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About 22,115 results

Local Anesthetic Concentration and Rebound Pain
https://clinicaltrials.gov/ct2/show/NCT04457557

Sep 30th, 2022 - Shoulder surgery is related to more than moderate pain after surgery. Interscalene nerve block could reduce the postoperative pain effectively. When the effect of nerve block ends, however, rebound pain could appear. The rebound pain could interfere with patient's recovery and rehabilitation. The mechanism of rebound pain is not well known. One of possible mechanism is that the pain stimulus th...

Comparing in Dexmedetomidine With po/pr Midazolam for Procedural Sedation in the Pediatric Emergency Department
https://clinicaltrials.gov/ct2/show/NCT03399838

Sep 30th, 2022 - Pediatric sedation and analgesia is a major aspect in emergency procedures and treatments: anxiety and stress in children need to be purposefully addressed in order to perform procedures where a child needs to lie still, and to prevent anxiety in the future. An important factor to reduce stress and anxiety is the use of medication without the need of an intravenous access. To date, options for ...

Effect of Intrathecal Dexamethasone on Intra-operative Hemodynamic in Elderly Patients Undergoing Urologic Endoscopic Surgery
https://clinicaltrials.gov/ct2/show/NCT05549895

Sep 30th, 2022 - Spinal anesthesia is the most consistent block for lower abdomen and lower limb surgery. Spinal anesthesia avoids the risks of general anesthesia such as aspiration of gastric contents and difficulty with airway management. Post-spinal anesthesia hypotension in elderly patients is challenging. Correction of Post-spinal anesthesia hypotension by fluids either colloids or crystalloids or by vasoc...

Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management
https://clinicaltrials.gov/ct2/show/NCT05561309

Sep 30th, 2022 - Phase Ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection adductor canal block with HR18034 for postoperative pain management compared with ropivacaine.

Understanding Pain Mechanisms in Knee Osteoarthritis
https://clinicaltrials.gov/ct2/show/NCT05561010

Sep 30th, 2022 - Osteoarthritis (OA) of the knee joint is a common cause of chronic pain, disability and impaired quality of life. Knee OA affects ~ 1 in 5 adults over 45 years, with many requiring major knee surgery to alleviate pain and restore mobility. However, > 1 in 5 patients will continue to suffer from pain despite surgery. It remains largely unknown who will fail to respond, and why. Chronic postopera...

Assessment of New Magnetic Resonance Imaging (MRI) Pulse Sequences for Imaging Hyperpolarised Xenon in Lung, Heart and Brain in Volunteers
https://clinicaltrials.gov/ct2/show/NCT02736422

Sep 30th, 2022 - The primary endpoints are to test the pulse sequences under development to image lung ventilation and perfusion, cardiac perfusion and brain uptake of xenon The study will seek to test the given pulse sequence under investigation in a group of up to 40 volunteers. To be eligible, each subject will have no contraindications to MRI scanning and will have signed the necessary volunteer consent for...

Quadratus Lumborum Type 2 as Chronic Hip Pain Treatment
https://clinicaltrials.gov/ct2/show/NCT04438265

Sep 30th, 2022 - The lumbar square block is an interfascial block of the posterior wall of the abdomen, initially described for the management of postoperative pain in abdominal surgery due to its suggested effect on the T7-11 roots. The analgesic efficacy of type 1 lumbar square block (QL1) in hip surgery was subsequently published. Regarding chronic pain, QL2 has been successfully performed in posttherniorrha...

Different Volumes of Erector Spinae Plane Block for Breast Surgery
https://clinicaltrials.gov/ct2/show/NCT05232084

Sep 30th, 2022 - Various methods may be performed to reduce the use of systemic opioids and for effective pain treatment following mastectomy and axillary dissection surgery. Ultrasound (US)-guided interfascial plane blocks have been used increasingly due to the advantages of ultrasound in anesthesia practice. The US-guided erector spina plane block (ESPB) provides thoracic analgesia at T5 level and abdominal a...

A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure
https://clinicaltrials.gov/ct2/show/NCT05285813

Sep 30th, 2022 - Primary Objectives: AML MRD cohort: To determine the MRD negativity rate after 4 cycles of vibecotamab in patients with AML with MRD MDS post-HMA cohort: To determine the response rate (defined as CR + marrow CR [mCR] + partial remission [PR] + hematologic improvement [HI]) after 4 cycles of vibecotamab in patients with MDS after HMA failure Secondary Objectives: To assess other efficacy endpoi...

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses
https://clinicaltrials.gov/ct2/show/NCT03928366

Sep 30th, 2022 - Main goal: Develop a system for monitoring the effect of anesthetics on consciousness and pain, based on synchronous changes in functional neuroimaging, EEG and clinical responses. Secondary objectives: Analyze the changes produced in the cortical connectivity map during the induction of anesthesia to understand the process of "advancement". Know more accurately the neuronal circuits involved i...

Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers
https://clinicaltrials.gov/ct2/show/NCT05417425

Sep 30th, 2022 - The study will have three phases: screening, treatment and healing confirmation. The screening phase is to determine eligibility of subjects and chronicity of the diabetic foot ulcer and will include off-loading. The treatment phase begins with assessment to confirm continued eligibility and if met, subjects will be treated weekly with the Omeza combination therapy and standard of care to conti...

Multi-System Analysis of Opioid Receptor Binding
https://clinicaltrials.gov/ct2/show/NCT05528848

Sep 30th, 2022 - This study in up to 20 healthy subjects (including 10 females and 10 males) will use [11C]carfentanil whole-body PET imaging to examine the CNS and broader systemic opioid binding and its blockade by the non-selective opioid antagonist naloxone administered parenterally in 2 scan sessions, which can be done the same day or on different days. Findings from this study will demonstrate the distrib...

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block
https://clinicaltrials.gov/ct2/show/NCT05543109

Sep 30th, 2022 - All subjects after entering operation room will be connected to standard monitor electrocardiograph, non-invasive blood pressure, heart rate, oxygen saturation. Three mg/kg of propofol, 0.2 μg/kg of fentanyl and 0.1 mg/kg midazolam will be used for sedation. Oxygen at the concentration of 100% will be administrated under the mask in all patients after satisfactory sedation, tracheal intubation ...

The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery
https://clinicaltrials.gov/ct2/show/NCT05560035

Sep 29th, 2022 - The surgical stress response to tumour removal causes bloodstream release of a variety of pro-inflammatory cytokines and other molecules which may affect perioperative immune response and other conditions conducive to residual tumour cell survival that could later emerge as clinical recurrences or metastasis. Lidocaine has analgesic and anti-inflammatory effects, and may also have specific anti...

PET/CT Guided Robotic Arm-assisted Pain Palliation in Chronic Nociceptive Low Backache
https://clinicaltrials.gov/ct2/show/NCT05560165

Sep 29th, 2022 - Chronic pain in the lower back may be due to a variety of causes such as neuropathic causes, musculoskeletal causes, visceral causes, malignancy-related or primary pain where in there is no obvious cause of pain. Musculoskeletal pain usually affects the muscles, joints, bones or their surrounding soft tissue structures. These participants are usually evaluated with clinical examination and radi...

Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery
https://clinicaltrials.gov/ct2/show/NCT05527314

Sep 29th, 2022 - As a novel ultra-short-acting benzodiazepines drugs, Remimazolam has been accepted for induction and maintenance of clinical anesthesia. Compared to the traditional benzodiazepines drugs, Remimazolam combines the safety of midazolam with the effectiveness of propofol, and also has the advantages of acting quickly, short half-life, no injection pain, slight respiratory depression, independent of...

PENG vs Intra-articular Injection for Hip Arthroscopy
https://clinicaltrials.gov/ct2/show/NCT04698746

Sep 29th, 2022 - Hip arthroscopy is a popular surgical method that is increasingly being used for both intraarticular and extraarticular hip surgeries. Postoperative acute pain is difficult to control in hip surgeries due to the complex nature of hip innervation and the large number of surgical interventions. Optimal treatment of postoperative pain in hip arthroscopy is very important to be able to perform reha...

Clinical Response to Magnesium Sulfate as an Adjunct in the Anesthesia
https://clinicaltrials.gov/ct2/show/NCT05227716

Sep 29th, 2022 - The participant selection process will be carried out through direct invitation to patients scheduled for surgery under regional or general anesthesia at the General Hospital of Zone No. 51 of the IMSS, Gómez Palacio, Durango. Explaining what their participation consists of for the subsequent signing of the informed consent letter in case of accepting. Afterwards, according to the type of surge...

Effect of Propofol on Postoperative Nausea and Vomiting.
https://clinicaltrials.gov/ct2/show/NCT05071794

Sep 29th, 2022 - Cesarean Section is one of the most commonly performed surgical procedures in the obstetric patients. Adequate intra and postoperative analgesia is very important in providing comfort to the mother, early breastfeeding, ambulation and discharge as well as enhancing patient satisfaction.Spinal anesthesia is widely accepted as the anesthesia of choice for cesarean section owing to its safety and ...

EP Intravenous Anesthesia in Hysteroscopy
https://clinicaltrials.gov/ct2/show/NCT05259787

Sep 29th, 2022 - Hysteroscopy is a gold standard method for evaluating the uterine cavity and diseases, which is gradually becoming a day-surgery in China. For hysteroscopic surgery using bipolar resectoscopes, hysteroscopic morcellators or shavers, it is considered efficient and safe to be performed under general anaesthesia, such as intravenous anesthesia. Propofol is one of the most commonly used intravenous...