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Carbon dioxide increases with face masks but remains below short-term NIOSH limits.
https://doi.org/10.1186/s12879-021-06056-0 10.1183/13993003.01260-2020 10.1016/j.tmaid.2020.101751 10.3390/ijerph17186655 10.1001/jama.2020.21905 10.1111/j.1600-0404.2005.00560.x 10.1111/head.13811 10.1016/j.jns.2020.117078 10.1093/annhyg/mes068 10.1080/00140139.2013.777128 10.1016/j.rinp.2020.103425 10.1038/s41370-018-0055-8 10.1016/j.envint.2018.08.059 10.1289/ehp.1104789 10.1152/jappl.1987.63.1.25 10.5271/sjweh.2327 10.1080/15298667991429912 10.1001/jama.2008.894
BMC Infectious Diseases; Rhee MSM, Lindquist CD et. al.

Apr 16th, 2021 - COVID-19 pandemic led to wide-spread use of face-masks, respirators and other personal protective equipment (PPE) by healthcare workers. Various symptoms attributed to the use of PPE are believed to be, at least in part, due to elevated carbon-dioxide (CO2) levels. We evaluated concentrations of CO2 under various PPE. In a prospective observational study on healthy volunteers, CO2 levels were m...

Safely Social: Promoting and Sustaining Adolescent Engagement in Social Distancing Duri...
https://doi.org/10.1016/j.jadohealth.2021.03.014
The Journal of Adolescent Health : Official Publication O... Wang MT, Scanlon CL et. al.

Apr 16th, 2021 - Adolescents are at risk for violating COVID-19 social distancing measures owing to salient developmental needs for autonomy and relatedness. This intensive longitudinal study investigated the initiation and sustainment of adolescents' daily social distancing behaviors. Focus group and daily-diary approaches were used to collect 6,216 assessments from a nationwide American adolescent sample (n =...

Use of Kids Helpline by Children and Young People in Australia During the COVID-19 Pand...
https://doi.org/10.1016/j.jadohealth.2021.03.015
The Journal of Adolescent Health : Official Publication O... Batchelor S, Stoyanov S et. al.

Apr 16th, 2021 - The benefits of helplines are particularly valuable during a pandemic when face-to-face services and natural supports are difficult to access. Kids Helpline, Australia's national youth helpline, provides children and young people with free 24/7 information and counseling through telephone, WebChat, and e-mail. We aimed to examine the use of Kids Helpline during the COVID-19 pandemic. We analyze...

Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospit...
https://doi.org/10.2337/dc20-2676
Diabetes Care; Longmore DK, Miller JE et. al.

Apr 16th, 2021 - Obesity is an established risk factor for severe coronavirus disease 2019 (COVID-19), but the contribution of overweight and/or diabetes remains unclear. In a multicenter, international study, we investigated if overweight, obesity, and diabetes were independently associated with COVID-19 severity and whether the BMI-associated risk was increased among those with diabetes. We retrospectively ex...

Impact of the COVID-19 pandemic on anxiety and depression symptoms of young people in t...
https://doi.org/10.1136/bmjopen-2021-049653
BMJ Open; Porter C, Favara M et. al.

Apr 16th, 2021 - To provide evidence on the effect of the COVID-19 pandemic on the mental health of young people who grew up in poverty in low/middle-income countries (LMICs). A phone survey administered between August and October 2020 to participants of a population-based longitudinal cohort study established in 2002 comprising two cohorts born in 1994-1995 and 2001-2002 in Ethiopia, India (Andhra Pradesh and ...

Host barriers to SARS-CoV-2 demonstrated by ferrets in a high-exposure domestic setting.
https://doi.org/10.1073/pnas.2025601118 10.1101/2020.11.20.392381
Proceedings of the National Academy of Sciences of the Un... Sawatzki K, Hill NJ et. al.

Apr 16th, 2021 - Ferrets (Mustela putorius furo) are mustelids of special relevance to laboratory studies of respiratory viruses and have been shown to be susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and onward transmission. Here, we report the results of a natural experiment where 29 ferrets in one home had prolonged, direct contact and constant environmental exposure t...

Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vacci...
https://doi.org/10.1073/pnas.2025622118 10.1053/j.gastro.2020.12.001 10.1093/cid/ciaa1421 10.1093/cid/ciaa1330
Proceedings of the National Academy of Sciences of the Un... Maeda DLNF, Tian D et. al.

Apr 16th, 2021 - As the coronavirus disease 2019 (COVID-19) pandemic rages on, it is important to explore new evolution-resistant vaccine antigens and new vaccine platforms that can produce readily scalable, inexpensive vaccines with easier storage and transport. We report here a synthetic biology-based vaccine platform that employs an expression vector with an inducible gram-negative autotransporter to express...

Covid-19: Single dose of Pfizer or AstraZeneca vaccine produces strong antibody respons...
https://doi.org/10.1136/bmj.n979
BMJ (Clinical Research Ed.); Mahase E

Apr 16th, 2021 - Covid-19: Single dose of Pfizer or AstraZeneca vaccine produces strong antibody response in over 80s.|2021|Mahase E,|

Carbapenem resistant bacteria in Intensive Care Unit during COVID-19 pandemic: multicen...
https://doi.org/10.1017/ice.2021.144
Infection Control and Hospital Epidemiology; Pascale R, Bussini L et. al.

Apr 16th, 2021 - To assess the incidence of colonization and infection with carbapenemase producing Enterobacteriaceae (CPE) and carbapenem resistant Acinetobacter baumannii (CR-Ab) in the ICUs of our city hospitals before and during COVID-19 pandemic. Multicentre before-after cross sectional study to compare the rates of colonization and infection with CPE and/or CR-Ab in two study periods, period 1 (Jan-Apr 2...

Why Should Businesses Support Public Health?
https://doi.org/10.1177/08901171211009050
American Journal of Health Promotion : AJHP; Myburgh I, Goetzel RZ et. al.

Apr 16th, 2021 - The COVID-19 pandemic presents a unique opportunity to gain support from the business community for rebuilding a more effective and resilient public health infrastructure in the U.S. This commentary provides the rationale for more engaged business involvement in efforts to promote public health during the time of COVID-19. Drawing on the current pandemic, the commentary highlights the implicati...

Current update on SARS-CoV-2 vaccine development with a special emphasis on gene therap...
https://doi.org/10.1089/hum.2021.052
Human Gene Therapy; Bisgin A, Sanlioglu AD et. al.

Apr 16th, 2021 - Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease (COVID-19) caused by the novel coronavirus SARS-CoV-2. To combat the devastating spread of SARS-CoV-2, extraordinary efforts from numerous laboratories have focused on the development of effective and safe vaccines. Traditional live-attenuated or inactivated viral vaccines are not recommended for immunocompromised p...

Coronavirus management and control: Nutrition and alternative medicines.
https://doi.org/10.1177/02601060211009704
Nutrition and Health; Guha S, Chakraborty A

Apr 16th, 2021 - In late December 2019, the outbreak of COVID-19 caused by the coronavirus severe acute respiratory syndrome-CoV-2, originated in Wuhan Province, the People's Republic of China (PRC). The rapid and highly infectious virus quickly spread around the country and has become a global pandemic. Thousands of people have been infected, and have died. Scientists around the world are working on the vaccin...

A Comparison of Thrombosis and Hemorrhage Rates in Patients With Severe Respiratory Fai...
https://doi.org/10.1097/CCM.0000000000004971
Critical Care Medicine; Doyle AJ, Hunt BJ et. al.

Apr 16th, 2021 - Extracorporeal membrane oxygenation is a lifesaving therapy for patients with severe acute respiratory distress syndrome refractory to conventional mechanical ventilation. It is frequently complicated by both thrombosis and hemorrhage. A markedly prothrombotic state associated with high rates of venous thromboembolism has been described in patients with severe acute respiratory syndrome coronav...

Surge and Mortality in ICUs in New York City's Public Healthcare System.
https://doi.org/10.1097/CCM.0000000000004972
Critical Care Medicine; Toth AT, Tatem KS et. al.

Apr 16th, 2021 - To evaluate the impact of ICU surge on mortality and to explore clinical and sociodemographic predictors of mortality. Retrospective cohort analysis. NYC Health + Hospitals ICUs. Adult ICU patients with coronavirus disease 2019 admitted between March 24, and May 12, 2020. None. Hospitals reported surge levels daily. Uni- and multivariable analyses were conducted to assess factors impacting in-h...

Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Pat...
https://doi.org/10.1097/CCM.0000000000005053
Critical Care Medicine; Wongtangman K, Santer P et. al.

Apr 16th, 2021 - In patients with coronavirus disease 2019-associated acute respiratory distress syndrome, sedatives and opioids are commonly administered which may lead to increased vulnerability to neurologic dysfunction. We tested the hypothesis that patients with coronavirus disease 2019-associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma compared...

Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multi...
https://doi.org/10.1097/CCM.0000000000005010
Critical Care Medicine; Santoro F, Núñez-Gil IJ et. al.

Apr 16th, 2021 - No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival. Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019). Hospitalized patients wi...

Outcomes and Safety of Early Percutaneous Tracheostomy in Coronavirus Disease 2019 Pati...
https://doi.org/10.1097/CCM.0000000000004925
Critical Care Medicine; Olanipekun T, Ezeagu R

Apr 16th, 2021 - Outcomes and Safety of Early Percutaneous Tracheostomy in Coronavirus Disease 2019 Patients Admitted to the ICU.|2021|Olanipekun T,Ezeagu R,|

Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Ch...
https://doi.org/10.1097/CCM.0000000000005012
Critical Care Medicine; Higgins TL, Stark MM et. al.

Apr 16th, 2021 - To compare Acute Physiology and Chronic Health Evaluation-IV-adjusted mortality and length of stay outcomes of adult ICU patients who tested positive for coronavirus disease 2019 with patients admitted to ICU with other viral pneumonias including a subgroup with viral pneumonia and concurrent acute respiratory distress syndrome (viral pneumonia-acute respiratory distress syndrome). Retrospectiv...