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About 41,243 results

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
https://clinicaltrials.gov/ct2/show/NCT03797378

Oct 14th, 2022 - The proposed intervention efficacy trial examines a remotely-delivered, rhythmic-based movement-2-music (eM2M) intervention with 108 adults with physical/mobility disabilities who are randomized into one of two groups: a) eM2M or b) waitlist control. The primary aim is to determine the effects of a 12-week eM2M intervention on physical and psychosocial health outcomes in participants with physi...

Serratus Anterior Block and Catheter Use in Rib Fractures in the Emergency Department
https://clinicaltrials.gov/ct2/show/NCT03711812

Oct 14th, 2022 - The main aim of this study is to determine whether Serratus Anterior Plane (SAP) blockade provides improved pain relief after rib fractures compared to epidural administration of local anaesthetic. The investigators aim to show that SAP catheters (SAPC) can be placed in more situations and are less operator-dependent then thoracic epidural anaesthesia (TEA). This reduces the waiting time requir...

Estimating Brain Biomechanics Using MRI
https://clinicaltrials.gov/ct2/show/NCT01633268

Oct 14th, 2022 - Objective In this study we will develop and apply imaging techniques to perform the first three-dimensional (3-D) measurements of brain biomechanics during mild head movement in healthy human subjects. Biomechanics is the application of mechanics, or the physical principles in action when force is applied to an object, to the anatomical structure and/or function of organisms. Such techniques wi...

Using Virtual Reality to Improve Job Reentry in Adults With TBI
https://clinicaltrials.gov/ct2/show/NCT04820634

Oct 14th, 2022 - The current study will examine a virtual reality (VR) intervention entitled "Virtual Reality Job Interview Training (VR-JIT)" which targets social competency skills needed for successful job interviewing, and its efficacy when applied to individuals with traumatic brain injury (TBI). Preliminary evidence suggests that the VR-JIT is successful in individuals with autism spectrum disorder and sch...

Post-market Assessment of Biodesign Dural Repair Grafts
https://clinicaltrials.gov/ct2/show/NCT04057157

Oct 14th, 2022 - The purpose of this clinical study is to gather post-market clinical evidence on the use of the Biodesign® Dural and Duraplasty Grafts when used as a dura substitute of the dura mater.

The Use of a Platform Wound Device for Reducing Infection
https://clinicaltrials.gov/ct2/show/NCT04753723

Oct 14th, 2022 - This is a prospective, randomized, controlled clinical trial comparing the use of a platform wound device as compared to standard of care to prevent or eliminate infection in torso and extremity wounds. Patients 18-85 years of age admitted for treatment of open wound(s) will be screened for inclusion criteria and asked to consent to participate in the randomized study. The first 10 patients wil...

Physical and Mental Practice for Bimanual Coordination Rehabilitation
https://clinicaltrials.gov/ct2/show/NCT03817086

Oct 14th, 2022 - Moderate and severe Traumatic Brain Injury (TBI) commonly causes upper extremity physical impairments that persist even after years of injury; these deficits are attributed to damage in brain structure and changes in structural and functional connectivity. Bimanual coordination deficits and muscle weakness have a significant impact on TBI survivors' well-being, and conventional therapy did not ...

PMZ-1620 (Sovateltide) in Mild to Moderate Alzheimer's Disease
https://clinicaltrials.gov/ct2/show/NCT04052737

Oct 14th, 2022 - Alzheimer's is not just a disease of old age, approximately 200,000 Americans under the age of 65 having younger-onset Alzheimer's disease (AD). In 2015, there were approximately 29.8 million people worldwide with AD. The person with Alzheimer's disease can live an average of eight years after their symptoms become noticeable to others, but survival range is 4 to 20 years, depending on the age ...

The Effects of Chronic Exposure to Low-Level Blasts
https://clinicaltrials.gov/ct2/show/NCT01524822

Oct 14th, 2022 - The purpose of this study is to evaluate the cognitive and neurophysiological effects of chronic exposure to repeated low-level blast overpressure. Previous studies show converging evidence for a neurophysiological effect from cumulative exposure to blast, which is consistent with subjective reports of cognitive impairment by individuals trained to use explosives to gain entry to structures (br...

Ultrasound-Guided Treatments for Shoulder Pain in Wheelchair Users With Spinal Cord Injury
https://clinicaltrials.gov/ct2/show/NCT04136743

Oct 14th, 2022 - This is randomized controlled trial to determine the efficacy of autologous, micro-fragmented adipose tissue (MFAT) injection under ultrasound guidance for chronic, nonresponsive shoulder pain due to rotator cuff disease (i.e., rotator cuff tendinopathy) in persons with spinal cord injury (SCI). The control for this study, to which MFAT will be compared, is corticosteroid injection into the sub...

Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS)
https://clinicaltrials.gov/ct2/show/NCT03372525

Oct 14th, 2022 - Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membran...

Role and Molecular Mechanism of Farnesoid X Receptor(FXR) and RIPK3 in the Formation of Acute Respiratory Distress Syndrome in Neonates
https://clinicaltrials.gov/ct2/show/NCT02598648

Oct 14th, 2022 - Divided into 3 Arms ALI :Diagnostic criteria: 1.Acute onset;2.FiO2/ PaO2< 40.0 kPa (300mmHg, ALI); 3.Chest X-ray showed that the double lung texture increased, the increase of crude, fuzzy, visible diffuse patchy infiltration shadow with compensatory emphysema, for the most early performance; B. double lung field large sheet, asymmetric, edge fuzzy infiltration shadow, the most dense in the lu...

Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury
https://clinicaltrials.gov/ct2/show/NCT01287156

Oct 14th, 2022 - Objective This screening and registry protocol is designed to facilitate subject recruitment for the Center for Neuroscience and Regenerative Medicine (CNRM) sponsored clinical research studies on traumatic brain injury (TBI) at the National Institutes of Health (NIH) and participating CNRM sites. This protocol will serve as a first step for evaluating subjects for possible inclusion in CNRM sp...

Intravenous Fluid Administration's Effect on Pediatric Lumbar Puncture
https://clinicaltrials.gov/ct2/show/NCT05302765

Oct 14th, 2022 - Lumbar Puncture is a common procedure performed in the Pediatric Emergency Department. This procedure is often performed to assess the cerebrospinal fluid for infection. At Children's of Alabama, approximately 75% of patients undergoing this procedure are ages 3 months of age or younger. There is hypothesis that intravenous fluid administration prior to performing a lumbar puncture in this age ...

RibFix Advantage™ Post-Market Follow-Up
https://clinicaltrials.gov/ct2/show/NCT05179005

Oct 14th, 2022 - Retrospective review of subject demographic and hospital data with a prospective follow-up component evaluating clinical outcomes and quality of life for patients receiving RibFix Advantage for surgical stabilization of rib fractures from 2019 to 2021

A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery...
https://clinicaltrials.gov/ct2/show/NCT05253209

Oct 14th, 2022 - This is a randomized, double-blind, placebo controlled, multicenter study that will compare the efficacy and safety of L- citrulline versus placebo in patients undergoing surgery for congenital heart defects. Eligible patients undergoing repair of a large unrestrictive ventricular septal defect (VSD), a partial or complete atrioventricular septal defect (AVSD), or an ostium primum atrial septal...

Florida Cerebrovascular Disease Biorepository and Genomics Center
https://clinicaltrials.gov/ct2/show/NCT05491980

Oct 14th, 2022 - The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from families affected by cerebrovascular disease. The information and blood samples collected may be used in future research for the study of cerebrovascular disease and to learn about, prevent or trea...

All-Inside Single-Bundle for Anterior Cruciate Ligament Reconstruction With Full Thickness of the Peroneus Longus Tendon Compared to the Six-strand-hamstring Autograft (ACL)
https://clinicaltrials.gov/ct2/show/NCT05580133

Oct 14th, 2022 - prospective randomized clinical study to compare the results of all-inside anatomical ACL reconstruction using the AHPLT and using Six-strand- tendon autograft. Randomization will be done with inclusion criteria of primary ACL rupture in adult patients and exclusion criteria of serious osteoarthritis, revision cases, and multiple ligament injuries. Preoperatively, physical examinations includin...

An Investigation of the Effect of Types of Catheters on Bloodstream Infection in Patients With Major Burns: Prediction With Procalcitonin and Prognosis
https://clinicaltrials.gov/ct2/show/NCT05581316

Oct 14th, 2022 - Aim: Bloodstream infections and catheter-related infections frequently occur in burn patients. It is important to correctly assess and manage these infections. The present study aimed to investigate the effects of catheter types used in major burn patients on bloodstream infections as well as to predict sepsis status and manage its prognosis using a procalcitonin biomarker. Materials and Method...

Wrist Arthroscopy During Surgical Treatment of Distal Radius Fractures
https://clinicaltrials.gov/ct2/show/NCT05580848

Oct 14th, 2022 - Wrist arthroscopy (WA) is a potentially useful adjuvant procedure in the surgical treatment (osteosynthesis) of distal radius fractures (DRFs). Previous research on the contribution of WA to DRF treatment has shown different results. Objectives of the study: (1) Validate wrist funcional outcome questionnaires; (2) To determine whether arthroscopically assisted repositioning of fracture fragment...