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About 8,185 results

Fall-Related Mortality Rising Among Older Canadians
https://www.medscape.com/viewarticle/975780

Jun 16th, 2022 - Emergency department (ED) visits and mortality from falls among older Canadians are trending upwards, data indicate. Hospitalization rates have held generally steady, but they are increasing among Canadians older than 65 years. Most falls occurred in the home and while the person was walking. “This information provides guideposts for prioritizing prevention efforts, such as targeting women, tho...

Study Sees Surge in Use of Medical Cannabis
https://www.medscape.com/viewarticle/975763

Jun 16th, 2022 - In 2020 nearly 3 million people in the United States sought out medical cannabis, in marijuana or other forms, more than four times the number who did so in 2016, a new study has found. Much of the increase involved people seeking medical cannabis for chronic pain, which remains the leading reason Americans say they require the drug, according to research published June 14 in the Annals of Inte...

Pediatric Case Challenge: A 7-Year-Old Boy With a Limp and Obesity Who Fell in the Street
https://www.medscape.com/viewarticle/868041

Jun 15th, 2022 - Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please ...

Updated Pediatric Uveitis Recommendations Advise on Expanded Treatment Options
https://www.medscape.com/viewarticle/975672

Jun 15th, 2022 - Glucocorticoids should be bridging therapies in the treatment of juvenile idiopathic arthritis–associated uveitis (JIAU) and idiopathic chronic anterior uveitis (CAU), according to recently released recommendations from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC). The recommendations cover literature from December 2014 to June 2020 and represent an update...

Biomarkers Hold Promise for Identifying Juvenile Arthritis Likely to Stay in Four or Fewer Joints
https://www.medscape.com/viewarticle/975567

Jun 14th, 2022 - Ongoing research in patients with oligoarticular juvenile idiopathic arthritis (JIA) so far suggests that a set of biomarkers in synovial fluid may help to predict which patients may be more likely to stay with persistent oligoarticular disease rather than progress to polyarticular disease, according to new research presented at the Childhood Arthritis and Rheumatology Research Alliance (CARRA)...

Deucravacitinib and Orelabrutinib Perform Well in Lupus Trials
https://www.medscape.com/viewarticle/975397

Jun 10th, 2022 - Deucravacitinib and orelabrutinib — two novel oral drugs under investigation for the treatment of systemic lupus erythematosus (SLE) — have performed well in early clinical trials reported as late-breaking abstracts at the annual European Congress of Rheumatology. In the phase 2 PAISLEY study, up to 58% of patients treated with deucravacitinib versus 34% of placebo-treated patients met the prim...

Izokibep Improves Multiple PsA Symptoms in Phase 2 Study
https://www.medscape.com/viewarticle/975169

Jun 7th, 2022 - A host of psoriatic arthritis symptoms can be improved by the investigational interleukin (IL)-17 blocker izokibep, according to the results of a phase 2 trial presented at the annual European Congress of Rheumatology. Around half of all participants in the trial who were treated with izokibep achieved a 50% or higher improvement in American College of Rheumatology response criteria (ACR50) at ...

Opioid Use in the Elderly a Dementia Risk Factor?
https://www.medscape.com/viewarticle/975164

Jun 7th, 2022 - Opioid use in the elderly is associated with an almost 40% increased risk of dementia, in new findings that suggest exposure to these drugs may be another modifiable risk factor for dementia. "Clinicians and others may want to consider that opioid exposure in those aged 75-80 increases dementia risk, and to balance the potential benefits of opioid use in old age with adverse side effects," Step...

Methotrexate's First Evidence of Disease Modification in Pre-RA
https://www.medscape.com/viewarticle/975080

Jun 6th, 2022 - COPENHAGEN — Temporary methotrexate in clinically suspected arthralgia delays but does not prevent clinical arthritis development; however, it does lead to sustained reduction of disease burden and MRI-detected inflammation in all at-risk groups, shows the 2-year Treat Earlier study. Dr Doortje Krijbolder "These data provide the first evidence for disease modification when intervening in 'pre-R...

ACL Repair: Long-Term Improvement Worse in Females
https://www.medscape.com/viewarticle/975040

Jun 3rd, 2022 - Elizabeth S. Bjornsen Males who underwent anterior cruciate ligament reconstruction (ACLR) improved more quickly than females who underwent the same procedure, according to a study based on data from 218 adolescents and young adults. Patient-reported outcomes (PROs) are essential for monitoring recovery and effectiveness of interventions for joint injury, as well as for assessing quality of lif...

European AxSpA Guidelines Reflect Recent Changes in Drug Therapy
https://www.medscape.com/viewarticle/975012

Jun 3rd, 2022 - COPENHAGEN, Denmark — European recommendations and overarching principles for the management of patients with axial spondyloarthritis (axSpA) have remained largely unchanged since 2016 – with a few notable but very important exceptions. Dr Sofia Ramiro The 2022 updated recommendations include a new point regarding which biologic agents to use for patients with recurrent uveitis, active inflamma...

Upadacitinib Effective Against Nonradiographic AxSpA
https://www.medscape.com/viewarticle/974913

Jun 1st, 2022 - COPENHAGEN — The Janus kinase (JAK) inhibitor upadacitinib (Rinvoq, AbbVie) was associated with significant improvements in disease activity, pain, function, and quality of life compared with placebo in patients with nonradiographic axial spondyloarthritis (nr-axSpA), results of the first efficacy analysis of the phase 3 randomized SELECT-AXIS-2 trial showed. Dr Filip Van den Bosch The trial me...

Lupus Mutation May Unlock Targeted Drugs for Patient Subset
https://www.medscape.com/viewarticle/974872

Jun 1st, 2022 - Scientists have confirmed that a receptor long suspected to be linked to lupus is, in fact, a major driver of the autoimmune disease for at least some subset of patients, according to a study recently published in Nature. Researchers discovered the crucial role of toll-like receptor 7 (TLR7) because of a rare mutation in a pediatric patient with systemic lupus erythematosus (SLE) who had a part...

Pfizer COVID Vaccine Performs Well in Youth With Rheumatic Diseases
https://www.medscape.com/viewarticle/974098

May 17th, 2022 - The Pfizer-BioNTech mRNA vaccine (Comirnaty) showed a good safety profile with minimal short-term side effects and no negative impact on disease activity in a cohort of adolescents and young adults with rheumatic diseases, according to research presented at the 2022 annual meeting of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Only 3% of patients experience a severe tran...

Risk Factors for COVID Death Studied in U.K. Arthritis Patients
https://www.medscape.com/viewarticle/974101

May 17th, 2022 - Being identified as someone that was advised to stay at home and shield, or keep away from face-to-face interactions with others, during the COVID-19 pandemic was indicative of an increased risk for dying from COVID-19 within 28 days of infection, a U.K. study of inflammatory arthritis patients versus the general population suggests. In fact, shielding status was the highest ranked of all the r...

Lyme Disease May Cost US Nearly $970 Million per Year
https://www.medscape.com/viewarticle/973766

May 11th, 2022 - The annual cost of Lyme disease in the United States could be nearly $970 million, according to new research. But not all cases of Lyme disease are equally costly. Costs for patients with disseminated Lyme disease were more than twice as high as those for patients with localized disease. "These findings emphasize the importance of early and accurate diagnosis to reduce both illness and its asso...

Relugolix Combo Eases Long-Neglected Fibroid Symptom: Pain
https://www.medscape.com/viewarticle/973813

May 11th, 2022 - Combination therapy with relugolix (Orgovyx, Relumina), a gonadotropin-releasing hormone antagonist, significantly reduced the pain of uterine fibroids, an undertreated aspect of this disease. In pooled results from the multicenter randomized placebo-controlled LIBERTY 1 and 2 trials, relugolix combination therapy (CT) with the progestin norethindrone (Aygestin, Camila) markedly decreased both ...

Prior Authorizations Delay TNF Inhibitors for Children With JIA
https://www.medscape.com/viewarticle/973816

May 11th, 2022 - Children with juvenile idiopathic arthritis (JIA) who need a tumor necrosis factor (TNF) inhibitor after failing conventional disease-modifying antirheumatic drug (DMARD) treatment often experience insurance delays before beginning the new drug because of prior authorization denials, according to research presented at the 2022 annual meeting of the Childhood Arthritis and Rheumatology Research ...

Intra-articular Steroid/lidocaine Injection Improves Hip Arthritis Pain, Function
https://www.medscape.com/viewarticle/973522

May 6th, 2022 - NEW YORK (Reuters Health) - A single injection into the hip of steroid and local anesthetic improved pain and function in patients with hip osteoarthritis in a randomized controlled trial, with most of the benefit seen early after treatment. Researchers at two community-based clinics in England assigned 199 volunteers to receive either an ultrasound guided intra-articular hip injection of 40 mg...

Genes Flag Older Patients at Risk for Severe OA
https://www.medpagetoday.com/rheumatology/arthritis/98567

May 5th, 2022 - Genome-wide association studies have had a generally poor track record for yielding actionable information, but a new study in older adults at risk for severe osteoarthritis (OA) might allow early intervention to avoid joint replacement. Risk scores based on analysis of 47 single-nucleotide polymorphisms (SNPs) identified in previous association studies significantly predicted eventual knee and...