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About 26,128 results

Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
https://clinicaltrials.gov/ct2/show/NCT01123187

Jan 9th, 2018 - The beneficial effects of glycemic control on both survival and function of transplanted kidneys in patients with type 1 diabetes mellitus have been recognized. The purpose of this study is to reverse hyperglycemia and insulin dependency, by islet cell transplantation, in patients with type 1 diabetes mellitus who have a stable kidney allograft. The study primary efficacy endpoint is graft surv...

Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
https://clinicaltrials.gov/ct2/show/NCT00198510

Mar 14th, 2013 - The purpose of this study is to determine if intravitreal injection of Vitrase (ovine hyaluronidase) clears vitreous hemorrhage

Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
https://clinicaltrials.gov/ct2/show/NCT00536796

Oct 29th, 2014 - A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy. Lipid profile and rate of patients who are treated to target (which is <100mg/dl for patients with high risk and <70mg/dl for patients at very high risk) are screened (hospital-based specialists). The doctors therapy decisions after th...

A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus
https://clinicaltrials.gov/ct2/show/NCT00963768

Apr 22nd, 2014 - This is a randomized (study drug assigned by chance), double-blind (neither physician, patient nor the sponsor knows the assigned treatment), placebo-controlled, single and multiple (14 days) ascending dose, parallel group study in 3 study centers (United States, Germany and South Korea). Five cohorts (groups) of patients with Type 2 diabetes mellitus (T2DM) will be studied. One dose level will...

Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
https://clinicaltrials.gov/ct2/show/NCT02307110

Jan 2nd, 2018 - Purpose: This study is designed to evaluate the prevalence of different stages of diabetic retinopathy and diabetic macular edema among patients suffering from type 1 diabetes for 5 to 25 years and have been treated with intensified insulin therapy aiming near-normal blood glucose levels for the whole duration of disease. Objectives: The primary objective is to examine the prevalence (percentag...

The Guardcontrol Trial: Study to Assess if Type 1 Diabetics Can Improve Using the Real-Time Values of Guardian RT
https://clinicaltrials.gov/ct2/show/NCT00111228

Oct 24th, 2006 - Finger-stick based self-testing (SBGM), as well as diagnostic continuous glucose monitoring (CGMS®) allow diabetic patients to find a balance between the two hyper- and hypoglycemic extremes. Nevertheless, there are still patients who fail to achieve good control due to fear of hypoglycemia, or who underestimate post-prandial hyperglycemias. The Guardian® RT Telemetered Glucose Monitoring Syste...

Fetal Front-abdominal Wall Thickness and Perinatal Outcome
https://clinicaltrials.gov/ct2/show/NCT03232294

Jul 26th, 2017 - Abnormal fetal development such as macrosomia can cause some complications on both fetus and mother.The measurement of fetal anterior abdominal wall thickness (FAWT) is an easy examination that it can be obtained during an examination of a pregnant woman by ultrasound. Macrosomia for fetus can lead to some morbidities. It can affect perinatal outcome and increase childbirth complications and op...

CV Disease in Adolescents With Type 2 Diabetes
https://clinicaltrials.gov/ct2/show/NCT00114998

Jul 31st, 2012 - BACKGROUND: The prevalence of type 2 diabetes mellitus has increased dramatically in adolescents. This appears to be a direct result of the increase in prevalence and severity of obesity in the pediatric population. In adults with type 2 diabetes, it is well known that the risk for cardiovascular disease (CVD) is quite high. This has led to current clinical recommendation that adults with diabe...

Treating Periodontal Infection: Effects on Glycemic
https://clinicaltrials.gov/ct2/show/NCT00016835

Jul 18th, 2017 - There is compelling epidemiological and clinical evidence to suggest that periodontal infection adversely affects glycemic control in people with type 2 diabetes mellitus. The purpose of this pilot project is to obtain important preliminary data necessary to support design of a full scale, multi-center randomized clinical trial (RCT) to evaluate the effect of treating periodontal infection on g...

Comparison of SAR341402 to NovoLog/NovoRapid in Adult Patients With Diabetes Mellitus Also Using Insulin Glargine
https://clinicaltrials.gov/ct2/show/NCT03211858

Sep 26th, 2018 - The study will consist of a 2-week screening period, a 26-week treatment period, a 26-week comparative safety extension period, and a 1-day follow-up period. The maximum study duration will then be 54 weeks per patient and a 1 day safety follow-up.

A Study of LY3298176 in Japanese Participants With Type 2 Diabetes
https://clinicaltrials.gov/ct2/show/NCT03322631

Oct 1st, 2018 - The purposes of this study are to determine: The safety of LY3298176 and any side effects that might be associated with it. How much LY3298176 gets into the bloodstream and how long it takes the body to remove it. How LY3298176 affects the levels of blood sugar. This study includes eight weekly doses of LY3298176 or placebo given as subcutaneous (SC) injections just under the skin. The study wi...

Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot Ulcers
https://clinicaltrials.gov/ct2/show/NCT00387101

May 1st, 2008 - The study is a pivotal, prospective, randomized, controlled, open-label, multi-center study that will evaluate the effectiveness and safety of topically applied Dermal-LSR in chronic DFUs.

Comparison of Biphasic Human Insulin 30 With Biphasic Insulin Aspart in Subjects With Diabetes
https://clinicaltrials.gov/ct2/show/NCT01520818

Jan 3rd, 2017 - This trial is conducted in Europe. The aim of this trial is to compare the glycaemic control of biphasic insulin aspart (BIAsp) 70 and/or BIAsp 50 with biphasic human insulin (BHI) 30 treatment.

The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
https://clinicaltrials.gov/ct2/show/NCT01507493

Sep 2nd, 2014 - Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.

Adding Liraglutide to High Dose Insulin: Breaking the Cycle
https://clinicaltrials.gov/ct2/show/NCT01505673

Jan 15th, 2018 - Type 2 diabetes is a progressive disease with incessant beta-cell dysfunction that often ultimately requires insulin treatment. Patients requiring high insulin dosages represent a particular treatment challenge and often have uncontrolled glycemia despite progressive dose increases and are especially prone to insulin related lipotoxicity and weight gain. Glucagon-like peptide agonists (GLP-1) s...

Observational Study on Blood Glucose Control in Patients With Diabetes Using Modern Insulin
https://clinicaltrials.gov/ct2/show/NCT00670722

Oct 27th, 2016 - This study is conducted in Europe. An observational study evaluating the blood glucose control in patients using a modern insulin: NovoRapid®, NovoMix® 30 or Levemir® for treatment of Type 2 diabetes mellitus in Czech Republic.

Preschool CGM Use and Glucose Variability in Type 1 Diabetes
https://clinicaltrials.gov/ct2/show/NCT03293082

Oct 2nd, 2017 - The objectives of this clinical study is to evaluate the efficacy continuous glucose monitoring (CGM) use on glucose variability (GV) in preschool children with T1D treated with CSII. Downloads from CGM and CSII saved in pdf from will be retrospectively reviewed and analysed for all preschool children with type 1 diabetes in Slovenia. Glucose variability and other glycemic parameters will be an...

Impact of a Short-term Treatment With Canagliflozin (Canacardia-HF)
https://clinicaltrials.gov/ct2/show/NCT03298009

Aug 21st, 2018 - Non-invasive Positron Emission Tomography (PET) imaging method allows to measure myocardial uptake and organ-specific partitioning of dietary fatty acids (DFA). It allows to study kidney, liver, skeletal muscles and adipose tissues DFA utilization, whole body fatty acid turnover and oxidation rates, myocardial oxidative metabolism and left ventricular (LV) function that are other likely targets...

Blood Glucose, Cognition and Wellbeing @ Work
https://clinicaltrials.gov/ct2/show/NCT03295578

Jan 1st, 2018 - Many people in the Western world have an unhealthy lifestyle, including an unhealthy dietary pattern. Numerous approaches have been taken to stimulate people to maintain a more healthy diet, but results are highly variable across studies and subjects. One explanation for this is that in many approaches the individuals' specific needs and the context they live and work in are not sufficiently ta...

Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome
https://clinicaltrials.gov/ct2/show/NCT00968708

May 1st, 2014 - Alogliptin is a selective and potent dipeptidyl peptidase-4 inhibitor developed by Takeda for use in patients with type 2 diabetes mellitus. Cardiovascular outcomes is of special interest in the type 2 diabetes mellitus population, particularly in type 2 diabetes mellitus patients who have cardiovascular disease and are at high risk for major adverse cardiac events, such as those patients who h...