test in a store and at a price that makes frequent tests affordable.

Jan 20th, 2022 - Couples who were vaccinated against COVID-19 did not have a lower likelihood of getting pregnant, but previous infection with SARS-CoV-2 could affect male fertility, according to a prospective study. Both female and male partners who had at least one COVID-19 vaccine dose did not face lower chances of getting pregnant than unvaccinated patients (female fecundability ratio [FR] 1.08, 95% CI 0.95...

Jan 20th, 2022 - Patients recovering from COVID-19 showed cardiac dysfunction on transthoracic echocardiography 3 to 4 months after hospital discharge, according to a Norwegian study. Compared with matched controls, 204 COVID patients had worse right ventricular longitudinal strain (RVLS; adjusted estimated mean difference 1.5 percentage points, 95% CI 0.5-2.6), lower tricuspid annular plane systolic excursion ...

Jan 20th, 2022 - Young adults performed worse on memory and attention tests several months after an acute case of mild COVID-19, according to a small study that may support the "brain fog" reported by many. Most cognitive abilities tested -- including working memory, executive function, and planning -- were normal, but COVID-19 patients displayed significantly worse episodic memory for up to 6 months after infe...

Jan 20th, 2022 - Outcomes for older patients were similar regardless of whether or not hospitalists were having their busiest days, a large national study using data from 2018 found. Among older Medicare recipients (mean age 80), those admitted on hospitalists' busiest days did not experience any "meaningful differences" in outcomes for common conditions, compared to those that were admitted during less busy da...

Jan 20th, 2022 - Note that some links may require registration or subscription. A top Florida health official was placed on leave after encouraging his colleagues to get vaccinated against COVID-19. (Washington Post) NIAID Director Anthony Fauci, MD, suggested that Pfizer's COVID-19 vaccine could be authorized for kids under 5 as soon as next month. (Fortune) Due to the Omicron variant, updated NIH COVID guidel...

Jan 20th, 2022 - Background In multisystem inflammatory syndrome in children, there is paucity of longitudinal data on cardiac outcomes. We analyzed cardiac outcomes 3 to 4 months after initial presentation using echocardiography and cardiac magnetic resonance imaging. Methods and Results We included 60 controls and 60 cases of multisystem inflammatory syndrome in children. Conventional echocardiograms and defo...

Jan 20th, 2022 - The current study aimed to evaluate the satisfaction level of parents from telemedicine use in the long-term follow-up of children operated for craniosynostosis during the COVID-19 pandemic. A cross-sectional 9-question survey analysis using Qualtrics survey software. An institutional study carried out at a national, tertiary level academic center in the Slovak Republic. All patients operated f...

Jan 20th, 2022 - Reducing ageism is a significant social issue. The current study involved a novel experimental examination of whether a one-time simulated online intergenerational friendship would reduce ageism. Undergraduate participants were randomly assigned to complete an interpersonal closeness exercise (the "fast friends" procedure, Aron et al., 1997; Lytle & Levy, 2015) with a confederate who used a scr...

Jan 20th, 2022 - Ivermectin (IVM), an approved anthelminthic drug, has been reported to have antiviral, antibacterial, and anticancer activities. Antiviral activity is due to the inhibition of nuclear cargo importin (IMP) protein. The anti-SARS CoV-2 activity through in vitro study was first reported by an Australian team. Later, many studies were conducted, and most of the study results were available as non-p...

Jan 20th, 2022 - The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network - ADDENDUM.|2022|Weiner-Lastinger LM,Pattabiraman V,Konnor RY,Patel PR,Wong E,|

Jan 20th, 2022 - In the United States, infection with SARS-CoV-2 caused 380,000 reported deaths from March to December 2020. We adapted the Moving Epidemic Method to all-cause mortality data from the United States to assess the severity of the COVID-19 pandemic across age groups and all 50 states. By comparing all-cause mortality during the pandemic with intensity thresholds derived from recent, historical all-...

Jan 20th, 2022 - Background: Emergency Departments (EDs) can serve as surveillance sites for infectious diseases. The objective of this study was to determine the burden of SARS-CoV-2 infection and to monitor the prevalence of vaccination against COVID-19 among patients attending an urban ED in Baltimore City. Methods: Using 1,914 samples of known exposure status, we developed an algorithm to differentiate prev...

Jan 20th, 2022 - The Gammacoronavirus infectious bronchitis virus (IBV) is a highly contagious global pathogen prevalent in all types of poultry flocks. IBV is responsible for economic losses and welfare issues in domestic poultry resulting in a significant risk to food security. IBV vaccines are currently generated by serial passage of virulent field isolates of IBV through embryonated hen's eggs. The differen...

Jan 20th, 2022 - Due to the high mutation rate of influenza virus and the rapid increase of drug resistance, it is imperative to discover host-targeting antiviral agents with broad-spectrum antiviral activity. Considering the discrepancy between the urgent demand of antiviral drugs during an influenza pandemic and the long-term process of drug discovery and development, it is feasible to explore host-based anti...

Jan 20th, 2022 - COVID-19 has infected millions of people and upended the lives of most humans on the planet. Researchers from across the psychological sciences have sought to document and investigate the impact of COVID-19 in myriad ways, causing an explosion of research that is broad in scope, varied in methods, and challenging to consolidate. Because policy and practice aimed at helping people live healthier...

Jan 20th, 2022 - Frontline Healthcare workers (HCWs) caring for patients with COVID-19 have a high risk of developing mental health problems. Recognizing the risk factors and consequences of care in this group of people can lead to preventive and interventional measures to maintain and improve their mental health and ultimately improve the quality of their care. This qualitative content analysis study was condu...

Jan 20th, 2022 - Neurological and neuroradiological manifestations in patients with COVID-19 have been extensively reported. Available imaging data are, however, very heterogeneous. Hence, there is a growing need to standardise clinical indications for neuroimaging, MRI acquisition protocols, and necessity of follow-up examinations. A NeuroCovid working group with experts in the field of neuroimaging in COVID-1...

Jan 20th, 2022 - We aimed to find out the asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among pediatric patients with rheumatic diseases and healthy children and to compare them with each other. Patients with familial Mediterranean fever (FMF), juvenile idiopathic arthritis (JIA), and juvenile systemic lupus erythematosus (jSLE) and healthy children as healthy control ...

Jan 20th, 2022 - The COVID-19 pandemic led to rapid and widespread adoption of telemedicine in rheumatology care. The Asia Pacific League of Associations for Rheumatology (APLAR) working group was tasked with developing evidence-based recommendations for rheumatology practice to guide maintenance of the highest possible standards of clinical care and to enable broad patient reach. A systematic review of English...

Jan 20th, 2022 - Primary ciliary dyskinesis (PCD) is an autosomal recessive disorder associated with impaired mucociliary clearance caused by defects in ciliary structure and function. The major clinical feature of PCD is recurring or persistent respiratory tract infection. Respiratory tract colonization with drug-resistant organisms impacts the frequency of infections and lung function decline. Protective gear...

Jan 20th, 2022 - Global Representation During a Global Pandemic.|2022|Mlia-Phiri E,Lissauer S,Weatherhead JE,|

Jan 20th, 2022 - Little is known about COVID-19 outcomes among children and adolescents in sub-Saharan Africa, where preexisting comorbidities are prevalent. To assess the clinical outcomes and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa. This cohort study was a retrospective record review of data from 25 hospitals in the Democr...

Jan 20th, 2022 - Optimal nutrition therapy has not yet been established for the acute phase of severe coronavirus disease 2019 (COVID-19) infection. To examine the effects of nutrition delivery in the acute phase on the mortality and long-term outcomes of post-intensive care syndrome (PICS). A multicenter prospective study was conducted on adult patients with COVID-19 infection requiring mechanical ventilation ...

Jan 20th, 2022 - This paper presents data from the Love and Sex in the Time of COVID survey, an online survey with US gay, bisexual and other men who have sex with men. The first round of the Love and Sex in the Time of COVID-19 survey was conducted online from April to May, 2020: the second round was collected November 2020 to January 2021. GBMSM were recruited through advertisements featured on social network...

Jan 20th, 2022 - The oral mucosa is one of the first lines of the innate host defense system against microbial invasion. Interferon (IFN) lambda-1 (IFN-λ1), a type III IFN, exhibits type I IFN-like antiviral activity. In contrast to ubiquitously expressed type I IFN receptors, IFN-λ receptor 1 (IFN-λR1), which has higher affinity for type III IFNs than low-affinity interleukin (IL)-10 receptor 2, is mainly expr...

Jan 20th, 2022 - The outbreak of the coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an evolving global health crisis. Currently, a number of risk factors have been identified to have a potential impact on increasing the morbidity of COVID-19 in adults, including old age, male sex, pre-existing comorbidities, and racial/ethnic dis...

Jan 20th, 2022 - This study examined the association between serious mental illness diagnoses and COVID-19 vaccination among Veterans Health Administration (VHA) patients. The sample (N=4,890,693) comprised veterans ages ≥18 years with VHA outpatient visits from March 1, 2018, through February 29, 2020. Veterans with serious mental illness were identified with ICD-10 diagnostic codes from electronic health reco...

Jan 20th, 2022 - Major efforts are being made to control the spread and impacts of the coronavirus pandemic using vaccines. Ethiopia began on March 13, 2021, to vaccinate healthcare workers (HCWs) for COVID-19 with the AstraZeneca vaccine. However, willingness to be vaccinated depends to a large extent on factors beyond the availability of vaccines. This study aimed to determine the rate of intention to refuse ...

Jan 20th, 2022 - Educators who train healthcare students to provide behavioral health services in primary care settings frequently encounter challenges as they work to ensure that students acquire the knowledge and skills to effectively function on interprofessional practice teams. This has become increasingly important during COVID-19, as interprofessional collaborative practice is needed more than ever to add...

Jan 20th, 2022 - The COVID-19 pandemic has disproportionately impacted 2SLGBTQ+ youth experiencing homelessness. Little is known about vaccine attitudes and uptake among this population. To address this, the objectives of this study were to explore this group's COVID-19 vaccine attitudes, and facilitators and barriers impacting vaccine uptake. 2SLGBTQ+ youth experiencing homelessness in the Greater Toronto Area...

Jan 20th, 2022 - Postgraduate entrance examination (the Unified National Graduate Entrance Examination) is the major way for Chinese medical undergraduate student to apply for postgraduate studies. It consists of two stages: the preliminary basic written test and the re-examination in form of both written tests and interviews. With the spread of COVID-19, the traditional on-site re-examination of postgraduates ...

Jan 20th, 2022 - A higher mortality and morbidity rate has been reported in COVID-19 patients undergoing surgery. To reduce the morbidity and mortality rate in COVID-19 patients undergoing orthopedic procedures, we aimed to increase the threshold for surgical planning. In a prospective cohort study, COVID-19 patients who underwent elective or emergent orthopedic surgery in three orthopedic surgery centers from ...

Jan 20th, 2022 - The COVID-19 pandemic has caused an unprecedented disruption in medical education. Students and lecturers had to adapt to online education. The current study aimed to investigate the level of satisfaction and future preference for online lectures among clinical clerkship students and elucidated the factors that affect these outcomes. We selected a sample of 114 medical students undergoing clini...

Jan 20th, 2022 - Vaccination of youth could be key to preventing future outbreaks of SARS-CoV-2. Given the limited direct health benefit for young people, it is important to understand how youth themselves perceive obtaining a vaccination. This survey study in a representative sample of Dutch youth aged 12-18 showed that 73% were willing to get vaccinated against COVID-19. In regression analyses, vaccination wi...

Jan 20th, 2022 - While population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of SARS-CoV-2 exposure, is less understood. We conducted a national cohort study of health care workers in Wales (UK) from 7 December 2020 to 30 September 2021. We examined uptake of any COVID-19 vaccine, and the effectiveness of BNT162b2 mRN...

Jan 20th, 2022 - COVID-19 originated in Wuhan city, China, in 2019 erupted a global pandemic that had put down nearly 3 million lives and hampered the socio-economic conditions of all nations. Despite the available treatments, this disease is not being controlled totally and spreading swiftly. The deadly virus commences infection by hACE2 receptor and its co-receptors (DPP4) engagement with the viral spike prot...

Jan 20th, 2022 - The coronavirus pandemic upended in-person radiology education and led to a transition to virtual platforms. We needed a new method to monitor lecture attendance, previously relying on a physical badge system. Our goal was to develop and implement a virtual conference attendance system that is user-friendly, automated, useable in any virtual conference environment, and accurate. We developed a ...

Jan 20th, 2022 - There is increasing concern about the impact of the SARS-CoV-2 pandemic on mental and physical health. Among the many possible outcomes of COVID-19, reports of sleep disturbances, and erectile dysfunction are becoming prevalent worldwide. We sought to evaluate the recent literature on this subject to produce a narrative review of the topic. We performed an extensive literature search to identif...

Jan 20th, 2022 - Covid-19: Reassess effects of mandatory vaccination on staffing, urge unions.|2022|Waters A,|

Jan 20th, 2022 - Covid-19: Brazil sees omicron cases soar but data blackout obscures true impact.|2022|Taylor L,|

Jan 20th, 2022 - This is the first British multicentre study observing the impact of the COVID-19 pandemic on orthopaedic trauma with respect to referrals, operative caseload and mortality during its peak. A longitudinal, multicentre, retrospective, observational, cohort study was conducted during the peak 6 weeks of the first wave from 17 March 2020 compared with the same period in 2019. Hospitals from six maj...

Jan 20th, 2022 - Covid-19: Lateral flow tests in children fail minimum performance standards, study finds.|2022|Mahase E,|

Jan 20th, 2022 - To systematically assess the diagnostic accuracy of rapid point-of-care tests for diagnosis of current SARS-CoV-2 infections in children under real-life conditions. Systematic review and meta-analysis. MEDLINE, Embase, Cochrane Database for Systematic Reviews, INAHTA HTA database, preprint servers (via Europe PMC), ClinicalTrials.gov, WHO ICTRP from 1 January 2020 to 7 May 2021; NICE Evidence S...

Jan 20th, 2022 - Political polarization impeded public support for policies to reduce the spread of COVID-19, much as polarization hinders responses to other contemporary challenges. Unlike previous theory and research that focused on the United States, the present research examined the effects of political elite cues and affective polarization on support for policies to manage the COVID-19 pandemic in seven co...

Jan 20th, 2022 - Genomic RNA of severe acute respiratory syndrome-associated coronavirus type 2 (SARS-CoV-2) has been detected in the breast milk of lactating women, but its pathological significance has remained uncertain due to the small size of prior studies. Breast milk from 110 lactating women was analyzed by reverse transcription-polymerase chain reaction (285 samples) and viral culture (160 samples). Tho...

Jan 20th, 2022 - The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with previous years. Based on data from the multicenter German Diabetes Prospective Follow-up Registry, we analyzed the incidence of type 1 diabetes per 100,000 patient-years in children and adolescents from 1 January 2...

Jan 20th, 2022 - The beneficial effect of glucocorticoids in coronavirus disease (COVID-19) is established, but whether adrenal cortisol secretion is impaired in COVID-19 is not fully elucidated. In this case-control study, we investigated the diurnal free bioavailable salivary cortisol secretion in COVID-19 patients. Fifty-two consecutive COVID-19 patients-before dexamethasone treatment in cases required-recru...

Jan 20th, 2022 - Remdesivir is a broad-spectrum antiviral agent able to inhibit the RNA polymerase of SARS-CoV-2. At present, studies focusing on the effect of remdesivir on viral load (VL) are few and with contrasting results. Aim of the present study was to evaluate the effect of remdesivir on SARS-CoV-2 VL from nasopharyngeal swabs (cycle threshold criterion) in a sample of patients treated with the drug, co...