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About 575,404 results

Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer
https://clinicaltrials.gov/ct2/show/NCT00003994

Jun 13th, 2013 - Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy. It is not yet known which chemotherapy regimen is most effective for children and young adults with liver cancer. This rand...

Interleukin-2 Plus Histamine Dihydrochloride in Treating Patients With Acute Myeloid Leukemia
https://clinicaltrials.gov/ct2/show/NCT00003991

Nov 5th, 2013 - OBJECTIVES: I. Compare the efficacy of interleukin-2 plus histamine dihydrochloride (Maxamine) vs no further therapy in prolonging the leukemia free survival in patients with acute myeloid leukemia in first or subsequent complete remission (CR) following consolidation therapy. II. Compare the relapse rate, overall survival, and quality of life in this patient population treated with interleukin...

The Guardcontrol Trial: Study to Assess if Type 1 Diabetics Can Improve Using the Real-Time Values of Guardian RT
https://clinicaltrials.gov/ct2/show/NCT00111228

Oct 24th, 2006 - Finger-stick based self-testing (SBGM), as well as diagnostic continuous glucose monitoring (CGMS®) allow diabetic patients to find a balance between the two hyper- and hypoglycemic extremes. Nevertheless, there are still patients who fail to achieve good control due to fear of hypoglycemia, or who underestimate post-prandial hyperglycemias. The Guardian® RT Telemetered Glucose Monitoring Syste...

A Phase 1, Open-label, Dose Escalation Trial to Investigate SNDX-6352 in Patients With Solid Tumors
https://clinicaltrials.gov/ct2/show/NCT03238027

Jun 26th, 2018 - This is an open label, multi-center Phase 1 study consisting of Phase 1a and Phase 1b. The study will evaluate SNDX-6352 monotherapy (in Phase 1a) and SNDX-6352 combined with durvalumab (in Phase 1b) in patients with advanced solid tumors which must have progressed following prior treatment and have no standard therapy alternatives left (i.e.. patients must not be candidates for regimens known ...

Effects of H.Pylori Eradication on Microbiome
https://clinicaltrials.gov/ct2/show/NCT03231332

Aug 21st, 2018 - The aim of this Project is, within the scope of industrial research, to evaluate the long term effects of H.pylori eradication on microbiome (gut microbiome, upper respiratory tract microbiome) and lasting adverse events. In addition, the project aims to evaluate its effects on abundance and prevalence of extended-spectrum beta-lactamases coding genes and develop cost effective ESBL screening t...

Multicentre, Randomised Phase III Study of the Efficacy and Safety of Hetrombopag Olamine in Idiopathic Thrombocytopenic Purpura (ITP) Patient
https://clinicaltrials.gov/ct2/show/NCT03222843

Jul 18th, 2017 - A multicentre, randomised, double-blind,4-stages phase III study enrolled 414 patients with chronic, previously treated ITP. Dosage could be adjusted (2.5~.75 mg/day) to maintain platelet counts 50~250×109/L

Fat Metabolites and Gut Hormones
https://clinicaltrials.gov/ct2/show/NCT03223389

Jul 25th, 2017 - Dietary triglycerides are hydrolyzed during digestion to two fatty acids and one 2-monoacyl glycerol. The study will investigate the effects of these different fat components on gut hormone secretion in gastric bypass operated patients and non-operated BMI-matched controls.

Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia
https://clinicaltrials.gov/ct2/show/NCT00003619

Jun 25th, 2013 - OBJECTIVES: I. Determine the safety of topotecan in combination with fludarabine, cytarabine, and filgrastim (FLAG) in patients with poor prognosis acute myeloid leukemia, myelodysplastic syndrome, or recurrent or refractory acute lymphocytic leukemia. II. Determine the maximum tolerated dose of topotecan in the FLAG regimen in these patients. III. Assess the complete remission rates in patient...

Amifostine Plus Topotecan in Treating Patients With Myelodysplastic Syndrome
https://clinicaltrials.gov/ct2/show/NCT00003415

Jan 30th, 2013 - OBJECTIVES: I. Evaluate the hematologic and cytogenetic response to treatment with amifostine plus topotecan in patients with myelodysplastic syndromes. II. Evaluate the toxic effects of this treatment in these patients. III. Evaluate the effects of this treatment on bone marrow recovery in these patients. OUTLINE: This is a dose escalation study of topotecan. Patients receive amifostine IV fol...

Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
https://clinicaltrials.gov/ct2/show/NCT00101296

Feb 3rd, 2013 - PRIMARY OBJECTIVES: I. To define the maximum tolerated dose (MTD) of R115777 (tipifarnib) in patients with relapsed, refractory, or high risk myeloid leukemias treated according to this regimen. II. To assess the toxicity and preliminary assessment of efficacy of R115777 in patients with relapsed, refractory, or high risk myeloid leukemias. OUTLINE: This is a dose-escalation, multicenter study....

Safety and Acceptability of a Vaginal Microbicide
https://clinicaltrials.gov/ct2/show/NCT00111943

Mar 26th, 2012 - While the male condom is effective in preventing sexual transmission of HIV, its use is hampered by deeply rooted cultural and social barriers. About half of all HIV infections worldwide occur in women, yet the only available female-controlled method of HIV prevention is the female condom. Alternative prevention tools, such as vaginal microbicides, are urgently needed to slow the rapid spread o...

Canderel:Effects on Blood Glucose Concentration and Appetite Scores
https://clinicaltrials.gov/ct2/show/NCT03232008

Jul 26th, 2017 - This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores. Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric breakfast. Blood gl...

Safety and Efficacy of TrueTear™ for the Treatment of Meibomian Gland Disease
https://clinicaltrials.gov/ct2/show/NCT03226769

Nov 8th, 2017 - This study will compare the safety and efficacy of TrueTear to standardized moist heat compress (Thermalon® Dry Eye Compress) for the treatment of Meibomian Gland Disease (MGD).

Evaluation of Approved and Investigational Contact Lenses
https://clinicaltrials.gov/ct2/show/NCT03228212

May 1st, 2018 - This study is a randomized, 5-visit, partial subject masked, 2x3 bilateral crossover, dispensing clinical trial. During the study, each test article will be worn in a daily wear modality for at least 6 hours per day and 5 days per week for approximately 2 weeks each. The subject will wear either the Test or Control article twice and the other study article once. The primary objective of this st...

Title: Randomized Trial of an EHR Embedded Risk Calculator vs. Standard VTE Prophylaxis for Medical Patients
https://clinicaltrials.gov/ct2/show/NCT03243708

Dec 6th, 2017 - Specific Aim: Assess the effects of a VTE risk calculator embedded in the admission order set vs. usual care on physician behavior and patient outcomes in a randomized trial Research Strategy: Utilizing a Step-Wedge design, this randomized controlled trial (RCT) will be conducted at 10 Cleveland Clinic hospitals in efforts to assess the effects of a VTE (venous thromboembolism) risk calculator ...

Patient Management of Depression Through Technology: a Study of Digitally Enabled Engagement
https://clinicaltrials.gov/ct2/show/NCT03242213

Jun 25th, 2018 - This pilot study will be a randomized, real-world effectiveness study. Patients diagnosed with major depressive disorder starting a new prescription for an antidepressant monotherapy will be eligible for participation. The study will enroll 40 patients (20 in an observational arm of usual care and 20 with access to a mobile health application). No intervention will occur in the usual care arm. ...

Evaluation of Marginal Integrity of Hydroxyapatite Nano-Fiber Reinforced Flowable Composite Versus Conventional Resin-Based Flowable Composite in Initially Demineralized Pits and Fissure: A One Yea...
https://clinicaltrials.gov/ct2/show/NCT03242291

Aug 7th, 2017 - A total of 26 volunteer patients with at least 2 non-cavitated molar teeth will be assigned in this study. Patients will be divided into two groups according to type of flowable composite (R) where groups R1 the pits and fissure will be sealed with Hydroxyapatite Nanofiber reinforced flowable composite while groups R2 the pits and fissure will be sealed with conventional resin-based flowable co...

Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia
https://clinicaltrials.gov/ct2/show/NCT00002700

Jun 11th, 2013 - RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with radiation therapy may kill more tumor cells. Bone marrow transplantation can replace immune cells that were destroyed by chemotherapy. PURPOSE: Randomized phase III trial to study the effectiveness of chemotherapy compared with or without bone marro...

A 6-Month Consumer Behavior Study of a Self-Management System (0803-084)(COMPLETED)
https://clinicaltrials.gov/ct2/show/NCT00092846

Oct 1st, 2017 - The duration of treatment is 6 months.

PROCLAIM: Effect of AC2592 Administered by Continuous Subcutaneous Infusion in Subjects With Advanced Chronic Congestive Heart Failure
https://clinicaltrials.gov/ct2/show/NCT00099580

Jan 18th, 2015 - This Phase 2, randomized, placebo-controlled, multicenter outpatient study is designed to test the safety and tolerability of AC2592 as well as examine the effect of AC2592 on oxygen consumption during maximal tolerated exercise in adult subjects with chronic congestive heart failure.