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About 275 results

Guidelines for clinical evaluation of anti-cancer drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253284
Cancer Science; Minami H, Kiyota N et. al.

May 16th, 2021 - Clinical studies intended for regulatory approval must demonstrate the clinical benefits of the drug in a target population. Clinical development of a drug proceeds by stepwise clinical studies; after safety and pharmacokinetics are evaluated and the recommended dosage and administration are determined, efficacy and safety are evaluated in an exploratory manner, and finally clinical benefits ar...

A living WHO guideline on drugs to prevent covid-19.
https://doi.org/10.1136/bmj.n526
BMJ (Clinical Research Ed.); Lamontagne F, Agoritsas T et. al.

Mar 3rd, 2021 - What is the role of drugs in preventing covid-19? WHY DOES THIS MATTER?: There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline focuses on the evidence for hydroxychloroquine. Subsequent updates will cover other drugs being investigated fo...

Options for Prevention and Management of Menstrual Bleeding in Adolescent Patients Unde...
https://doi.org/10.1097/AOG.0000000000004209
Obstetrics and Gynecology;

Jan 6th, 2021 - Obstetrician-gynecologists frequently are consulted either before the initiation of cancer treatment to request menstrual suppression or during an episode of severe heavy bleeding to stop bleeding emergently. Adolescents presenting emergently with severe uterine bleeding usually require only medical management; surgical management rarely is required. Surgical management should be considered for...

Alcohol-based hand sanitisers as first line of defence against SARS-CoV-2: a review of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550876
Epidemiology and Infection; Singh D, Joshi K et. al.

Sep 30th, 2020 - The pandemic due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has emerged as a serious global public health issue. Since the start of the outbreak, the importance of hand-hygiene and respiratory protection to prevent the spread of the virus has been the prime focus for infection control. Health regulatory organisations have produced guidelines for the formulation of hand sani...

Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803830
Journal of Atherosclerosis and Thrombosis; Yamashita S, Masuda D et. al.

Aug 31st, 2020 - Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia.|2020|Yamashita S,Masuda D,Akishita M,Arai H,Asada Y,|pharmacology,standards,blood,drug therapy,therapy,blood,

Medication Abortion Up to 70 Days of Gestation: ACOG Practice Bulletin, Number 225.
https://doi.org/10.1097/AOG.0000000000004082
Obstetrics and Gynecology;

Aug 18th, 2020 - Medication abortion, also referred to as medical abortion, is a safe and effective method of providing abortion. Medication abortion involves the use of medicines rather than uterine aspiration to induce an abortion. The U.S. Food and Drug Administration (FDA)-approved medication abortion regimen includes mifepristone and misoprostol. The purpose of this document is to provide updated evidence-...

Cervical Ripening and Labor Induction and Augmentation, 5th Edition.
https://doi.org/10.1016/j.jogn.2020.04.005
Journal of Obstetric, Gynecologic, and Neonatal Nursing :... Simpson KR

Aug 12th, 2020 - Cervical ripening and induction and augmentation of labor are common procedures in labor and birth units. The potential risks and benefits for the procedure should be explained to women so that they can make informed decisions. Clinicians should be knowledgeable about the methods and medications used and be skilled in maternal-fetal assessment. Adequate nurse staffing is required to monitor the...

Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert...
https://doi.org/10.1016/j.annonc.2020.07.010
Annals of Oncology : Official Journal of the European Soc... Curigliano G, Banerjee S et. al.

Aug 4th, 2020 - We established an international consortium to review and discuss relevant clinical evidence in order to develop expert consensus statements related to cancer management during the severe acute respiratory syndrome coronavirus 2-related disease (COVID-19) pandemic. The steering committee prepared 10 working packages addressing significant clinical questions from diagnosis to surgery. During a vi...

Antiemetics: ASCO Guideline Update.
https://doi.org/10.1200/JCO.20.01296
Journal of Clinical Oncology : Official Journal of the Am... Hesketh PJ, Kris MG et. al.

Jul 14th, 2020 - To update the guideline to include new anticancer agents, antiemetics, and antiemetic regimens and to provide recommendations on the use of dexamethasone as a prophylactic antiemetic in patients receiving checkpoint inhibitors (CPIs). ASCO convened an Expert Panel and updated the systematic review to include randomized controlled trials (RCTs) and meta-analyses of RCTs published between June 1,...

2020 International Society of Hypertension Global Hypertension Practice Guidelines.
https://doi.org/10.1161/HYPERTENSIONAHA.120.15026
Hypertension (Dallas, Tex. : 1979); Unger T, Borghi C et. al.

May 7th, 2020 - 2020 International Society of Hypertension Global Hypertension Practice Guidelines.|2020|Unger T,Borghi C,Charchar F,Khan NA,Poulter NR,|classification,pharmacology,methods,standards,methods,diagnosis,drug therapy,psychology,standards,

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical ...
https://doi.org/10.6004/jnccn.2020.0006
Journal of the National Comprehensive Cancer Network : JN... Wierda WG, Byrd JC et. al.

Feb 6th, 2020 - Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are characterized by a progressive accumulation of leukemic cells in the peripheral blood, bone marrow, and lymphoid tissues. Treatment of CLL/SLL has evolved significantly in recent years because of the improved understanding of the disease biology and the development of novel targeted therapies. In patients with indicatio...

Thyroid disease assessment and management: summary of NICE guidance.
https://doi.org/10.1136/bmj.m41
BMJ (Clinical Research Ed.); Vasileiou M, Gilbert J et. al.

Jan 31st, 2020 - Thyroid disease assessment and management: summary of NICE guidance.|2020|Vasileiou M,Gilbert J,Fishburn S,Boelaert K, ,|pharmacology,methods,methods,standards,pharmacology,classification,diagnosis,drug therapy,etiology,methods,diagnostic imaging,blood,pharmacology,methods,

Nutraceuticals and blood pressure control: a European Society of Hypertension position ...
https://doi.org/10.1097/HJH.0000000000002353 10.1016/j.clnu.2019.08.015
Journal of Hypertension; Borghi C, Tsioufis K et. al.

Jan 25th, 2020 - : High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The aim of this position document is to highlight which of these prod...

Japan society of clinical oncology/Japanese society of medical oncology-led clinical re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046581
International Journal of Clinical Oncology; Naito Y, Mishima S et. al.

Jan 25th, 2020 - The development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we published provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors. Recently, efficacy of tropomyosin receptor kinase inhibitors against neurotrophic receptor tyrosine kinase (NTRK) fusion gene...

Improving Quality of Patient Data for Treatment of Multidrug- or Rifampin-Resistant Tub...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045826
Emerging Infectious Diseases; Campbell JR, Falzon D et. al.

Jan 11th, 2020 - International policy for treatment of multidrug- and rifampin-resistant tuberculosis (MDR/RR TB) relies largely on individual patient data (IPD) from observational studies of patients treated under routine conditions. We prepared guidance on which data to collect and what measures could improve consistency and utility for future evidence-based recommendations. We highlight critical stages in da...

Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelin...
https://doi.org/10.6004/jnccn.2020.0001
Journal of the National Comprehensive Cancer Network : JN... Brown P, Inaba H et. al.

Jan 8th, 2020 - Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Advancements in technology that enhance our understanding of the biology of the disease, risk-adapted therapy, and enhanced supportive care have contributed to improved survival rates. However, additional clinical management is needed to improve outcomes for patients classified as high risk at presentation (eg, T-ALL, i...

New scenarios in secondary hyperparathyroidism: etelcalcetide. Position paper of workin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118036
Journal of Nephrology; Bellasi A, Cozzolino M et. al.

Dec 20th, 2019 - Bone mineral abnormalities (defined as Chronic Kidney Disease Mineral Bone Disorder; CKD-MBD) are prevalent and associated with a substantial risk burden and poor prognosis in CKD population. Several lines of evidence support the notion that a large proportion of patients receiving maintenance dialysis experience a suboptimal biochemical control of CKD-MBD. Although no study has ever demonstrat...

Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985752
Antimicrobial Agents and Chemotherapy; Pogue JM, Jones RN et. al.

Nov 27th, 2019 - The polymyxins are important agents for carbapenem-resistant Gram-negative bacilli. The United States Committee on Antimicrobial Susceptibility Testing breakpoint recommendations for colistin and polymyxin B are that isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacteriaceae are considered susceptible at MIC values of ≤2 mg/liter. These recommendations are contingent up...

Patient Counseling Guidelines for the Use of Cannabis for the Treatment of Chemotherapy...
https://doi.org/10.1080/15360288.2019.1598531
Journal of Pain & Palliative Care Pharmacotherapy; Makary P, Parmar JR et. al.

May 10th, 2019 - The use of cannabis medications has grown in recent years for the symptomatic relief of chemotherapy-induced nausea/vomiting (CINV) and chronic pain (cancer-related and non-cancer-related). As states legalize the use of cannabis, it is important for pharmacists and other health care professionals to be aware of how to counsel patients receiving prescriptions for cannabis medications. The aim of...

The 2018 Cholesterol Management Guidelines: Topics in Secondary ASCVD Prevention Clinic...
https://doi.org/10.1007/s11883-019-0784-8
Current Atherosclerosis Reports; Jia X, Al Rifai M et. al.

Apr 4th, 2019 - The 2018 ACC/AHA Multisociety blood cholesterol guidelines provide updated recommendations based on contemporary evidence on the management of serum cholesterol for the prevention of atherosclerotic cardiovascular disease (ASCVD) events. This review discusses clinically important topics in the new guidelines related to secondary ASCVD prevention. Since the 2013 ACC/AHA blood cholesterol guideli...