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About 147,573 results

Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
https://clinicaltrials.gov/ct2/show/NCT03414775

Sep 10th, 2021 - The gastrointestinal microbiome has been shown to be altered in critically-ill children such that there is a larger shift toward pathogenic bacteria. Previous studies have shown that probiotics, fecal transplants, antibiotic decontamination, and dietary interventions can shift the gastrointestinal microbiome toward a metabolically favorable microbiome profile and be associated with improvements...

Developing Non-Communicable Disease Registries in Africa : A Step Towards Providing Quality Data for Improving Patient Outcomes
https://clinicaltrials.gov/ct2/show/NCT03473795

Sep 10th, 2021 - This umbrella protocol seeks to develop robust data registries for non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) with the aim of providing accurate and comprehensive data for the evaluation of such diseases in sub-Saharan African countries.Healthy volunteers will be included in the study for comparison. Additionally, the investigators aim to describe the gut microbiome community ...

A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis
https://clinicaltrials.gov/ct2/show/NCT03521232

Sep 10th, 2021 - This will be a phase I/IIa, open-label, three-stage, single center study aimed at investigating the safety, the efficacy (clinical and endoscopic effects) and the pharmacokinetics of Niclosamide enema 150 mg/60 ml and 450 mg/60 ml in subjects with mild-to-moderate UP and UPS, defined as a Modified Mayo Score (MMS) ≥ 4 and < 8, with a stool frequency subscore (SFS) ≥ 1, a rectal bleeding sub-sco...

Prospective Follow-up of Elderly Patients Undergoing Instrumented Lumbar Arthrodesis Supplemented by the Implanet Jazz System(TM)
https://clinicaltrials.gov/ct2/show/NCT03434223

Sep 10th, 2021 - To collect and organize data into a repository from the Principal Investigator's and other Site Investigators' elderly patients (aged ≥ 60 years) who are undergoing single, two-level, or three-level lumbar instrumented arthrodesis procedures supplemented by the Implanet Jazz SystemTM at participating centers. This device is designed to provide a stable interface between spinal constructs and th...

Training Inhibition in Alcohol Use Disorder
https://clinicaltrials.gov/ct2/show/NCT03530384

Sep 10th, 2021 - Our hypothesis is that a computerized program aiming to retrain deficits involved in addiction in itself and not only due to alcohol toxicity i.e.inhibition training on tasks which do not refer to alcohol, combined with a debriefing promoting transferability of the enhanced skills, in addition to treatment as usual, is more effective than a control condition in addition to treatment as usual. T...

WAVES for Mal de Debarquement Syndrome
https://clinicaltrials.gov/ct2/show/NCT04612010

Sep 10th, 2021 - The main device class used in this study will be an app that was designed by one of the investigators. The app is called "WAVES" and can be run on either an Android or iOS platform. The program presents a split screen of flashing lights with a different frequency on each half screen. The frequency of the lights can be changed according to either standard parameters or parameters set by EEG metr...

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study
https://clinicaltrials.gov/ct2/show/NCT03724136

Sep 10th, 2021 - Cognition is the process of generating thoughts, recalling memories, processing information, and higher order associations including social interactivity that all take place in the brain. It requires sufficient health and interactivity of neurons in the brain including their ability to form and maintain synaptic connections. Cognitive impairment results from the loss of these abilities. ACIST w...

IV Tranexamic Acid Prior to Hysterectomy
https://clinicaltrials.gov/ct2/show/NCT02911831

Sep 10th, 2021 - Tranexamic acid (TXA) is a synthetic lysine analog that inhibits plasmin fibrinolysis. It may be administered orally, intravenously, or topically, with a rapid onset of action (tmax = appx 3 hours) and 11-hour half-life. It is 6 to 10 times more potent than aminocaproic acid, another commonly used synthetic antifibrinolytic agent. Typical IV dosing is 10 mg/kg followed by infusion of 1mg/kg/hou...

Incidence of Intracranial Hemorrhage in Glioma Patients With Venous Thromboembolism Converted From LMWH to Apixaban
https://clinicaltrials.gov/ct2/show/NCT04895553

Sep 10th, 2021 - Primary Objectives To estimate the incidence of intracranial hemorrhage (ICH) in glioma patients with history of venous thromboembolism (VTE) after the conversion from low molecular weight heparin (LMWH) injections to oral Apixaban. Secondary Objective To estimate the incidence of recurrent VTE in glioma patients with history of venous thromboembolism after the conversion from low molecular wei...

Assessing the Feasibility of an Intervention for Youth and Parents Transitioning to Adult Eating Disorder Services
https://clinicaltrials.gov/ct2/show/NCT04888273

Sep 10th, 2021 - Eating disorders (EDs) are severe psychiatric illnesses that negatively impact the health and quality of life of sufferers and their families. EDs typically begin in adolescence and often progress into adulthood, often requiring youth to transition from pediatric to adult mental health services. However, patients often experience a discontinuity in care due to a lack of coordinated transition b...

Neurologic Stem Cell Treatment Study
https://clinicaltrials.gov/ct2/show/NCT02795052

Sep 10th, 2021 - Various clinical studies have registered with the National Institutes of Health (NIH) to study neurologic diseases and damage. There have also been a number of journal reports of the benefits of treatment with BMSC for diseases and damage to nervous tissue. The investigators hope to add to the volume of literature regarding the use of BMSC in those neurologic diseases and conditions identified ...

Randomized Evaluation of Shenfu Injection to Reduce Myocardial Injury
https://clinicaltrials.gov/ct2/show/NCT04493840

Sep 10th, 2021 - Shenfu injection is a traditional Chinese medicine formulation containing ginseng (Panax; family: Araliaceae) and aconite (Radix aconiti lateralis preparata, Aconitum carmichaeli Debx; family: Ranunculaceae) with Ginsenosides and aconite alkaloids as the main active ingredients. Its quality is strictly controlled in compliance with the standard of the China Ministry of Public Health (official a...

Wake Forest Post-ICU Telehealth (WFIT) Program
https://clinicaltrials.gov/ct2/show/NCT04576065

Sep 10th, 2021 - Wake Forest Baptist Health (WFBH) discharges over 1,000 patients annually after a critical illness such as septic shock and/or acute respiratory failure. This number is expected to be even higher due to the ongoing coronavirus pandemic. To try to bridge this gap, the Wake Forest Intensive Care Unit (ICU) Recovery Clinic was created in 2014. WFBH ICU Recovery Clinic (1 of ~15 nationwide) uses a ...

Efficacy of Ginger on Intraoperative and Postoperative Nausea and Vomiting in Elective Cesarean Section Patients
https://clinicaltrials.gov/ct2/show/NCT01733212

Sep 10th, 2021 - Two hundred and thirty nine ASA class I and II patients, scheduled for elective c-section will be assigned randomly to receive either 1g ginger tablet PO (Group 1) or 1 g placebo PO (Group 2) preoperatively, immediately before surgery. The usual preoperative anti-emetic and antacid regimen will be continued for both groups. Initial blood pressure, pulse and hemoglobin and hematocrit will be doc...

PIRA vs Standard Preoperative Education
https://clinicaltrials.gov/ct2/show/NCT04586569

Sep 10th, 2021 - The purpose of this study is to determine the feasibility and acceptability of enhanced preoperative education using a Pediatric Interactive Relational Agent (PIRA), designed for children ages 4 through10 years and their families, compared to the standard preoperative education currently provided. The study will also look at any differences in anxiety between the two educational groups.

Collecting Information About Treatment Results for Patients With Cushing's Syndrome
https://clinicaltrials.gov/ct2/show/NCT03364803

Sep 10th, 2021 - The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.

Sepsis: From Syndrome to Personalized Care
https://clinicaltrials.gov/ct2/show/NCT04203979

Sep 10th, 2021 - The study will prospectively include adult patients (>18 years) with suspected sepsis admitted to Oslo University Hospital, Ullevål (OUH-Ullevål). Patients admitted to the emergency department and managed by the medical rapid response team or the sepsis rapid response team are considered eligible for inclusion. Informed consent will be collected at the emergency department if possible, or withi...

Efficacy of a Novel Hemostatic Powder in GI Bleeding
https://clinicaltrials.gov/ct2/show/NCT02595853

Sep 10th, 2021 - Hemospray™ is a new endoscopic hemostatic powder. Aims of this multicenter prospective study is to determine effectiveness of Hemospray™ on short and medium term in different clinical situations, predictive factors of rebleeding after Hemospray™ application, and feasibility of the application of hemostatic powder in routine clinical practice studying in a large sample of patients.

Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
https://clinicaltrials.gov/ct2/show/NCT04291092

Sep 10th, 2021 - To evaluate the efficacy and safety of Camrelizumab Combined with Chemotherapy and Local Treatment of brain metastases (WBRT, r-knife, SRS, etc.) in non-small cell lung cancer patients with brain metastases .

INTERCOMEX Donor-Derived Cell Free DNA Study
https://clinicaltrials.gov/ct2/show/NCT04239703

Sep 10th, 2021 - There is a need for better screening of kidney transplant patients for rejection. Patients with kidney transplants are routinely tested (creatinine, urine protein, histology and donor specific antibody (DSA) as standard of care to detect rejection, but these tests are not adequate. Rejection is often missed by these tests (false negatives) and other processes such as acute kidney injury can pro...