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Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
https://doi.org/10.1097/AOG.0000000000004401
Obstetrics and Gynecology;

May 21st, 2021 - Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women. They are the leading indication for hysterectomy (1, 2), which is a definitive and effective surgical treatment for leiomyoma. However, many patients benefit from and seek out management options other than hysterectomy because they desire future childbearing or wish to retain their uterus. The purpose of ...

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver In...
https://doi.org/10.14309/ajg.0000000000001259
The American Journal of Gastroenterology; Chalasani NP, Maddur H et. al.

May 1st, 2021 - Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver failure, or chronic hepatitis. Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g., tyrosine kinase inhibitors or ...

Controversies in optimal anemia management: conclusions from a Kidney Disease: Improvin...
https://doi.org/10.1016/j.kint.2021.03.020
Kidney International; Babitt JL, Eisenga MF et. al.

Apr 12th, 2021 - In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and associated with significant adverse consequences. In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) issued an anemia guideline for managing the diagnosis, evaluation, and treatment of anemia in chronic kidney disease. Since then, new data have accrued from basic research, epidemiological studies, and ra...

CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care...
https://doi.org/10.1016/j.cjca.2021.01.017
The Canadian Journal of Cardiology; McDonald M, Virani S et. al.

Apr 9th, 2021 - In this update of the Canadian Cardiovascular Society heart failure (HF) guidelines, we provide comprehensive recommendations and practical tips for the pharmacologic management of patients with HF with reduced ejection fraction (HFrEF). Since the 2017 comprehensive update of the Canadian Cardiovascular Society guidelines for the management of HF, substantial new evidence has emerged that has i...

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057973
Clinical & Translational Oncology : Official Publication ... Mesia R, Iglesias L et. al.

Feb 27th, 2021 - Head and neck cancers (HNC) are defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2017 publication, the Spanish Society of Medical Oncology (SEOM) presents an update of the squamous cell HNC diagnosis and treatme...

Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ES...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128706
Nature Reviews. Nephrology; Boyer O, Schaefer F et. al.

Jan 31st, 2021 - Congenital nephrotic syndrome (CNS) is a heterogeneous group of disorders characterized by nephrotic-range proteinuria, hypoalbuminaemia and oedema, which manifest in utero or during the first 3 months of life. The main cause of CNS is genetic defects in podocytes; however, it can also be caused, in rare cases, by congenital infections or maternal allo-immune disease. Management of CNS is very ...

SEOM clinical guideline in ovarian cancer (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058000
Clinical & Translational Oncology : Official Publication ... Redondo A, Guerra E et. al.

Jan 31st, 2021 - Despite remarkable advances in the knowledge of molecular biology and treatment, ovarian cancer remains the leading cause of death from gynecologic cancer. In the last decade, there have been important advances both in systemic and surgical treatment. However, there is no doubt that the incorporation of PARP inhibitors as maintenance after the response to platinum-based chemotherapy, first in r...

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Adults.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903287
Current Oncology (Toronto, Ont.); Bebb DG, Banerji S et. al.

Jan 21st, 2021 - The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase (NTRK) gene fusions. These NTRK gene fusions are oncogenic drivers found in most tumour types at a low frequency (<5%), and at a higher frequency (>80%) in a small number of rare tumours (e.g., secretory ...

Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Rece...
https://doi.org/10.1016/j.chest.2020.11.027
Chest Johkoh T, Lee KS et. al.

Jan 16th, 2021 - Use of molecular targeting agents and immune checkpoint inhibitors (ICIs) has increased the frequency and broadened the spectrum of lung toxicity, particularly in patients with cancer. The diagnosis of drug-related pneumonitis (DRP) is usually achieved by excluding other potential known causes. Awareness of the incidence and risk factors for DRP is becoming increasingly important. The severity ...

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Pediatri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903261
Current Oncology (Toronto, Ont.); Perreault S, Chami R et. al.

Jan 14th, 2021 - Neurotrophic tyrosine receptor kinase gene fusions (NTRK) are oncogenic drivers present at a low frequency in most tumour types (<5%), and at a higher frequency (>80%) in a small number of rare tumours (e.g., infantile fibrosarcoma [IFS]) and considered mutually exclusive with other common oncogenic drivers. Health Canada recently approved two tyrosine receptor kinase (TRK) inhibitors, larotrec...

AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor...
https://doi.org/10.1053/j.gastro.2020.08.063
Gastroenterology Dougan M, Wang Y et. al.

Oct 21st, 2020 - Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in a subset of patients, but also a broad range of potentially life-threatening inflammatory toxicities, many of which involve the gastrointestinal (GI) tract and liver. The purpose of this expert review was to update gastroenterologists on the gastrointestinal and hepatic to...

Cardio-oncology care in the era of the coronavirus disease 2019 (COVID-19) pandemic: An...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934086
CA: a Cancer Journal for Clinicians; Lenihan D, Carver J et. al.

Sep 11th, 2020 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has given rise to a pandemic of unprecedented proportions in the modern era because of its highly contagious nature and impact on human health and society: coronavirus disease 2019 (COVID-19). Patients with cardiovascular (CV) risk factors and established CV disease (CVD) are among those initially identified at the highest risk fo...

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evide...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472403
Military Medical Research; Jin YH, Zhan QY et. al.

Sep 6th, 2020 - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 201...

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471521
Supportive Care in Cancer : Official Journal of the Multi... Shannon VR, Anderson R et. al.

Sep 4th, 2020 - The immune checkpoints associated with the CTLA-4 and PD-1 pathways are critical modulators of immune activation. These pathways dampen the immune response by providing brakes on activated T cells, thereby ensuring more uniform and controlled immune reactions and avoiding immune hyper-responsiveness and autoimmunity. Cancer cells often exploit these regulatory controls through a variety of immu...

Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020...
https://doi.org/10.7326/M20-2470
Annals of Internal Medicine; Doyle-Delgado K, Chamberlain JJ et. al.

Sep 1st, 2020 - The American Diabetes Association (ADA) updates the Standards of Medical Care in Diabetes annually to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of diabetes. To develop the 2020 Standards, the ADA Professional Practice Committee, comprising physicians, adult and pediatric endocrinologists, ...

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://doi.org/10.1007/s00520-020-05706-4
Supportive Care in Cancer : Official Journal of the Multi... Choi J, Anderson R et. al.

Aug 29th, 2020 - Immune checkpoint inhibitors (ICIs) frequently result in cutaneous immune-related adverse events (IrAEs). Although the majority of these events are mild-to-moderate in severity, up to 5% are severe, which may lead to morbidity and dose interruption or discontinuation of ICI therapy. In addition, up to 25% of dermatologic IrAEs are corticosteroid-refractory or corticosteroid-dependent. These 202...

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507388
Supportive Care in Cancer : Official Journal of the Multi... Dougan M, Blidner AG et. al.

Aug 29th, 2020 - Immune-related adverse events (IrAEs) affecting the gastrointestinal (GI) tract and liver are among the most frequent and most severe inflammatory toxicities from contemporary immunotherapy. Inflammation of the colon and or small intestines (entero)colitis is the single most common GI IrAE and is an important cause of delay of discontinuation of immunotherapy. The severity of these GI IrAEs can...

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://doi.org/10.1007/s00520-020-05709-1
Supportive Care in Cancer : Official Journal of the Multi... Cooksley T, Girotra M et. al.

Aug 29th, 2020 - Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment, transforming outcomes in melanoma and showing benefit in a range of malignancies. Immune-mediated toxicities, stemming from increased activity within the T cell lineage, range from asymptomatic or mild complications to those that are fulminant and potentially fatal. Immune-mediated endocrinopathies includ...

Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice r...
https://doi.org/10.1007/s00520-020-05710-8
Supportive Care in Cancer : Official Journal of the Multi... Suarez-Almazor ME, Pundole X et. al.

Aug 29th, 2020 - Immune checkpoint inhibitors (ICIs) have emerged as the newest pillar of cancer treatment. Immune-mediated toxicities, stemming from increased activity within the T cell lineage, range from asymptomatic or mild complications to those that are fulminant and potentially fatal. Although they are of variable occurrence, cardiovascular, rheumatic, and renal immune-mediated toxicities are among the m...

PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
https://doi.org/10.1200/JCO.20.01924
Journal of Clinical Oncology : Official Journal of the Am... Tew WP, Lacchetti C et. al.

Aug 14th, 2020 - To provide recommendations on the use of poly(ADP-ribose) polymerase inhibitors (PARPis) for management of epithelial ovarian, tubal, or primary peritoneal cancer (EOC). Randomized, controlled, and open-labeled trials published from 2011 through 2020 were identified in a literature search. Guideline recommendations were based on the review of the evidence, US Food and Drug Administration approv...