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About 575,424 results

Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
https://clinicaltrials.gov/ct2/show/NCT02307110

Jan 2nd, 2018 - Purpose: This study is designed to evaluate the prevalence of different stages of diabetic retinopathy and diabetic macular edema among patients suffering from type 1 diabetes for 5 to 25 years and have been treated with intensified insulin therapy aiming near-normal blood glucose levels for the whole duration of disease. Objectives: The primary objective is to examine the prevalence (percentag...

Self-management of Anticoagulation Treatment
https://clinicaltrials.gov/ct2/show/NCT02371772

Feb 25th, 2015 - Patients (n=23) on anticoagulant treatment with warfarin participated in a 27 weeks training program where they learned how to analyse International Normalised Ratio (INR) using the point-of-care instrument CoaguChek® XS and dose warfarin. The patients had to display their skills through a test before considered self-managing. They continued to measure INR weekly for 28 weeks. All INR values du...

Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
https://clinicaltrials.gov/ct2/show/NCT01588301

Sep 11th, 2014 - Scientific Context: High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing. It's well-known that this test has significantly contributed to the reduction of mortality and morbidity due to cervical cancer. In France, it now seems that the screening strategy could be optimized. Th...

Deep Brain Stimulation in Treatment Resistant Schizophrenia
https://clinicaltrials.gov/ct2/show/NCT02377505

Feb 26th, 2017 - The first phase of the study will consist of implanting electrodes. Recruited patients will be random to 2 targets: (1) medial prefrontal cortex (mPFC); (2) nucleus accumbens (NAcc). Continuous stimulation will be applied until the patients stabilise clinically. This period is anticipated between 6 and 9 months. After this stage, the next phase will consist of the crossover study. Those patient...

Multi-Center Study of New Medications to Treat Vaginal Infections
https://clinicaltrials.gov/ct2/show/NCT02308007

Jun 28th, 2018 - The purpose of this study is to evaluate the safety and efficacy of terconazole/metronidazole gel in the treatment of vaginal infections

FR901228 in Treating Patients With Refractory Stomach Cancer or Gastroesophageal Junction Cancer
https://clinicaltrials.gov/ct2/show/NCT00098527

Jul 1st, 2013 - PRIMARY OBJECTIVES: I. Determine the radiographic response rate (complete response and partial response) in patients with refractory adenocarcinoma of the stomach or gastroesophageal junction treated with FR901228 (depsipeptide). SECONDARY OBJECTIVES: I. Determine the median time to progression and progression-free survival of patients treated with this drug. II. Determine the grade 3 and 4 tox...

Study of Viramidine to Ribavirin in Patients With Chronic Hepatitis C Who Are Treatment Naive
https://clinicaltrials.gov/ct2/show/NCT00093093

Jun 21st, 2012 - Compare the efficacy and safety of viramidine 600 mg twice a day (BID) versus ribavirin 1000/1200 mg/day, both drugs administered in combination with pegylated interferon alfa-2a to treatment-naive patients with chronic hepatitis C (CHC)

Podocyte Retinoids
https://clinicaltrials.gov/ct2/show/NCT00098020

Dec 12th, 2017 - Retinoids are analogues of vitamin A that regulate cellular differentiation, leading to therapeutic use in skin diseases and malignancy. In animal models of kidney diseases, retinoids restore podocyte phenotype toward normal and reduce proteinuria. The objective of this phase II trial is to evaluate safety and develop preliminary evidence of efficacy of retinoid treatment in patients with podoc...

Fenretinide and Lonafarnib in Treating Patients With Advanced or Recurrent Head and Neck Cancer
https://clinicaltrials.gov/ct2/show/NCT00103090

Nov 13th, 2012 - OBJECTIVES: Primary Determine the biological activity and tolerability of fenretinide and lonafarnib in patients with advanced or recurrent squamous cell carcinoma of the head and neck. Determine the toxicity profile of this regimen in these patients. Determine the maximum tolerated dose of this regimen in these patients. Secondary Determine the dose-limiting toxicity of this regimen in these p...

A Study for Treatment of Partial Seizures in Children
https://clinicaltrials.gov/ct2/show/NCT00102713

May 20th, 2007 - The purpose of the study is to assess the safety profile of the investigational medication, Depakote Sprinkle Capsules, in the treatment of partial seizures in children ages 3-10.

Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion
https://clinicaltrials.gov/ct2/show/NCT00103766

This is a randomized, double-blind, placebo-controlled pilot study. Patients with empyema and complicated parapneumonic effusion who are felt to require fibrinolytic therapy will be considered for study enrollment. Enrolled patients will be randomized to one of five potential treatment arms (saline placebo, 4 mg once daily, 4 mg twice daily, 10 mg once daily, or 10 mg twice daily) in a double-b...

An Investigational Drug Study in Healthy Adult Volunteers in a Model of Insomnia (0928-007)
https://clinicaltrials.gov/ct2/show/NCT00102154

Jan 13th, 2015 - A study to evaluate the safety and effectiveness of an investigational drug for insomnia (a sleep disorder).

Quitlink : A Leveraging Solution to Tobacco Counseling
https://clinicaltrials.gov/ct2/show/NCT00112268

Oct 26th, 2006 - Among the most important evidence-based interventions in primary care is to offer counseling and pharmacotherapy to patients who use tobacco, but studies suggest that only a fraction of tobacco users receive this assistance. Office systems and other strategies can improve counseling rates but are not widely adoptable in primary care. We propose a novel solution that couples a simple office syst...

Electrochemoterapy With Bleomycin for the Treatment of Unresectable Pancreatic Cancer
https://clinicaltrials.gov/ct2/show/NCT03225781

Aug 8th, 2018 - Electrochemotherapy is a type of electroporation that allows the delivery of drugs to the cells through the local creation of pores in the cell membrane. The electric pulses can be applied directly to the neoplastic cells, allowing for the local concentration of a possible chemotherapeutic agent administered through the bloodstream. This technique does not use heat nor other thermal energies an...

Effectiveness of Distraction Techniques on Pain Intensity During Immunization Among Infants
https://clinicaltrials.gov/ct2/show/NCT03222050

Jul 18th, 2017 - Immunization is an important part of public health intervention and cost effective strategy to control the infectious diseases especially in children and it is one of the most common painful procedure in infants. Pain during immunization leads to distressing experience for the infant, parents and health care worker. Distraction is non pharmacological method which is used for diverting attention...

Study Evaluating Nivolumab (Anti-PD-1 Antibody) Alone Versus Nivolumab Plus Ipilimumab (Anti-CTLA-4 Antibody) in Patients With Resectable and Potentially Resectable Hepatocellular Carcinoma (HCC) (...
https://clinicaltrials.gov/ct2/show/NCT03222076

Jul 30th, 2018 - Objectives: Primary Objective: 1. To evaluate the safety and tolerability of therapy with nivolumab alone or nivolumab + ipilimumab in resectable HCC in the context of presurgical therapy; to evaluate the safety and tolerability of therapy with nivolumab + ipilimumab in potentially resectable HCC in the context of pre-biopsy therapy. Secondary Objectives: To assess the efficacy of presurgical n...

Ultrasound for Scoliosis Diagnostic Evaluation
https://clinicaltrials.gov/ct2/show/NCT03222739

Apr 17th, 2018 - All patients who present to Children's National Medical Center for initial evaluation of idiopathic or juvenile scoliosis will be approached.

Neoadjuvant Trial of Nivolumab in Combination With HF10 Oncolytic Viral Therapy in Resectable Stage IIIB, IIIC, IVM1a Melanoma
https://clinicaltrials.gov/ct2/show/NCT03259425

Sep 12th, 2018 - This is a single-arm, open label, Phase II study evaluating the safety and efficacy of neoadjuvant Nivolumab and HF10 in resectable stage IIIB, IIIC, and IVM1a melanoma.

Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
https://clinicaltrials.gov/ct2/show/NCT03244072

Jun 25th, 2018 - Subjects will receive either intracameral injection of 0.1% moxifloxacin solution or placebo after cataract surgery. They will be followed for one month to determine if there is a statistically significant difference in the incidence of endophthalmitis.

Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer
https://clinicaltrials.gov/ct2/show/NCT00002819

Apr 10th, 2013 - OBJECTIVES: I. Compare progression-free and overall survival of patients with drug-sensitive, low-volume ovarian cancer that is persistent following standard therapy treated with salvage therapy comprising standard-dose paclitaxel and carboplatin vs high-dose carboplatin, mitoxantrone, and cyclophosphamide followed by bone marrow reconstitution. II. Compare the toxic effects of these two salvag...