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About 22,546 results

Pediatric Epilepsy Study
https://clinicaltrials.gov/ct2/show/NCT00050934

Nov 22nd, 2011 - This study will evaluate the safety and effectiveness of oxcarbazepine (Trileptal) as add-on therapy in the treatment of partial seizures in pediatric patients 1 month to 3 years of age.

An Investigational Drug Study in Healthy Adult Volunteers in a Model of Insomnia (0928-007)
https://clinicaltrials.gov/ct2/show/NCT00102154

Jan 13th, 2015 - A study to evaluate the safety and effectiveness of an investigational drug for insomnia (a sleep disorder).

Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer
https://clinicaltrials.gov/ct2/show/NCT00002819

Apr 10th, 2013 - OBJECTIVES: I. Compare progression-free and overall survival of patients with drug-sensitive, low-volume ovarian cancer that is persistent following standard therapy treated with salvage therapy comprising standard-dose paclitaxel and carboplatin vs high-dose carboplatin, mitoxantrone, and cyclophosphamide followed by bone marrow reconstitution. II. Compare the toxic effects of these two salvag...

Interleukin-2 Plus Histamine Dihydrochloride in Treating Patients With Acute Myeloid Leukemia
https://clinicaltrials.gov/ct2/show/NCT00003991

Nov 5th, 2013 - OBJECTIVES: I. Compare the efficacy of interleukin-2 plus histamine dihydrochloride (Maxamine) vs no further therapy in prolonging the leukemia free survival in patients with acute myeloid leukemia in first or subsequent complete remission (CR) following consolidation therapy. II. Compare the relapse rate, overall survival, and quality of life in this patient population treated with interleukin...

Interleukin-2 in Treating Patients With Metastatic Kidney Cancer
https://clinicaltrials.gov/ct2/show/NCT00018941

Jun 16th, 2013 - OBJECTIVES: I. Determine the response rate and overall survival of patients with metastatic renal cell carcinoma treated with either low-dose or high-dose intravenous interleukin-2 (IL-2) or subcutaneous IL-2. II. Compare the toxic effects of these 3 regimens in this patient population. OUTLINE: This is a randomized study. Patients are stratified according to presence of renal tumor (yes vs no)...

Pharmacotherapy and Intensive Treatment - 2
https://clinicaltrials.gov/ct2/show/NCT00000218

Jan 11th, 2017 - The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.

Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma
https://clinicaltrials.gov/ct2/show/NCT00019448

Jun 19th, 2013 - OBJECTIVES: I. Determine the clinical response of patients receiving DNA gp100 antigen alone or in combination with interleukin-2 for recurrent metastatic melanoma. II. Identify the immunologic response in these patients prior to and after these treatments. III. Determine the toxicity of these treatments in these patients. PROTOCOL OUTLINE: Patients are accrued for the first three cohorts and t...

Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease
https://clinicaltrials.gov/ct2/show/NCT01562795

Jan 2nd, 2014 - This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical corticosteroids.

Effect of Affective Content on Drug Induced Amnesia of Episodic Memory
https://clinicaltrials.gov/ct2/show/NCT00142493

Dec 23rd, 2015 - The protocol "Effect of Affective Content on Drug Induced Amnesia of Episodic Memory" investigates the relationship between the ability of affective ('emotional') content to modulate the formation of episodic memory, and the memory impairment ('amnestic') effects of several common intravenous anesthetic drugs. Because memory modulation by affective content appears to be a distinct memory proces...

Pregabalin In Partial Seizures Extension Study
https://clinicaltrials.gov/ct2/show/NCT00143130

Mar 4th, 2015 - To evaluate long-term efficacy and safety of pregabalin (150 to 600mg/day) as adjunctive treatment in patients with partial seizures.

All-Trans Retinoic Acid in Combination With Standard Induction and Consolidation Therapy in Older Patients With Newly Diagnosed Acute Myeloid Leukemia
https://clinicaltrials.gov/ct2/show/NCT00151255

Apr 18th, 2017 - First Induction Therapy: Cytarabine 100 mg/m² cont. i.v. days 1-5 Idarubicin 12 mg/m² i.v. days 1, 3 ATRA 45 mg/m² p.o. days 4-6, ATRA 15 mg/m² p.o. days 7-28 Second Induction Therapy: Cytarabine 100 mg/m² cont. i.v. days 1-5 Idarubicin 12 mg/m² i.v. days 1, 3 ATRA 45 mg/m² p.o. days 4-6, ATRA 15 mg/m² p.o. days 7-28 First Consolidation Therapy: Cytarabine 1000 mg/m² bid i.v. days 1-3 Mitoxantr...

Effects Of PF-02545920 On Ketamine-Induced Abnormal Prefrontal Brain Response To Associative Learning In Healthy Subjects
https://clinicaltrials.gov/ct2/show/NCT01244880

Mar 20th, 2014 - The study was terminated on November 2, 2012 due to a reassessment of the likelihood of the study meeting its scientific objectives in light of data with the investigational drug obtained from another clinical study. The decision to terminate the trial was not based on any safety concerns.

Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy
https://clinicaltrials.gov/ct2/show/NCT01512511

Jan 18th, 2012 - There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters. Assigned randomly to carbon dioxide or nitrous oxide group, the hemodynamic and respiratory parameters (heart rate, mean arterial blood pressure, end-tidal CO2, minute ventilation, and O2 s...

Evaluation of the Role of the Noradrenergic System in Pain Perception in Parkinson's Disease
https://clinicaltrials.gov/ct2/show/NCT01504178

Feb 22nd, 2017 - Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be, in part, due to a central modification of nociception mechanisms. Previous studies have shown that pain perception was altered in Parkinson's disease (subjective and objective pain thresholds and pain-induced cerebral activity) and that administration of L-Dopa normalized this alteration. I...

Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia
https://clinicaltrials.gov/ct2/show/NCT00944294

May 31st, 2012 - Binodenoson (an experimental drug) and adenosine (an FDA-approved drug that is currently used by doctors) are used to increase blood flow to the heart just like when a person exercises on a treadmill. Using imaging techniques, this increased blood flow can help determine if areas of the heart are not getting enough blood and oxygen during exercise. The purpose of the study is to determine if bi...

A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
https://clinicaltrials.gov/ct2/show/NCT00849901

Sep 10th, 2017 - The purpose of this study is to assess whether duloxetine is superior to placebo in the treatment of children and adolescents with major depressive disorder (MDD)

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
https://clinicaltrials.gov/ct2/show/NCT01436162

Nov 6th, 2014 - This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms. Eligible patients will remain on their antidepressant but will be randomized to either receive supplemental SPD489 or placebo (i.e. sugar pill). The purpose of this study is to help answer the following ques...

Quality of Life Outcomes Following Minimally Invasive and Open Esophagectomy for Esophageal Cancer
https://clinicaltrials.gov/ct2/show/NCT01558648

Apr 3rd, 2018 - The goal of this study is to evaluate how surgery for esophageal cancer affects the patient's quality of life over time. The investigators hope this study will provide important information that can be used to improve the quality of life of patients with esophageal cancer. This study will also look at how standard tests and information collected from the patients difficulty swallowing can predi...

Apremilast for Chronic Plaque Psoriasis (CPP) Patients Who Have Failed One Course of Biologic Therapy
https://clinicaltrials.gov/ct2/show/NCT01200264

Jul 14th, 2014 - Data Analysis Data will be analyzed and reported after all subjects have completed follow-up phase of study. All subsequent data collected will be analyzed and reported in a follow-up clinical report. Data & Safety Monitoring Dr. Murray will be following all laboratory values and adverse events during this trial. In addition, Celgene will provide a study monitor to, at regular intervals, review...

A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin
https://clinicaltrials.gov/ct2/show/NCT00175032

Jul 21st, 2010 - This study was designed to compare the effectiveness of reducing the incidence of gastroduodenal ulcers between lansoprazole 30mg QD + naproxen 500mg BID vs celecoxib 200mg QD in subjects with osteoarthritis taking low dose aspirin. Approximately 100 sites across the U.S. will enroll subjects with normal endoscopic findings and negative H.pylori. The duration of the study will be a maximum of 1...