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About 19,938 results

The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose
https://clinicaltrials.gov/ct2/show/NCT04977479

Jun 24th, 2022 - Study Description: This is a single-site study to determine the safety of administering a dose of the Pfizer-BioNTech mRNA coronavirus disease 2019 (COVID-19) vaccine (Comirnaty) to individuals who experienced a systemic allergic reaction to their first full dose of the same vaccine or the Moderna mRNA vaccine, and to investigate possible mechanisms underlying allergic reactions. Objectives: Pr...

A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans
https://clinicaltrials.gov/ct2/show/NCT04852289

Jun 24th, 2022 - STUDY DESCRIPTION: This study is to identify SARS-CoV-2 S protein specific CD8 T cells in the blood of COVID-19 vaccinated participants. Pfizer and Moderna made vaccines will be used in this study. As both vaccines are mRNA based encoding S protein of SARS-CoV-2 and require two doses, the CD8 T cell response is expected to be comparable. We will also measure general health factors using blood s...

Emotional, Social, Cognitive and Behavioral Sequalae of the COVID-19 Pandemic
https://clinicaltrials.gov/ct2/show/NCT04823988

Jun 24th, 2022 - Title: Emotional, Social, Cognitive and Behavioral sequalae of the COVID-19 pandemic Study Description: The goal of this protocol is to examine individual consequences of the COVID-19 pandemic, in the transition resolution phase with the arrival and distribution of the vaccine. Specifically, this protocol will capture the 'after-effects' of the pandemic at all levels of functioning (cognitive, ...

Natural History Study of COVID-19 Using Digital Wearables
https://clinicaltrials.gov/ct2/show/NCT04927442

Jun 24th, 2022 - Study Description: COVID-19 patients experience varying degrees of illness. Factors associated with prolonged illness remain unknown especially in outpatients. This study uses digital wearables to collect high-resolution physiological data to understand the clinical course of COVID-19 in patients with a positive COVID-19 diagnosis. We hypothesize that wearables-based physiological data are asso...

A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects
https://clinicaltrials.gov/ct2/show/NCT04880642

Jun 24th, 2022 - The trial consists of 3 consecutive periods: a screening period of up to 48 hours, a 2-week IMP treatment period and a follow-up period of up to 7 weeks after last IMP intake. All subjects will undergo a series of efficacy, safety, and laboratory assessments. Safety laboratory tests and samples for future exploratory analysis will be obtained at the screening visit. The trial duration for an in...

The Impact of the COVID-19 Pandemic on Eating Behavior and Weight Change
https://clinicaltrials.gov/ct2/show/NCT04896060

Jun 24th, 2022 - Study Description: We will recruit previous NIDDK study participants as well as newly recruited individuals from the general population to examine how the COVID-19 pandemic has exacerbated the impact of psychosocial stressors that impact eating behavior and weight. The study will describe the relationship between specific COVID-19 related stressors (e.g. fear of becoming sick) and self-rated me...

Effects of Bronchial Segmental Endotoxin Instillation in Humans
https://clinicaltrials.gov/ct2/show/NCT02392442

Jun 24th, 2022 - Defining the mechanisms that limit tissue injury during acute inflammation may provide the basis for preventing secondary organ dysfunction during serious infections. We plan to use the human endotoxin lung challenge model to study mechanisms associated with the initiation and resolution of lung inflammation. Endotoxin (LPS), an outer membrane component of Gram-negative bacteria, is a major mic...

Surveillance of Individuals Following SARS-CoV-2 Infection
https://clinicaltrials.gov/ct2/show/NCT04383444

Jun 24th, 2022 - Study Description: This is a prospective longitudinal cohort study of individuals who have recently tested positive or are highly suspected to be positive for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV- 2) infection. The aim is to correlate results of reverse transcription-polymerase chain reaction (RT-PCR) using various sample types, assays, and culture. We will enroll individua...

Health Care Use During the Covid19 Crisis
https://clinicaltrials.gov/ct2/show/NCT04372030

Jun 24th, 2022 - Context: Belgium has put in place confinement measures on March 13th 2020 with the aim to reduce contagion related to Covid19 in the population and manage the number of patients to be treated in the hospital. However, some weeks after those confinement measures, health care professionals are worry about other patients than Covid19 since they have observed a significantly lower use of emergency ...

Mental Health Impact of COVID-19 Pandemic on NIMH Research Participants and Volunteers
https://clinicaltrials.gov/ct2/show/NCT04339790

Jun 24th, 2022 - Study Description: This protocol leverages existing NIMH studies and participants to accomplish time-sensitive research on the mental health impact of environmental stressors imposed by the COVID-19 pandemic. The study will describe the relationship between stressors related to COVID-19 and self-rated measures of mental health symptoms and distress among a range of participants including variou...

Transmissibility and Viral Load of SARS-CoV-2 in Oral Secretions
https://clinicaltrials.gov/ct2/show/NCT04348240

Jun 24th, 2022 - COVID-19 is a worldwide pandemic without an effective therapy. A series of reports have implicated that asymptomatic transmission occurs in at least 25% SARS-CoV-2 cases. We hypothesize that droplet emission from oral fluids generated during speaking could be an important and actionable factor driving asymptomatic transmission. We aim to collect oral and nasal secretions, conjunctival fluid and...

SARS-COV2 Pandemic Serosurvey and Blood Sampling
https://clinicaltrials.gov/ct2/show/NCT04334954

Jun 24th, 2022 - It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-COV2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population. ...

Plasma Collection From Convalescent and/or Immunized Donors for the Treatment of COVID-19
https://clinicaltrials.gov/ct2/show/NCT04360278

Jun 24th, 2022 - Emerging infectious diseases such as the Coronavirus disease 2019 (COVID-19) pandemic cause substantial morbidity and mortality. During the early emergent phases of such diseases, there is often no vaccine to prevent infection, nor specific therapeutic agent to treat the disease. The objective of this protocol is the collection of immune plasma from persons post-recovery from COVID-19 or vaccin...

Investigation of the B- and T-cell Repertoire and Immune Response in Patients With Acute and Resolved COVID-19 Infection
https://clinicaltrials.gov/ct2/show/NCT04362865

Jun 24th, 2022 - Background: Patients infected with COVID-19 have an unpredictable risk to worsen and die, making it difficult to decide who can quarantine at home and who should be monitored for respiratory failure as an inpatient. This risk may be related in part to the patient s immune response which can be characterized with respect to the B- and T-cell repertoire. Determining patterns of immune response wh...

Study of Lung Proteins in Patients With Pneumonia
https://clinicaltrials.gov/ct2/show/NCT00077909

Jun 24th, 2022 - OBJECTIVE: The objective of this study is to analyze bronchoalveolar lavage (BAL) fluid from patients with lung infiltrates in order to discover new biomarkers and protein/peptide expression patterns that are associated with specific types of pulmonary diseases and infections. Bronchoalveolar lavage (BAL) is a standard method to obtain lower airway samples to evaluate pulmonary infiltrates in o...

A Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases
https://clinicaltrials.gov/ct2/show/NCT05035420

Jun 24th, 2022 - Study Description: This observational pilot study will characterize the performance of a multimodal biosensor device (a portable and a wireless NIRS device, PPG and temperature sensor) in measuring human vital signs, which later will be explored as a point-of-care method for screening and treatment response monitoring of individuals with an infectious respiratory illness. The devices will ...

Stereotype Threat Effect On the Performance of the Non-Intensivist Physicians Assigned in Covid-19 Intensive Care Unit
https://clinicaltrials.gov/ct2/show/NCT05074446

Jun 24th, 2022 - Stereotype threat (ST) is an important issue that has been studied repeatedly in the psychology literature. ST is the thought that a person will be negatively evaluated and judged regarding a negative stereotype that belongs to the group to which he/she belongs. Most people are members of a social group associated with at least one negative stereotype. Therefore, many people in society may be t...

Respiratory Physiotherapy and Neurorehabilitation in Patients With Post-covid19 Sequelae.
https://clinicaltrials.gov/ct2/show/NCT05195099

Jun 24th, 2022 - The objectives are to reduce dyspnoea, increase exertional capacity, increase vital capacity and respiratory muscle strength. vital capacity and respiratory muscle strength. In addition to increasing the sensibility of smell and taste, observing if there is a relationship between the decrease of these senses with the senses with appetite and whether appetite has normalised in post-SARS-CoV-2 pa...

Effect of Lactoferrin in Pneumonia Treatment
https://clinicaltrials.gov/ct2/show/NCT05431023

Jun 24th, 2022 - Lactoferrin (LF) is iron-binding glycoprotein of the transferrin family that is expressed and secreted by glandular cells and is found in most body fluids . It appears at especially high concentrations in mammalian milk and was first identified in bovine milk , and was subsequently isolated from human milk. LFs bacteriostatic function is due to its ability to take up the Fe3+ ion, limiting use ...

Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function
https://clinicaltrials.gov/ct2/show/NCT02743468

Jun 24th, 2022 - This is a prospective, cross-sectional study designed to provide a consistent method for obtaining biological samples and respiratory health-related information from participants for use in research that evaluates lung function (e.g., responses to environmental agents such as air pollution particles, engineered nanomaterials, or immune ligands; the role of genetics on cellular responses or func...