Oct 31st, 2020 - To assess the role of in-flight transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we investigated a cluster of cases among passengers on a 10-hour commercial flight.

Oct 31st, 2020 - In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China, ultimately causing the coronavirus disease (COVID-19) pandemic. Many persons with SARS-CoV-2 infection have since flown into and out of COVID-19–affected areas. Some countries quarantine arriving passengers. Airports are also screening passenger body temperatures before boarding and after arrival. Recent inv...

Oct 21st, 2020 - Video consultations in primary and specialist care during the covid-19 pandemic and beyond.|2020|Car J,Koh GC,Foong PS,Wang CJ,|

Oct 21st, 2020 - Covid-19: Fauci awarded for "unprecedented public service" while Trump fires more insults.|2020|Tanne JH,|

Oct 21st, 2020 - Prediction models for covid-19 outcomes.|2020|Sperrin M,McMillan B,|

Oct 21st, 2020 - To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Population based cohort study. QResearch database, comprising 1205 general practices in England with linkage to covid-19 test results, Hospital Episode Statistics, and death registry data. 6.08 million adults aged 19-100 years were included...

Oct 21st, 2020 - The COVID-19 outbreak has caused enormous strain on healthcare systems, and healthcare trainees, which comprise the future healthcare workforce, may be a vulnerable group. It is essential to assess the psychological distress experienced by healthcare trainees during the COVID-19 outbreak. A cross-sectional study with 4184 healthcare trainees at Sichuan University in China was implemented during...

Oct 21st, 2020 - Assess the impacts of the COVID-19 pandemic on service delivery by frontline healthcare providers in acute care medical and emergency department settings and identify strategies used to cope with pandemic-related physical and mental health demands. Rapid clinical ethnography of patient-provider encounters during an initial pandemic 'surge' conducted by a team of clinician-researchers using a st...

Oct 21st, 2020 - Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis remains unclear. Clinical and immunological features of patients with COVID-19 have highlighted a potential role for changes in immune activity in regulating disease severity. However, little is known about the responses in human...

Oct 21st, 2020 - The economic and mortality impacts of the COVID-19 pandemic have been widely discussed, but there is limited evidence on their relationship across demographic and geographic groups. We use publicly available monthly data from January 2011 through April 2020 on all-cause death counts from the Centers for Disease Control and Prevention and employment from the Current Population Survey to estimate...

Oct 21st, 2020 - COVID-19 may have a profound impact on sexual health, reproductive health and social life across the world. Shelter in place regulations that have extended across the globe may influence condomless sex, exacerbate intimate partner violence and reduce access to essential reproductive health services. Population representative research is challenging during shelter in place, leaving major gaps in...

Oct 21st, 2020 - Diagnoses of syphilis and HIV infection during the COVID-19 pandemic in Taiwan.|2020|Chia CC,Chao CM,Lai CC,|

Oct 21st, 2020 - We sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations. Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19. We used multivariable regression with a generalised est...

Oct 21st, 2020 - ACE2 has emerged as a double agent in the COVID-19 ordeal being physiologically protective yet conducive of viral infection. The identification of ACE2 in as many as 72 tissues suggests that extra-pulmonary invasion and damage is likely, which indeed has already been demonstrated by cardiovascular and gastro-intestinal symptoms. On the other hand, identifying ACE2 dysregulation in patients with...

Oct 21st, 2020 - This is a report of the first three cases of endovascular aneurysm treatment that were proctored by a remote interventionalist using a novel high-resolution low-latency streaming technology. The proctor was located in a neurovascular centre and supported the treating interventional teams in two distant cities (up to 800 km/500 miles apart). All aneurysms were treated using the Woven EndoBridge ...

Oct 21st, 2020 - Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study in...

Oct 21st, 2020 - COVID-19 vaccines: time to talk about the uncertainties.|2020|Subbarao K,|

Oct 21st, 2020 - Question hubris in nations' COVID-19 responses.|2020|Mundt AP,|

Oct 21st, 2020 - Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.|2020|Callaway E,|

Oct 21st, 2020 - Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic human variable heavy (VH) domains toward neutralizing epitopes. We constructed a VH-phage library and targeted the angiotensin-converting enzyme 2 (ACE2) binding interface of the SARS-CoV-2 Spike receptor-binding domain ...

Oct 21st, 2020 - Several coronavirus disease 2019 (COVID-19) vaccines are currently in human trials. In June 2020, we surveyed 13,426 people in 19 countries to determine potential acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Of these, 71.5% of participants reported that they would be very or somewhat likely to take a COVID-19 vaccine, and 61.4% reported that they would accept their...

Oct 21st, 2020 - The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in an unprecedented public health challenge worldwide. Despite urgent and extensive global efforts, the existing evidence is inconclusive regarding the medications used for the treatment of COVID-19. To generate an up-to-date evidence for the clinical safety and ef...

Oct 21st, 2020 - A systematic review of mental health outcomes and needs of children and families during past pandemics was conducted based on the PRISMA protocol. The objectives were to evaluate the quality of existing studies on this topic, determine what is known about mental health outcomes and needs of children and families, and provide recommendations for how COVID-19 policies can best support children an...

Oct 21st, 2020 - It is critical to identify potential causal targets for SARS-coronavirus 2, which may guide drug repurposing options. We assessed the associations between genetically predicted protein levels and COVID-19 severity. Leveraging data from The COVID-19 host genetics initiative comparing 6,492 hospitalized COVID-19 patients and 1,012,809 controls, we identified 18 proteins with genetically predicted...

Oct 21st, 2020 - Extra-cardiac multifocal lung uptake of 99mTc-sestamibi in myocardial perfusion imaging: An asymptomatic case with coronavirus infection features.|2020|Malek H,Maghsudi M,Yaghoobi N,|

Oct 21st, 2020 - This paper presents a brief overview of the complex interaction between age, hypertension, the renin-angiotensin-aldosterone system (RAAS), inflammation, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Coronavirus disease 2019 (COVID-19) is more frequent and more severe in comorbid elderly patients, especially those with hypertension, diabetes, obesity, or cardiovascu...

Oct 21st, 2020 - The cytokine storm has been frequently reported to occur in patients with severe coronavirus disease 2019 (COVID-19). Data from the literature suggest that elevated levels of inflammatory mediators, such as interleukin (IL)-6, IL-8, and tumor necrosis factor, indicate a severe course or the fatality of the disease. Several therapeutic options have been employed to treat critically ill patients,...

Oct 21st, 2020 - SARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia - COVID-19 - but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We quantified immun...

Oct 21st, 2020 - Treatment of COVID-19 induced chilblains with topical nitroglycerin.|2020|Weingarten M,Abittan B,Rivera-Oyola R,Abittan AI,Weingarten M,|

Oct 21st, 2020 - Two cases of skin manifestations prior to the onset of COVID-19 respiratory symptoms.|2020|Altayeb A,Cordaro A,Caesar J,Vyas J,Ingram J,|

Oct 21st, 2020 - Italy was severely affected by the severe acute respiratory syndrome coronavirus 2 pandemic. Our Institution, Piedmont's largest tertiary referral center, was designated as a non-COVID-19 hospital and activities were reorganized to prioritize critical services like oncological care. The aim of this study was to investigate the efficacy in preserving the oncological surgical practice at our Inst...

Oct 21st, 2020 - Obesity is a global health problem that affects all age groups in both developing and developed countries. In recent years, the prevalence of overweight and obesity has reached pandemic levels, resulting in a dramatic increase in the incidence of various comorbidities, such as cardiovascular diseases, type 2 diabetes, and cancer, consequently leading to massive health and socioeconomic burdens....

Oct 21st, 2020 - The coronavirus disease 2019 (COVID-19) pandemic has put an enormous strain on healthcare systems and intensive care unit (ICU) capacity, leading to suspension of most elective procedures, including transcatheter aortic valve replacement (TAVR). However, deferment of TAVR is associated with significant wait-time mortality in patients with severe aortic valve stenosis. Conversely, there is curre...

Oct 21st, 2020 - It is unknown if solid organ transplant recipients are at higher risk for severe COVID-19. The management of a lung transplantation (LTx) program and the therapeutic strategies to adapt the immunosuppressive regimen and antiviral measures is a major issue in the COVID-19 era, but little is known about worldwide practice. We sent out to 180 LTx centers worldwide in June 2020 a survey with 63 que...

Oct 21st, 2020 - In light of the current evolving coronavirus disease 2019 (COVID-19) pandemic, and the need to learn from past infectious disease outbreaks to provide better psychological support for our frontline health care workers (HCW), we conducted a rapid review of extant studies that have reported on both psychological and coping responses in HCW during recent outbreaks. We performed a systematic search...

Oct 21st, 2020 - Rebuilding survivorship care during Covid-19.|2020|Pagedar NA,Seaman AT,|

Oct 21st, 2020 - The risk of environmental contamination by SARS-CoV-2 in the intensive care unit (ICU) is unclear. We aimed to evaluate the extent of environmental contamination in the ICU and correlate this with patient and disease factors, including the impact of different ventilatory modalities. Observational study where surface environmental samples collected from ICU patient rooms and common areas were te...

Oct 21st, 2020 - During the world-wide coronavirus disease 2019 (COVID-19) outbreak, there is an urgent need to rapidly increase the readiness of hospitals. Emergency departments (EDs) are at high risk of facing unusual situations and need to prepare extensively in order to minimize risks to health care providers (HCPs) and patients. In situ simulation is a well-known method used in training to detect system ga...

Oct 21st, 2020 - Mental health and wellbeing during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study.|2020|O'Connor RC,Wetherall K,Cleare S,McClelland H,Melson AJ,|

Oct 21st, 2020 - Neurological Manifestations in Coronavirus Disease 2019 (COVID-19) Patients: A Systematic Review of Literature.|2020|Ibrahim W,|

Oct 21st, 2020 - Obsessive-compulsive disorder-contamination fears, features and treatment: Novel smartphone therapies in light of global mental health and pandemics (COVID-19).|2020|Jalal B,Chamberlain SR,Robbins TW,Sahakian BJ,|

Oct 21st, 2020 - The impact of COVID-19 pandemic on post-operative follow-up after total hip and knee joints replacement.|2020|Abobaker A,Oluwalana I,|

Oct 21st, 2020 - The remote neuro-otology assessment - managing dizziness in the coronavirus disease 2019 era.|2020|Murdin L,Saman Y,Rea P,|

Oct 21st, 2020 - How I do it: a simulator of the ear for developing otomicroscopy skills during the coronavirus disease 2019 pandemic.|2020|Shenton C,Aucott W,|

Oct 21st, 2020 - This current volume is, in many ways, a 2020 update to the important 1999-2000 compendium by Sir Fred Hoyle and Professor N. Chandra Wickramasinghe's "Astronomical Origins of life: Steps towards Panspermia." The emerging new paradigm of biology that connects life on Earth with the wider cosmos is covered in considerable depth showing that terrestrial biological evolution is best understood as a...

Oct 21st, 2020 - WHO's pronouncement of the 2019 novel coronavirus outbreak as a pandemic disease came months after we published a warning that the present deepest minimum of the sunspot cycle would be likely to facilitate the onset of a viral pandemic. During a deep sunspot minimum (deepest in 100 years) such as we are now witnessing, two space related phenomena could have an effect on the disposition of viral...

Oct 21st, 2020 - The origins and global spread of two recent, yet quite different, pandemic diseases is discussed and reviewed in depth: Candida auris, a eukaryotic fungal disease, and COVID-19 (SARS-CoV-2), a positive strand RNA viral respiratory disease. Both these diseases display highly distinctive patterns of sudden emergence and global spread, which are not easy to understand by conventional epidemiologic...

Oct 21st, 2020 - Coronaviruses are enveloped RNA viruses from the Coronaviridae family affecting neurological, gastrointestinal, hepatic and respiratory systems. In late 2019 a new member of this family belonging to the Betacoronavirus genera (referred to as COVID-19) originated and spread quickly across the world calling for strict containment plans and policies. In most countries in the world, the outbreak of...

Oct 21st, 2020 - The World Health Organization (WHO) announced that the novel coronavirus pneumonia pandemic caused by SARS-CoV-2 was classified as a public health emergency of international concern on January 30, 2020 Egypt's health ministry had announced the first case in the country at Cairo International Airport involving a Chinese national on 14 February 2020. Case decisions in the cath labs should be indi...

Oct 21st, 2020 - During the coronavirus disease 2019 (COVID-19) pandemic, strained acute care resources, the potential for rapid clinical decompensation, and concerns about staff safety has prompted a conservative management approach for acute coronary syndrome patients. We present our experience of COVID-19 patients at Elmhurst Hospital Center presenting with ST-Elevation Myocardial Infarction and compared out...