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Retrobulbar Injection of Amphotericin B in Patients With COVID-19 Associated Orbital Mu...
https://doi.org/10.1097/IOP.0000000000002256
Ophthalmic Plastic and Reconstructive Surgery; Sharifi A, Akbari Z et. al.

Aug 10th, 2022 - Following COVID-19 infection a rising count of rhino-orbito-cerebral mucormycosis is observed, requiring orbital exenteration, a disabling lifetime affecting surgery. One of the potential interventions for globe salvage in these patients is retrobulbar injections of amphotericin B. This study was conducted to review protocols, outcomes, and side effects of retrobulbar injection of amphotericin ...

Between a Rock and a Hard Place: The Challenges of Caregiving During a Pandemic for Par...
https://doi.org/10.1177/10499091221119462
The American Journal of Hospice & Palliative Care; Seshadri S, Norton SA et. al.

Aug 10th, 2022 - Aim: To understand Parkinson's Disease (PD) care partners' a) specific challenges that led to worsening strain and b) their suggestions for supports to help them during the ongoing pandemic. Method: Using a qualitative descriptive design, semi-structured interviews with family care partners (n = 19) were completed. Participants were recruited from 10 sites across the United States that varied i...

Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection...
https://doi.org/10.1007/s00228-022-03372-5
European Journal of Clinical Pharmacology; Foletto VS, da Rosa TF et. al.

Aug 10th, 2022 - The absence of specific treatments for COVID-19 leads to an intense global effort in the search for new therapeutic interventions and better clinical outcomes for patients. This review aimed to present a selection of accepted studies that reported the activity of antidepressant drugs belonging to the selective serotonin receptor inhibitor (SSRI) class for treating the novel coronavirus. A searc...

Home urinary tract infection testing: patient experience and satisfaction with polymera...
https://doi.org/10.1007/s00192-022-05309-z
International Urogynecology Journal; Melnyk AI, Toal C et. al.

Aug 10th, 2022 - We sought to evaluate patient satisfaction with a novel multiplex PCR UTI home collection kit for symptomatic UTI in a urogynecologic population. We secondarily sought to characterize reported uropathogens and resistance profiles of uropathogens in this population. We hypothesized that patients would be satisfied. This was a cross-sectional study of women who were surveyed later about their exp...

Acute kidney injury following multisystem inflammatory syndrome associated with SARS-Co...
https://doi.org/10.1007/s00467-022-05701-3
Pediatric Nephrology (Berlin, Germany); Tripathi AK, Pilania RK et. al.

Aug 10th, 2022 - Multisystem inflammatory syndrome (MIS-C) is a rare paediatric hyper-inflammatory disorder that occurs following SARS-CoV-2 infection. Acute kidney injury (AKI) occurs in approximately one-quarter to one-third of the patients with MIS-C and is associated with poor prognosis in critically ill children. This systematic review is aimed to evaluate the incidence of AKI, mortality, and the need for ...

Global patterns of antigen receptor repertoire disruption across adaptive immune compar...
https://doi.org/10.1073/pnas.2201541119
Proceedings of the National Academy of Sciences of the Un... Joseph M, Wu Y et. al.

Aug 10th, 2022 - Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) β and δ chain loci of 95 individuals. Our approach detecte...

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading ...
https://doi.org/10.1073/pnas.2117089119
Proceedings of the National Academy of Sciences of the Un... Yang Z, Wu D et. al.

Aug 10th, 2022 - The COVID-19 pandemic has incurred tremendous costs worldwide and is still threatening public health in the "new normal." The association between neutralizing antibody levels and metabolic alterations in convalescent patients with COVID-19 is still poorly understood. In the present work, we conducted absolutely quantitative profiling to compare the plasma cytokines and metabolome of ordinary co...

Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COV...
https://doi.org/10.1371/journal.pone.0272839
PloS One; Nka AD, Ka'e AC et. al.

Aug 10th, 2022 - COVID-19 has been the most important public health concern worldwide since 2020. Several vaccines are now available to help in controlling COVID-19 associated morbidity and mortality. This study will aim to provide the global and regional prevalence of SARS-CoV-2 infection as well as an estimate of disease severity among COVID-19 vaccinated individuals. In order to determine the global burden o...

Stressors, manifestations and course of COVID-19 related distress among public sector n...
https://doi.org/10.1371/journal.pone.0271824
PloS One; Marsden KM, Robertson IK et. al.

Aug 10th, 2022 - Impacts of the COVID-19 pandemic on the mental health of healthcare workers has been established, linking workplace factors with high levels of stress, anxiety, depression, insomnia and burnout. Less established is how COVID-19 affects both work, home and social life of nurses and midwives concurrently. This study describes the prevalence and severity of anxiety, depression, post-traumatic stre...

Impact of COVID-19 on the food security and identifying the compromised food security d...
https://doi.org/10.1371/journal.pone.0272859
PloS One; Gebeyehu DT, East L et. al.

Aug 10th, 2022 - Food security is substantially affected directly by COVID-19 and/or indirectly by the measures adopted for the prevention of COVID-19 transmission. The aim of this systematic review is to summarize the impact of COVID-19 on food security and identify the most compromised food security dimension to ease the food security regulators and actors' intervention prioritisation. Primary research focuse...

Risk factors of SARS-CoV-2 infection in cancer patients pre- and post-vaccination.
https://doi.org/10.1371/journal.pone.0272869
PloS One; Alsagaby SA, Alharbi NK et. al.

Aug 10th, 2022 - Severe complications from COVID-19 and poor responses to SARS-CoV-2 vaccination were commonly reported in cancer patients compared to those without cancer. Therefore, the identification of predisposing factors to SARS-CoV-2 infection in cancer patients would assist in the prevention of COVID-19 and improve vaccination strategies. The literature lacks reports on this topic from the Kingdom of Sa...

Long-term quality of life impairment in patients with more than one-year COVID-19-relat...
https://doi.org/10.1002/alr.23071
International Forum of Allergy & Rhinology; Pendolino AL, Tan HQM et. al.

Aug 10th, 2022 - Long-term quality of life impairment in patients with more than one-year COVID-19-related olfactory dysfunction.|2022|Pendolino AL,Tan HQM,Choi D,Ottaviano G,Andrews PJ,|

To Wait or Not to Wait? Covid-19 Vaccination Mitigates Adverse Surgical Outcomes.
https://doi.org/10.1097/SLA.0000000000005675
Annals of Surgery; Baiu I, Hawn M

Aug 10th, 2022 - To Wait or Not to Wait? Covid-19 Vaccination Mitigates Adverse Surgical Outcomes.|2022|Baiu I,Hawn M,|

Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID...
https://doi.org/10.1128/jvi.00967-22
Journal of Virology; Undi RB, Larabee JL et. al.

Aug 10th, 2022 - Host factors play critical roles in SARS-CoV-2 infection-associated pathology and the severity of COVID-19. In this study, we systematically analyzed the roles of SARS-CoV-2-induced host factors, doublecortin-like kinase 1 (DCLK1), and S100A9 in viral pathogenesis. In autopsied subjects with COVID-19 and pre-existing chronic liver disease, we observed high levels of DCLK1 and S100A9 expression ...

Severe Vitamin D Deficiency in Youth with Autism Spectrum Disorder During the COVID-19 ...
https://doi.org/10.1097/DBP.0000000000001096
Journal of Developmental and Behavioral Pediatrics : JDBP; Ganta A, S Pillai S et. al.

Aug 10th, 2022 - Decrease in sunlight exposure during periods of social distancing during the COVID-19 pandemic increased the risk of severe manifestations of vitamin D deficiency (VDD) in a particular "high-risk" population. Our objective was to highlight the importance of vitamin D screening in youth with autism spectrum disorder (ASD) and restrictive eating. We describe 3 adolescent male patients with ASD wh...

Reduced HIV Testing and Diagnoses During COVID-19 Pandemic.
https://doi.org/10.1001/jama.2022.12790
JAMA Kuehn BM

Aug 10th, 2022 - Reduced HIV Testing and Diagnoses During COVID-19 Pandemic.|2022|Kuehn BM,|

Seizures following COVID-19 vaccination in Mexico: a nationwide observational study.
https://doi.org/10.1111/epi.17390
Epilepsia Núñez I, García-Grimshaw M et. al.

Aug 10th, 2022 - The COVID-19 pandemic led to the development and emergency approval of an array of effective vaccines against SARS-CoV-2. Given the relatively small number of patients included in vaccine trials, post-approval epidemiological surveillance is crucial to detect infrequent vaccine-related adverse events. We conducted a nationwide retrospective descriptive study evaluating the incidence of seizures...

Rural-Urban Differences in the Associations Between Aging and Disability Services and C...
https://doi.org/10.1177/07334648221119457
Journal of Applied Gerontology : the Official Journal of ... Sun Y, Rhubart DC

Aug 10th, 2022 - Aging services were poised to play an important role in supporting the COVID-19 vaccination rollout for older adults. In this study, we use ordinary least squares regression models of county-level data (N = 3086) to examine if density of aging and disability services is associated with COVID-19 vaccination rates for older adults in rural and urban areas of the United States. We find that net of...

Influenza Clinical Presentation
http://emedicine.medscape.com/article/219557-clinical

Aug 10th, 2022 - History The presentation of influenza virus infection varies; however, it usually includes many of the symptoms described below. Patients with influenza who have preexisting immunity or who have received vaccine may have milder symptoms. Onset of illness can occur suddenly over the course of a day, or it can progress more slowly over the course of several days. Typical signs and symptoms includ...

Influenza Clinical Presentation
https://emedicine.medscape.com/article/219557-clinical

Aug 10th, 2022 - History The presentation of influenza virus infection varies; however, it usually includes many of the symptoms described below. Patients with influenza who have preexisting immunity or who have received vaccine may have milder symptoms. Onset of illness can occur suddenly over the course of a day, or it can progress more slowly over the course of several days. Typical signs and symptoms includ...