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AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Sy...
https://doi.org/10.1053/j.gastro.2022.04.016
Gastroenterology Chang L, Sultan S et. al.

Jun 24th, 2022 - Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline. The Grading of Recommendations Assess...

AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Sy...
https://doi.org/10.1053/j.gastro.2022.04.017
Gastroenterology Lembo A, Sultan S et. al.

Jun 24th, 2022 - Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder associated with significant disease burden. This American Gastroenterological Association Guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS with predominant diarrhea (IBS-D) and is an update of a prior technical review and guideline. Th...

Current Role of Immunotherapy in Gastric, Esophageal and Gastro-Esophageal Junction Can...
https://doi.org/10.3390/curroncol29050257
Current Oncology (Toronto, Ont.); Mulder K, Lim H et. al.

May 28th, 2022 - Gastric, esophageal and gastro-esophageal junction cancers are associated with inferior outcomes. For early-stage disease, perioperative chemotherapy or chemoradiation followed by surgery is the standard treatment. For most patients with advanced upper gastrointestinal tract cancers, platinum-based chemotherapy remains a standard treatment. Recently, several randomized clinical trials have demo...

A Guide to Implementing Immune Checkpoint Inhibitors within a Cancer Program: Experienc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870472
Current Oncology (Toronto, Ont.); Cheema PK, Iafolla MAJ et. al.

Feb 25th, 2022 - The increased use of immune checkpoint inhibitors across cancer programs has created the need for standardized patient assessment, education, monitoring, and management of immune-related adverse events (irAEs). At William Osler Health System in Brampton, Ontario, a practical step-wise approach detailing the implementation of cancer immunotherapy in routine practice was developed. The approach f...

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review.
https://doi.org/10.1053/j.gastro.2021.12.247
Gastroenterology Targownik LE, Fisher DA et. al.

Feb 21st, 2022 - Proton pump inhibitors (PPIs) are among the most commonly used medications in the world. Developed for the treatment and prevention of acid-mediated upper gastrointestinal conditions, these agents are being used increasingly for indications where their benefits are less certain. PPI overprescription imposes an economic cost and contributes to polypharmacy. In addition, PPI use has been increasi...

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Managem...
https://doi.org/10.1016/j.cgh.2022.01.025
Clinical Gastroenterology and Hepatology : the Official C... Yadlapati R, Gyawali CP et. al.

Feb 6th, 2022 - As many as one-half of all patients with suspected gastroesophageal reflux disease (GERD) do not derive benefit from acid suppression. This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms. The Best Practice Advice statements presented here were developed from expert review of existing literature combined with extensive discussion and expert opinion to provide...

Clinical practice guidelines for management of hyperglycaemia in adults with diabetic k...
https://doi.org/10.1111/dme.14769
Diabetic Medicine : a Journal of the British Diabetic Ass... Karalliedde J, Winocour P et. al.

Jan 27th, 2022 - A significant percentage of people with diabetes develop chronic kidney disease and diabetes is also a leading cause of end-stage kidney disease (ESKD). The term diabetic kidney disease (DKD) includes both diabetic nephropathy (DN) and diabetes mellitus and chronic kidney disease (DM CKD). DKD is associated with high morbidity and mortality, which are predominantly related to cardiovascular dis...

Evidence-based clinical practice guidelines for functional dyspepsia 2021.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831363
Journal of Gastroenterology; Miwa H, Nagahara A et. al.

Jan 22nd, 2022 - Functional dyspepsia (FD) is a disorder that presents with chronic dyspepsia, which is not only very common but also highly affects quality of life of the patients. In Japan, FD became a disease name for national insurance in 2013, and has been gradually recognized, though still not satisfactory. Following the revision policy of Japanese Society of Gastroenterology (JSGE), the first version of ...

Management of hypertension and renin-angiotensin-aldosterone system blockade in adults ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722287
BMC Nephrology; Banerjee D, Winocour P et. al.

Jan 5th, 2022 - People with type 1 and type 2 diabetes are at risk of developing progressive chronic kidney disease (CKD) and end-stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. Blood pressure control has been shown to be beneficial in people with diabetes...

Canadian Consensus Recommendations on the Management of MET-Altered NSCLC.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628757
Current Oncology (Toronto, Ont.); Cheema PK, Banerji SO et. al.

Dec 14th, 2021 - In Canada, the therapeutic management of patients with advanced non-small cell lung cancer (NSCLC) with rare actionable mutations differs between provinces, territories, and individual centres based on access to molecular testing and funded treatments. These variations, together with the emergence of several novel mesenchymal-epithelial transition (MET) factor-targeted therapies for the treatme...

2021 update of the EULAR points to consider on the use of immunomodulatory therapies in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507408
Annals of the Rheumatic Diseases; Alunno A, Najm A et. al.

Oct 9th, 2021 - To update the EULAR points to consider (PtCs) on the use of immunomodulatory therapies in COVID-19. According to the EULAR standardised operating procedures, a systematic literature review up to 14 July 2021 was conducted and followed by a consensus meeting of an international multidisciplinary task force. The new statements were consolidated by formal voting. We updated 2 overarching principle...

United European Gastroenterology (UEG) and European Society for Neurogastroenterology a...
https://doi.org/10.1111/nmo.14237
Neurogastroenterology and Motility : the Official Journal... Schol J, Wauters L et. al.

Aug 17th, 2021 - Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning diagnosis and management of gastroparesis. A Delphi consensus was undertaken by 40 experts from 19 European countries who conducted a literature summary and voti...

Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST G...
https://doi.org/10.1016/j.chest.2021.07.056
Chest Stevens SM, Woller SC et. al.

Aug 6th, 2021 - This is the 2nd update to the 9th edition of these guidelines. We provide recommendations on 17 PICO (Population, Intervention, Comparator, Outcome) questions, four of which have not been addressed previously. We generate strong and weak recommendations based on high-, moderate-, and low-certainty evidence, using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) method...

Adjuvant PARP Inhibitors in Patients With High-Risk Early-Stage HER2-Negative Breast Ca...
https://doi.org/10.1200/JCO.21.01532
Journal of Clinical Oncology : Official Journal of the Am... Tung NM, Zakalik D et. al.

Aug 4th, 2021 - ASCO Rapid Recommendations Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an evidence review and follow the guideline development processes outlined in the ASCO Guideline Methodology Manual. The goal of these articles is to disseminate updated recommendations, in a timely m...

Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
https://doi.org/10.1097/AOG.0000000000004401
Obstetrics and Gynecology;

May 21st, 2021 - Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women. They are the leading indication for hysterectomy (1, 2), which is a definitive and effective surgical treatment for leiomyoma. However, many patients benefit from and seek out management options other than hysterectomy because they desire future childbearing or wish to retain their uterus. The purpose of ...

Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatme...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390422
Clinical & Translational Oncology : Official Publication ... Garcia-Carbonero R, Matute Teresa F et. al.

May 8th, 2021 - Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. The heterogeneity in its etiology makes PPGL diagnosis and treatment very complex. The aim of this article was to provide practical clinical guidelines for the diagnosis and treatment of PPGLs from a...

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver In...
https://doi.org/10.14309/ajg.0000000000001259
The American Journal of Gastroenterology; Chalasani NP, Maddur H et. al.

May 1st, 2021 - Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver failure, or chronic hepatitis. Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g., tyrosine kinase inhibitors or ...

Controversies in optimal anemia management: conclusions from a Kidney Disease: Improvin...
https://doi.org/10.1016/j.kint.2021.03.020
Kidney International; Babitt JL, Eisenga MF et. al.

Apr 12th, 2021 - In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and associated with significant adverse consequences. In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) issued an anemia guideline for managing the diagnosis, evaluation, and treatment of anemia in chronic kidney disease. Since then, new data have accrued from basic research, epidemiological studies, and ra...

CCS/CHFS Heart Failure Guidelines Update: Defining a New Pharmacologic Standard of Care...
https://doi.org/10.1016/j.cjca.2021.01.017
The Canadian Journal of Cardiology; McDonald M, Virani S et. al.

Apr 9th, 2021 - In this update of the Canadian Cardiovascular Society heart failure (HF) guidelines, we provide comprehensive recommendations and practical tips for the pharmacologic management of patients with HF with reduced ejection fraction (HFrEF). Since the 2017 comprehensive update of the Canadian Cardiovascular Society guidelines for the management of HF, substantial new evidence has emerged that has i...

Cancer immunotherapy in special challenging populations: recommendations of the Advisor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009216
Journal for Immunotherapy of Cancer; Gonzalez-Cao M, Puertolas T et. al.

Mar 31st, 2021 - Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or...