Aug 2nd, 2020 - This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 2012, tremendous advances have been made in several aspects of the management of hemophilia. These include genetic assessment as well as therapy with ma...
This collection features the best content from AFP, as identified by the AFP editors, on chronic obstructive pulmonary disease (COPD) and related issues, including acute and chronic COPD, spirometry, pulmonary rehabilitation, oxygen therapy, corticosteriods, and pulmonary complications. New research may affect the interpretation and application of this material. Clinical judgment is advised. No...
Insurers’ administrative hurdles commonly delay access to care and pose intrusions into the patient-physician decision-making process. These requirements are harmful to patients and there are costs to physician practices in completing insurers’ administrative requirements such as prior authorization and step therapy. While the AMA normally works to reduce these barriers, under the exceptiona...
If your patients have myasthenia gravis, should they come in for an infusion therapy? Is it safe to start patients on a new B-cell depleting therapy? And should patients stop their immunosuppressive therapies? As the COVID-19 pandemic rages on, neurologists working with patients with neuromuscular diseases are fielding these questions with little overall specific data on the overall effect of ...
In these clinical practice guidelines, specific recommendations are made for determining the most effective methods of diagnosing and treating hypogonadism in adult male patients. The target populations for these guidelines include the following: (1) men with primary testicular failure requiring testosterone replacement (hypergonadotropic hypogonadism); (2) male patients with gonadotropin defic...
Journal of Clinical Oncology; Davendra P.S, .
The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options after first-line treatment.
Journal of the American Academy of Dermatology; Craig A. Elmets, MD et. al.
Psoriasis is a chronic, inflammatory, multisystem disease which affects up to 3.2% of the U.S population. This guideline addresses important clinical questions that arise in psoriasis management and care and provides recommendations based on the available evidence.
Journal of the National Comprehensive Cancer Network;
Evolving standard first-line approaches to the treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are once again focusing on the integration of minimal residual disease (MRD) status as a response assessment tool. MRD status correlates with clinical outcomes, therefore making it a good early indicator of response and expected outcomes, noted William G. Wierda, MD, Ph...
Journal of the American College of Cardiology; Kumbhani DJ, .
The American College of Cardiology (ACC) has a long history of developing documents (e.g., decision pathways, health policy statements, appropriate use criteria) to provide members with guidance on both clinical and nonclinical topics relevant to cardiovascular care. In most circumstances, these documents have been created to complement clinical practice guidelines and to inform clinicians abou...
NCCN COVID-19 Vaccination Advisory Committee
Jan 20th, 2021 - Patients with cancer should be prioritized for vaccination (CDC priority group 1b/c) and should be immunized when vaccination is available to them. Immunization is recommended for all patients receiving active therapy, with the understanding that there are limited safety and efficacy data in these patients.
National Institutes of Health (NIH)
Chloroquine is an antimalarial drug that was developed in 1934. Hydroxychloroquine, an analogue of chloroquine, was developed in 1946. Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, in addition to malaria. In general, hydroxychloroquine has fewer and less severe toxicities (including less propensity to prolong the QT...
National Institutes of Health (NIH)
Mar 3rd, 2021 - Tocilizumab is a recombinant humanized anti-interleukin (IL)-6 receptor monoclonal antibody approved by the Food and Drug Administration (FDA) for the treatment of certain rheumatologic disorders and cytokine release syndrome induced by chimeric antigen receptor T cell (CAR-T cell) therapy. It is hypothesized that modulating the levels of proinflammatory IL-6 or its effects may reduce the durat...
Sep 5th, 2017 - This statement updates the recommendations for routine use of the seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The American Academy of Pediatrics recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2017-2018 season include the followin...
Gastroenterology Hadjiliadis D, Khoruts A et. al.
Dec 31st, 2017 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendatio...
Neil F. Goodman
Nov 30th, 2011 - This consensus document will present recommendations for the use of MHT for the relief of menopausal symptoms. It will consider the possible role of MHT in the prevention of chronic disorders associated with estrogen deficiency.
Jennifer B. Smilowitz
Sep 7th, 2015 - The treatment planning system (TPS) is an essential component of external beam radiation therapy. TPSs are used to plan the beam arrangements, energies, field sizes, fluence patterns, and modifiers that provide optimum dose distributions to treat disease and minimize dose to the healthy tissues.
John N. Galgiani
Sep 14th, 2016 - Coccidioidomycosis, also known as San Joaquin Valley fever, is a systemic infection endemic to parts of the southwestern United States and elsewhere in the Western Hemisphere. Residence in and recent travel to these areas are critical elements for the accurate recognition of patients who develop this infection.