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About 67,588 results

Feeding Trial to Determine How Combinations of Different Dietary Bioactive Ingredients Influence High Density Lipoprotein (HDL) Metabolism
https://clinicaltrials.gov/ct2/show/NCT01803594

Sep 30th, 2022 - This study a partial randomized crossover study designed to determine how consumption of bioactive dietary ingredients in various combinations on three separate test days influences postprandial lipoprotein metabolism in participants with low circulating HDL-cholesterol. The dietary ingredients include: Dairy phospholipids(PC700); krill oil (K); lutein (L); and Niacin Eligible participants will...

Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
https://clinicaltrials.gov/ct2/show/NCT01811329

Sep 30th, 2022 - Phase 1 is a randomized crossover study designed to determine how inclusion of dairy fractions rich in milk fat globule membrane (MFGM) to shakes rich in dairy or palm fat influence postprandial inflammation. Participants who have 2 or more risk factors of metabolic syndrome or BMI ≥ 30 will consume four shakes on separate days. The four shakes are: high dairy fat, high dairy fat + MFGM, high p...

Precision Medicine for Liver Tumours With Quantitative Magnetic Resonance Imaging and Whole Genome Sequencing
https://clinicaltrials.gov/ct2/show/NCT04597710

Sep 30th, 2022 - This will be a prospective, observational, cohort study to determine the impact of integrated diagnostics using quantitative magnetic resonance imaging, whole genome sequencing and digital pathology on intended patient management for liver cancer patients referred for liver resection. Participants with primary or secondary liver cancer will be recruited from Hampshire Hospitals NHS Foundation T...

FitMum: Fitness for Good Health of Mother and Child
https://clinicaltrials.gov/ct2/show/NCT03679130

Sep 30th, 2022 - Low levels of physical activity during pregnancy constitute a significant public health issue as increasing evidence suggests that the mother's lifestyle during pregnancy may influence the future health of her child. A physically active lifestyle during pregnancy has potential to improve metabolic health of mother and child and thus may play an important role in relation to counteracting the ob...

A Cue-based Developmental Approach Toward the Preterm Infants During Feeding Transition Period
https://clinicaltrials.gov/ct2/show/NCT03755999

Sep 30th, 2022 - The coordination of sucking, swallowing, and breathing during the transition from gavage to oral feeding is a challenge for preterm infants. Efficient management of the feeding transition without other comorbidities can not only improve their oral movements and gastrointestinal function development, facilitate their oral feeding learning behavior, but also facilitate them to direct breastfeedin...

Time-restricted Eating in Morning Chronotype
https://clinicaltrials.gov/ct2/show/NCT04618133

Sep 30th, 2022 - Overweight and obesity are highly prevalent conditions worldwide, despite active research of new interventions over decades. Current interventions include medications or bariatric surgery, but these approaches cannot be used in all patients and require clear indications and a close multidisciplinary management. Therefore most patients and physicians rely on lifestyle interventions, focusing on ...

RCT Comparing Non-operative vs Operative Treatment of Suprasyndesmotic Ankle Fractures.
https://clinicaltrials.gov/ct2/show/NCT04615650

Sep 30th, 2022 - Suprasyndesmotic fractures (Weber type C) are historically treated operatively because of the assumption that the distal tibiofibular syndesmosis is ruptured, leading to joint instability (Lauge-Hansen 1950, Boden 1989). However, the medial deltoid ligament may function as the main stabiliser of the ankle joint by preventing external rotation of the talus and therefore maintains the dynamic con...

The Effects of an Intensive Lifestyle Intervention for Type 2 Diabetes on Disability Insurance
https://clinicaltrials.gov/ct2/show/NCT04515745

Sep 30th, 2022 - Starting in 2001, the Look AHEAD study randomized 5145 patients with type 2 diabetes to an intensive lifestyle intervention (ILI) focused on weight loss versus a control group receiving diabetes education ("Diabetes Support and Education").The Look AHEAD study tested whether participants with type 2 diabetes assigned to an intensive lifestyle intervention (ILI) for weight loss exhibited reducti...

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
https://clinicaltrials.gov/ct2/show/NCT01168271

Sep 30th, 2022 - Malaria caused by Plasmodium falciparum continues to be a global problem withdevastating consequences. A greater understanding of the immunologic and parasitologic factors associated with infection and disease is badly needed; and will accelerate the development of highly protective vaccines for both mothers and children. Pregnancy malaria is associated with low birth weight, maternal anemia, a...

Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder
https://clinicaltrials.gov/ct2/show/NCT05303064

Sep 30th, 2022 - To compare changes in body mass index (BMI) Z-score following treatment with OLZ/SAM vs olanzapine

Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias
https://clinicaltrials.gov/ct2/show/NCT05502783

Sep 30th, 2022 - Study Description: This open label phase II trial is designed to evaluate the efficacy of fostamatinib in the treatment of post-transplant cytopenias as assessed by hematologic improvement in anemia and/or thrombocytopenia following a 12-week treatment course. Patients who respond to the 12-week treatment course on this single arm study are eligible and have the option to enroll on the extended...

Phenylalanine, Methionine and Histidine Requirements in TPN Fed Neonates
https://clinicaltrials.gov/ct2/show/NCT05562310

Sep 30th, 2022 - The study is based on the carbon oxidation protocol. Each baby will receive one or two levels of either phenylalanine or methionine or histidine. Each level will be assessed over a two-day period. On day 1: each baby will receive a standard pediatric amino acid solution, Primene used in the NICU and L-[1-13C]Na Bicarbonate will be given to measure carbon dioxide production. On day 2: he/she wil...

Proteomic Study of Tears From Patients With a PAX6 Mutation
https://clinicaltrials.gov/ct2/show/NCT05562115

Sep 30th, 2022 - The transcription factor PAX6 is required for the normal development of all elements constituting the eyeball, including the lacrimal gland. In patients with PAX6 gene mutations, the cornea presents a limbal anomaly that has been evolving since childhood and is responsible for variable damage. It evolves from a simple peripheral keratopathy to an advanced stage with complete corneal opacificati...

Development and Testing of a Peer-Coaching Model for the Treatment of Eating Disorders
https://clinicaltrials.gov/ct2/show/NCT05562258

Sep 30th, 2022 - A total of 70 adolescents with eating disorders between the ages of 12-18 and their parents/caregivers will be enrolled in a randomized-controlled trial comparing parent coaching/patient education to parent education/patient coaching. Measures will include demographics, vitals, parent and patient self-efficacy, quality of life, illness related distress/impairment, and changes in eating disorder...

Lateral Approach Versus Anterior Approach in Total Ankle Replacement
https://clinicaltrials.gov/ct2/show/NCT05562154

Sep 30th, 2022 - A minimum of 50 patients with ankle end-stage arthritis will be randomized in two parallel groups for surgery. One group will receive a total ankle replacement through an anterior approach and the other group a total ankle replacement via a lateral approach. Patients will be evaluated for a mean follow-up of two years in terms of complications, implant survival and functional results. One of th...

Effect of Coconut Water on Hydration Status in Pediatric Population
https://clinicaltrials.gov/ct2/show/NCT05562401

Sep 30th, 2022 - For current epidemiological reasons of Covid-19, an increase of 30% of losses has been considered already established in the sample size, giving a total of 22 participants per group (44 in total). For the same reason, two groups of 22 participants (11 experimental and 11 controls) will be divided in order to reduce the population and the risk of contagion, following the health protocols establi...

Program for Fully Understanding Eating and Lifestyle Change (FUEL)
https://clinicaltrials.gov/ct2/show/NCT05562427

Sep 30th, 2022 - The purpose of this 5-year study is to conduct multimodal real-time assessment of behavioral, psychosocial, and contextual characteristics to uncover lapse phenotypes. The data from this project will ultimately inform future personalized interventions to promote dietary adherence by providing critical data on which lapses to target and how to best target them. Participants (N=150) will receive ...

FOOD PRESCRIPTION APP
https://clinicaltrials.gov/ct2/show/NCT05562180

Sep 30th, 2022 - We are specifically planning app to create meal plans that are affordable, meet the recommended dietary allowances (RDAs) and adhere to sustainability guidelines to reduce the food-related carbon footprint. The app will enable participants to customize their weekly meal plans. We hypothesize that having the ability to customize the weekly menus through a FoodRx app will improve outcomes, as the...

Oxidative Stress in the Patient With Peroperative Analgesia by Intravenous Lidocaine
https://clinicaltrials.gov/ct2/show/NCT05562141

Sep 30th, 2022 - Intraoperatively, depending on the habits of the anesthesiologist, lidocaine may be started after induction (bolus of 1.5 mg/kg then relay at 1.5 mg/kg/h until the end of the procedure) or not (control group). Three blood samples will be taken. The first one (T0) during the placement of the venous line before induction and the second one (T1) one hour after the end of induction when the blood g...

Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
https://clinicaltrials.gov/ct2/show/NCT05560971

Sep 30th, 2022 - Specific aims of the study are as follows: 1) To test whether supplementation of POA, as compared to placebo, improves insulin sensitivity. 2) To test whether supplementation of POA, as compared to placebo, ameliorates hepatosteatosis and decreases whole-body fat mass, serum triglyceride, and LDL cholesterol. 3)To determine whether supplementation of POA, as compared to placebo, decreases plasm...