About 349,090 results

Prenatal Thalidomide and Cancer Risk; MDS Combo Shows Promise; Symptoms Often Missed

Mar 31st, 2023 - Another potential risk from prenatal exposure to thalidomide when it was used as an antiemetic during pregnancy in the 1960s and 1970s: colorectal cancer in adulthood. (UTHealth Houston, JNCI Cancer Spectrum) A novel combination treatment for high-risk myelodysplastic syndrome produced a high response rate in previously untreated patients. (University of Texas MD Anderson Cancer Center, Journal...

Sleep, Exercise, and Death; Pope Improving, Eats Pizza; Obesity Med Strategies

Mar 31st, 2023 - Note that some links may require subscriptions. Higher levels of physical activity may diminish the mortality risk associated with poor sleep, according to findings from the U.K. Biobank. (European Journal of Preventive Cardiology) Despite saying he strongly opposes it, President Biden has no plans to veto a Republican-led measure to end the national COVID-19 emergency; however, the public heal...

Commentary: Disease activity, JAK inhibitors, and pregnancy risks in PsA, April 2023
Vinod Chandran, MBBS, MD, DM, PhD

Mar 30th, 2023 - Vinod Chandran, MBBS, MD, DM, PhD Psoriatic arthritis (PsA) affects both skin and musculoskeletal structures. Typically, the arthritic manifestations occur after the onset of cutaneous psoriasis.

Sweaty treatment for social anxiety could pass the sniff test
Lucas Franki, Richard Franki et. al.

Mar 30th, 2023 - Getting sweet on sweat Are you the sort of person who struggles in social situations? Have the past 3 years been a secret respite from the terror and exhaustion of meeting new people? We understand your plight. People kind of suck.

Mucus plugging phenotype associated with adverse features
Walter Alexander, MDedge News

Mar 30th, 2023 - In a real-life clinic setting study aimed at determining phenotypic associations of mucus plugging in moderate to severe asthma patients, those with mucus plugging had worse lung function, more frequent severe exacerbations needing oral corticosteroids, and higher T2 biomarkers. Rory Chan, MBChB, of the University of Dundee (Scotland) and colleagues found conversely that the presence of these f.

Stutz: The psychiatrist as movie star
Dinah Miller, MD

Mar 29th, 2023 - For as long as I can remember, psychiatrists have talked about what the appropriate boundaries are for self-disclosure about personal issues with patients. There is obviously no exact answer as to what is acceptable to disclose; this depends on the doctor, the patient, the “brand” of psychotherapy, the patient’s issues, the nature of what is being disclosed, and maybe the alignment of the stars.

Cluster Headache, Migraine Linked to Circadian System

Mar 29th, 2023 - Cluster headache and migraine were linked to the circadian system, data from a meta-analysis and other research showed. Across 16 studies, cluster headache had a prominent circadian pattern of attacks in 70.5% of 4,953 participants, with a clear peak between 21:00 and 03:00 and circannual peaks in the spring and autumn, reported Mark Joseph Burish, MD, PhD, of the University of Texas Health Sci...

Osteoarthritis adjunctive therapies offer negligible added benefit to exercise
Tara Haelle

Mar 29th, 2023 - DENVER – Adding therapies such as acupuncture, electrophysical stimulation, or other interventions to standard exercise therapy does not appear to offer much benefit in pain relief or physical function for patients with knee osteoarthritis, according to a study presented at the OARSI 2023 World Congress. The findings were also published in the Cochrane Database of Systematic Reviews in October.

Antidepressants benefit some patients with osteoarthritis pain
Tara Haelle

Mar 29th, 2023 - DENVER – Using antidepressants to treat osteoarthritis pain can benefit some individuals but appears to have a clinically unimportant reduction in pain when looking at all patients who have tried them, according to a study presented at the OARSI 2023 World Congress. The review was also published in the Cochrane Database of Systematic Reviews in October 2022.

Gender-Affirming Care Has a Long History in the US – And Not Just for Transgender People
Clinical Advisor

Mar 29th, 2023 - The Conversation — In 1976, a received a prescription for 2 drugs: estrogen and progestin. Twelve months later, a local reporter noted Rhoda’s surprisingly soft skin and visible breasts. He wrote that the drugs had made her “so completely female.” Indeed, that was the point. The University of Virginia Medical Center in nearby Charlottesville had a clinic specifically for women like Rhoda. In fa...

Commentary: Chemotherapies and gynecologic surgeries relative to breast cancer, April 2023
Erin Roesch, MD

Mar 29th, 2023 - Erin Roesch, MD The goals of adjuvant chemotherapy for early breast cancer are to eradicate micrometastatic disease, reduce distant recurrence risk, and improve survival. Older patients may potentially be at higher risk for chemotherapy-related complications and are often underrepresented in clinical trials.

Pre-Existing Heart Failure Tied to Higher Mortality in Lymphoma

Mar 29th, 2023 - Patients with diffuse large B-cell lymphoma (DLBCL) and pre-existing heart failure (HF) were less likely to receive standard -- but cardiotoxic -- anthracycline treatment, likely resulting in worse survival outcomes, according to a longitudinal cohort study using Medicare data. HF at diagnosis was present in 14% of the 30,000 DLBCL patients in the study, and multivariable analysis showed this g...

COVID-19 potentially induced adult-onset IgA vasculitis
Heidi Splete

Mar 29th, 2023 - Plasma exchange successfully improved symptoms of immunoglobulin A vasculitis in an adult female patient who developed the condition after infection with COVID-19, according to a case report published in Cureus. Immunoglobulin A (IgA) vasculitis can affect all ages, but is relatively rare in adults, and the etiology remains unclear, wrote Hassan Alwafi, MD, of Umm Al-Qura University, Makkah, Sa.

Acetaminophen as Renoprotective Treatment in a Patient With Severe Malaria
Joshua Shultz, MD, Marina Antar-Shultz, DO et. al.

Mar 28th, 2023 - Renal impairment in severe falciparum malaria independently predicts a poor outcome in both adults and children. 1 Prompt recognition of malaria-associated renal failure and immediate management with renal replacement therapy reduces mortality and can support the recovery of renal function.

Cognition-Exercise Link; Telomere Length and Dementia; Slow Breathing and Amyloid

Mar 28th, 2023 - An umbrella review of meta-analyses showed a positive overall effect of exercise on cognition, but the underlying studies had substantial limitations. (Nature Human Behaviour) SARS-CoV-2 infection during pregnancy was associated with a higher risk of neurodevelopmental disorders in male offspring. (JAMA Network Open) The FDA will hold an advisory committee meeting to discuss the investigational...

Dupilumab moves forward as possible COPD treatment
Heidi Splete, MDedge News

Mar 28th, 2023 - Dupilumab, a fully human monoclonal antibody, significantly improved quality of life and respiratory symptoms compared with placebo in a phase 3 trial of more than 900 adults with uncontrolled chronic obstructive pulmonary disease. In the study, known as the BOREAS trial, dupilumab met its primary and secondary endpoints, with a significant reduction compared with placebo in exacerbations for a.

Subclinical Coronary Plaques Still Boost MI Risk

Mar 28th, 2023 - Clinically silent obstructive coronary atherosclerosis was linked to substantially elevated heart attack risk in middle-aged persons without known cardiovascular disease, a Danish population-based study showed. Over a median 3.5 years of follow-up, myocardial infarction (MI) risk was 9.19-fold higher with obstructive subclinical coronary atherosclerosis and 7.65-fold elevated with extensive sub...

RA in Remission? Stopping DMARDs May Be OK

Mar 28th, 2023 - Most rheumatoid arthritis (RA) patients who maintained remission with half-doses of conventional disease-modifying anti-rheumatic drug (DMARD) therapy and then proceeded to full stoppage stayed flare-free for 1 year, results from a small randomized trial indicated. Ten of 26 patients assigned to DMARD discontinuation experienced a disease flare within 12 months, compared with five of 30 who rem...

A Whole Person Approach to Lifting the Burden of Chronic Pain Among Service Members and...
NIH Director's Blog;

Mar 28th, 2023 - Chronic pain and its companion crisis of opioid misuse have taken a terrible toll on Americans. But the impact has been even greater on U.S. service members and veterans, who often deal with the compounded factors of service-related injuries and traumatic stress. For example, among soldiers in a leading U.S. Army unit, 44 percent had chronic pain and 15 percent used opioids after a combat deplo...

Cartesian Therapeutics expands clinical advisory board with five internationally recognized experts in autoimmunity

Mar 28th, 2023 - Gaithersburg, MD—March 28, 2023 – Cartesian Therapeutics, a fully integrated biopharmaceutical company pioneering RNA cell therapy for autoimmune diseases and cancer, today announced the appointment of five internationally recognized experts in autoimmune diseases. Cartesian’s appointments include distinguished physicians and scientists as leaders in clinical trials and medicine. “Cartesian is ...