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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 During Long Flight
https://wwwnc.cdc.gov/eid/article/26/11/20-3299_article
Emerging Infectious Diseases;

Oct 31st, 2020 - To assess the role of in-flight transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we investigated a cluster of cases among passengers on a 10-hour commercial flight.

In-Flight Transmission of Severe Acute Respiratory Syndrome Coronavirus 2
https://wwwnc.cdc.gov/eid/article/26/11/20-3254_article
Emerging Infectious Diseases;

Oct 31st, 2020 - In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China, ultimately causing the coronavirus disease (COVID-19) pandemic. Many persons with SARS-CoV-2 infection have since flown into and out of COVID-19–affected areas. Some countries quarantine arriving passengers. Airports are also screening passenger body temperatures before boarding and after arrival. Recent inv...

Video consultations in primary and specialist care during the covid-19 pandemic and bey...
https://doi.org/10.1136/bmj.m3945
BMJ (Clinical Research Ed.); Car J, Koh GC et. al.

Oct 21st, 2020 - Video consultations in primary and specialist care during the covid-19 pandemic and beyond.|2020|Car J,Koh GC,Foong PS,Wang CJ,|

Covid-19: Fauci awarded for "unprecedented public service" while Trump fires more insults.
https://doi.org/10.1136/bmj.m4064
BMJ (Clinical Research Ed.); Tanne JH

Oct 21st, 2020 - Covid-19: Fauci awarded for "unprecedented public service" while Trump fires more insults.|2020|Tanne JH,|

Prediction models for covid-19 outcomes.
https://doi.org/10.1136/bmj.m3777
BMJ (Clinical Research Ed.); Sperrin M, McMillan B

Oct 21st, 2020 - Prediction models for covid-19 outcomes.|2020|Sperrin M,McMillan B,|

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality ...
https://doi.org/10.1136/bmj.m3731
BMJ (Clinical Research Ed.); Clift AK, Coupland CAC et. al.

Oct 21st, 2020 - To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Population based cohort study. QResearch database, comprising 1205 general practices in England with linkage to covid-19 test results, Hospital Episode Statistics, and death registry data. 6.08 million adults aged 19-100 years were included...

COVID-19 outbreak-related psychological distress among healthcare trainees: a cross-sec...
https://doi.org/10.1136/bmjopen-2020-041671
BMJ Open; Wang Y, Li Y et. al.

Oct 21st, 2020 - The COVID-19 outbreak has caused enormous strain on healthcare systems, and healthcare trainees, which comprise the future healthcare workforce, may be a vulnerable group. It is essential to assess the psychological distress experienced by healthcare trainees during the COVID-19 outbreak. A cross-sectional study with 4184 healthcare trainees at Sichuan University in China was implemented during...

Rapid ethnographic assessment of the COVID-19 pandemic April 2020 'surge' and its impac...
https://doi.org/10.1136/bmjopen-2020-041772
BMJ Open; Palinkas LA, Whiteside L et. al.

Oct 21st, 2020 - Assess the impacts of the COVID-19 pandemic on service delivery by frontline healthcare providers in acute care medical and emergency department settings and identify strategies used to cope with pandemic-related physical and mental health demands. Rapid clinical ethnography of patient-provider encounters during an initial pandemic 'surge' conducted by a team of clinician-researchers using a st...

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases.
https://doi.org/10.1073/pnas.2018030117 10.1056/NEJMoa2020283 10.1056/NEJMoa2007764.0028-4793 10.1056/nejmoa2021436
Proceedings of the National Academy of Sciences of the United States of America; Wu M, Chen Y et. al.

Oct 21st, 2020 - Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis remains unclear. Clinical and immunological features of patients with COVID-19 have highlighted a potential role for changes in immune activity in regulating disease severity. However, little is known about the responses in human...

Initial economic damage from the COVID-19 pandemic in the United States is more widespr...
https://doi.org/10.1073/pnas.2014279117 10.3386/w26918
Proceedings of the National Academy of Sciences of the United States of America; Polyakova M, Kocks G et. al.

Oct 21st, 2020 - The economic and mortality impacts of the COVID-19 pandemic have been widely discussed, but there is limited evidence on their relationship across demographic and geographic groups. We use publicly available monthly data from January 2011 through April 2020 on all-cause death counts from the Centers for Disease Control and Prevention and employment from the Current Population Survey to estimate...

International Sexual Health And REproductive health (I-SHARE) survey during COVID-19: s...
https://doi.org/10.1136/sextrans-2020-054664
Sexually Transmitted Infections; Michielsen K, Larrson EC et. al.

Oct 21st, 2020 - COVID-19 may have a profound impact on sexual health, reproductive health and social life across the world. Shelter in place regulations that have extended across the globe may influence condomless sex, exacerbate intimate partner violence and reduce access to essential reproductive health services. Population representative research is challenging during shelter in place, leaving major gaps in...

Diagnoses of syphilis and HIV infection during the COVID-19 pandemic in Taiwan.
https://doi.org/10.1136/sextrans-2020-054802
Sexually Transmitted Infections; Chia CC, Chao CM et. al.

Oct 21st, 2020 - Diagnoses of syphilis and HIV infection during the COVID-19 pandemic in Taiwan.|2020|Chia CC,Chao CM,Lai CC,|

Effect of IBD medications on COVID-19 outcomes: results from an international registry.
https://doi.org/10.1136/gutjnl-2020-322539
Gut Ungaro RC, Brenner EJ et. al.

Oct 21st, 2020 - We sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations. Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19. We used multivariable regression with a generalised est...

Dysregulation of ACE2 Expression and Function in Co-morbid Disease Conditions Possibly ...
https://doi.org/10.1124/molpharm.120.000119
Molecular Pharmacology; Hammoud S, Wehbe Z et. al.

Oct 21st, 2020 - ACE2 has emerged as a double agent in the COVID-19 ordeal being physiologically protective yet conducive of viral infection. The identification of ACE2 in as many as 72 tissues suggests that extra-pulmonary invasion and damage is likely, which indeed has already been demonstrated by cardiovascular and gastro-intestinal symptoms. On the other hand, identifying ACE2 dysregulation in patients with...

Republished: Interhospital teleproctoring of endovascular intracranial aneurysm treatme...
https://doi.org/10.1136/neurintsurg-2020-016722.rep
Journal of Neurointerventional Surgery; Bechstein M, Elsheikh S et. al.

Oct 21st, 2020 - This is a report of the first three cases of endovascular aneurysm treatment that were proctored by a remote interventionalist using a novel high-resolution low-latency streaming technology. The proctor was located in a neurovascular centre and supported the treating interventional teams in two distant cities (up to 800 km/500 miles apart). All aneurysms were treated using the Woven EndoBridge ...

A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine ...
https://doi.org/10.1038/s41467-020-19056-6
Nature Communications; Lyngbakken MN, Berdal JE et. al.

Oct 21st, 2020 - Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study in...

COVID-19 vaccines: time to talk about the uncertainties.
https://doi.org/10.1038/d41586-020-02944-8
Nature Subbarao K

Oct 21st, 2020 - COVID-19 vaccines: time to talk about the uncertainties.|2020|Subbarao K,|

Question hubris in nations' COVID-19 responses.
https://doi.org/10.1038/d41586-020-02930-0
Nature Mundt AP

Oct 21st, 2020 - Question hubris in nations' COVID-19 responses.|2020|Mundt AP,|

Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.
https://doi.org/10.1038/d41586-020-02821-4
Nature Callaway E

Oct 21st, 2020 - Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.|2020|Callaway E,|

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
https://doi.org/10.1038/s41589-020-00679-1
Nature Chemical Biology; Bracken CJ, Lim SA et. al.

Oct 21st, 2020 - Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic human variable heavy (VH) domains toward neutralizing epitopes. We constructed a VH-phage library and targeted the angiotensin-converting enzyme 2 (ACE2) binding interface of the SARS-CoV-2 Spike receptor-binding domain ...