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Covid-19: Poland's medical council sees mass resignations over government inaction on p...
https://doi.org/10.1136/bmj.o137
BMJ (Clinical Research Ed.); Dyer O

Jan 20th, 2022 - Covid-19: Poland's medical council sees mass resignations over government inaction on pandemic.|2022|Dyer O,|

Covid-19: Brazil sees omicron cases soar but data blackout obscures true impact.
https://doi.org/10.1136/bmj.o133
BMJ (Clinical Research Ed.); Taylor L

Jan 20th, 2022 - Covid-19: Brazil sees omicron cases soar but data blackout obscures true impact.|2022|Taylor L,|

Cerebral arterial and venous thrombosis due to COVID-19 vaccine-induced immune thrombot...
https://doi.org/10.1136/bcr-2021-245445
BMJ Case Reports; Pang E, Ghosh S et. al.

Jan 20th, 2022 - Vaccine-induced immune thrombotic thrombocytopenia (VITT) rarely develops after many COVID-19 vaccines. A 51-year-old woman re-presented to hospital with a 4 day history of headache, vomiting, diarrhoea and left calf pain, 11 days after her first dose of ChAdOx1nCoV-19 (AstraZenica) vaccine. Her neurological examination was normal. Blood tests demonstrated a low platelet count, raised D-dimer a...

Novel case of takotsubo cardiomyopathy following COVID-19 vaccination.
https://doi.org/10.1136/bcr-2021-247291
BMJ Case Reports; Stewart C, Gamble DT et. al.

Jan 20th, 2022 - We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management ...

COVID-19 in two children with new-onset diabetes: case reports.
https://doi.org/10.1136/bcr-2021-247309
BMJ Case Reports; Lança A, Rodrigues C et. al.

Jan 20th, 2022 - Delayed diagnosis, low socioeconomic status and infection have been associated with diabetic ketoacidosis (DKA) at type 1 diabetes mellitus presentation. A teenager from a low socioeconomic status family, with longstanding weight loss, polyphagia, polyuria, vomiting and abdominal pain, attended the emergency department, also complaining of anosmia and odynophagia. He was diagnosed with COVID-19...

Patterns of neutralizing humoral response to SARS-CoV-2 infection among hematologic mal...
https://doi.org/10.1038/s41408-022-00608-6 10.1182/blood.2020008824 10.1186/s13045-020-00970-7 10.1158/2159-8290.CD-20-0773 10.1016/S2352-3026(20)30251-9 10.1016/j.ccell.2021.07.001 10.1016/j.ccell.2021.06.009 10.1016/S2352-3026(21)00169-1 10.1038/s41408-021-00534-z 10.1038/s41577-020-0359-5 10.1002/hon.2872 10.1038/s41591-021-01386-7 10.1016/j.ccell.2021.01.001 10.1038/s41375-020-01030-2 10.1038/s43018-021-00191-y 10.1016/S1470-2045(21)00213-8 10.1038/s41408-021-00530-3 10.3390/cancers13174480 10.1186/s13045-021-01090-6 10.1016/S2352-3026(21)00199-X 10.1002/jmv.26886 10.1016/S2352-3026(21)00110-1 10.1016/j.ccell.2021.06.002 10.1016/j.ccell.2021.06.014 10.1182/bloodadvances.2021005094 10.1182/blood.2021011568 10.1038/s41375-020-01103-2 10.1038/s41591-020-0913-5 10.1016/j.chom.2020.06.021 10.1002/jmv.27200 10.1038/s41591-021-01377-8 10.1038/s41591-019-0707-9 10.1002/cti2.1136 10.1016/j.chom.2021.04.015 10.3390/v13112270 10.1038/s41467-020-19943-y 10.3390/vaccines9030238 10.1128/JCM.02107-20
Blood Cancer Journal; Borgogna C, Bruna R et. al.

Jan 20th, 2022 - Understanding antibody-based SARS-CoV-2 immunity in hematologic malignancy (HM) patients following infection is crucial to inform vaccination strategies for this highly vulnerable population. This cross-sectional study documents the anti-SARS-CoV-2 humoral response and serum neutralizing activity in 189 HM patients recovering from a PCR-confirmed infection. The overall seroconversion rate was 8...

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2.
https://doi.org/10.1038/s41467-021-27745-z
Nature Communications; Garcia-Flores V, Romero R et. al.

Jan 20th, 2022 - Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Here we show that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, whi...

Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic i...
https://doi.org/10.2337/dc21-0969
Diabetes Care; Kamrath C, Rosenbauer J et. al.

Jan 20th, 2022 - The aim of this study was to investigate the incidence of type 1 diabetes in children and adolescents during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with previous years. Based on data from the multicenter German Diabetes Prospective Follow-up Registry, we analyzed the incidence of type 1 diabetes per 100,000 patient-years in children and adolescents from 1 January 2...

Remdesivir significantly reduces SARS-CoV-2 viral load on nasopharyngeal swabs in hospi...
https://doi.org/10.1002/jmv.27598
Journal of Medical Virology; Biancofiore A, Mirijello A et. al.

Jan 20th, 2022 - Remdesivir is a broad-spectrum antiviral agent able to inhibit the RNA polymerase of SARS-CoV-2. At present, studies focusing on the effect of remdesivir on viral load (VL) are few and with contrasting results. Aim of the present study was to evaluate the effect of remdesivir on SARS-CoV-2 VL from nasopharyngeal swabs (cycle threshold criterion) in a sample of patients treated with the drug, co...

The Unintended Consequences of COVID-19 Public Health Measures on Healthcare for Childr...
https://doi.org/10.1111/cch.12968
Child: Care, Health and Development; Baumbusch J, Lloyd JEV et. al.

Jan 20th, 2022 - To explore the unintended consequences of pandemic public health measures on healthcare service usage by children with medical complexity. Medical complexity is characterized by the presence of complex, chronic conditions requiring specialized care, substantial health needs, functional dependence and/or limitations, and frequent healthcare usage. Children with medical complexity are among the h...

Vaccine Group Gavi Says Additional $5.2 Bln Needed to Ensure Supply
https://www.medscape.com/viewarticle/966831

Jan 20th, 2022 - (Reuters) - The chairman of the Gavi vaccine alliance, Jose Manuel Barroso, said on Wednesday that an additional $5.2 billion is needed to continue to deliver vaccines at scale. Speaking at a news briefing, Barroso said it was critical to continue to keep up the pace of vaccine supply through the COVAX global vaccine-sharing programme, as more than 3 billion people in the world have yet to rece...

Greece Imposes Rolling Fines to Push COVID-19 Vaccinations in Older People
https://www.medscape.com/viewarticle/966830

Jan 20th, 2022 - ATHENS (Reuters) - Greece has begun imposing recurring fines on those over the age of 60 who are unvaccinated against COVID-19 to try to boost inoculation in the most vulnerable age group even as infection rates from the fast-spreading Omicron variant are slowing. After hitting an all-time high of 50,126 registered coronavirus infections on Jan. 4, mainly driven by the spread of the Omicron var...

Hospital Rooms Housing COVID-19 Patients Usually Not Contaminated With Virus
https://www.medscape.com/viewarticle/966828

Jan 20th, 2022 - NEW YORK (Reuters Health) - The rate of contamination of surfaces in rooms with hospitalized COVID-19 patients is low, researchers report. Of the 347 individual samples collected from the rooms of 20 patients infected with SARS-CoV-2, less than 6% were positive via RT-PCR and only one demonstrated cytopathic effect (CPE), researchers report in Clinical Infectious Diseases. "The presence of SARS...

How the Pandemic Led to Disarray ― and Discovery
https://www.medscape.com/viewarticle/966838

Jan 20th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In March 2020, as the world was waking up to the dawn of a global pandemic, 61 members of the Skagit Valley Chorale in northwest Washington State gathered for a 2-hour rehearsal. They followed the precautions recommended by local health officials, avoiding physical contact, using hand sanitizer,...

Swiss Researchers Launch Trial for COVID 'Patch' Vaccine
https://www.medscape.com/viewarticle/966878

Jan 20th, 2022 - LAUSANNE, Switzerland (Reuters) - Swiss medical researchers said on Wednesday they have launched an early-stage study to test a next-generation COVID-19 vaccine candidate which would be administered via an arm patch, the latest to look at alternative methods of giving injections. Unlike conventional vaccines that focus on stimulating antibody production, the new PepGNP-Covid19 vaccine candidate...

COVID-19 Families and Experts Share Pandemic 'Silver Linings'
https://www.medscape.com/viewarticle/966899

Jan 20th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. A Medscape Special Report: COVID at 2 As we mark the second anniversary of the first COVID-19 case identified in the United States, many negative aspects of our shared trauma — political disagreements, family members hospitalized, and over 850,000 American deaths — are well known to us. But no m...

Some Apartment Dwellers Blocked From Ordering Rapid Tests
https://www.medscape.com/viewarticle/966919

Jan 20th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Some residents of apartments and other multi-unit buildings report being unable to order free COVID-19 tests from the U.S. Postal Service website. The Biden administration rolled out the website on Tuesday, part of a promise to make 1 million home testing kits available to the public. Four tests...

Tough Questions on the COVID Pandemic
https://www.medscape.com/viewarticle/966931

Jan 20th, 2022 - Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. We asked. You answered. Here's how our readers feel about the pandemic. Like is it almost over? This interview originally appeared on WebMD on January 20, 2022 Follow Medscape on Facebook, Twitter, Instagram, and YouTube

Are Hospital Admissions Still the Best Way to Gauge the COVID Crisis?
https://www.medscape.com/viewarticle/966821

Jan 20th, 2022 - MADRID/LONDON (Reuters) - Using the number of people in hospital with COVID-19 to gauge the severity of the pandemic may not give an accurate picture in the Omicron era as more and more patients with the virus are being admitted for other reasons, some scientists say. Governments have focused on hospitalisations to determine the need for restrictions but the data does not typically differentiat...