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About 860 results

Diabetes management in chronic kidney disease: a consensus report by the American Diabe...
https://doi.org/10.1016/j.kint.2022.08.012
Kidney International; de Boer IH, Khunti K et. al.

Oct 7th, 2022 - People with diabetes and chronic kidney disease (CKD) are at high risk for kidney failure, atherosclerotic cardiovascular disease, heart failure, and premature mortality. Recent clinical trials support new approaches to treat diabetes and CKD. The 2022 American Diabetes Association (ADA) Standards of Medical Care in Diabetes and the Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinica...

Swiss Recommendations for Cutaneous Basal Cell Carcinoma.
https://doi.org/10.1159/000526478
Dermatology (Basel, Switzerland); Ramelyte E, Nägeli MC et. al.

Sep 23rd, 2022 - Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in Switzerland and worldwide. Most BCCs can be treated in a curative setting. However, patients can develop locally destructive and, rarely, metastatic tumors that require a different treatment approach. The clinical subtype of individual lesions provides prognostic information and influences management decisions. Surgical ex...

2022 Canadian Cardiovascular Society Guideline for Use of GLP-1 Receptor Agonists and S...
https://doi.org/10.1016/j.cjca.2022.04.029
The Canadian Journal of Cardiology; Mancini GBJ, O'Meara E et. al.

Aug 13th, 2022 - This guideline synthesizes clinical trial data supporting the role of glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter 2 inhibitors (SGLT2i) for treatment of heart failure (HF), chronic kidney disease, and for optimizing prevention of cardiorenal morbidity and mortality in patients with type 2 diabetes. It is on the basis of a companion systematic review and meta-anal...

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Dise...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9398982
Gastroenterology Long MT, Noureddin M et. al.

Jul 17th, 2022 - Nonalcoholic fatty liver disease (NAFLD) is well recognized as a leading etiology for chronic liver disease, affecting >25% of the US and global populations. Up to 1 in 4 individuals with NAFLD have nonalcoholic steatohepatitis, which is associated with significant morbidity and mortality due to complications of liver cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Although NAF...

AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Sy...
https://doi.org/10.1053/j.gastro.2022.04.017
Gastroenterology Lembo A, Sultan S et. al.

Jun 24th, 2022 - Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder associated with significant disease burden. This American Gastroenterological Association Guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS with predominant diarrhea (IBS-D) and is an update of a prior technical review and guideline. Th...

AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Sy...
https://doi.org/10.1053/j.gastro.2022.04.016
Gastroenterology Chang L, Sultan S et. al.

Jun 24th, 2022 - Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline. The Grading of Recommendations Assess...

Current Role of Immunotherapy in Gastric, Esophageal and Gastro-Esophageal Junction Can...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139288
Current Oncology (Toronto, Ont.); Mulder K, Lim H et. al.

May 28th, 2022 - Gastric, esophageal and gastro-esophageal junction cancers are associated with inferior outcomes. For early-stage disease, perioperative chemotherapy or chemoradiation followed by surgery is the standard treatment. For most patients with advanced upper gastrointestinal tract cancers, platinum-based chemotherapy remains a standard treatment. Recently, several randomized clinical trials have demo...

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - ...
https://doi.org/10.1016/j.ejca.2022.04.018
European Journal of Cancer (Oxford, England : 1990); Garbe C, Amaral T et. al.

May 28th, 2022 - A unique collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on cutaneous melanoma diagnosis and treatment, based on the systematic literature reviews and the experts' experience. Cutaneous melanomas a...

A Guide to Implementing Immune Checkpoint Inhibitors within a Cancer Program: Experienc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870472
Current Oncology (Toronto, Ont.); Cheema PK, Iafolla MAJ et. al.

Feb 25th, 2022 - The increased use of immune checkpoint inhibitors across cancer programs has created the need for standardized patient assessment, education, monitoring, and management of immune-related adverse events (irAEs). At William Osler Health System in Brampton, Ontario, a practical step-wise approach detailing the implementation of cancer immunotherapy in routine practice was developed. The approach f...

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review.
https://doi.org/10.1053/j.gastro.2021.12.247
Gastroenterology Targownik LE, Fisher DA et. al.

Feb 21st, 2022 - Proton pump inhibitors (PPIs) are among the most commonly used medications in the world. Developed for the treatment and prevention of acid-mediated upper gastrointestinal conditions, these agents are being used increasingly for indications where their benefits are less certain. PPI overprescription imposes an economic cost and contributes to polypharmacy. In addition, PPI use has been increasi...

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Managem...
https://doi.org/10.1016/j.cgh.2022.01.025
Clinical Gastroenterology and Hepatology : the Official C... Yadlapati R, Gyawali CP et. al.

Feb 6th, 2022 - As many as one-half of all patients with suspected gastroesophageal reflux disease (GERD) do not derive benefit from acid suppression. This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms. The Best Practice Advice statements presented here were developed from expert review of existing literature combined with extensive discussion and expert opinion to provide...

Clinical practice guidelines for management of hyperglycaemia in adults with diabetic k...
https://doi.org/10.1111/dme.14769
Diabetic Medicine : a Journal of the British Diabetic Ass... Karalliedde J, Winocour P et. al.

Jan 27th, 2022 - A significant percentage of people with diabetes develop chronic kidney disease and diabetes is also a leading cause of end-stage kidney disease (ESKD). The term diabetic kidney disease (DKD) includes both diabetic nephropathy (DN) and diabetes mellitus and chronic kidney disease (DM CKD). DKD is associated with high morbidity and mortality, which are predominantly related to cardiovascular dis...

Evidence-based clinical practice guidelines for functional dyspepsia 2021.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831363
Journal of Gastroenterology; Miwa H, Nagahara A et. al.

Jan 22nd, 2022 - Functional dyspepsia (FD) is a disorder that presents with chronic dyspepsia, which is not only very common but also highly affects quality of life of the patients. In Japan, FD became a disease name for national insurance in 2013, and has been gradually recognized, though still not satisfactory. Following the revision policy of Japanese Society of Gastroenterology (JSGE), the first version of ...

Management of hypertension and renin-angiotensin-aldosterone system blockade in adults ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722287
BMC Nephrology; Banerjee D, Winocour P et. al.

Jan 5th, 2022 - People with type 1 and type 2 diabetes are at risk of developing progressive chronic kidney disease (CKD) and end-stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. Blood pressure control has been shown to be beneficial in people with diabetes...

Canadian Consensus Recommendations on the Management of MET-Altered NSCLC.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628757
Current Oncology (Toronto, Ont.); Cheema PK, Banerji SO et. al.

Dec 14th, 2021 - In Canada, the therapeutic management of patients with advanced non-small cell lung cancer (NSCLC) with rare actionable mutations differs between provinces, territories, and individual centres based on access to molecular testing and funded treatments. These variations, together with the emergence of several novel mesenchymal-epithelial transition (MET) factor-targeted therapies for the treatme...

2021 update of the EULAR points to consider on the use of immunomodulatory therapies in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507408
Annals of the Rheumatic Diseases; Alunno A, Najm A et. al.

Oct 9th, 2021 - To update the EULAR points to consider (PtCs) on the use of immunomodulatory therapies in COVID-19. According to the EULAR standardised operating procedures, a systematic literature review up to 14 July 2021 was conducted and followed by a consensus meeting of an international multidisciplinary task force. The new statements were consolidated by formal voting. We updated 2 overarching principle...

United European Gastroenterology (UEG) and European Society for Neurogastroenterology a...
https://doi.org/10.1111/nmo.14237
Neurogastroenterology and Motility : the Official Journal... Schol J, Wauters L et. al.

Aug 17th, 2021 - Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning diagnosis and management of gastroparesis. A Delphi consensus was undertaken by 40 experts from 19 European countries who conducted a literature summary and voti...

Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST G...
https://doi.org/10.1016/j.chest.2021.07.056
Chest Stevens SM, Woller SC et. al.

Aug 6th, 2021 - This is the 2nd update to the 9th edition of these guidelines. We provide recommendations on 17 PICO (Population, Intervention, Comparator, Outcome) questions, four of which have not been addressed previously. We generate strong and weak recommendations based on high-, moderate-, and low-certainty evidence, using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) method...

Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Ca...
https://doi.org/10.1200/JCO.21.01532
Journal of Clinical Oncology : Official Journal of the Am... Tung NM, Zakalik D et. al.

Aug 4th, 2021 - ASCO Rapid Recommendations Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual. The goal of these articles is to disseminate updated recommendations, in a timely m...

Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
https://doi.org/10.1097/AOG.0000000000004401
Obstetrics and Gynecology;

May 21st, 2021 - Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women. They are the leading indication for hysterectomy (1, 2), which is a definitive and effective surgical treatment for leiomyoma. However, many patients benefit from and seek out management options other than hysterectomy because they desire future childbearing or wish to retain their uterus. The purpose of ...