Apr 14th, 2021 - In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (...

Apr 14th, 2021 - Highlighting socio-economic constraints on mobility reductions during COVID-19 restrictions in France can inform effective and equitable pandemic response.|2021|Valdano E,Lee J,Bansal S,Rubrichi S,Colizza V,|

Apr 14th, 2021 - Cholinergic urticaria is a common disorder that has been associated with anaphylaxis. We report the events, workup, and eventual second dose vaccination of a patient at the Walter Reed National Military Medical Center, who had immediate anaphylaxis after administration of the first Pfizer-BioNTech Covid-19 (BNT162b2) vaccine dose. During the initial evaluation after anaphylaxis, the patient des...

Apr 14th, 2021 - The COVID-19 epidemic is not only the medical issue, but also a sophisticated social problem. We propose a network dynamics model of epidemic transmission introducing a heterogeneous control factor. The proposed model applied the classical SEIR model to the network based on effective distance, and was modified by introducing a heterogeneous control factor with temporal and spatial characteristi...

Apr 14th, 2021 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19 infection which has emerged as a global pandemic causing serious concerns. Lack of specific and effective therapeutics for the treatment of COVID-19 is a major concern and the development of vaccines is another important aspect in managing the infection effectively. The first step in the SARS-CoV-2 p...

Apr 14th, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has infected over 109,000,000 people with 2,423,443 deaths as of February 17, 2021. Currently, there are no approved or consistently effective treatments, and conventional vaccines may take several years for development and testing. In silico methods of bioinformatics, vaccinogenomics, immunoinformatics, structural biology and molecu...

Apr 14th, 2021 - MER-CoV is one of the recently identified zoonotic coronaviruses. The one-hump camels are believed to play important roles in the evolution and transmission of the virus. The animal-to-animal, as well as the animal-to-human transmission in the context of MERS-CoV infection, were reported. The camels shed the virus in some of their secretions especially the nasal tract. However, there are many a...

Apr 14th, 2021 - The accurate laboratory detection of the SARS-CoV-2 is a crucial element in the fight against COVID-19. RT-PCR testing on combined oral and nasopharyngeal swab (ONPS) suffers from several limitations, including the need for qualified personnel, the discomfort caused by invasive nasopharyngeal sample collection and the possibility of swab and transport media shortage. Testing on saliva would rep...

Apr 14th, 2021 - The relation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and demyelinating Guillain Barre Syndrome (GBS) has been defined. We aim to report the clinical features of a child with axonal GBS associated with SARS-CoV-2. A 6-year-old male presented with symmetric ascending paralysis progressed over a 4-day course and 2-day of fever. He had bilateral lower and uppe...

Apr 14th, 2021 - It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of twenty days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected indiv...

Apr 14th, 2021 - Postponing cardiac procedures during the pandemic: The balance between elective and selective!|2021|Garzon S,Lemos PA,|

Apr 14th, 2021 - This paper describes how an anatomy and physiology laboratory class transitioned from a paper-based lab to an online learning platform that updated the curriculum to rely more on face-to-face small group collaboration and peer teaching. Student perceptions of the new format were positive, but halfway through the transition a global pandemic challenged the new instruction method. The face-to-fac...

Apr 14th, 2021 - We describe the utilization of telemedicine visits (video or telephone) across the T1D Exchange Quality Improvement Collaborative (T1DX-QI) during the COVID-19 pandemic. Metrics, site-level survey results, and examples of interventions conducted to support telemedicine in type 1 diabetes (T1D) are shown. Thirteen clinics (11 pediatric, 2 adult) provided monthly telemedicine metrics between Dece...

Apr 14th, 2021 - As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread, several variants have emerged. Variants B.1.1.7 and B.1.351 have attracted significant attention owing to their widespread transmission and possible immune evasion. A total of 19 SARS-CoV-2 vaccines based on original strains have entered clinical studies, including nine vaccines that have ob...

Apr 14th, 2021 - The National Institute for Health and Care Excellence (NICE) has been presented as politically independent, asserting it is free from industry influence and conflicts of interest so that its decisions may be led by evidence and science. We consider the ways in which soft political factors operate in guideline development processes at NICE such that guidelines are not truly led by science. We su...

Apr 14th, 2021 - COVID-19 vaccines, hesitancy and mental health.|2021|Smith K,Lambe S,Freeman D,Cipriani A,|

Apr 14th, 2021 - Rising incidence of thromboembolism secondary to COVID-19 has become a global concern, with several surveys reporting increased mortality rates. Thrombogenic potential of the SARS-CoV-2 virus has been hypothesised to originate from its ability to produce an exaggerated inflammatory response leading to endothelial dysfunction. Anticoagulants have remained the primary modality of treatment of thr...

Apr 14th, 2021 - The Influence of the COVID-19 Pandemic on Pediatric Firearm Injuries.|2021|Bell TM,Robbins C,Gosain A,|

Apr 14th, 2021 - Firearms Injuries Involving Young Children in the United States During the COVID-19 Pandemic.|2021|Cohen JS,Donnelly K,Patel SJ,Badolato GM,Boyle MD,|

Apr 14th, 2021 - To assess infection rates predischarge and postdischarge in breast milk-fed newborns with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers who were separated postdelivery from their mothers and discharged from the hospital. Also, we aim to evaluate breastfeeding rates predischarge and postdischarge. Nasopharyngeal swabs for SARS-CoV-2 were obtained from symptomatic ...