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About 32,458 results

Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study
https://clinicaltrials.gov/ct2/show/NCT00779324

Sep 10th, 2021 - PURPOSE OF PROJECT: To study the effect of amantadine 100 mg administered twice daily compared to placebo on irritability from baseline to treatment Day 28. SUMMARY OF PROJECT: It is anticipated that 168 subjects with 168 corresponding subject informants will be recruited for the study. Carolinas Rehabilitation, the lead center, and 5 collaborating centers will enroll approximately 28 subjects ...

Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome
https://clinicaltrials.gov/ct2/show/NCT02520921

Sep 10th, 2021 - Patients who show high persistent platelet reactivity under aspirin are increasingly becoming an issue of clinical concern. Several studies have suggested that giving aspirin more frequently is very effective for reducing aspirin high persistent platelet reactivity, especially in diabetic patientsor in patients with a known risk factor. The aim of the study is to evaluate low dose of aspirin tw...

Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery
https://clinicaltrials.gov/ct2/show/NCT04710277

Sep 10th, 2021 - The study is a randomized controlled trial investigating a multimodal postoperative pain management protocol which will include use of ice therapy and scheduled opioid-sparing medications for pain control after minimally invasive gynecologic surgery. The study will include women >/= 18yo who speak English and are admitted for observation after a qualifying laparoscopic or robotic gynecologic pr...

Premedication With Intranasal Dexmedetomidine in Sedation of Patients Undergoing Total Knee Arthroplasty
https://clinicaltrials.gov/ct2/show/NCT04859283

Sep 10th, 2021 - Patients undergoing total knee arthroplasty (TKA) under spinal anesthesia often request sedation to alleviate anxiety. Dexmedetomidine may be ideally suited to provide sedation during surgery as it offers sedation and analgesia without causing significant respiratory depression. Furthermore, dexmedetomidine has beneficial synergistic interactions with opioids and sedative drugs. Altogether 80 p...

Effect of Tramadol on Postoperative Sore Throat After General Anesthesia
https://clinicaltrials.gov/ct2/show/NCT04991493

Sep 10th, 2021 - Design: A prospective, randomized, controlled study. Setting: Single-center university hospital. Participants: The study included 168 patients undergoing thyroid surgery under general anesthesia with endotracheal intubation. Interventions: The patients were allocated randomly into the following 3 groups: the control group: patients will be injected intravenously 5ml of normal saline 15 minutes ...

Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures
https://clinicaltrials.gov/ct2/show/NCT03220880

Sep 10th, 2021 - Dexmedetomidine (DEX) is an alpha-2 receptor agonist with sedative, anxiolytic, and analgesics properties. DEX has been used extensively for sedation in children to facilitate different non-painful procedures, such magnetic resonance imaging (MRI), auditory brainstem response (ABR) tests, and computed tomography (CT) scans. In particular, DEX can be administered by the intranasal (IN) route. In...

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
https://clinicaltrials.gov/ct2/show/NCT03573349

Sep 10th, 2021 - Aims: This feasibility study aims to better understand the neurobiology of major depression and how ketamine may therapeutically impact brain function. This research may provide important insights into the mechanism of ketamine response, thus, potentially increasing the likelihood of successful treatment interventions and decrease the number of ineffective treatments and/or risk for serious sid...

Behavioral Effects of Pregabalin and Cannabis
https://clinicaltrials.gov/ct2/show/NCT01511640

Sep 10th, 2021 - Cannabis is the most commonly used illicit drug in the United States, and its use is associated with rates of development of abuse and dependence, treatment admission and relapse that are comparable to other illicit drugs. Currently there is no effective pharmacological treatment for cannabis-use disorders. The purpose of the present study is to evaluate the ability of pregabalin to reduce cann...

Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores
https://clinicaltrials.gov/ct2/show/NCT02840240

Sep 10th, 2021 - Opioids are effective analgesics, but cause side effects including sedation, respiratory depression, low blood pressure, nausea, and constipation. Gabapentin enacarbil, which is a FDA approved drug for post herpetic neuralgia (nerve pain related to shingles) and restless leg syndrome, may decrease your need for narcotics and thus decrease the risk of side effects. The investigator hopes this st...

Terameprocol in Treating Patients With Recurrent High Grade Glioma
https://clinicaltrials.gov/ct2/show/NCT02575794

Sep 10th, 2021 - PRIMARY OBJECTIVES: I. To estimate the maximum tolerated dose (MTD) of terameprocol given orally on days 1-5 every 28 days in patients with high grade glioma. (Part 1) II. To evaluate terameprocol tumor to plasma ratios in resected high grade gliomas following 5 days of oral terameprocol administration. (Part 2) III. To assess the maximum duration of terameprocol that can be safely administered...

Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19
https://clinicaltrials.gov/ct2/show/NCT04365985

Sep 10th, 2021 - There is an urgent need to develop new treatments for Novel Coronavirus-19 (COVID-19) infection using easily available and affordable medications. We need to develop a treatment protocol which prevents progression of the disease and a treatment protocol to rescue those with advanced disease. In addition to anti-viral therapeutics currently under investigation in other trials, the addition of im...

Resveratrol and Cardiovascular Health in the Elderly
https://clinicaltrials.gov/ct2/show/NCT01842399

Sep 9th, 2021 - Resveratrol is found in the leaves and skin of grapes, in peanuts and in the roots of the plant polygonum cupsidatum. Although used since early years in Indian Ayurvedic and Chinese medicine, it came into prominence in the 1990 s as it was believed to be the major reason for the positive effect of wine on cardiovascular health and the French Paradox. Since then, studies have shown that resverat...

Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
https://clinicaltrials.gov/ct2/show/NCT03483870

Sep 9th, 2021 - The study will be carried on 40 parturients scheduled for elective cesarean section (CS) under intrathecal anesthesia. They will be randomly allocated into two equal groups of 20 parturients each: Group A: (placebo group) will receive 200 ug morphine sulphate will be injected intrathecally & 2 mL of normal saline 0.9%. Group B: (treatment group) will receive 200 ug morphine sulphate will be inj...

Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
https://clinicaltrials.gov/ct2/show/NCT03521505

Sep 9th, 2021 - Patients undergoing flexible bronchoscopy (FB) experience procedure-related symptoms. Current guidelines of FB recommend sedation to all patients undergoing FB, except when there are contraindications. Propofol plus an opioid is the common combination used to improve patient tolerance and satisfaction during FB. However, controversy about combining propofol and opioids persists because of the r...

Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy
https://clinicaltrials.gov/ct2/show/NCT03534505

Sep 9th, 2021 - The study design is a prospective randomized, double-blind, controlled trial of patients who are undergoing elective unilateral inguinal herniorrhaphy at Ramathibodi Hospital during the period 1 July 2018 - 30 June 2020 The primary outcome is to study the effectiveness of Ketorolac injections in pain relief after herniorrhaphy surgery and the secondary outcome is to study the adverse effects an...

Scheduled Ketorolac Administration After Cesarean Section and Its Effect on Opioid Consumption: a Randomized Control Trial
https://clinicaltrials.gov/ct2/show/NCT03678675

Sep 9th, 2021 - Subjects who consented to be part of the trial will be randomized at the time of skin closure of their cesarean section to either the standard group or the study group. The standard group will receive the standard treatment of 2 doses of 30mg IV Ketorolac on an as needed basis. The study group will receive 6 doses of 30mg IV Ketorolac scheduled every 6 hours. The subject will receive her first ...

A Clinical Investigation to Evaluate The Orkla Corn Plaster
https://clinicaltrials.gov/ct2/show/NCT04601259

Sep 9th, 2021 - This is a prospective, randomized, controlled, open-labelled investigation to assess performance and safety of Orkla Corn Plaster in subject with corns. The hypothesis is that there is an improvement in the size of corns at day 28 compared to baseline.

Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
https://clinicaltrials.gov/ct2/show/NCT04291508

Sep 9th, 2021 - Hypothesis 1A: Acetaminophen (APAP) or Vitamin C infusion will increase the days alive and free of organ support to day 28. Hypothesis 1B: APAP or Vitamin C will have a favorable effect on other secondary outcomes including pulmonary and non-pulmonary organ dysfunction and biomarkers of inflammation and endothelial injury The investigators plan to carry out two multi-center phase 2b randomized ...

Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
https://clinicaltrials.gov/ct2/show/NCT04724252

Sep 9th, 2021 - This study is a double-blind, placebo controlled, randomized study to explore the effects of gabapentin peri and post operatively. Physician and families will be blinded to the treatment. 60 subjects will be randomized in a 1:1 ratio to either: Gabapentin treatment group Placebo - control group We aim to understand the impact that gabapentin use peri and post operatively has on: opioid use base...

Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients
https://clinicaltrials.gov/ct2/show/NCT04428424

Sep 9th, 2021 - This study is to evaluate available local data in Iraqi patients with rheumatoid arthritis on Enbrel treatment with regards to the impact of Rheumatoid factor and Anti-cyclic citrullinated peptide using data from the Baghdad Teaching Hospital registry.