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Intracranial Atherosclerotic Disease Clinical Practice Guidelines (ESO, 2022)

Oct 3rd, 2022 - Guidelines for the management of patients with intracranial atherosclerotic disease (ICAD) were published in September 2022 by the European Stroke Organisation (ESO) in European Stroke Journal.[1] Oral anticoagulation is not recommended over aspirin in patients with an ischemic stroke or transient ischemic attack due to high-grade stenosis related to intracranial atherosclerotic disease (ICAD)....

SMART-CHOICE 3-Year Results Support Dropping Aspirin After PCI

Sep 30th, 2022 - Shortening the duration of dual antiplatelet therapy (DAPT) and continuing with a P2Y12 inhibitor alone after percutaneous coronary intervention (PCI) was associated with a similar rate of ischemic events but with less bleeding than prolonged DAPT after 3 years of follow-up in the SMART-CHOICE trial. "The current results of extended follow-up from the SMART-CHOICE trial support evidence of an a...

Do Older vs Younger Docs Treat Atrial Fibrillation Differently?

Sep 29th, 2022 - This transcript has been edited for clarity. Robert A. Harrington, MD: Hi. I'm Bob Harrington from Stanford University. I'm here in Barcelona at the European Society of Cardiology (ESC) meeting. First, I have to say, wow, it's fantastic to be back at a live, face-to-face meeting, getting to see friends and colleagues from around the globe in addition to hearing about great science. While here, ...

Alopecia Areata: Positive Results Reported for Two Investigational JAK Inhibitors

Sep 29th, 2022 - Treatment with deuruxolitinib and ritlecitinib, two investigational Janus kinase (JAK) inhibitors, resulted in substantial regrowth of scalp hair for patients with alopecia areata (AA) in separate studies reported at the European Academy of Dermatology and Venereology (EADV) 2022 Annual Meeting. In the THRIVE-AA1 study, the primary endpoint of a Severity of Alopecia Tool (SALT) score of ≤20 ― w...

Food Insecurity a Growing Problem for Many With CVD

Sep 29th, 2022 - A growing number of Americans with cardiovascular disease (CVD) have limited or uncertain access to food, results of a new study suggest. An analysis of data from the National Health and Nutrition Examination Survey (NHANES) representing more than 300 million American adults found that, overall, 38.1% of people with cardiovascular disease were food insecure in 2017-2019. Twenty years earlier, t...

PROACT Xa Trial of Apixaban With On-X Heart Valve Stopped

Sep 29th, 2022 - Artivion Inc. has halted the PROACT Xa clinical trial that was testing whether patients with an On-X mechanical aortic valve could be safely and effectively managed with the direct oral anticoagulant (DOAC) apixaban (Eliquis) rather than warfarin. The decision to stop the trial was based on the recommendation of the independent data and safety monitoring board (DSMB), which cited a lack of evid...

Positive Topline Phase 3 Data for Lecanemab in Early Alzheimer's

Sep 28th, 2022 - Lecanemab (Eisai/Biogen), an investigational amyloid-clearing monoclonal antibody, reduced cognitive decline by 27% compared to placebo and decreased amyloid levels in the brain of adults enrolled in a phase 3 trial. The Clarity AD trial included 1795 adults with early AD and confirmed amyloid pathology in the brain. Treatment consisted of lecanemab 10 mg/kg biweekly or matching placebo. Treatm...

Associations Observed Between Sleep Disorders and RA Disease Activity, Pain
Clinical Advisor

Sep 27th, 2022 - A significant percentage of patients with rheumatoid arthritis (RA) met the criteria for sleep disorders, including obstructive sleep apnea (OSA), restless legs syndrome (RLS), and short sleep, according to results of a study published in Arthritis Care & Research (Hoboken). In addition, RA disease activity and pain were also found to be linked to the sleep conditions. Although poor sleep is of...

New Data on Stroke Recovery Patterns May Guide Rehabilitation

Sep 26th, 2022 - Long-term recovery patterns after a stroke differ in different functional domains and vary by patient age, stroke severity, and stroke type, a new study shows.   The results also suggest that improvements occur in many functional domains over a longer timescale than previously thought, with consequent implications for rehabilitative care.  "Understanding the diversity of long-term functional re...

Will Factor XI Be the Goldilocks Anticoagulant Target?

Sep 26th, 2022 - This transcript has been edited for clarity. John M. Mandrola, MD: Hi, everyone. This is John Mandrola from theheart.org | Medscape Cardiology. I'm here in Barcelona, Spain, at the European Society of Cardiology meeting. I'm really happy to have Professor John Eikelboom from Hamilton and McMasters University. Dr Eikelboom is an expert in anticoagulation, and we're going to talk about this new a...

Case Challenge: Woman Presents to Emergency Department With Headache and Hypertension

Sep 23rd, 2022 - Background A 25-year-old woman presents to the emergency department (ED) with report of a severe headache. The pain is constant, throbbing, and located in the occipital region of her head. Additional symptoms include occasional episodes of blurred vision. Two days prior, she presented to an ED at a different hospital for severe headache. Her blood pressure was 152/98 mm Hg at admission and 156/...

Sep 23, 2022 This Week in Cardiology Podcast

Sep 23rd, 2022 - Please note that the text below is not a full transcript and has not been copyedited. For more insight and commentary on these stories, subscribe to the This Week in Cardiology podcast on Apple Podcasts, Spotify, or your preferred podcast provider. This podcast is intended for healthcare professionals only. In This Week’s Podcast For the week ending September 23, 2022, John Mandrola, MD comment...

Fast Five Quiz: Dizziness and Vertigo

Sep 22nd, 2022 - Large, population-based studies indicate that 15%-20% of the world's adult population experiences dizziness annually. This includes a high prevalence of various forms of vertigo. Whether occurring independently or caused by drug use or serious conditions, addressing dizziness and vertigo in patients can be challenging. Do you know key causes and risk factors associated with dizziness and vertig...

Deprescribing Aspirin for Warfarin Patients May Reduce Bleeding

Sep 22nd, 2022 - Many patients receiving long-term warfarin are also taking aspirin, often unnecessarily. Stopping aspirin for these patients reduces bleeding complications without any apparent harm, a new study has shown. "Many patients on anticoagulation are taking aspirin without a clear indication, which is putting them at an increased risk of bleeding without offering them any benefits," senior author Geof...

Children With Sickle Cell Anemia Not Getting Treatments, Screening

Sep 21st, 2022 - Fewer than half of children aged 2-16 years with sickle cell anemia are receiving recommended annual screening for stroke, a common complication of the disease, according to a new Vital Signs report from the Centers for Disease Control and Prevention. Many of these children also are not receiving the recommended medication, hydroxyurea, which can reduce pain and acute chest syndrome and improve...

Unresolved Kidney Injury Ups Death Risk After COVID-19 Hospitalization
Cardiology Advisor

Sep 20th, 2022 - Patients with acute kidney injury (AKI) during a COVID-19 hospitalization remain at high risk for death after discharge, especially when AKI does not resolve, according to a new study. Among 1017 patients hospitalized with COVID-19 who survived until discharge, 298 patients (29.3%) experienced in-hospital AKI. Of these, 178 patients (59.7%) still had unresolved kidney injury at the time of disc...

Trivia Quiz: Diseases of World Leaders

Sep 20th, 2022 - Illnesses of world leaders are always of interest, but often concealed, to the public. Do you know what diseases and health issues world leaders endured? Test yourself with this quick quiz.

Consider Life Expectancy When Referring for LAA Closure?

Sep 20th, 2022 - Almost 1 in 6 patients undergoing percutaneous left atrial appendage (LAA) closure die within a year, new registry data show, suggesting that assessment of life expectancy may be needed before performing this procedure. The study also identified five risk factors independently associated with death within a year of LAA closure. These were older age (over 78 years), low body mass index (below 23...

Cardiovascular Disease Risk in Patients With Pyoderma Gangrenosum
Dermatology Advisor

Sep 19th, 2022 - Patients diagnosed with pyoderma gangrenosum face an increased risk for myocardial infarction (MI) and peripheral vascular disease (PVD), according to study findings published in the Journal of the European Academy of Dermatology and Venereology. Researchers aimed to evaluate the risk for and prognostic outcomes of pulmonary embolism (PE), peripheral vascular disease (PVD), cerebrovascular acci...

Home BP Monitoring in Older Adults Falls Short of Recommendations

Sep 19th, 2022 - Just over 51% of older hypertensive adults regularly check their own blood pressure, compared with 48% of those with blood pressure–related health conditions (BPHCs), based on a 2021 survey of individuals aged 50-80 years. "Guidelines recommend that patients use self-measured blood pressure monitoring (SBPM) outside the clinic to diagnose and manage hypertension," but just 61% of respondents wi...