Advances and challenges in Nintedanib drug delivery.
Expert Opinion on Drug Delivery; Velagacherla V, Suresh A et. al.

Sep 25th, 2021 - Nintedanib (NTB) is an orally administered tyrosine kinase inhibitor that has been approved recently by USFDA for idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). NTB is also prescribed in COVID-19 patients associated with IPF. However, it has an extremely low bioavailability of around 4.7% hence researchers are attempting to address thi...

The host immune response of a discharged COVID-19 patient with twice reemergence of SAR...
https://doi.org/10.1186/s12879-021-06679-3 10.1016/j.cell.2020.10.049 10.1007/s11427-020-1661-4 10.1002/jmv.26114 10.1080/22221751.2020.1852058 10.1016/j.ebiom.2020.102960 10.1080/22221751.2020.1762515 10.1080/22221751.2020.1729071 10.1016/j.cell.2020.10.001 10.1093/infdis/jiaa252 10.1016/S0140-6736(20)32656-8
BMC Infectious Diseases; Zao X, Zhou Y et. al.

Sep 25th, 2021 - The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. There have been reports that long-term SARS-CoV-2 RNA shedding and re-infection of COVID-19 patients existed. However, the specific mechanism, diagnosis, and treatment of COVID-19 are still unclarified. In this case, we reported a 64-year-old patient who h...

The impact of the COVID-19 pandemic on patterns of attendance at emergency departments ...
https://doi.org/10.1186/s12913-021-07008-9 10.1136/emermed-2020-209980 10.1016/S0140-6736(20)31356-8 10.1016/j.puhe.2020.04.046 10.1186/s12873-020-00395-y 10.1038/s41598-021-81930-0
BMC Health Services Research; Vollmer MAC, Radhakrishnan S et. al.

Sep 25th, 2021 - Hospitals in England have undergone considerable change to address the surge in demand imposed by the COVID-19 pandemic. The impact of this on emergency department (ED) attendances is unknown, especially for non-COVID-19 related emergencies. This analysis is an observational study of ED attendances at the Imperial College Healthcare NHS Trust (ICHNT). We calibrated auto-regressive integrated mo...

COVID-19 Pediatric Dermatology.
Dermatologic Clinics; Neale H, Hawryluk EB

Sep 25th, 2021 - Children are a unique subset of patients in relation to the COVID-19 pandemic, often presenting asymptomatically, mildly, or atypically. Manifestations of the skin may be a primary (or the only) presenting sign. Recognizing cutaneous manifestations of COVID-19 in the pediatric population is important to guiding precautions, testing, and management for patients and close contacts. Whereas some d...

Clinical Patterns and Morphology of COVID-19 Dermatology.
Dermatologic Clinics; Agnihothri R, Fox LP

Sep 25th, 2021 - Coronavirus disease 2019 (COVID-19), an emergent disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the globe since its discovery in December 2019. Although first appreciated to cause pneumonia, numerous organ systems are now known to be involved. The objective of this article is to review the broad spectrum of cutaneous manifestations ...

Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease.
Dermatologic Clinics; Gallman AE, Fassett MS

Sep 25th, 2021 - Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of corona...

Cutaneous Manifestations of COVID-19 in the Inpatient Setting.
Dermatologic Clinics; Do MH, Stewart CR et. al.

Sep 25th, 2021 - Cutaneous findings have increasingly been reported in patients with coronavirus disease 2019 (COVID-19). This review discusses associated skin findings in patients with COVID-19 in the inpatient setting, ranging from vasculopathy-related lesions associated with high hospitalization rate and poor prognosis to inflammatory vesicular and urticarial eruptions that are rarely associated with prolong...

Coronavirus Disease 2019 and Race in Dermatology.
Dermatologic Clinics; Desai SR, McMichael AJ et. al.

Sep 25th, 2021 - Coronavirus Disease 2019 disproportionately affects Black and Hispanic/Latino populations. Racial disparities inherently exist in dermatology because of underrepresentation of skin of color populations in literature, reduced access to care for minority populations, and low diversity within the specialty of dermatology itself. Lack of imagery in dermatology can have detrimental consequences for ...

Occupational Dermatoses Related to Personal Protective Equipment Used During the COVID-...
Dermatologic Clinics; Abdali S, Yu J

Sep 25th, 2021 - The recent coronavirus disease 2019 (COVID-19) pandemic has led to the dramatic increase in use of personal protective equipment (PPE) among health care providers and the general public. Herein the authors discuss the various occupational dermatoses including allergic and irritant contact dermatitis, acne, seborrheic dermatitis, and rosacea related to frequent handwashing, disinfecting of surfa...

The Use of Biologics During the COVID-19 Pandemic.
Dermatologic Clinics; Jones ME, Kohn AH et. al.

Sep 25th, 2021 - During the coronavirus disease 2019 (COVID-19) pandemic, there has been considerable discussion regarding the use of biologics in patients with inflammatory skin conditions, such as psoriasis, hidradenitis suppurativa, and atopic dermatitis. This article discusses clinical trial data, real-world evidence, and guidelines and recommendations for biologics that inhibit tumor necrosis factor, inter...

Impact of COVID-19 on Dermatology Residency.
Dermatologic Clinics; Samimi S, Choi J et. al.

Sep 25th, 2021 - COVID-19 has created challenges across medicine, including in medical education, with deeply rooted impacts in the dermatology residency experience. Its effects are both acute and chronic, including: shifts to virtual education and conferences, skewed clinical experiences, negatively impacted wellness, and uncertainty in the future. As educators and mentors, it is important to recognize and add...

Dermatology COVID-19 Registries: Updates and Future Directions.
Dermatologic Clinics; Freeman EE, Chamberlin GC et. al.

Sep 25th, 2021 - During the COVID-19 pandemic, rapid, real-world evidence is essential for the development of knowledge and subsequent public health response. In dermatology, provider-facing and patient-facing registries focused on COVID-19 have been important sources of research and new information aimed at guiding optimal patient care. The 7 dermatology registries included in this update now include more than...

Coronavirus Disease 2019 and Dermatology Practice Changes.
Dermatologic Clinics; Torres AE, Ozog DM et. al.

Sep 25th, 2021 - The impact of the COVID-19 pandemic on dermatology practice cannot be overstated. At its peak, the pandemic resulted in the temporary closure of ambulatory sites as resources were reallocated towards pandemic response efforts. Many outpatient clinics have since reopened and are beginning to experience a semblance of pre-pandemic routine, albeit with restrictions in place. We provide an overview...

The Impact of COVID-19 on Teledermatology: A Review.
Dermatologic Clinics; Yeboah CB, Harvey N et. al.

Sep 25th, 2021 - The accelerated implementation and use of teledermatology during the coronavirus disease 2019 pandemic has met with successes and challenges. This review explores how telemedicine was used in dermatology before the pandemic, the regulatory adaptions made in response to the pandemic, and the effectiveness of the rapid implementation of teledermatology during the coronavirus disease 2019 pandemic...

Effect of the COVID-19 Pandemic on Delayed Skin Cancer Services.
Dermatologic Clinics; Rashid S, Tsao H

Sep 25th, 2021 - The COVID-19 pandemic has presented a unique set of challenges to cancer care centers around the world. Diagnostic and treatment delays associated with lockdown periods may be expected to increase the total number of avoidable skin cancer deaths. During this unprecedented time, dermatologists have been pressed to balance early surgical interventions for skin cancer with the risk of viral transm...

The Impact of the COVID-19 Pandemic on Global Health Dermatology.
Dermatologic Clinics; Hannah C, Williams V et. al.

Sep 25th, 2021 - In this article, we discuss the impact of the COVID-19 pandemic on various areas of global health dermatology, including patient care, neglected tropical diseases, education, and collaborations. Information was collected from literature review and informal interviews with more than 20 dermatologists from around the world. Many of the setbacks and hardships experienced by the global health commu...

COVID-19 and Dermatology: One Year in Review.
Dermatologic Clinics; Freeman EE, McMahon DE

Sep 25th, 2021 - COVID-19 and Dermatology: One Year in Review.|2021|Freeman EE,McMahon DE,|

Atrial Arrhythmias and the Pandemic.
JACC. Clinical Electrophysiology; Chinitz LA

Sep 25th, 2021 - Atrial Arrhythmias and the Pandemic.|2021|Chinitz LA,|

The changing epidemiology of acute kidney injury syndromes in the face of emerging resp...
Kidney International; Thakkar J, Golestaneh L

Sep 25th, 2021 - In this issue, Birkelo et al. performed a rigorous analysis of acute kidney injury (AKI) differences in patients hospitalized with coronavirus disease 2019 versus influenza. Coronavirus disease 2019 AKI was more severe, with worse outcomes, than influenza, despite adjustment for confounders. Their findings highlight the need for development of a new category of AKI syndrome, "viral pandemic-ass...

Is Early COVID-19 in Kidney Transplant Recipients Concerning Enough to Halt Transplanta...
Transplantation Proceedings; Meshram HS, Kute VB et. al.

Sep 25th, 2021 - Limited data exist on the incidence and outcome of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR). A retrospective multicenter research study was conducted across 12 centers in India. We explored the symptomatology, demographic, laboratory findings, and outcome of COVID-19 within 30 days of transplantation. The outcome was compared with the overall KTR and ...