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About 64,078 results

Primary Breast Tumors Often Switch HER2 Status on Relapse
https://www.medscape.com/viewarticle/950912

May 10th, 2021 - A substantial proportion of primary breast tumors that are HER2 negative (HER2-0) switch to showing HER2-low expression upon relapse, a first-of-its-kind study suggests. This switch may allow patients to be treated with HER2-targeted therapies, giving a treatment option where there may be few available, inasmuch as HER2-negative tumors are also hormone negative (so-called triple-negative tumors...

'Calcium Imbalance' Linked to Bipolar Severity
https://www.medscape.com/viewarticle/950877

May 10th, 2021 - Calcium homeostasis may play a role in bipolar disorder (BD) severity, with raised serum vitamin D and parathyroid hormone (PTH) levels linked to worse clinical outcomes and high psychological burden, new research suggests. After measuring serum PTH, vitamin D, and calcium levels in patients with type I or type II BD, investigators found that the number of hospitalizations and prior psychiatric...

Novavax Delays COVID-19 Vaccine Production Timeline, Sees Filing for Authorization in 3rd Qtr
https://www.medscape.com/viewarticle/950865

May 10th, 2021 - (Reuters) - Novavax Inc said on Monday production of its COVID-19 vaccine will ramp up at a slower pace than it had previously anticipated and it does not expect to file for regulatory authorization in the United States, Britain or Europe until the third quarter of 2021. Novavax said it does not expect to hit its production target of 150 million shots per month until the fourth quarter of 2021,...

Europe Dares to Reopen as 200 Millionth Vaccine Dose Delivered
https://www.medscape.com/viewarticle/950827

May 10th, 2021 - MADRID/LONDON (Reuters) - As its vaccination drive reaches a third of adults and COVID-19 infections ease, Europe is starting to reopen cities and beaches, raising hopes that this summer's holiday season can be saved before it is too late. Exhilarated Spaniards chanting "freedom" danced in the streets as a COVID-19 curfew ended in most of the country at the weekend, while Greece reopened public...

Freezing Breast Cancer to Death Avoids Surgery
https://www.medscape.com/viewarticle/950821

May 9th, 2021 - In the United States, cryoablation or freezing tissue to death is a primary treatment option for a variety of cancers, including those originating in or spread to the bone, cervix, eye, kidney, liver, lung, pancreas, and prostate. Cryoablation for prostate cancer, one of the most common cancers in men, was first approved in the 1990s. But unlike in Europe, this nonsurgical approach is not appro...

Key EU Countries Rebuff Biden on Sharing COVID Vaccine Patents
https://www.medscape.com/viewarticle/950772

May 9th, 2021 - BRUSSELS (Reuters) - European countries distanced themselves on Friday from a proposal backed by U.S. President Joe Biden to waive patent rights on coronavirus vaccines, arguing that key to ending the COVID-19 pandemic was making and sharing vaccines more quickly. French President Emmanuel Macron said the question of sharing patents was not the issue of the day, and called out Britain and the U...

Fast Five Quiz: How Much Do You Know About HIV?
https://reference.medscape.com/viewarticle/842465

May 9th, 2021 - HIV remains one of the most pressing public health issues around the world. Globally in 2019, 38 million individuals were living with HIV/AIDS, including nearly 27 million people in Eastern and Southern Africa, 4.9 million people in Western and Central Africa, 5.8 million people in Asia and the Pacific, and 2.2 million people in Western and Eastern Europe and North America. Also in 2019, estima...

Multiple Studies Highlight Pandemic's Impact on Patients With Rheumatic Disease
https://www.medscape.com/viewarticle/950730

May 6th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Reduced access to medical care, increased mental health issues, poor lifestyle habits, and concern over future care are just some of the patient-reported problems associated with the early phases of the COVID-19 pandemic, according to the results of multiple studies. Data from the Europe-based R...

Going Viral: Social Media May Be Increasing Cases of New-Onset Tics
https://www.medscape.com/viewarticle/949882

May 5th, 2021 - This transcript has been edited for clarity. Kathrin LaFaver, MD: Hello. I'm Dr Kathrin LaFaver, a movement disorders specialist at Northwestern University here in Chicago. It is my great pleasure today to interview Dr Tamara Pringsheim on the topic of acute-onset explosive tic-like behaviors. Dr Pringsheim is an associate professor in the Department of Clinical Neurosciences, Psychiatry, Pedia...

EU Regulator Begins Real-time Review of First Chinese COVID-19 Vaccine
https://www.medscape.com/viewarticle/950441

May 4th, 2021 - (Reuters) - Europe's medicines regulator said on Tuesday it has started a real-time review of Sinovac's COVID-19 vaccine, based on preliminary results from animal and human trials that suggested the vaccine produces an immune response against the coronavirus. Data on the vaccine, COVID-19 Vaccine (Vero Cell) Inactivated, will be assessed as they are made available to help speed up potential app...

Denmark Ditches J&J COVID-19 Shots From Vaccination Programme
https://www.medscape.com/viewarticle/950362

May 3rd, 2021 - COPENHAGEN (Reuters) - Denmark on Monday became the first country to exclude Johnson & Johnson's COVID-19 shots from its vaccination programme over a potential link to a rare but serious form of blood clot. The move comes after the Nordic country last month stopped using AstraZeneca's vaccine altogether citing similar concerns.

Restrict J&J COVID Vaccine in Women Under 50?
https://www.medscape.com/viewarticle/950501

May 3rd, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Use of mRNA COVID-19 vaccines should be considered as the preferable option in the US rather than Johnson & Johnson's (J&J) Janssen COVID-19 vaccine in women under the age of 50 years, according to one group of experts. The 12 US case reports, three of which were fatal, show many similarities to...

Baricitinib Continuation Rate High in Real-World Practice
https://www.medscape.com/viewarticle/950481

May 3rd, 2021 - Around three-quarters of patients remained on treatment with baricitinib (Olumiant) for rheumatoid arthritis after their first 6-month assessment in an independent analysis of British Society for Rheumatology Biologics Register (BSRBR) data. The rate of continuation was even higher, at almost 85%, in patients who had not previously been treated with a biologic or targeted synthetic disease-modi...

EU Aims to Open Up to More Foreign Tourists This Summer Despite COVID-19
https://www.medscape.com/viewarticle/950342

May 3rd, 2021 - BRUSSELS (Reuters) - The European Union's executive has recommended easing COVID-19 travel restrictions next month to let foreign travellers from more countries enter the EU, hoping to boost the stricken tourism industry this summer. Under current restrictions, people from only seven countries, including Australia and Singapore, can enter the EU on holiday, regardless of whether they have been ...

Some EU Nations Still Want Valneva COVID-19 Vaccine Deal: Sources
https://www.medscape.com/viewarticle/950292

May 2nd, 2021 - PARIS (Reuters) - Some EU countries still want Brussels to strike a deal to buy Valneva's COVID-19 vaccine candidate despite a recent setback in talks, as the bloc aim to shore up and diversify supplies, sources familiar with the talks told Reuters. A spokesman for the European Commission said last week the French vaccine maker had not met conditions required to reach an agreement, two days aft...

Brodalumab Shows Promise in Axial Spondyloarthritis
https://www.medscape.com/viewarticle/950264

May 2nd, 2021 - NEW YORK (Reuters Health) - Brodalumab may be a potential therapeutic option for patients with axial spondyloarthritis (axSpA), according to interim results of a phase-3 study. Brodalumab, which selectively inhibits interleukin-17 receptor A (IL-17RA), is approved for the treatment of plaque psoriasis in North America, Canada, Europe, Japan and other Asian countries.

No Regrets: AstraZeneca's Soriot Defends COVID-19 Vaccine Supply
https://www.medscape.com/viewarticle/950254

May 2nd, 2021 - LONDON (Reuters) - Pascal Soriot, who is under intense fire from the European Union over the delivery of AstraZeneca's COVID-19 vaccines, said on Friday the drugmaker he runs had not overpromised on the supply of shots. The European Commission has launched legal proceedings against the Anglo-Swedish drugmaker, alleging that it did not respect its contract or have a "reliable" plan to ensure tim...

EMA to Quickly Review Eli Lilly, Incyte Arthritis Drug for COVID-19 Use
https://www.medscape.com/viewarticle/950192

Apr 29th, 2021 - ZURICH (Reuters) - The European Medicines Agency will conduct an accelerated review of Eli Lilly and Co's rheumatoid arthritis drug Olumiant for hospitalized COVID-19 patients getting oxygen, the agency said on Thursday, as the search for treatment options continues. Olumiant, on which Lilly partners with U.S. drugmaker Incyte Corp, is the latest arthritis medicine to be repurposed in efforts t...

BioNTech Expects Vaccine Trial Results for Babies by September
https://www.medscape.com/viewarticle/950183

Apr 29th, 2021 - BERLIN (Reuters) - BioNTech expects results by September from trials testing the COVID-19 vaccine that it and Pfizer have developed in babies as young as six months old, German magazine Spiegel cited the company's CEO as saying. "In July, the first results could be available for the five to 12 year olds, in September for the younger children," BioNTech Chief Executive Ugur Sahin told Spiegel. H...

A New, Potentially Safer Birth Control Pill
https://www.medscape.com/viewarticle/949975

Apr 29th, 2021 - On April 16, 2021, the US Food and Drug Administration approved Nextstellis, a new oral contraceptive (OC) that combines a novel estrogen, estetrol, with the well-known progestin drospirenone. (Full disclosure: The University of Florida receives research funding from the manufacturer, and in past years I have been a consultant to the company.) The new OC contains 14.2 mg of estetrol and 3 mg of...