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About 22,693 results

Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES
https://clinicaltrials.gov/ct2/show/NCT05688943

Feb 3rd, 2023 - Anesthesia is a controlled, temporary loss of sensation or awareness used to perform surgical procedures. Spinal anesthesia is commonly used in obstetrics and gynecology for vaginal procedures as well as cesarean sections. The use of spinal anesthesia for laparoscopic surgery is an adequate and safe alternative to general anesthesia which remains the gold standard. Vaginal Natural Orifice Endos...

Dexmedetomidine-Ropivacine Versus Sufentanil-Ropivacaine for Epidural Labor Analgesia
https://clinicaltrials.gov/ct2/show/NCT05698407

Feb 3rd, 2023 - Sufentanil combined with ropivacaine is commonly used for epidural labor anesthesia. However, this combination is associated with some adverse events including increased risk of neonatal depression. Dexmedetomidine is a high selective alpha2-adrenoceptor agonist and possesses opioid-sparing and analgesic effects when used in combination with local anesthetics. Recently published data suggest th...

Transcutaneous Pulsed Radiofrequency in Migraine
https://clinicaltrials.gov/ct2/show/NCT05499689

Feb 3rd, 2023 - Migraine is the second most common primary headache. Greater occipital nerve (GON) block is an effective method in the treatment of migraine. Transcutaneous pulsed radiofrequency (RF) therapy is used in the treatment of pain. However, its use in headaches is not widespread yet. Investigator aimed to compare the efficacy of transcutaneous pulsed radiofrequency therapy applied through the GON tra...

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy
https://clinicaltrials.gov/ct2/show/NCT05597878

Feb 3rd, 2023 - Primary Objective(s): Compare the effectiveness of opioid and opioid-free pathways in treating post-surgical pain following robotic-assisted radical prostatectomy. Secondary Objective(s) To determine the opioid usage in the opioid and non-opioid group from the start of the pain treatment administration until discharge in patients following robotic-assisted radical prostatectomy. Determine and a...

Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department
https://clinicaltrials.gov/ct2/show/NCT05325580

Feb 3rd, 2023 - Rate of Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department

Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain
https://clinicaltrials.gov/ct2/show/NCT05046639

Feb 3rd, 2023 - Participants with chronic, refractory phantom limb pain (PLP) or residual limb pain (RLP) for more than 6 months will be enrolled in this clinical trial. Aim: Define the attributable pain relief and functional improvement in participants with PLP/RLP after contralateral limb sciatic nerve block. Also, contribute to the basic science understanding of the crossed-withdraw reflex by demonstrating ...

Action of Intra-auricular Topical Lidocaine on Tinnitus
https://clinicaltrials.gov/ct2/show/NCT05711641

Feb 3rd, 2023 - Adult patients who have had continuous, uni or bilateral tinnitus, for at least 6 months are being evaluated. Exclusion criteria are: otological infection, tympanic membrane perforation, anatomical alteration of the external ear, pulsatile tinnitus, objective tinnitus, known allergy to lidocaine or other topical anesthetic and pregnancy All patients receive both lidocaine and placebo at an inte...

Spinal Anaesthesia vs. General Anaesthesia for THA, TKA and UKA
https://clinicaltrials.gov/ct2/show/NCT05706844

Feb 3rd, 2023 - The goal of this randomized clinical trial is to investigate the postoperative recovery following hip and knee arthroplasty procedures depending on the use of either spinal anaesthesia (SA) or general anaesthesia (GA). The main questions are: Are more patients able to be safely mobilized within 6 hours postoperatively when using GA compared to SA? Does postoperative pain, nausea and vomiting, d...

Predictive Factors for Prescribing a Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea
https://clinicaltrials.gov/ct2/show/NCT05677620

Feb 3rd, 2023 - This study will present 66 adult patients diagnosed with mild or moderate OSA (5

Supraclavicular Brachial Plexus Block During Upper Limb Surgeries
https://clinicaltrials.gov/ct2/show/NCT05315271

Feb 3rd, 2023 - Comparative Study Between Ketamine-Bupivacaine Versus Bupivacaine With Intravenous Ketamine Infusion In Supraclavicular Brachial Plexus Block During Upper limb Surgeries The techniques of regional anesthesia have become very popular as they provide several advantages in comparison with general anesthesia and systemic analgesia. They provide perfect pain control, decreased complications and redu...

Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients
https://clinicaltrials.gov/ct2/show/NCT04613830

Feb 3rd, 2023 - Sixty patients will be included in this prospective randomized study. The patients will be allocated into two groups: the ESPB group (group E, n = 30) and the tramal group (group T, n =30). All patients will receive standard general anesthesia. Ultrasound-guided ESPB will be performed to group erector spinae plane block

Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
https://clinicaltrials.gov/ct2/show/NCT03471182

Feb 3rd, 2023 - Cocaine use disorder (CUD) remains a significant public health concern that is resistant to current treatments. Challenges to treating CUD include an imbalance in neurobiological systems that 're-wire' the brain such that appetitive and habitual processes influence decision-making and behavior. This research project aims to provide insight into this reorganized circuitry in CUD by investigating...

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
https://clinicaltrials.gov/ct2/show/NCT03864042

Feb 3rd, 2023 - This is an open-label, 3-arm, fixed-sequence study to evaluate the effect of single and multiple oral doses of encorafenib in combination with binimetinib on the single oral dose pharmacokinetics (PK) of cytochrome P450 (CYP) enzyme probe substrates using a probe cocktail, on an organic anion-transporting polypeptide/breast cancer resistance protein (OATP/BCRP) substrate using rosuvastatin and ...

Nitrous Oxide for Analgesia During Nasogastric Tube Placement in Young Children
https://clinicaltrials.gov/ct2/show/NCT04008628

Feb 3rd, 2023 - In the context of mild to moderate dehydration in young children, enteral rehydration is the treatment of choice because it is more physiological than parenteral rehydration which has more serious side effects. Thus, nasogastric tube placement has become a more common procedure in the pediatric emergency care setting. Although, it is widely accepted that this procedure is invasive and painful, ...

Evolution of Mouth Opening After Mandibular Block
https://clinicaltrials.gov/ct2/show/NCT04961554

Feb 3rd, 2023 - The aim of this study is to avoid recourse to awake fiberoptic intubation, which causes discomfort during the procedure and post-traumatic stress disorder, in patients with a very limited mouth opening (less than 20mm) and who must undergo anesthesia general for mandibular surgery. As a reminder, the definition of limited mouth opening (MO) is a lower 35mm mouth opening, according to the Sociét...

Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia
https://clinicaltrials.gov/ct2/show/NCT05338320

Feb 2nd, 2023 - It was proven that intrathecal opioids are considered as an effective means of pain control in several major surgical interventions including spine surgeries. Intrathecal morphine added to a spinal anesthesia reduces acute pain after spine surgeries but has side effects, including dose dependent respiratory depression, nausea, vomiting, pruritus, and sedation. Ultrasound guided Erector Spinae P...

Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children
https://clinicaltrials.gov/ct2/show/NCT05686863

Feb 2nd, 2023 - It is planned to observe the painless two-way endoscopic examination of children in Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology from November 2022 to May 2023.To observe the sedative effect and safety of remiazolam combined with small dose of esketamine in painless bidirectional endoscopy in children, and to provide a more reasonable and...

Comparison of Pharmacological and Non-Pharmacological Interventions For Alleviating Preoperative Anxiety In Children
https://clinicaltrials.gov/ct2/show/NCT05469412

Feb 2nd, 2023 - Preparation for surgery with the induction of general anesthesia can be a stressful experience for a child. Preoperative anxiety can prolong induction of anesthesia and postoperative recovery, as well as increasing the risk of postoperative delirium, pain, and analgesic use. Pharmacological interventions are associated with increased cost to the hospital, potential surgical delay while waiting ...

Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure
https://clinicaltrials.gov/ct2/show/NCT05582213

Feb 2nd, 2023 - Critical pulmonary stenosis (PS) is a life-threatening congenital heart disease which manifest during the neonatal period with cyanosis. Surgical valvotomy was the procedure of choice for critical PS; however, balloon pulmonary valvoplasty (BPV) has now become the standard management. Ketamine is often used for procedural sedation or as adjunct agent for general anesthesia in pediatrics with co...

Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine
https://clinicaltrials.gov/ct2/show/NCT05218733

Feb 2nd, 2023 - Total abdominal hysterectomy (TAH) is a major surgical procedure after which significant post-operative pain and discomfort are anticipated. Abdominal field blocks have been followed for many years and extensively used for pain management following abdominal surgeries such as laparotomies and appendicectomies. Erector Spinae Plane Block (ESPB)-first recently described for the treatment of thora...