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About 2,785 results

Unmet clinical needs in the management of CALR-mutated essential thrombocythaemia: a co...
https://doi.org/10.1016/S2352-3026(21)00204-0
The Lancet. Haematology; Alvarez-Larrán A, Sant'Antonio E et. al.

Aug 28th, 2021 - Recommendations regarding management of essential thrombocythaemia rely on studies done before the discovery of the CALR mutation. On May 20, 2020, the European LeukemiaNet annual meeting was held with the goal to identify unmet clinical needs in myeloproliferative neoplasms. Because patients with a CALR mutation have specific clinical characteristics, treatment of CALR-mutated essential thromb...

Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: ...
https://doi.org/10.1097/JU.0000000000002183
The Journal of Urology; Lerner LB, McVary KT et. al.

Aug 14th, 2021 - Benign prostatic hyperplasia (BPH) is a histologic diagnosis describing proliferation of smooth muscle and epithelial cells within the prostatic transition zone. The prevalence and severity of lower urinary tract symptoms (LUTS) in aging men are progressive and impact the health and welfare of society. This revised Guideline provides a useful reference on effective evidence-based management of ...

The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines fo...
https://doi.org/10.1530/EJE-21-0479
European Journal of Endocrinology; Bartalena L, Kahaly GJ et. al.

Jul 24th, 2021 - Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). Choice of treatment should be based on the assessment of clinical activity and severity of GO. Early referral to specialized centers is fundamental for most patients with GO. Risk factors include smoking, thyroid dysfunction, high serum level of thyrotropin receptor antibodies, radioactive iodine (RAI) tr...

ENDOCRINOLOGY IN THE TIME OF COVID-19-2021 UPDATES: The management of diabetes insipidu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428073
European Journal of Endocrinology; Christ-Crain M, Hoorn EJ et. al.

Jul 23rd, 2021 - COVID-19 has changed the nature of medical consultations, emphasizing virtual patient counselling, with relevance for patients with diabetes insipidus (DI) or hyponatraemia. The main complication of desmopressin treatment in DI is dilutional hyponatraemia. Since plasma sodium monitoring is not always possible in times of COVID-19, we recommend to delay the desmopressin dose once a week until aq...

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Pa...
https://doi.org/10.1097/PAP.0000000000000308
Advances in Anatomic Pathology; Amin MB, Comperat E et. al.

Jun 16th, 2021 - The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder neoplasia with a focus on issues relevant to the practicing surgical pathologist for the understanding and effective reporting of bladder cancer, emphasizing particularly on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. The work is presented in 2 ma...

The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1...
https://doi.org/10.1097/PAP.0000000000000309
Advances in Anatomic Pathology; Compérat E, Amin MB et. al.

Jun 16th, 2021 - The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data...

Renal Mass and Localized Renal Cancer: Evaluation, Management, and Follow-up: AUA Guide...
https://doi.org/10.1097/JU.0000000000001912
The Journal of Urology; Campbell SC, Uzzo RG et. al.

Jun 12th, 2021 - This AUA Guideline focuses on active surveillance (AS) and follow-up after intervention for adult patients with clinically-localized renal masses suspicious for cancer, including solid enhancing tumors and Bosniak 3/4 complex cystic lesions. In January 2021, the Renal Mass and Localized Renal Cancer guideline underwent additional amendment based on a current literature-search. This literature s...

Renal Mass and Localized Renal Cancer: Evaluation, Management, and Follow-Up: AUA Guide...
https://doi.org/10.1097/JU.0000000000001911
The Journal of Urology; Campbell SC, Clark PE et. al.

Jun 12th, 2021 - This AUA Guideline focuses on evaluation/counseling/management of adult patients with clinically-localized renal masses suspicious for cancer, including solid-enhancing tumors and Bosniak 3/4 complex-cystic lesions. The Renal Mass and Localized Renal Cancer guideline underwent an update literature review which resulted in the 2021 amendment. When sufficient evidence existed, the body of evidenc...

SEOM clinical guideline for management of adult medulloblastoma (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057961
Clinical & Translational Oncology : Official Publication ... Luque R, Benavides M et. al.

Apr 2nd, 2021 - Recent advances in molecular profiling, have reclassified medulloblastoma, an undifferentiated tumor of the posterior fossa, in at least four diseases, each one with differences in prognosis, epidemiology and sensibility to different treatments. The recommended management of a lesion with radiological characteristics suggestive of MB includes maximum safe resection followed by a post-surgical M...

SEOM clinical guidelines for pancreatic and biliary tract cancer (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058005
Clinical & Translational Oncology : Official Publication ... Gómez-España MA, Montes AF et. al.

Mar 5th, 2021 - Pancreatic cancer (PC) and biliary tract cancer (BTC) are both aggressive and highly fatal malignancies. Nowadays we have a profound knowledge about the molecular landscape of these neoplasms and this has allowed new therapeutic options. Surgery is the only potentially curative therapy in both cancers, but disease recurrence is frequent. In PC, adjuvant treatment with mFOLFIRINOX has improved o...

SEOM clinical guideline for the management of cutaneous melanoma (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057998
Clinical & Translational Oncology : Official Publication ... Majem M, Manzano JL et. al.

Mar 3rd, 2021 - Melanoma affects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines to homogenize the management of these patients. The diagnosis must be histological and determination of BRAF status has to be performed in patients with stage ≥ III. Stage I-III resec...

Role of tubal surgery in the era of assisted reproductive technology: a committee opinion.
https://doi.org/10.1016/j.fertnstert.2021.01.051
Fertility and Sterility;

Mar 2nd, 2021 - This document reviews surgical options for reparative tubal surgery and the factors that must be considered when deciding between surgical repair and in vitro fertilization. This document replaces the document of the same name, last published in 2012 (Fertil Steril 2015;103:e37-43). This document reviews surgical options for reparative tubal surgery and the factors that must be considered when ...

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057973
Clinical & Translational Oncology : Official Publication ... Mesia R, Iglesias L et. al.

Feb 27th, 2021 - Head and neck cancers (HNC) are defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2017 publication, the Spanish Society of Medical Oncology (SEOM) presents an update of the squamous cell HNC diagnosis and treatme...

Glucocorticoid use in patients with adrenal insufficiency following administration of t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872824
Pituitary Katznelson L, Gadelha M

Feb 11th, 2021 - Side effects of the coronavirus disease 2019 (COVID-19) vaccines include pain at the injection site, fatigue, headache, myalgias, arthralgias, chills, and fever, all of which can be early indicators of an increased need for glucocorticoid replacement in patients with adrenal insufficiency. The Pituitary Society surveyed its membership to understand planned approaches to glucocorticoid managemen...

SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057959
Clinical & Translational Oncology : Official Publication ... Nadal E, Bosch-Barrera J et. al.

Feb 5th, 2021 - Mesothelioma is a rare and aggressive tumour with dismal prognosis arising in the pleura and associated with asbestos exposure. Its incidence is on the rise worldwide. In selected patients with early-stage MPM, a maximal surgical cytoreduction in combination with additional antitumour treatment may be considered in selected patients assessed by a multidisciplinary tumor board. In patients with ...

Surgical management of paratesticular rhabdomyosarcoma: A consensus opinion from the Ch...
https://doi.org/10.1002/pbc.28938
Pediatric Blood & Cancer; Rogers TN, Seitz G et. al.

Feb 2nd, 2021 - The treatment of paratesticular rhabdomyosarcoma (PT-RMS) has varied over time and by cooperative group. The International Soft Tissue Sarcoma Database Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS). The INSTRuCT surg...

SEOM clinical guideline in ovarian cancer (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058000
Clinical & Translational Oncology : Official Publication ... Redondo A, Guerra E et. al.

Jan 31st, 2021 - Despite remarkable advances in the knowledge of molecular biology and treatment, ovarian cancer remains the leading cause of death from gynecologic cancer. In the last decade, there have been important advances both in systemic and surgical treatment. However, there is no doubt that the incorporation of PARP inhibitors as maintenance after the response to platinum-based chemotherapy, first in r...

Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage ...
https://doi.org/10.1200/JCO.20.03237
Journal of Clinical Oncology : Official Journal of the Am... Chen YP, Ismaila N et. al.

Jan 7th, 2021 - The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other healthcare providers on definitive-intent chemoradiotherapy for patients with stage II-IVA nasopharyngeal carcinoma (NPC). The Chinese Society of Clinical Oncology (CSCO) and ASCO convened an expert panel of radiation oncology, medical oncology, surgery, and advocacy representatives. ...

SEOM Clinical Guideline of management of soft-tissue sarcoma (2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057970
Clinical & Translational Oncology : Official Publication ... de Juan Ferré A, Álvarez Álvarez R et. al.

Jan 7th, 2021 - Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of mesenchymal origin. Diagnosis, treatment, and management should be performed by an expert multidisciplinary team. MRI/CT of the primary tumor and biopsy is mandatory before any treatment. Wide surgical resection with tumor-free tissue margin is the mainstay for localized disease. Radiotherapy is indicated in large,...

Breast conservation and axillary management after primary systemic therapy in patients ...
https://doi.org/10.1016/S1470-2045(20)30580-5
The Lancet. Oncology; Dubsky P, Pinker K et. al.

Jan 3rd, 2021 - Primary systemic therapy is increasingly used in the treatment of patients with early-stage breast cancer, but few guidelines specifically address optimal locoregional therapies. Therefore, we established an international consortium to discuss clinical evidence and to provide expert advice on technical management of patients with early-stage breast cancer. The steering committee prepared six wo...