Mar 31st, 2023 - Another potential risk from prenatal exposure to thalidomide when it was used as an antiemetic during pregnancy in the 1960s and 1970s: colorectal cancer in adulthood. (UTHealth Houston, JNCI Cancer Spectrum) A novel combination treatment for high-risk myelodysplastic syndrome produced a high response rate in previously untreated patients. (University of Texas MD Anderson Cancer Center, Journal...

Mar 31st, 2023 - Note that some links may require subscriptions. Higher levels of physical activity may diminish the mortality risk associated with poor sleep, according to findings from the U.K. Biobank. (European Journal of Preventive Cardiology) Despite saying he strongly opposes it, President Biden has no plans to veto a Republican-led measure to end the national COVID-19 emergency; however, the public heal...

Mar 30th, 2023 - Vinod Chandran, MBBS, MD, DM, PhD Psoriatic arthritis (PsA) affects both skin and musculoskeletal structures. Typically, the arthritic manifestations occur after the onset of cutaneous psoriasis.

Mar 30th, 2023 - Getting sweet on sweat Are you the sort of person who struggles in social situations? Have the past 3 years been a secret respite from the terror and exhaustion of meeting new people? We understand your plight. People kind of suck.

Mar 30th, 2023 - In a real-life clinic setting study aimed at determining phenotypic associations of mucus plugging in moderate to severe asthma patients, those with mucus plugging had worse lung function, more frequent severe exacerbations needing oral corticosteroids, and higher T2 biomarkers. Rory Chan, MBChB, of the University of Dundee (Scotland) and colleagues found conversely that the presence of these f.

Mar 29th, 2023 - For as long as I can remember, psychiatrists have talked about what the appropriate boundaries are for self-disclosure about personal issues with patients. There is obviously no exact answer as to what is acceptable to disclose; this depends on the doctor, the patient, the “brand” of psychotherapy, the patient’s issues, the nature of what is being disclosed, and maybe the alignment of the stars.

Mar 29th, 2023 - Cluster headache and migraine were linked to the circadian system, data from a meta-analysis and other research showed. Across 16 studies, cluster headache had a prominent circadian pattern of attacks in 70.5% of 4,953 participants, with a clear peak between 21:00 and 03:00 and circannual peaks in the spring and autumn, reported Mark Joseph Burish, MD, PhD, of the University of Texas Health Sci...

Mar 29th, 2023 - DENVER – Adding therapies such as acupuncture, electrophysical stimulation, or other interventions to standard exercise therapy does not appear to offer much benefit in pain relief or physical function for patients with knee osteoarthritis, according to a study presented at the OARSI 2023 World Congress. The findings were also published in the Cochrane Database of Systematic Reviews in October.

Mar 29th, 2023 - DENVER – Using antidepressants to treat osteoarthritis pain can benefit some individuals but appears to have a clinically unimportant reduction in pain when looking at all patients who have tried them, according to a study presented at the OARSI 2023 World Congress. The review was also published in the Cochrane Database of Systematic Reviews in October 2022.

Mar 29th, 2023 - The Conversation — In 1976, a received a prescription for 2 drugs: estrogen and progestin. Twelve months later, a local reporter noted Rhoda’s surprisingly soft skin and visible breasts. He wrote that the drugs had made her “so completely female.” Indeed, that was the point. The University of Virginia Medical Center in nearby Charlottesville had a clinic specifically for women like Rhoda. In fa...

Mar 29th, 2023 - Erin Roesch, MD The goals of adjuvant chemotherapy for early breast cancer are to eradicate micrometastatic disease, reduce distant recurrence risk, and improve survival. Older patients may potentially be at higher risk for chemotherapy-related complications and are often underrepresented in clinical trials.

Mar 29th, 2023 - Patients with diffuse large B-cell lymphoma (DLBCL) and pre-existing heart failure (HF) were less likely to receive standard -- but cardiotoxic -- anthracycline treatment, likely resulting in worse survival outcomes, according to a longitudinal cohort study using Medicare data. HF at diagnosis was present in 14% of the 30,000 DLBCL patients in the study, and multivariable analysis showed this g...

Mar 29th, 2023 - Plasma exchange successfully improved symptoms of immunoglobulin A vasculitis in an adult female patient who developed the condition after infection with COVID-19, according to a case report published in Cureus. Immunoglobulin A (IgA) vasculitis can affect all ages, but is relatively rare in adults, and the etiology remains unclear, wrote Hassan Alwafi, MD, of Umm Al-Qura University, Makkah, Sa.

Mar 28th, 2023 - Renal impairment in severe falciparum malaria independently predicts a poor outcome in both adults and children. 1 Prompt recognition of malaria-associated renal failure and immediate management with renal replacement therapy reduces mortality and can support the recovery of renal function.

Mar 28th, 2023 - An umbrella review of meta-analyses showed a positive overall effect of exercise on cognition, but the underlying studies had substantial limitations. (Nature Human Behaviour) SARS-CoV-2 infection during pregnancy was associated with a higher risk of neurodevelopmental disorders in male offspring. (JAMA Network Open) The FDA will hold an advisory committee meeting to discuss the investigational...

Mar 28th, 2023 - Dupilumab, a fully human monoclonal antibody, significantly improved quality of life and respiratory symptoms compared with placebo in a phase 3 trial of more than 900 adults with uncontrolled chronic obstructive pulmonary disease. In the study, known as the BOREAS trial, dupilumab met its primary and secondary endpoints, with a significant reduction compared with placebo in exacerbations for a.

Mar 28th, 2023 - Clinically silent obstructive coronary atherosclerosis was linked to substantially elevated heart attack risk in middle-aged persons without known cardiovascular disease, a Danish population-based study showed. Over a median 3.5 years of follow-up, myocardial infarction (MI) risk was 9.19-fold higher with obstructive subclinical coronary atherosclerosis and 7.65-fold elevated with extensive sub...

Mar 28th, 2023 - Most rheumatoid arthritis (RA) patients who maintained remission with half-doses of conventional disease-modifying anti-rheumatic drug (DMARD) therapy and then proceeded to full stoppage stayed flare-free for 1 year, results from a small randomized trial indicated. Ten of 26 patients assigned to DMARD discontinuation experienced a disease flare within 12 months, compared with five of 30 who rem...

Mar 28th, 2023 - Chronic pain and its companion crisis of opioid misuse have taken a terrible toll on Americans. But the impact has been even greater on U.S. service members and veterans, who often deal with the compounded factors of service-related injuries and traumatic stress. For example, among soldiers in a leading U.S. Army unit, 44 percent had chronic pain and 15 percent used opioids after a combat deplo...

Mar 28th, 2023 - Gaithersburg, MD—March 28, 2023 – Cartesian Therapeutics, a fully integrated biopharmaceutical company pioneering RNA cell therapy for autoimmune diseases and cancer, today announced the appointment of five internationally recognized experts in autoimmune diseases. Cartesian’s appointments include distinguished physicians and scientists as leaders in clinical trials and medicine. “Cartesian is ...