×
ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection
https://www.medrxiv.org/content/10.1101/2020.02.12.20022418v1

In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health. ACE2 (Angiotensin Converting Enzyme 2) has been shown to be one of the major receptors that mediate the entry of 2019-nCoV into human cells, which also happens in severe acute respiratory syndrome coronavirus (SARS). Several res...

Covid-19 pandemic and the skin - What should dermatologists know?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102542/
Clinics in Dermatology;

The World has changed dramatically since the COVID-19 pandemic began. Together with our social, occupational, and personal life, the new corona virus poses novel challenges for all physicians, including dermatologists. Despite the virus not being dermatotropic, several skin conditions have emerged, mainly as a result of prolonged contact to personal protective equipment and excessive personal h...

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China
https://jamanetwork.com/journals/jamacardiology/fullarticle/2763524
JAMA Cardiology;

Importance Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury in patients affected by COVID-19 is limited. Objective To explore the association between cardiac injury and mortality in patients with COVID-19. Design, Setting, and Participants This cohort study was conducted from J...

Cardiovascular disease and COVID-19
https://www.sciencedirect.com/science/article/pii/S1871402120300539
Diabetes & Metabolic Syndrome: Clinical Research & Reviews;

Many patients with coronavirus disease 2019 (COVID-19) have underlying cardiovascular (CV) disease or develop acute cardiac injury during the course of the illness. Adequate understanding of the interplay between COVID-19 and CV disease is required for optimum management of these patients.

Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals
https://www.tandfonline.com/doi/full/10.1080/09273948.2020.1738501
Ocular Immunology and Inflammation;

In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause var...

Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
https://www.biorxiv.org/content/10.1101/2020.03.25.009084v2.full

Recent reports suggest an association between COVID-19 and altered olfactory function. Here we analyze bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV-2), the causal agent in COVID-19. We find in both mouse and human datasets that olfactory sensory neurons do not express two key genes invol...

Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously
https://www.ijidonline.com/article/S1201-9712(20)30235-6/pdf
International Journal of Infectious Diseases;

Since the outbreak of coronavirus disease (COVID-19) in Wuhan in December 2019, by March 10, 2020, a total of 80,932 confirmed cases have been reported in China. Two consecutively negative RTPCR test results in respiratory tract specimens is required for the evaluation of discharge from hospital, and oropharyngeal swabs were the most common sample. However, false negative results occurred in ...

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext
The Lancet;

Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. We assessed the efficacy and safety of combined interferon beta-1b, lopinavir–ritonavir, and ribavirin for treating patients with COVID-19.

Ethical guidance for the COVID-19 era
https://www.apa.org/ethics/covid-19-guidance

The rapid spread of COVID-19 and social distancing measures are changing the way psychologists work across the breadth of the field. And in the transition from face-to-face to remote communication, new ethical challenges are cropping up. American Psychological Association

ACOG COVID-19 Resources
https://www.acog.org/topics/covid-19

Resources and clinical information to help cope with challenges brought about by COVID-19. American College of Obstetricians and Gynecologists

Evaluating and Testing Persons for Coronavirus Disease 2019 (COVID-19)
https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html

Clinicians considering diagnostic testing of people with possible COVID-19 should continue to work with their local and state health departments to coordinate testing through public health laboratories, or work with commercial or clinical laboratories using diagnostic tests authorized for emergency use by the U.S. Food and Drug Administration.

Serology Testing for COVID-19 at CDC
https://www.cdc.gov/coronavirus/2019-ncov/lab/serology-testing.html

CDC has developed a laboratory blood test to assist with efforts to determine how much of the U.S. population has been infected with SARS-CoV-2, the virus that causes COVID-19. CDC is also using its serologic test (antibody) to evaluate the performance of commercial antibody tests.

CDC Activities and Initiatives Supporting the COVID-19 Response and the President’s Plan for Opening America Up Again
https://www.cdc.gov/coronavirus/2019-ncov/downloads/php/CDC-Activities-Initiatives-for-COVID-19-Response.pdf

The principal objectives of COVID-19 surveillance are to monitor the spread and intensity of the pandemic, to enable contact tracing to slow transmission, and to identify disease clusters requiring special intervention. Secondary objectives include understanding the severity and spectrum of disease, identifying risk factors for and methods of preventing infection, and producing data essentia...

Remdesivir Clinical Trials
https://www.gilead.com/purpose/advancing-global-health/covid-19/remdesivir-clinical-trials

The remdesivir clinical trial program was designed to answer multiple scientific questions in parallel, to rapidly evaluate the potential for remdesivir to treat COVID-19 patients.