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Children and COVID: Severe illness rising as vaccination effort stalls
https://www.mdedge.com/pediatrics/article/256935/covid-19-updates/children-and-covid-severe-illness-rising-vaccination
Richard Franki

Aug 9th, 2022 - New cases of COVID-19 rose among children for the fourth consecutive week, but the size of the increase declined for the second consecutive week, based on data from the American Academy of Pediatrics and the Children’s Hospital Association. After new child cases jumped by 22% during the week of July 15-21, the two successive weeks have produced increases of 3.

Differences in Underrepresented in Medicine Applicant Backgrounds and Outcomes in the 2020-2021 Dermatology Residency Match
https://www.mdedge.com/dermatology/article/256914/diversity-medicine/differences-underrepresented-medicine-applicant
Fatuma-Ayaan Rinderknecht, MS, Caitlin M. Brumfiel, MD et. al.

Aug 9th, 2022 - Dermatology is one of the least diverse medical specialties with only 3% of dermatologists being Black and 4% Latinx. 1 Leading dermatology organizations have called for specialty-wide efforts to improve diversity, with a particular focus on the resident selection process.

FDA Roundup: August 9, 2022 | FDA
https://www.fda.gov/news-events/press-announcements/fda-roundup-august-9-2022

Aug 9th, 2022 - For Immediate Release: August 09, 2022 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency: Today, the FDA’s Office of Global Policy and Strategy published “How a European Data Law is Impacting FDA,” which looks at how the European Union’s General Data Protection Regulation may be impacting the FDA’s public health activities. So far, t...

Impact of SARS-CoV-2 Omicron on Rapid Antigen Testing Developed for Early-Pandemic SARS-CoV-2 Variants
https://journals.asm.org/doi/10.1128/spectrum.02006-22
Microbiology Spectrum; Leuzinger K, .

Aug 9th, 2022 - Rapid antigen tests (RATs) are widely used for point-of-care or self-testing to identify SARS-CoV-2 (SCoV2), but currently circulating Omicron variants may impair detection. In this study, we prospectively evaluated the Roche-SARS-CoV-2-Antigen and Acon-FlowFlex-SARS-CoV-2-Antigen in 150 consecutively collected nasopharyngeal patient swabs (50 SCoV2 RNA undetectable; 100 SCoV2 Omicron BA.1).

Covid-19: What we know about the BA.4 and BA.5 omicron variants
https://www.bmj.com/content/378/bmj.o1969
BMJ Mahase E.

Aug 9th, 2022 - When and where were these subvariants detected? BA.4 and BA.5 were first detected in South Africa in January and February 2022, respectively.1 They are offshoots of the omicron variant BA.2, though their additional mutations seem to have given them a transmission advantage

Hong Kong Cuts COVID Quarantine Stay for Incoming Travelers
https://www.medscape.com/viewarticle/978789

Aug 9th, 2022 - HONG KONG (Reuters) - Hong Kong will shorten the COVID-19 hotel quarantine period for all arrivals to three days from seven, taking another step to gradually unwind stringent pandemic rules that have isolated the Asian financial hub. The measures will be effective from Friday, the city's leader, John Lee, told a news conference on Monday. Arrivals will need to self monitor for a further four da...

Monkeypox and HIV: Same but Different?
https://www.medscape.com/viewarticle/978856

Aug 9th, 2022 - As a medical student in the mid-1980s in New York City, I had a firsthand experience of the tragedy and devastation wrought by HIV. Federal and local responses were underwhelming. As a medical student, I was more preoccupied with learning the basics of doctoring and understanding whether we should wear gloves when drawing blood or pulling drains after the 1985 Centers for Disease Control and Pr...

Group of 23 States Tells U.S. Court CDC Lacks Authority to Set Transit Mask Rules
https://www.medscape.com/viewarticle/978876

Aug 9th, 2022 - WASHINGTON (Reuters) -A group of 23 state attorneys general led by Florida told a federal court on Monday that the U.S. Centers for Disease Control and Prevention (CDC) lacks the legal authority to impose a nationwide transportation mask mandate to address COVID-19. The CDC sought "an unprecedented masking mandate regulating every breath of millions of Americans," said the brief in support of t...

Novavax Sinks After Halving Sales Forecast on Low Vaccine Demand, Supply Glut
https://www.medscape.com/viewarticle/978890

Aug 9th, 2022 - (Reuters) - Novavax Inc on Monday halved its full-year revenue forecast as it does not expect further sales of its COVID-19 shot this year in the United States in the face of a global supply glut and soft demand, sending its shares down 33%. Novavax said it now expects 2022 total revenue in the range of $2 billion to $2.3 billion, compared with its prior forecast of $4 billion to $5 billion. Th...

Monkeypox Found in Illinois Adult Working in Daycare and Home Healthcare
https://www.medscape.com/viewarticle/978925

Aug 9th, 2022 - Dr Sameer Vohra An adult working at a daycare center in Rantoul, an agricultural community about 15 miles north of Urbana-Champaign, has tested positive for monkeypox virus (MPV), Illinois health officials report. The patient also had one home healthcare client. The infected person is in isolation, being medically monitored, and is doing well, Illinois public health officials said in a media br...

COVID Sewage Surveillance Labs Join the Hunt for Monkeypox
https://www.medscape.com/viewarticle/978938

Aug 9th, 2022 - The same wastewater surveillance techniques that have emerged as a critical tool in early detection of covid-19 outbreaks are being adapted for use in monitoring the startling spread of monkeypox across the San Francisco Bay Area and some other U.S. communities. Before the covid pandemic, wastewater sludge was thought to hold promise as an early indicator of community health threats, in part be...

Hospital Safety Composite Measure Restored by the Government
https://www.medscape.com/viewarticle/978958

Aug 9th, 2022 - A hospital quality and safety data reporting requirement that the government had proposed to place on hold for Fiscal Year 2023 — owing to the confounding effects of the COVID pandemic on hospital performance and data-gathering — was reinstated last week by the Centers for Medicare and Medicaid Services (CMS). The preliminary Inpatient Prospective Payment System rule, used for making annual adj...

Recreation as Rx? Why You Should Prescribe Nature
https://www.medscape.com/viewarticle/978654

Aug 9th, 2022 - Every time I go to the beach, I bring a book but hardly open it. Instead, I look at the waves and listen to the gulls. My eyelids get heavy and my heart rate decreases. My stiff joints relax as I walk along the shore. The fatigue in my feet melts away as they sink in the sand. The beach at Sandy Hook National Recreation Area is one of my happy places. It revives me and reminds me that nature is...

Correlation Analysis of Positive Therapy Based on High Content Image Analysis Technolog...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297126
Contrast Media & Molecular Imaging; Zheng T, Lin J et. al.

Aug 9th, 2022 - To investigate the correlation between posttraumatic stress disorder (PTSD) and the incidence of anxiety, depression, and mental disorders in patients with novel coronavirus pneumonia. Novel coronavirus pneumonia patients in Wuhan from 2020 to April were selected for treatment from hospitals and isolation wards from 1 to April. 70 rehabilitated patients were randomly divided into the control gr...

SARS-CoV-2-Specific T Cell Immunity in HIV-Associated Kaposi Sarcoma Patients in Zambia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352483
Journal of Immunology Research; Ngalamika O, Mukasine MC et. al.

Aug 9th, 2022 - Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) virus is the cause of coronavirus disease 2019 (COVID-19). It has caused millions of infections and deaths globally over a 2-year period. Some populations including those living with HIV and/or cancer are reported to be at a higher risk of infection and severe disease. HIV infection leads to a depletion of CD4+ T cells which impa...

SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355782
Journal of Immunology Research; Delgado JF, Vidal-Pla M et. al.

Aug 9th, 2022 - Immune imprinting or original antigenic sin (OAS) is the process by which the humoral memory response to an antigen can inhibit the response to new epitopes of that antigen originating from a second encounter with the pathogen. Given the situation of the COVID-19 pandemic, multiple vaccines have been developed against SARS-CoV-2 infection. These vaccines are directed to the spike protein (S pro...

The Relative Importance of Vulnerability and Efficiency in COVID-19 Contact Tracing Pro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346065
International Journal of Public Health; Wang Y, Faradiba D et. al.

Aug 9th, 2022 - Objectives: This study aims to assess the trade-offs between vulnerability and efficiency attributes of contact tracing programmes based on preferences of COVID-19 contact tracing practitioners, researchers and other relevant stakeholders at the global level. Methods: We conducted an online discrete choice experiment (DCE). Respondents were recruited globally to explore preferences according to...

Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8+ T Ce...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346304
International Journal of Nanomedicine; Shen AR, Jin XX et. al.

Aug 9th, 2022 - Current vaccines for the SARS-CoV-2 virus mainly induce neutralizing antibodies but overlook the T cell responses. This study aims to generate an exosomal vaccine carrying T cell epitope peptides of SARS-CoV-2 for the induction of CD8+ T cell response. Thirty-one peptides presented by HLA-A0201 molecule were conjugated to the DMPE-PEG-NHS molecules, and mixed with DSPE-PEG to form the peptide-P...

Mental Health Inequities Amid the COVID-19 Pandemic: Findings From Three Rounds of a Cr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349347
International Journal of Public Health; Jenkins EK, Slemon A et. al.

Aug 9th, 2022 - Objectives: Adverse mental health impacts of the COVID-19 pandemic are well documented; however, there remains limited data detailing trends in mental health at different points in time and across population sub-groups most impacted. This paper draws on data from three rounds of a nationally representative cross-sectional monitoring survey to characterize the mental health impacts of COVID-19 o...

A Cross-Sectional Study of Depression, Anxiety, and Insomnia Symptoms in People in Quar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346268
International Journal of Public Health; Lin C, Fu X

Aug 9th, 2022 - Objective: To investigate the status and influential factors of depression, anxiety, and insomnia among people in quarantine during COVID-19. Methods: Data was collected from August 2020 to November 2021 through an online survey of 1,360 people in a quarantined hotel. The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Insomnia Severity Index (ISI) were used ...