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About 32,385 results

Long-term Beta-blocker Therapy After Acute Myocardial Infarction
https://clinicaltrials.gov/ct2/show/NCT04769362

Feb 3rd, 2023 - β-blockers have anti-ischemic, anti-arrhythmic, and anti-adrenergic properties. In order to reduce cardiovascular mortality and morbidity, current major guidelines recommend that oral treatment of β-blockers should be continued during and after hospitalization in patients with acute myocardial infarction (AMI) and without contraindications to β-blocker use. A clinically important but difficult ...

Computerized Medical History Taking for Acute Chest Pain
https://clinicaltrials.gov/ct2/show/NCT03439449

Feb 3rd, 2023 - The purpose of this study is to determine the value of a detailed medical history, acquired by computer-directed, patient self-entry of data, for efficient disposition of patients presenting to the emergency department (ED) with chest pain and non-diagnostic first ECG and/or serum markers for acute coronary syndrome (ACS). The research questions posed are: will the added data and systems-based ...

TAILored Versus COnventional AntithRombotic StratEgy IntenDed for Complex HIgh-Risk PCI
https://clinicaltrials.gov/ct2/show/NCT03465644

Feb 3rd, 2023 - This study evaluates the efficacy and safety of tailored antithrombotic therapy with early (<6-month post-PCI) intensified (low-dose ticagrelor [120 mg loading, then 60 mg bid maintenance] and aspirin) and late (>6-month post-PCI) deescalated (clopidogrel alone) strategy in patients undergoing high-risk complex PCI as compared with standard Dual Antiplatelet Therapy(aspirin and clopidogrel for ...

Investigation of the Ringer Perfusion Balloon Catheter (Ringer PTCA)
https://clinicaltrials.gov/ct2/show/NCT04862689

Feb 3rd, 2023 - A prospective, multicenter, single-arm clinical study. The study will be conducted in 3 to 5 investigational sites in the US and Canada and will enroll up to 60 participants. The population for this study is adult participants undergoing non-emergent percutaneous coronary intervention (PCI) as a stand-alone procedure or following non-emergent diagnostic angiography performed during the same pro...

Mediators of Atherosclerosis in South Asians Living in America
https://clinicaltrials.gov/ct2/show/NCT01207167

Feb 3rd, 2023 - South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asi...

Abbott Vascular Medical Device Registry
https://clinicaltrials.gov/ct2/show/NCT04573660

Feb 3rd, 2023 - The AV-MDR is a prospective, non-randomized, open-label, multi-center registry. The purpose of the AV-MDR study is to proactively collect and evaluate clinical data on the usage of the devices in scope within their intended use with the aim of confirming safety and performance throughout their expected lifetime, ensuring the continued acceptability of identified risks, detecting emerging risks ...

IRIS Ultimaster Cohort in the IRIS-DES Registry
https://clinicaltrials.gov/ct2/show/NCT02719106

Feb 3rd, 2023 - The purpose of this study is to evaluate the relative effectiveness and safety of Ultimaster stent compared to other drug eluting stents.

Closed or Open Abdomen for the Management of Abdominal Sepsis
https://clinicaltrials.gov/ct2/show/NCT03163095

Feb 3rd, 2023 - Severe complicated intra-abdominal sepsis (SCIAS) is a World-Wide challenge, with high mortality rates, and ever increasing incidence. Most cases are subjected to secondary peritonitis in which there is a physical disruption of the integrity of the gastrointestinal (GI) tract leading to contamination of the peritoneal cavity. Ultimately, the resultant organ damage results in auto-amplifying bio...

Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
https://clinicaltrials.gov/ct2/show/NCT03253692

Feb 3rd, 2023 - Cardiac CT angiography is a commonly used test to take detailed pictures of the heart to diagnose heart disease; however, it is associated with radiation exposure. Several technological advances in both scanner hardware and software are now available to reduce the radiation exposure to patients. The purpose of this study is to evaluate the worldwide usage of these radiation dose saving strategi...

Arm Boot Camp Study: Evaluation of a Program to Increase Upper Limb Recovery After Stroke
https://clinicaltrials.gov/ct2/show/NCT04232163

Feb 3rd, 2023 - Participants will be randomized into either the Immediate Treatment Group or the Delayed Treatment group. Both groups will complete the same intervention program. The Immediate treatment group will start the program right away while the Delayed Treatment group will start the program after a 3 week delay. The intervention program is 3 weeks in duration and consists of participants completing at ...

The Relationship Between MPV,PDW,PFT and ST Segment Resolution in STEMI Patients Treated With Thrombolytic or Primary PCI
https://clinicaltrials.gov/ct2/show/NCT03267199

Feb 3rd, 2023 - Reperfusion therapy as the main treatment strategy in patients with ST-segment elevation myocardial infarction (STEMI) consists of either thrombolysis or primary percutaneous coronary intervention (pPCI). Primary percutaneous coronary intervention is the preferred therapy for STEMI; however, cardiac catheterization laboratories may not be widely available. Early recanalization of the infarct re...

Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina
https://clinicaltrials.gov/ct2/show/NCT05711849

Feb 3rd, 2023 - After being informed about the study and the potential risks and benefits, participants who provide written consent will be screened to make sure they fulfil the study entry requirements. They will undergo screening assessment and if they don't meet any exclusion factors and found to be eligible they will be randomised to one of two groups and start preparation for the investigational or sham b...

Metabolomics, Genomics and Nutrition for Cardiovascular Disease Precision Medicine
https://clinicaltrials.gov/ct2/show/NCT05706519

Feb 3rd, 2023 - In two independent samples, one of 600 subjects free of cardiovascular disease (control group) and the other of 600 subjects with a history of ischemic heart disease (established heart disease group) eating habits will be evaluated using Food Frequency Questionnaire, based on those repeatedly used in epidemiological studies carried out in Spain, as well as other nutritional evaluation tools. Ea...

Stellatar Ganglione Blockage for Ventricular Arrhytmias
https://clinicaltrials.gov/ct2/show/NCT05712122

Feb 3rd, 2023 - In our study, USG-guided left stellate ganglion blockade was applied to 10 VA and ES patients with ICD who were admitted to the Department of Cardiology at Çukurova University between 2020-2021. The 6-month results of the patients were evaluated retrospectively. An electrical storm was defined as 3 episodes of continuous VT/VF or ICD therapy for VT/VF over a 24-hour period. Demographic data and...

The Effects of Non-ischemic and Pain-free Exercise to Treat Claudication
https://clinicaltrials.gov/ct2/show/NCT05712395

Feb 3rd, 2023 - Specific Aims. We propose to test our central hypothesis that the NICE intervention performed without inducing leg ischemia and its' damaging sequela will be a superior exercise paradigm to increase peak walking time and HRQoL more than the Standard ischemic and painful exercise paradigm via greater improvement in microvascular mechanisms. This clinically relevant hypothesis will be tested thro...

Saphenous Vein as Y-composite Versus Aortocoronary Conduit for CABG
https://clinicaltrials.gov/ct2/show/NCT05704296

Feb 3rd, 2023 - The enrolled patient underwent routine sternotomy, and left internal thoracic artery (LITA) and saphenous vein (SV) are harvested. After harvest, the patient is randomized to Y-composite group or aortocoronary group. For Y-composite group, SV is anastomosed to LITA as Y-composite fashion. Then, LITA is anastomosed to left anterior descending artery. SV is anastomosed to the rest of the target v...

Peritoneal Vacuum Therapy to Reduce Inflammatory Response From Abdominal Sepsis/Injury
https://clinicaltrials.gov/ct2/show/NCT01355094

Feb 3rd, 2023 - Excessive pressure within the peritoneal cavity, known as intra-abdominal hypertension (IAH), can adversely affect not only intra-peritoneal organ function, but also other organ systems throughout the body. When IAH > 20 mmHg induces new organ dysfunction, a potentially lethal condition known as the abdominal compartment syndrome (ACS) is defined. Practically, this syndrome can be considered mu...

Dapagliflozin Effects on Cardiovascular Events in Patients With an Acute Heart Attack
https://clinicaltrials.gov/ct2/show/NCT04564742

Feb 3rd, 2023 - This is a multicentre, parallel group, event-driven, registry-based randomised controlled trial (R-RCT), double-blind, placebo-controlled phase 3 study in patients without diabetes presenting with myocardial infarction (MI) (ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI)) and evidence of impaired regional or global LV systolic funct...

The Efficacy of a Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Subacute Ischemic Stroke Patients - a Pivotal Study (THE "EMAGINE" STUDY)
https://clinicaltrials.gov/ct2/show/NCT05044507

Feb 3rd, 2023 - The study intervention will be initiated 4-21 days after the index stroke event and will consist of a total of 45 sessions over a period of 9 weeks (5 treatments per week). Each session will last 60 minutes during which 40 net minutes of active or sham study intervention using BQ 2.0 will be administered. Each study group will receive a standardized, pre-defined and evidence-based physical and ...

A Study of Modified Stem Cells in Stable Ischemic Stroke
https://clinicaltrials.gov/ct2/show/NCT01287936

Feb 3rd, 2023 - Chronic, stable stroke patients have no existing alternative treatments after rehabilitation therapy. SB623, a modified stem cell preparation, has been shown to improve motor function when administered in animal models of stable stroke. Safety studies in animals have shown no adverse events attributed to SB623. Patients who meet the entry criteria for this study will have regular examinations, ...