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About 18,270 results

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
https://clinicaltrials.gov/ct2/show/NCT02225106

Mar 28th, 2018 - OBJECTIVES: Deficits in memory, attention, cognitive, and executive functions are the most common disabilities after traumatic brain injury (TBI). Dopamine (DA) neurotransmission is implicated in these neural functions and dopaminergic pathways are recognized to be frequently disrupted after TBI. One of the most widely used DAergic drugs is methylphenidate (Ritalin ). Methylphenidate increases ...

The LIFE Study: Lifestyle Interventions and Independence for Elders, Pilot
https://clinicaltrials.gov/ct2/show/NCT00116194

Mar 24th, 2010 - As the life expectancy of older Americans increases, prevention of age-associated physical function decline and disabilities has emerged as a major clinical and public health priority. A critical factor in an older person's ability to function independently is mobility, the ability to move without assistance. Older people who lose mobility are less likely to remain in the community, have higher...

GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture
https://clinicaltrials.gov/ct2/show/NCT03226080

Aug 13th, 2018 - Eighty-four ASA I-IV patients presenting for operative repair of an unstable intertrochanteric femur fracture will be enrolled. This will include fractures classified according to the Orthopaedic Trauma Association / Arbeitsgemeinschaft fur Osteosynthesisfragen (OTA/AO) classification system as 31A2.2, 31A2.3, 31A3.1, 31A3.2, and 31A3.3.15 After consent and upon arrival to the operating room, p...

Guided Training for People With Cognitive Impairment
https://clinicaltrials.gov/ct2/show/NCT03225768

Aug 6th, 2018 - Method Design A single-group, repeated-measures design was adopted for this study. All participants received the participation-focused strategy training intervention and the assessments at baseline (T1) and at post-intervention (T2). The study protocols were approved by the university institutional review board. Intervention The intervention protocols were developed based on the strategy traini...

Asphyxia at Birth : Causes and Neonatal Outcome
https://clinicaltrials.gov/ct2/show/NCT03227536

Jul 23rd, 2017 - This is an historic cohort study based on the birth and delivery register of the HFME maternity ward. This study aim at understanding the evolution of asphyxia at birth, at all gestational ages, identifying causes and describing neonatal outcomes since 2000, when a second line strategy for foetal surveillance (fetal ECG) and systematic umbilical acid-gas cord blood were introduced in our matern...

Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma
https://clinicaltrials.gov/ct2/show/NCT00019864

Jun 7th, 2015 - OBJECTIVES: Determine the rate of in vivo histologic response in patients with osteosarcoma treated with neoadjuvant cisplatin, methotrexate, and doxorubicin with dexrazoxane (as cardioprotection). Determine the event-free and overall survival of patients with nonmetastatic disease who show good response to neoadjuvant therapy and receive adjuvant therapy with the same regimen. Determine the ev...

The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
https://clinicaltrials.gov/ct2/show/NCT00673517

Nov 16th, 2008 - Specific objectives: To measure known biomarkers conventionally associated with VILI and biotrauma To measure potential novel biomarkers of VILI and biotrauma To identify the best time point for biomarker measurement To collect and store samples for differential expression and genomic analysis

Hip-Fracture Surgery on Patients in Clopidogrel Therapy
https://clinicaltrials.gov/ct2/show/NCT02391883

Mar 17th, 2015 - Patients in Clopidogrel therapy alone or in combination with acetylsalicylic acid (Dual Antiplatelet Therapy (DAPT) presenting with a hip-fracture represent the surgeon with the dilemma of putting the patient at risk of a major blood loss during and after surgery, or putting the patient at risk of a thromboembolic event after surgery. The investigators hypothesize that the risk of a major blood...

Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates
https://clinicaltrials.gov/ct2/show/NCT00153855

Sep 7th, 2006 - Infants born prematurely are at significant risk for hemorrhagic and ischemic brain injury. Despite improved survival rates among this population in recent years, these forms of brain injury remain frequent and have considerable consequences. Periventricular leukomalacia (PVL), a disease characterized by necrosis of the cerebral white matter in a characteristic distribution, is one of the most ...

Mirror Therapy and Hand Rehabilitation
https://clinicaltrials.gov/ct2/show/NCT01503762

Feb 27th, 2012 - Objective: The purpose of this study is to determine effects of mirror therapy in restoring hand function in patients with flexor lag following orthopedic injuries. Methods: In a prospective randomized controlled trial, 22 patients with Flexor Lag will be measured. Intervention group will receive mirror therapy, 30-minute a day, 5 days a week for 3-week, as well, half an hour conventional rehab...

NMES and Pelvic Fracture Rehabilitation
https://clinicaltrials.gov/ct2/show/NCT03278834

Sep 11th, 2017 - Objectives: The acute care of pelvic fractures has improved recently however there are no formal guidelines for rehabilitation of these types of fractures. Patients have long periods of non-weight bearing causing muscle wastage. Neuromuscular electrical stimulation (NMES) has proven to minimise muscle loss. However, this has not previously been investigated within this patient population. Desig...

Effect of Red Wine, White Wine and Beer on Contrast-Medium Induced Acute Kidney Injury
https://clinicaltrials.gov/ct2/show/NCT01562925

Jul 7th, 2013 - Patients with impaired renal function are at elevated risk for development of contrast-medium induced acute kidney injury (CI-AKI). CI-AKI is associated with increased risk for cardiovascular morbidity and mortality. Effective CI-AKI prevention strategies are needed. The RenPro-II-WINE Trial was designed to test the hypothesis whether moderate red wine consumption prior to contrast-medium use i...

Home Study of an Advanced Upper Limb Prosthesis
https://clinicaltrials.gov/ct2/show/NCT01551420

Jul 17th, 2018 - The specific objectives of this study are to: identify and describe upper limb amputees who would be appropriate candidates for home use of this advanced prosthesis as well as those who would not be appropriate. Compare the extent of use of the existing prosthesis to that of the DEKA Arm.and quantify the impact of home use of the DEKA Arm on device satisfaction, performance of functional activi...

Applicability of the Ottawa Ankle Rules
https://clinicaltrials.gov/ct2/show/NCT01561365

Mar 22nd, 2012 - Objective. Ankle and midfoot injuries are common orthopedic complaints, both in general medicine and orthopedic practice. The percentage of fractures among these injuries is small, however many will undergo x-ray. Ottawa ankle rules (OAR) are clinical guidelines for determining whether to use radiography in such cases. The aim of this prospective study was to compare outcomes in patients handle...

Auxiliary Device to Alleviate Soldiers' Backload
https://clinicaltrials.gov/ct2/show/NCT01565876

Combat soldiers are required to perform under strenuous physical conditions; hence, their physical fitness is a crucial factor in their survivability. The Auxiliary Device- "Minkal", is suggested (by its manufactures) to be able to reduce the soldiers' physiological strain by lowering the absolute load being carried by the soldier. As a result, it may improve the soldier's physiological abiliti...

Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
https://clinicaltrials.gov/ct2/show/NCT00041717

May 30th, 2013 - Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs. In people with spinal cord injury, some fibers may be destroyed at the site of injury, while others remain connected but do not work correctly to carry electrical impulses. As a result, subjects with an incomplete spinal cord injury may have spasticity which...

Trauma Heart to Arm Time
https://clinicaltrials.gov/ct2/show/NCT01210417

Feb 21st, 2012 - In the prehospital setting it would be helpful to assess primary changes in central blood volume or preload (venous return, stroke volume, diastolic ventricular volume) that occur during the stability phase following injury when regulatory mechanisms are still functioning. Obviously in this setting a non invasive bedside beat-to-beat index would be helpful. Pulse Transit Time (PTT) is the sum o...

Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
https://clinicaltrials.gov/ct2/show/NCT00135291

Jan 10th, 2008 - Many severely injured patients survive their initial resuscitation only to suffer the late sequelae of nosocomial infection and multiple organ failure. The depth of hemorrhagic shock and the severity of anatomic injury are clearly associated with these adverse outcomes, however there is clear evidence to suggest that events during the resuscitation phase also play an important role in the patho...

Perception of Musculoskeletal Injury in Professional Dancers
https://clinicaltrials.gov/ct2/show/NCT00554957

Feb 12th, 2009 - Brief Rationale and Objective: The annual frequency of injury among dancers has been reported to range between 23-84% while as many as 95% of professional dancers have ongoing pain. The discrepancy between the number of reported injuries and the amount of pain reported at any given time could be related to the definition of injury, or how dancers' themselves perceive injury with respect to pain...

The Impact of Transcutaneous Spinal Cord Stimulation (TSCS) and Gait Training on Walking Function in Patients With Spinal Cord Injury
https://clinicaltrials.gov/ct2/show/NCT03384017

Dec 26th, 2017 - Aim 1: Determine the neurophysiologic impact of Transcutaneous Spinal Cord Stimulation (TSCS) within a single session. The investigators hypothesize that subjects will demonstrate increased volitional muscle activity and strength with TSCS. This will be assessed by surface EMG and hand-held dynamometry of the dominant-side quadriceps muscle during maximum volitional contraction (MVC) and measur...