May 23rd, 2022 - A clinical practice guideline for the diagnosis and management of gastrointestinal hamartomatous polyposis syndromes has just been published by the U. S.

May 21st, 2022 - The first prospective study to evaluate the accuracy of a blood test for people being screened for colorectal cancer (CRC) revealed a high sensitivity and specificity. At 90% specificity, the blood assay (Guardant Health) was 100% sensitive for detecting CRC. At 95% specificity, sensitivity was 88%. The blood assay detects circulating tumor DNA from cancer in the bloodstream, which is then anal...

May 20th, 2022 - On the basis of the patient's presentation, history, and imaging results, the likely diagnosis is metastatic small cell lung cancer (SCLC). Most patients with SCLC present with hematogenous metastases; only about one third present with limited disease confined to the chest that is amenable to multimodal therapy.

May 20th, 2022 - UPDATE: On May 19, 2022, the FDA updated this safety communication to provide the latest information about medical device reports (MDRs) associated with the breakdown of the polyester-based polyurethane (PE-PUR) foam used in the Philips Respironics ventilator, BiPAP machine, and CPAP machine recalls. In addition, the FDA has taken additional actions since this updated safety communication was i...

May 20th, 2022 - Thrombocytopenia is an abnormally low platelet count with various causes. Low levels of platelets present risks such as bleeding and thrombosis. The National Organization for Rare Diseases (NORD) estimates that more than 200,000 people have primary immune thrombocytopenia (ITP) worldwide; the incidence among adults in the United States is 3.3 cases per 100,000 adults/year. Would you be able to ...

May 20th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The association between gum disease and significant comorbidities has been highlighted in several recent studies. From inflammatory disorders to neurologic disord...

May 20th, 2022 - A comprehensive assessment of the benefits of medical cannabis for cancer-related pain found that for most oncology patients, pain measures improved significantly, other cancer-related symptoms also decreased, the consumption of painkillers was reduced, and the side effects were minimal. Published in Frontiers in Pain Research, these findings suggest that medicinal cannabis can be carefully con...

May 20th, 2022 - It is always difficult for doctors to determine why certain illnesses arise in our bodies. Old age, risk behavior such as smoking or genetics can all be part of the puzzle. However, the exact, individual reasons for serious diseases such as cancer remain elusive. Now, a new ground-breaking method called 'Deep Visual Proteomics' could help change just that. The method has been invented by an int...

May 20th, 2022 - An article published May 20 in Nature Digital Medicine provides a step-by-step plan for an international effort to create a digital twin of the human immune system. “This paper outlines a road map that the scientific community should take in building, developing and applying a digital twin of the immune system,” said Tomas Helikar, a University of Nebraska-Lincoln biochemist who is one of 10 c...

May 20th, 2022 - An article published in Scientific Reports describes a study demonstrating the effectiveness of a peptide developed by Brazilian scientists, called Rb4, to combat cancer progression in an animal model, especially malignant melanoma. The molecule holds promise for the treatment of drug-resistant tumors. Preclinical in vitro and in vivo trials indicated that Rb4 triggers necrosis in murine melano...

May 20th, 2022 - COLUMBUS, Ohio – Researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have identified a new molecular drug target that could result in new cancer drugs with fewer side effects. Previous studies have shown that vascular endothelial growth factor-A (VEGF-A) – a potent cytokine (signaling ...

May 20th, 2022 - BIRMINGHAM, Ala. – James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5. Cdk5 is a crucial regulator of signaling in brain neurons. Over three decades of study, it has been implicated in neuro...

May 20th, 2022 - Although adolescents and young adults (AYAs) who survive leukemia are living much longer than ever before, their life spans are still shorter than those of the general population, a new study concludes. The study found that the 10-year survival of AYA leukemia survivors was approximately 10% lower than that of the age-adjusted US general population at large. These differences persisted for up t...

May 20th, 2022 - The study was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways Patients with advanced gastric cancer who have active Helicobacter pylori infections were less likely to respond to anti-PD-1 antibody therapy than H pylori–negative patients. Those with active H pylori infections also demonstrated shorter progression-free survival (PFS) and overall sur...

May 20th, 2022 - Thrombocytopenia is an abnormally low platelet count with various causes. Low levels of platelets present risks such as bleeding and thrombosis. The National Organization for Rare Diseases (NORD) estimates that more than 200,000 people have primary immune thrombocytopenia (ITP) worldwide; the incidence among adults in the United States is 3.3 cases per 100,000 adults/year. Would you be able to ...

May 20th, 2022 - Each week, we identify one top search term, speculate about what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, share them with us on Twitter or Facebook.  The association between gum disease and significant comorbidities has been highlighted in several recent studies. From inflammatory disorders to neurologic disord...

May 20th, 2022 - This transcript has been edited for clarity. I'm Maurie Markman from Cancer Treatment Centers of America. I would like to briefly comment on the abstracts that have been released for the American Society of Clinical Oncology (ASCO) meeting coming up next month in Chicago and specifically the gynecologic oncology track. It's going to be a very interesting series of sessions. There's an oral abst...

May 20th, 2022 - The study was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways Men with metastatic castration-resistant prostate cancer (mCRPC) who began treatment on enzalutamide instead of abiraterone remained on treatment longer and lived a few more months. Older men and those with diabetes or cardiovascular disease also benefited more from enzalutamide. Why Th...

May 19th, 2022 - While most commonly known as “the powerhouses of the cell” because of their energy producing capabilities, mitochondria also play important roles in regulating the health of cells. These important structures can be damaged by alcohol consumption, which can cause them to rupture and release their DNA, proteins and lipids, collectively known as “damage associated molecular patterns” (DAMPs). Rupt...

May 19th, 2022 - AUGUSTA, Ga. (May 19, 2022) – A test for the common blood cancer multiple myeloma also holds clear clues that the patient has one of the most uncommon and deadly forms of this cancer, investigators say. While there is a specific test for this rare IgD multiple myeloma, the clues from standard testing are sufficient to rapidly initiate aggressive treatment to reduce or prevent kidney destruction...