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About 43,090 results

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
https://clinicaltrials.gov/ct2/show/NCT02717559

Mar 31st, 2023 - The purpose of this study is to identify risk factors for signs and symptoms of osteoarthritis two and ten year post ACL reconstruction from information available at the time of surgery. Hypothesis: Smoking status, older age, higher BMI, increased severity of cartilage injuries, increased meniscal resection, revision surgery, and incidence of additional arthroscopic procedures will result in mo...

A Post Market Study to Confirm the Safety and Performance of the Signia™ Stapling System.
https://clinicaltrials.gov/ct2/show/NCT03515811

Mar 31st, 2023 - This study will evaluate the use of Signia™ Stapling System using Signia™ Intelligent Loading Units with Tri-Staple™ 2.0 Intelligent Reloads in indicated abdominal or thoracic procedures (e.g., resection, transection of tissue, and creation of anastomoses). Subjects who meet the eligibility criteria will be considered for study participation at a minimum of 10 sites and will be followed up to a...

Eso-Sponge Registry
https://clinicaltrials.gov/ct2/show/NCT02662777

Mar 31st, 2023 - Anastomotic Leakages or other defects in the upper gastrointestinal tract can have serious consequences for the affected patients. Different parameters, like the size, location, time to diagnosis of the lesion, but also the general condition of the patient, have a significant influence on the clinical outcome of the patient. Often this situation is accompanied by symptoms of sepsis and a signif...

Register With Patients in Which Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) Was Performed
https://clinicaltrials.gov/ct2/show/NCT01617382

Mar 31st, 2023 - To register the follow-up data of patients who, because of a peritoneal surface malignancy, will undergo cytoreductive surgery and HIPEC. In this surgical intervention, the abdominal cavity is macroscopically cleared of tumor, by removing all visible tumor nodules, and is subsequently rinsed with hyperthermic (heated) chemotherapy, aiming to destroy all residual invisible tumor cells that might...

Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study
https://clinicaltrials.gov/ct2/show/NCT03414411

Mar 31st, 2023 - Up to a third of middle-aged people living with HIV infection (PLWH) experience falls each year. Falls are the most common cause of non-fatal injury in the US and the cost from emergency department visits and hospitalizations are enormous. PLWH are more susceptible to falls and their serious consequences because 1) despite control of HIV viremia, inflammation persists and underlies HIV-associat...

The Feasibility and Effects of Low-load Blood-flow Restricted Exercise Following Spinal Cord Injury
https://clinicaltrials.gov/ct2/show/NCT03690700

Mar 31st, 2023 - BACKGROUND Spinal cord injury (SCI) represents a major health concern; the World Health Organization estimates an incidence of 250,000 to 500,000 per year worldwide. On average in Denmark we register 130 new cases of SCI per year. SCI is a devastating condition, in which paresis/paralysis of the skeletal muscles below the injury site results in a partial or complete inability to walk, move and/...

Multicenter ACL Revision Study (MARS)
https://clinicaltrials.gov/ct2/show/NCT00625885

Mar 31st, 2023 - Injury to the anterior cruciate ligament (ACL) results in a threat to an active lifestyle and exposes the patient to risk of osteoarthritis. ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. The results of primary ACL reconstruction have in general been good at restoring functional stability. Primary ACL reconstruction has a gr...

Reduction of Concussion Symptoms Through the Use of Osteopathic Manipulative Therapy
https://clinicaltrials.gov/ct2/show/NCT04063618

Mar 31st, 2023 - Concussion incidence in high school and collegiate sports is high, especially in football. These injuries have become the focus of the sports world, as coaches, trainers, and medical personnel are more vigilant than ever in screening for concussions. Once diagnosed, return to play is dependent on recovery from symptoms followed by a specific protocol for clearance; the sooner the symptoms subsi...

CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection
https://clinicaltrials.gov/ct2/show/NCT04962646

Mar 31st, 2023 - Aortic dissection is a life-threatening condition and a consequence of a tear of the innermost of the three aortic layers- the intima. When a tear occurs, blood surges through the tear and causes the flow of blood between the aortic layers, causing a "false lumen". This causes a weakening of the aortic wall and hinders the blood from reaching its target organs and life saving emergent surgery i...

Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients
https://clinicaltrials.gov/ct2/show/NCT04141501

Mar 31st, 2023 - Two billion people globally consume alcohol, leading in 2016 to 2.8 million deaths (5.2% of all deaths) and 99.2 million Disability Adjusted Life Years (DALYs) lost (4.2% of all DALYs). Of all the diseases, conditions, and injuries attributable to alcohol use, alcohol use disorders (AUDs) create the largest health burden globally. However, approved pharmacological treatments for alcoholism are ...

Reduction of Surgical Site Infections in Elective Colorectal Surgery After the Implementation of a Bundle of Care.
https://clinicaltrials.gov/ct2/show/NCT04129177

Mar 31st, 2023 - Surgical location infection (ILQ) is the most frequent complication of surgery and an important source of clinical and economic problems for health systems. The reduction of its incidence is important because of its impact on patient comfort and the health resources used. The ILQ includes the categories of: superficial incisional (IIS, affects skin and subcutaneous tissue); deep incisional (IIP...

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up
https://clinicaltrials.gov/ct2/show/NCT00478894

Mar 31st, 2023 - The purpose of this study is identify risk factors for signs and symptoms of osteoarthritis two and ten year post ACL reconstruction from information available at the time of surgery; including patient characteristics (age, gender, body mass index (BMI), activity level, clinical knee alignment), their injuries ("pop" heard at the time of injury, concurrent meniscus, articular cartilage, and col...

Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
https://clinicaltrials.gov/ct2/show/NCT00463099

Mar 31st, 2023 - Disruption of the anterior cruciate ligament (ACL) is among the most frequent musculoskeletal injuries affecting physically active men and women. An estimated 200,000 ACL reconstructions (ACLR) are performed annually, and the incidence of this injury is roughly 1 in 3000 per year. ACL injury has both immediate and long-term implications for an injured person's quality of life, their risk for os...

Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures
https://clinicaltrials.gov/ct2/show/NCT03385304

Mar 31st, 2023 - The prevention of infection is the single most important goal influencing peri-operative care of patients with open fractures. Standard practice in the management of open fractures includes sterile technique and pre-operative skin preparation with an antiseptic solution. The available solutions kill bacteria and decrease the quantity of native skin flora, thereby decreasing surgical site infect...

This is a Study to Verify if Periarticular Hip Injection of Corticosteroid After Hip Replacement Reduce the Pain and the Hospitalisation Time
https://clinicaltrials.gov/ct2/show/NCT05023369

Mar 31st, 2023 - Hip endoprothesis is a common orthopaedic prosthetic procedure, with continuously growing numbers in the last years, and the demand for this procedure is predicted to increase 4-fold by 2030. Recently, major interest has been given to improve postoperative pain management, to decrease the discomfort of the patients and with an outlook for reducing the length of hospital stay and decrease health...

Anterior Cruciate Ligament (ACL) Reconstruction- Bioabsorbable Screw
https://clinicaltrials.gov/ct2/show/NCT01069588

Mar 31st, 2023 - This study will combine the use of survey response, MRI, and x-rays of the knees in Dr. Spindler's ACL reconstructed patients in order to examine long term healing of two types of bioabsorbable screw. We will use a 2-4 yr time point to look at patient reported symptoms of pain and swelling from the surveys and use the x-rays and MRIs to look at absorption of the screw, healing of the graft, and...

Ketogenic Diet for Traumatic Brain Injury
https://clinicaltrials.gov/ct2/show/NCT03982602

Mar 31st, 2023 - Traumatic Brain Injury (TBI) is a major health concern for United States contributing nearly one-third of injury-related deaths in United States. The Centers for Disease Control and Prevention (CDC) estimates that 1.7 million people in the United States sustain a TBI each year. It is responsible for significant disabilities and the total cost of productivity loss was estimated to be $76.5 billi...

Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
https://clinicaltrials.gov/ct2/show/NCT04684719

Mar 31st, 2023 - Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in patients at risk of hemorrhagic shock and to appropriately characterize the hemostatic competency of whole blood relative to its age.

Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study
https://clinicaltrials.gov/ct2/show/NCT03165331

Mar 31st, 2023 - A visible difference can have a profound impact in a society with a massive emphasis on appearance and "looks". A vulnerable group is adolescents with a condition affecting their appearance as a result of injuries (burns, accidents), treatment (cancer), skin conditions or congenital anomalies (birthmarks, craniofacial conditions). Research has identified potential psychological difficulties, wh...

Electrophysiological Evaluation of Voluntary Attention
https://clinicaltrials.gov/ct2/show/NCT02567201

Mar 31st, 2023 - Aim : To assess the ability of healthy subjects and patients with a severe motor disability to voluntary control their attention Material and Methods: Population: healthy subjects, patients with brain injury Electroencephalographic study to research attentional modulation during different kind of stimulation (visual, auditory, tactile) Sudy 1: passive recording. Study 2: active recording (instr...