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Will Slow and Steady Progress in Treating SCLC Win the Race?
https://www.onclive.com/view/will-slow-and-steady-progress-in-treating-sclc-win-the-race-

Oct 22nd, 2021 - Clinical advances in the treatment of small cell lung cancer (SCLC) have lagged behind those of other tumor types, but the delay is not for lack of effort. In recent years, however, improved understanding of disease biology has identified some novel targets that may make these tumors more vulnerable to treatment. One such approach in the frontline setting has been the integration of various imm...

Many States Frown Upon Medicaid Coverage of Penile Implants for ED
https://www.medpagetoday.com/urology/erectiledysfunction/95204

Oct 22nd, 2021 - SCOTTSDALE, Ariz. -- At least 21 states still don't provide Medicaid coverage for penile implants in patients with erectile dysfunction (ED), a new study found. In contrast, 49 states cover male urethral slings, and 48 states cover insertion of artificial urinary sphincters for male incontinence, reported John Barnard, MD, of West Virginia University in Morgantown, who presented the findings at...

Cabozantinib Shows Activity Against RCC Brain Metastases
https://www.medpagetoday.com/hematologyoncology/renalcellcarcinoma/95201

Oct 22nd, 2021 - The tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx) showed promising activity against brain metastases from renal cell carcinoma (RCC), researchers reported. In a retrospective cohort study of 88 patients with RCC brain metastases, the intracranial response rate with cabozantinib was 55% (95% CI 36-73%) in those with progressing brain metastases without concomitant brain-directed local...

Guidelines for dementia and age-related cognitive changes
https://www.mdedge.com/familymedicine/article/247740/neurology/guidelines-dementia-and-age-related-cognitive-changes
MDedge Family Medicine; Linda Girgis, MD

Oct 21st, 2021 - Dementia remains a major cause of disability in older adults. In addition, it places a strain on family members and other caregivers taking care of these patients.

New Class of Radiopharmaceutical Therapy Makes Headway in Prostate Cancer
https://www.onclive.com/view/new-class-of-radiopharmaceutical-therapy-makes-headway-in-prostate-cancer

Oct 21st, 2021 - Investigators have made great strides in the development of radiopharmaceuticals for prostate cancer diagnostics, culminating in recent FDA approvals for the first prostate-specific membrane antigen (PSMA)–targeted radioligands, gallium 68 (68Ga)–PSMA-11 and piflufolastat F 18 (Pylarify), for the detection of disease recurrence and metastatic lesions.1,2 Meanwhile, the use of PSMA-targeted rad...

Rare Aggressive Bladder Cancer Treated Successfully in Elderly Man
https://www.medpagetoday.com/hematologyoncology/othercancers/95172

Oct 21st, 2021 - A 71-year-old man presented to hospital in November 2014 upon referral after reporting pain and evidence of blood on urination. Imaging and cystoscopy assessments identified a vegetative lesion of the bladder wall. The patient reported being a heavy smoker for the past 30 years. His medical history over the past 3 decades included high blood pressure, elevated cholesterol, and psoriasis. His su...

IGHV Mutation Status Now Included in clonoSEQ Diagnostic Assay in CLL
https://www.onclive.com/view/ighv-mutation-status-now-included-in-clonoseq-diagnostic-assay-in-cll

Oct 20th, 2021 - An upgraded model of the clonoSEQ® B-cell Clonality diagnostic tool has been released, which will now include IGHV mutation status for patients with chronic lymphocytic leukemia (CLL), according to a press release from Adaptive Biotechnologies, the developer of the assay.1 Since September 30, 2021, all clonoSEQ B-cell Clonality evaluations have included IGHV mutation status. clonoSEQ is a...

Experience with Trastuzumab Deruxtecan in Breast Cancer
https://www.onclive.com/view/experience-with-trastuzumab-deruxtecan-in-breast-cancer

Oct 20th, 2021 - Transcript: Sara Tolaney, MD: In my clinical practice, when using trastuzumab deruxtecan [T-DXd] we also have seen these really impressive response rates and rates of disease control. As was noted in DESTINY-Breast03 [DB03], the response rate was about 80%. The complete response rate was about 16%. We’ve never seen a complete response rate this high, suggesting that this agent may be allowing ...

Role of HPV Vaccination and Screening to Prevent Cervical Cancer
https://www.onclive.com/view/role-of-hpv-vaccination-and-screening-to-prevent-cervical-cancer

Oct 19th, 2021 - Transcript: Bradley Monk, MD, FACOG, FACS: Dr. Thaker, you’ve been a passioned advocate for all levels of special populations. This is a preventable disease. We live now in the pandemic and vaccination is important. What’s the role of vaccination in preventing what Dr. Pothuri said, a virally-induced cancer? Tell us about that. Premal H. Thaker, MD, MS: It’s critical to know that we’ve had ...

Few poorly prepped colonoscopies repeated within 1 year
https://www.mdedge.com/internalmedicine/article/247580/gastroenterology/few-poorly-prepped-colonoscopies-repeated-within-1
MDedge Internal Medicine; Heidi Splete

Oct 19th, 2021 - Approximately one-third of colonoscopies with inadequate bowel preparation were repeated within 1 year despite current guidelines, according to data from a new study of more than 260,000 procedures. Eraxion/Thinkstock Previous studies have shown that poor bowel prep, which occurs in approximately 25% of colonoscopies, can lead to lesion miss rates of as much as 42%-48%, Audrey H.

UGN-102 May Provide Alternative to Repetitive Surgery in Low-Grade Intermediate-Risk NMIBC
https://www.onclive.com/view/ugn-102-may-provide-alternative-to-repetitive-surgery-in-low-grade-intermediate-risk-nmibc

Oct 19th, 2021 - Non-surgical primary chemoablation using mitomycin-containing reverse thermal gel UGN-102 produced significant, durable responses in those with low-grade intermediate-risk non–muscle invasive bladder cancer (NMIBC), according to data from the phase 2b OPTIMA II trial (NCT03558503) published in The Journal of Urology.1 Results showed that among 63 patients who received 1 or more installation of...

CIN Prophylaxis: When to Intervene
https://www.onclive.com/view/cin-prophylaxis-when-to-intervene

Oct 19th, 2021 - Hope S. Rugo, MD, FASCO: It’s important for us to understand when patients are at their greatest risk for CIN [cervical intraepithelial neoplasia], which is after they start chemotherapy. That’s something our patients also want to know, in terms of what their risk is if they’re going to travel or work. I don’t know that the guidelines address this and how it’s taken into our clinical decision-m...

Guideline Recommendations for CIN Prophylaxis
https://www.onclive.com/view/guideline-recommendations-for-cin-prophylaxis

Oct 19th, 2021 - Hope S. Rugo, MD, FASCO: It’s really important: the whole concept of why we worry about this and how we treat it and also prophylax. We’ll talk more about that later. Tiffany, there are clear risk factors, as Bill and Rita pointed out. Can you tell us a little more about the risk factors, how you monitor patients, and if the risk factors change either the chemotherapy you choose, the doses, or ...

Addressing AYA Cancer Requires a Tailored Approach to Practice
https://www.onclive.com/view/addressing-aya-cancer-requires-a-tailored-approach-to-practice

Oct 19th, 2021 - Investigators have expanded the scientific understanding of cancer in the adolescent young adult (AYA) patient population over the past decade. However, unmet needs remain in establishing treatment standards, addressing unique survivorship challenges, and providing a framework for patients to reference as they navigate their cancer journey. The AYA group, defined as patients aged 15 to 39 year...

Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August–October 2020
https://wwwnc.cdc.gov/eid/article/27/11/21-1306_article

Oct 19th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), can spread rapidly within congregate settings, including institutions of higher education (IHEs) (1,2). During August–December 2020, as IHEs around the United States resumed in-person instruction, IHE-associated SARS-CoV-2 cases began to rise (3). By February 2021, >530,000 COVID-19 cases ...

Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar
https://wwwnc.cdc.gov/eid/article/27/11/21-0726_article

Oct 19th, 2021 - Tuberculosis (TB) is the infectious disease that causes the most deaths worldwide (≈5,000/day) (1). Of major concern is the increasing prevalence of drug resistance worldwide (1). There are different forms of TB drug resistance: pre‒multidrug-resistant TB (pre‒MDR TB, resistant to 1 of 2 first-line drugs: isoniazid or rifampin); multidrug-resistant TB (MDR TB, resistant to 2 first-line drugs: i...

Bordetella hinzii Pneumonia and Bacteremia in a Patient with SARS-CoV-2 Infection
https://wwwnc.cdc.gov/eid/article/27/11/21-1468_article

Oct 19th, 2021 - Since the December 2019 beginning of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), there have been >180 million cases and >3.9 million deaths worldwide (1). Severe bacterial and fungal co-infections are a major concern with COVID-19 and increase disease mortality (2). The genus Bordetella comprises >10 known species of small, ...

Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Bacteremia and Monocyte Evasion, Rio de Janeiro, Brazil
https://wwwnc.cdc.gov/eid/article/27/11/21-0097_article

Oct 19th, 2021 - Methicillin-resistant Staphylococcus aureus (MRSA) is characterized by the mainly clonal structure of bacterial populations and the worldwide spread of a few highly successful lineages, sequence types (STs), and clonal complexes (CCs) that cycle through waves of dominance (1,2). During the late 1990s, the Brazilian endemic clone (BEC), which belongs to the ST239(CC8)–staphylococcal cassette chr...

Policy Review and Modeling Analysis of Mitigation Measures for Coronavirus Disease Epidemic Control, Health System, and Disease Burden, South Korea
https://wwwnc.cdc.gov/eid/article/27/11/20-3779_article

Oct 19th, 2021 - Since the first reported outbreak in Wuhan, China, on December 31, 2019, severe acute respiratory syndrome coronavirus 2 has infected >210 million persons and resulted in nearly 4.4 million deaths worldwide as of August 2021 (1). Many countries have responded to the coronavirus disease (COVID-19) pandemic with unprecedented large-scale anticontagion policies, including closure of nonessential b...

Fatal Co-infections with SARS-CoV-2 and Legionella pneumophila, England
https://wwwnc.cdc.gov/eid/article/27/11/20-4121_article

Oct 19th, 2021 - Legionnaires’ disease, caused by Legionella bacteria, is a factor in community and healthcare acquired pneumonia. Legionella infection occurs from manmade water sources, including water aerosolized from cooling towers, spa pools, and water features, and from plumbing in hotels, workplaces, and healthcare facilities (1), where patients can be more susceptible to infection (1). Severe acute respi...