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Diagnostic Value of Lung Ultrasonography in Children with COVID-19.
https://doi.org/10.1002/ppul.25127
Pediatric Pulmonology; Hizal M, Aykac K et. al.

Oct 21st, 2020 - Lung ultrasound (LUS) has been successfully used in the diagnosis of different pulmonary diseases. Present study design to determine the diagnostic value of LUS in the evaluation of children with COVID-19. Prospective multi-center study, 40 children with confirmed COVID-19 were included. LUS was performed to all patients at admission. The chest X-ray and CT were performed according to the decis...

Projected utility of pharmacogenomic testing among individuals hospitalized with COVID-...
https://doi.org/10.1111/cts.12919
Clinical and Translational Science; Stevenson JM, Alexander GC et. al.

Oct 21st, 2020 - Many academic institutions are collecting blood samples from patients seeking treatment for COVID-19 to build research biorepositories. It may be feasible to extract pharmacogenomic information from biorepositories for clinical use. We sought to characterize the potential value of multi-gene pharmacogenomic testing among individuals hospitalized with COVID-19 in the United States. We performed ...

Modification of a domiciliary ventilator to increase FiO2: an off-label modification wh...
https://doi.org/10.1136/thoraxjnl-2020-215487
Thorax Mebrate Y, Phillips S et. al.

Oct 20th, 2020 - Although nasal continuous positive airway pressure or non-invasive ventilation is used to manage some patients with acute lung injury due to COVID-19, such patients also demonstrate increased minute ventilation which makes it hard, if the device is used in line with the manufacturer's instructions, to achieve adequate oxygen delivery. In addition, if a hospital contains many such patients, then...

Integration of time-series meta-omics data reveals how microbial ecosystems respond to ...
https://doi.org/10.1038/s41467-020-19006-2
Nature Communications; Herold M, Martínez Arbas S et. al.

Oct 20th, 2020 - There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-match...

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length S...
https://doi.org/10.1038/s41581-020-00357-4
Nature Genetics; Onabajo OO, Banday AR et. al.

Oct 20th, 2020 - In December 2019, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a pathogenic condition that has been termed coronavirus disease 2019 (COVID-19) and has reached pandemic proportions. As of 17 September 2020, more than 30 million conf...

Commentary on: Trends and Challenges of Telehealth in an Academic Institution: The Unfo...
https://doi.org/10.1093/asj/sjaa272
Aesthetic Surgery Journal; Santosa KB, Cederna PS

Oct 20th, 2020 - Commentary on: Trends and Challenges of Telehealth in an Academic Institution: The Unforeseen Benefits of the COVID-19 Global Pandemic.|2020|Santosa KB,Cederna PS,|

Clinical Characteristics and Outcomes of COVID-19 Patients Receiving Compassionate Use ...
https://doi.org/10.1093/treephys/tpaa138
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Yang B, Fulcher JA et. al.

Oct 20th, 2020 - Conspicuous color is a common trait of foliar galls, but their relationship with gall-inducing insects is unknown. Red and green galls were taken from sunny or shady parts of peach species Prunus persica f. rubro-plena with peach aphid Tuberocephalus momonis infestation. We found that the loss of photosynthetic pigments was associated with the conspicuous coloration of green gall tissues. The c...

Building Trust to Achieve Confidence in COVID-19 Vaccines.
https://doi.org/10.1001/jamanetworkopen.2020.25672
JAMA Network Open; Opel DJ, Salmon DA et. al.

Oct 20th, 2020 - Building Trust to Achieve Confidence in COVID-19 Vaccines.|2020|Opel DJ,Salmon DA,Marcuse EK,|

Patient-Reported Social and Behavioral Determinants of Health and Estimated Risk of Hos...
https://doi.org/10.1001/jamanetworkopen.2020.25594
JAMA Network Open; Zulman DM, Maciejewski ML et. al.

Oct 20th, 2020 - There have been arguments on whether angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) treatment alters the risk of COVID-19 susceptibility and disease severity. We identified a total of 102 eligible studies for systematic review, in which 49 studies adjusting for confounders were included in the meta-analysis. We found no association between prior ACEI/ARB...

Impact of COVID-19 on cardiac procedure activity in England and associated 30-day morta...
https://doi.org/10.1093/ehjqcco/qcaa079
European Heart Journal. Quality of Care & Clinical Outcomes; Mohamed MO, Banerjee A et. al.

Oct 20th, 2020 - Pangong Tso is a long and narrow lake situated at an altitude of ~ 4266 m amsl in the Himalayan Plateau on the side of the India/China border. Biofilm has been observed in a small area near the shore of Pangong Tso. Bacterial communities of the lake sediment, water and biofilms were studied using amplicon sequencing of V3-V4 region of the 16S rRNA gene. The standard QIIME pipeline was used for ...

Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.
https://doi.org/10.1007/s00294-020-01116-5
Current Genetics; Ononye OE, Sausen CW et. al.

Oct 20th, 2020 - The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2, triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome-mediated release of interleukin-1 family cytokines is important in hyper-inflammatory syndromes, like happens in SARS-CoV-2-mediated cytokine release syndrome. We propose that an intense inflammasome formation characterizes the lungs of patien...

Interpretive discrepancies caused by target values inter-batch variations in chemilumin...
https://doi.org/10.1002/jmv.26612
Journal of Medical Virology; Selingerova I, Valik D et. al.

Oct 20th, 2020 - Plasma specimens from COVID-19 patients were double-tested for anti-SARS-CoV-2 antibodies by two different batches of MAGLUMI™ 2019-nCov IgM/IgG assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and (ii) measured anti...

Synthesis, antiproliferative activities, and DNA binding of coumarin-3-formamido deriva...
https://doi.org/10.1002/ardp.202000236
Archiv Der Pharmazie REFERENCES; Shi J, Lu W et. al.

Oct 20th, 2020 - The coronavirus disease 2019 (COVID-19) pandemic is straining the healthcare system, particularly for patients with severe outcomes requiring admittance to the intensive care unit (ICU). This study investigated the potential associations of obesity and diabetes with COVID-19 severe outcomes, assessed as ICU admittance. Medical history, demographic and patient characteristics of a retrospective ...

Factors Associated With US Adults' Likelihood of Accepting COVID-19 Vaccination.
https://doi.org/10.1001/jamanetworkopen.2020.25594
JAMA Network Open; Kreps S, Prasad S et. al.

Oct 20th, 2020 - The development of a coronavirus disease 2019 (COVID-19) vaccine has progressed at unprecedented speed. Widespread public uptake of the vaccine is crucial to stem the pandemic. To examine the factors associated with survey participants' self-reported likelihood of selecting and receiving a hypothetical COVID-19 vaccine. A survey study of a nonprobability convenience sample of 2000 recruited par...

The Effect of Prior ACEI/ARB Treatment on COVID-19 Susceptibility and Outcome: A System...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555717
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Xu J, Teng Y et. al.

Oct 20th, 2020 - Mitochondrial respiratory chain complexes play important roles in energy production via oxidative phosphorylation (OXPHOS) to drive various biochemical processes in eukaryotic cells. These processes require coordination with other cell organelles, especially the nucleus. Factors encoded by both nuclear and mitochondrial DNA are involved in the formation of active respiratory chain complexes and...

Characteristics of coagulation alteration in patients with COVID-19.
https://doi.org/10.1007/s00277-020-04305-x
Annals of Hematology; Luo HC, You CY et. al.

Oct 20th, 2020 - Abnormal blood coagulation often occurs in critically ill patients, which seriously affects their prognosis. This retrospective study investigated the implications of changes in blood coagulation in patients with coronavirus disease 2019 (COVID-19). Records were reviewed for patients admitted with COVID-19 between February 4 and 16, 2020. The primary outcome was in-hospital death. A total of 85...

Surviving the COVID-19 pandemic: early response of a gynecologic oncology unit in Singa...
https://doi.org/10.3802/jgo.2020.31.e77
Journal of Gynecologic Oncology; Lim YH, Chay WY et. al.

Oct 20th, 2020 - Surviving the COVID-19 pandemic: early response of a gynecologic oncology unit in Singapore.|2020|Lim YH,Chay WY,Wong WL,|

Impact of COVID-19 in gynecologic oncology: a Nationwide Italian Survey of the SIGO and...
https://doi.org/10.3802/jgo.2020.31.e92
Journal of Gynecologic Oncology; Bogani G, Apolone G et. al.

Oct 20th, 2020 - Coronavirus disease 2019 (COVID-19) has caused rapid and drastic changes in cancer management. The Italian Society of Gynecology and Obstetrics (SIGO), and the Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) promoted a national survey aiming to evaluate the impact of COVID-19 on clinical activity of gynecologist oncologists and to assess the implementation of co...

Hypothesis: Sex-Related Differences in ACE2 Activity May Contribute to Higher Mortality...
https://doi.org/10.1177/1074248420967792
Journal of Cardiovascular Pharmacology and Therapeutics; Salah HM, Mehta JL

Oct 20th, 2020 - The ecology of a biofilm is a complex function of different factors, including the presence of microbial metabolites excreted by the inhabitants of the biofilm. This study aimed to assess the effect of patulin, and N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) on inter-kingdom biofilm formation between a filamentous fungus and bacteria isolated from drinking water. The filamentous fu...

Delayed Time to Cryptosporidiosis in Bangladeshi Children is Associated with Greater Fe...
https://doi.org/10.4269/ajtmh.20-0657
The American Journal of Tropical Medicine and Hygiene; Steiner JZ, Kabir M et. al.

Oct 20th, 2020 - Italy has been one of the most severely affected countries by the COVID-19 pandemic, and the case fatality rate (CFR) estimated based on Italian data is one of the highest worldwide. We analyzed public data from the first 50 days of the epidemic in Italy (from February 24 to April 13, 2020) to evaluate whether evolving testing strategies and capacity could account for trends in the CFR. The CFR...