About 26,033 results

Effect of Curcumin on Systemic Lupus Erythematosus

Aug 5th, 2022 - The purpose of this investigator initiated study is to determine the efficacy of curcumin on disease activity of subjects with systemic lupus erythematous. Curcumin has been found to have anti-inflammatory effects and has been found to improve disease activity in lupus patients. In addition, subjects with rheumatoid arthritis as well as osteoarthritis have also found benefit for their disease a...

In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

Aug 5th, 2022 - In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes. To test these hypotheses, the investigators propose defining the epigenomic and transcriptomic alterations at single cell resolutio...

Efficacy and Safety of Escócia Association in the Treatment of Acute Pain

Aug 5th, 2022 - The purpose of this study is to evaluate the efficacy and safety of Escócia association in adults with acute pain.

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

Aug 5th, 2022 - Study Description: In this single center, single arm, open label, baseline versus treatment pilot clinical trial, sixteen subjects with HAM/TSP will receive teriflunomide 14mg by mouth once a day in an initial 9 month treatment phase, followed by a 3 month post treatment follow-up phase. Outcome measures will be collected every 3 months for the duration of the study. Objectives: We will determi...

Spinal or Intravenous Dexmedetomidine in Ambulatory Surgery

Aug 5th, 2022 - The study is designed as a multicenter study and randomization and inclusion of patients will be performed in three hospitals. Each hospital has its own randomisation sequence and coordinating investigator who will be responsible for appointing blinded and unblinded participators in the study. Patients scheduled for spinal anesthesia in ambulatory surgery will be randomized by sealed envelopes ...

Imaging Biomarker for Addiction Treatment Outcome

Aug 5th, 2022 - Objective: Despite recent advances in addiction neuroscience, achieving a breakthrough in predicting addiction treatment outcome has been difficult and long-term abstinence success unacceptably low. The aim of this study is to create a biomarker using various neuroimaging metrics that can predict treatment outcome in opioid, alcohol and dual opioid and alcohol use disorder patients. Study Popul...

Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics

Aug 5th, 2022 - This double-blind, parallel-group, randomized clinical study will recruiter anxious children who will undergo dental pulp therapy. The study participants will be allocated into two equal groups. Subjects in group I will receive ketofol solution (ketamine/propofol mixture, each mL contains 5 mg of ketamine plus 10 mg of propofol). A loading dose of 0.125 mL/kg will be administered intravenously ...

Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients

Aug 5th, 2022 - Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of an inflammatory nature among those affecting motor neurons, with a life expectancy of 3 to 5 years. It is characterised by the loss of motor neurons, and can be of the bulbar type when the pathology begins to affect the motor neurons located in the spinal bulb, or of the medullary type when it begins with a loss...

Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain

Aug 5th, 2022 - The purpose of this study is to evaluate the efficacy and safety of Tiradentes association in adolescents and adults with acute pain.

Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD

Aug 5th, 2022 - Background. Opioid-agonist medications (methadone and buprenorphine) are the most effective treatments available for opioid addiction. However, they are not effective in all cases, and with the vast number of people requiring treatment in the current crisis, even a modest increase in the percentage of people who respond to treatment would represent a substantial benefit in public health. Recent...

Immunomodulatory Effect of Dexmedetomidine as an Adjuvant Drug in Laparoscopic Cholecystectomies

Aug 5th, 2022 - The present study is a randomized, single-blind, prospective clinical trial. Its objective is to evaluate the possible qualitative changes in organic function and in the systemic inflammatory response when using dexmedetomidine associated with general anesthesia for laparoscopic cholecystectomy surgeries. The study was designed and executed according to the surgical routine of the Hospital Univ...

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.

Aug 5th, 2022 - Standard Operating Procedure: A non-probability consecutive sampling was done in a dental out patient department and 120 patients were included and randomly divided in the 4 groups (n=30) using simple randomization as per the inclusion criteria. A verbal informed consent was taken from each participant before including them in a group. The study was designed to be a double blinded study, where ...

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Aug 5th, 2022 - The United States is in the midst of an ongoing opioid crisis. In 2019, approximately 153 million opioid prescriptions were dispensed (46.7 per 100 persons) and 50,000 people died from opioid-involved overdoses. Orthopaedic and spine conditions account for 27.7% of opioid prescriptions and prior studies demonstrate that musculoskeletal pain is frequently reported by opioid abusers as their init...

Safety and Efficacy of Compound Methyl Salicylate Liniment for Topical Pain: a Multicenter Real-World Study in China

Aug 5th, 2022 - The investigators collected demographic data, vital signs, current medical history (type of soft tissue damage), and allergy history of the eligible patients on the day of Ammeltz prescription. At the same time, a doctor conducted the physical examination and evaluated the visual analog scale (VAS) score of each patient. On the seventh day of the drug administration (one course of the treatment...

Bellomic PCA in Laparoscopic Gynecologic Surgery

Aug 5th, 2022 - In laparoscopic gynecological surgery, when intravenous patient-controlled analgesia (IV-PCA) device is used after surgery, the degree of postoperative side effects and pain control is compared when a combination of fentanyl and ketorolac is administered compared to when fentanyl alone is used.

RM1 Project 1 - tAN Naloxone

Aug 5th, 2022 - The demand for chronic pain treatment has demonstrated an unprecedented increase over the last several decades, in part contributing to an unsustainable surge in opioid prescriptions. Countless patients were escalated to prolonged, high-dose opioid regimens over years of treatment. By 2014, 5.4% of US adults were estimated to use prescription opioids on a long-term basis. As the harms of opioid...

Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee

Aug 5th, 2022 - This will be a 13-week A randomized open labelled clinical trail in Iraqi Kurdistan Region, that will be designed to assess the efficacy of duloxetine tablet compared with other group (Nonsteroidal anti-inflammatory) drug on the reduction of pain caused by osteoarthritis of the knee. Patients will be divided into two groups, first group (case) will receive duloxetine tablet 30mg for two weeks t...

The Incidence of Thoracic Disc Herniation in Patients Presenting With Chronic Upper Back Pain

Aug 5th, 2022 - Patients who applied to the Private Medar Hospital between February 2016 and February 2021 with chronic upper back pain and were diagnosed with Thoaracic Disc Herniatin (TDH) (with Thoracic vertebral MRI) and followed up for at least 1 year will be included in the study. Patients diagnosed with TDH were included in the medical treatment and/or physical therapy program. Before and after these tr...

The Impact of Perioperative Ketamine Infusion on Surgical Recovery

Aug 4th, 2022 - Opioids are powerful analgesic medications that can reduce pain through action at the mu receptor. Unfortunately, activation of the mu receptor also results in undesirable side effects, such as respiratory depression, sedation, bowel ileus, nausea, itching, and tolerance. Therefore, in order to effectively treat pain with the least amount of opioids required, a multi-modal approach must include...

PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Primary Care Providers

Aug 4th, 2022 - To test the effects of these decision support tools for improving the quality of care for pain treatment, the investigators will implement a pragmatic clinic-randomized trial across the primary care clinics of Fairview Medical Group and University of Minnesota Physicians. The study has two parallel components. The decision support tools to be tested will differ somewhat depending on whether a g...