×
About 35,690 results

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study
https://clinicaltrials.gov/ct2/show/NCT03724136

Sep 10th, 2021 - Cognition is the process of generating thoughts, recalling memories, processing information, and higher order associations including social interactivity that all take place in the brain. It requires sufficient health and interactivity of neurons in the brain including their ability to form and maintain synaptic connections. Cognitive impairment results from the loss of these abilities. ACIST w...

Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer
https://clinicaltrials.gov/ct2/show/NCT03716583

Sep 10th, 2021 - The study will be a randomized, placebo-controlled, double-blinded clinical pivotal trial. Patients will be allocated in a ratio of 1:1 to the melatonin or placebo group. Patients will be stratified according to the type of surgery (lumpectomy or mastectomy). Randomization will be performed in blocks of randomized sizes. The study will be performed in the Department of Oncology, Rigshospitalet,...

Executive Functions and Preterm Children in 11 to 12 Year Old
https://clinicaltrials.gov/ct2/show/NCT03700619

Sep 10th, 2021 - It is an epidemiologic, observational, prospective study. All patients, included in the LIFT cohort, in 11 to 12 year old during the period study, are contacted by mail. Patients with congenital anomalies or genetic syndromes are excluded. Children with parents who do not speak French are excluded. Antenatal and postnatal criteria known to be associated with disorders of executive functions are...

Neurologic Stem Cell Treatment Study
https://clinicaltrials.gov/ct2/show/NCT02795052

Sep 10th, 2021 - Various clinical studies have registered with the National Institutes of Health (NIH) to study neurologic diseases and damage. There have also been a number of journal reports of the benefits of treatment with BMSC for diseases and damage to nervous tissue. The investigators hope to add to the volume of literature regarding the use of BMSC in those neurologic diseases and conditions identified ...

Effectiveness of a Preoperative Educational Video for Reducing Opioid Consumption After Hand Surgery
https://clinicaltrials.gov/ct2/show/NCT04625868

Sep 10th, 2021 - This study seeks to determine if watching a preoperative educational video influences opioid consumption and proper disposal following elective hand surgery. Patients undergoing elective hand surgery are randomized to either watch a preoperative educational video or not. Patients are asked to record their pain medication usage postoperatively, as well as their daily pain levels and satisfaction...

Nantou Hospital, Regional Teaching Hospital
https://clinicaltrials.gov/ct2/show/NCT04697342

Sep 10th, 2021 - The incidence of crush is one of the important indicators of the quality of health care in various medical institutions in the world. The Taiwan Hospital Evaluation and Medical Quality Council (referred to as the Medical Policy Council) listed crush as a quality indicator of clinical care in 2011 (Taiwan Clinical Effectiveness indicator system, 2011), the incidence of crush is also a sensitive ...

Physical Restraint of Critically Ill Patients
https://clinicaltrials.gov/ct2/show/NCT04771793

Sep 10th, 2021 - Background: Physical restraint of patients in the intensive care unit (ICU) is a common practice, with estimated prevalence of 50% of all ICU patients, with and without invasive ventilation support(1). The prevalence of physical restraint varies between ICU's according to patient population (surgical, cardiac, trauma, burns and general intensive care patients). In mechanically ventilated patien...

STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon
https://clinicaltrials.gov/ct2/show/NCT03935750

Sep 10th, 2021 - Anterior cruciate ligament reconstruction (ACLR) is complicated by high failure rates in young, active individuals, which is associated with worse outcomes and higher rates of osteoarthritis (OA). ACLR failure reduces quality of life (QOL) and has substantial socioeconomic costs. Therefore, strategies to reduce ACLR failure are imperative. Lateral extra-articular tenodesis (LET) may provide gre...

Objective Dual-task Turning Measures for Return-to-duty Assessments
https://clinicaltrials.gov/ct2/show/NCT03892291

Sep 10th, 2021 - The purpose of this project is to expand the investigators' prior preliminary work on wearable sensors to evaluate objective dual-task turning measures for use as rehabilitative outcomes and as tools for objective return-to-duty assessments following mild traumatic brain injury (mTBI). The investigators will assess the diagnostic accuracy, predictive capacity, and responsiveness to intervention...

Increasing Insulin Resistance as a Predictor of Impending Bacteremia
https://clinicaltrials.gov/ct2/show/NCT04992689

Sep 10th, 2021 - Insulin resistance is defined as a decrease in the ability of insulin to lower blood glucose levels. Various pathological conditions can cause an increase in insulin resistance, such as sepsis, administration of certain medications, various stressful situations, surgery or significant injuries, etc. Sepsis can cause extreme stress, which causes significant changes in metabolism, disruption of b...

LITES Task Order 0005 Prehospital Airway Control Trial (PACT)
https://clinicaltrials.gov/ct2/show/NCT04100564

Sep 10th, 2021 - The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outc...

Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study
https://clinicaltrials.gov/ct2/show/NCT00779324

Sep 10th, 2021 - PURPOSE OF PROJECT: To study the effect of amantadine 100 mg administered twice daily compared to placebo on irritability from baseline to treatment Day 28. SUMMARY OF PROJECT: It is anticipated that 168 subjects with 168 corresponding subject informants will be recruited for the study. Carolinas Rehabilitation, the lead center, and 5 collaborating centers will enroll approximately 28 subjects ...

Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
https://clinicaltrials.gov/ct2/show/NCT04044872

Sep 10th, 2021 - The global burden of cancer continues to rise with an incidence of 17.5 million cancer cases worldwide. Approximately 50% of all cancer patients receive radiation therapy as a component of their cancer care. While radiation therapy has demonstrable benefit in improving survival in patients with many types of malignancies, cardiotoxicity is a major concern in patients receiving chest radiotherap...

Distal Radius Fractures in Patients Over 65 Years, Operation or Cast?
https://clinicaltrials.gov/ct2/show/NCT02336035

Sep 10th, 2021 - The investigators want to investigate if there is a difference between operative treatment with volar locking plates and cast immobilization in patient above 65 years with unstable distal radius fractures AO/OTA type A and C . Eligible patients that meets the radiological criteria (see inclusion criteria) will be randomized to cast immobilization or operation with volar locking plate. The inves...

Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study
https://clinicaltrials.gov/ct2/show/NCT03225625

Sep 10th, 2021 - The Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality (SciExVR) study is based on the progress that researchers have made treating spinal cord injury (SCI) with bone marrow derived stem cells (BMSC). While major improvements have remained elusive with other approaches, modest benefits have been achieved. The use of subarachnoid BMSC provided via intrathecal injection has resulted in ...

STaR Trial: Multiple Ligament Knee Injuries
https://clinicaltrials.gov/ct2/show/NCT03543098

Sep 10th, 2021 - Background: Multiple ligament knee injuries (MLKIs) represent a spectrum of injury ranging from disruption of two ligaments to all four major ligaments of the knee. Concomitant injuries may include fractures and injuries to vessels, nerves, tendons, menisci and/or articular cartilage. As such, the treatment of MLKIs creates multiple complex problems fraught with complications such as poor wound...

CEUS for Blunt Abdominal Trauma in Children
https://clinicaltrials.gov/ct2/show/NCT03490929

Sep 10th, 2021 - In children with abdominal trauma, computed tomography (CT) of the abdomen is considered the gold standard for the initial evaluation of solid organ injuries. The major drawbacks to CT include risks due to radiation exposure and necessity of transport of the patient. Ultrasound without contrast uses safer non-ionizing radiation and can be performed at the bedside, however it has been shown to h...

Wearable Vibration Effect on Biomechanics and Biomarkers After ACL Reconstruction
https://clinicaltrials.gov/ct2/show/NCT05001594

Sep 10th, 2021 - The objective of this study is to investigate the effect of treatment for ACL reconstruction, including vibrational stimulation and pressure, on locomotion tasks (i.e. walking, stair ascending and descending), muscle function, and pain/function.

Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Inj...
https://clinicaltrials.gov/ct2/show/NCT04295538

Sep 10th, 2021 - Acute Spinal Cord Injury (SCI) is a rare injury that leads to permanent neuromotor impairment and sudden disability. Approximately 25,000 people experience cervical SCI in the United States, Europe, and Japan every year. The purpose of this study is to see if elezanumab is safe and assess change in Upper Extremity Motor Score (UEMS) in participants with acute traumatic cervical SCI. Elezanumab ...

A PMCF Investigation on Exuding Chronic Wounds Using Exufiber® as Primary Dressing, and Mepilex® Border Flex/Comfort
https://clinicaltrials.gov/ct2/show/NCT04960553

Sep 10th, 2021 - This investigation is as a prospective, open, non-comparative, multi-centre investigation with the aim to follow exuding chronic wound progression. The investigation will include subjects from three populations suffering from exuding chronic wounds (Venous Leg Ulcers, Diabetic Foot Ulcers and Pressure Ulcers). The target wound for all subjects will initially be treated with Exufiber® as primary...