×
About 26 results

Variants Spur New FDA Guidance on COVID Vaccines, Tests, Drugs
https://www.medscape.com/viewarticle/946266

Feb 21st, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. The US Food and Drug Administration (FDA) on Monday updated its October guidance for manufacturers developing COVID-19 vaccines, diagnostics, and treatments in the wake of circulating SARS-CoV-2 variants. The United States is currently facing three main variant threats, according to the Centers...

Batten Down the Hatches for Thyroid Storm
https://www.staging.medscape.com/viewarticle/937168

Sep 9th, 2020 - Thyroid storm is a life-threatening endocrine emergency for which, remarkably, there are no definitive diagnostic tests, and the management of which is supported by a startlingly weak evidence base. "What's tricky is there really are no specific biochemical level cutoffs for thyroid storm, and also no unique laboratory abnormalities. So in the end, it's a clinical diagnosis and a clinical judgm...

Fast Five Quiz: Chronic Spontaneous Urticaria
https://reference.medscape.com/viewarticle/920709_6

Jun 14th, 2020 - Answer 5/5 Which of the following treatment options is recommended for patients with severe CSU? Your peers chose: Combination antihistamine agents 0% Increasing the antihistamine dose 0% Switching to a different antihistamine 0% Prescribing a "cocktail" of antihistamines, antidepressant medications, and aspirin 0% When treating patients with severe CSU, both the AAAI and EAACI/GA2LEN/ EDF/WAO ...

Fast Five Quiz: Chronic Spontaneous Urticaria
https://reference.medscape.com/viewarticle/920709_5

Jun 14th, 2020 - Both the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the European Academy of Allergy and Clinical Immunology (EAACI)/Global Allergy and Asthma European Network (GA2LEN)/European Dermatology Forum (EDF)/World Allergy Organization (WAO) recommend second-generation antihistamines as the first-line treatment for CSU. Second-generation antihistamines are low-sedation antihistamin...

Fast Five Quiz: Chronic Spontaneous Urticaria
https://reference.staging.medscape.com/viewarticle/920709_2

Jun 14th, 2020 - CSU, which has a global prevalence of 0.5%-5% of the general population, occurs more frequently in adult women than in adult men. The average peak age of onset of CSU is between 20 and 40 years. Learn more about the epidemiology of CSU.

Fast Five Quiz: Chronic Spontaneous Urticaria
https://reference.medscape.com/viewarticle/920709

Jun 14th, 2020 - Chronic spontaneous urticaria (CSU) (also referred to as "chronic idiopathic urticaria") represents the majority of cases of chronic urticaria. CSU is defined as chronic urticaria of known or unknown etiology lasting for ≥ 6 weeks. In a subset of patients with CSU, there is an identifiable underlying autoimmune etiology (chronic autoimmune urticaria). CSU can be challenging to manage and often ...

'Major Impact': Olanzapine for CINV at 5 mg, Not 10 mg
https://www.staging.medscape.com/viewarticle/923291

Jan 1st, 2020 - For years, the antipsychotic olanzapine (Zyprexa, Lilly) has been used off label for chemotherapy-induced nausea and vomiting (CINV), but the currently recommended 10-mg dose causes daytime sedation. Now a phase 3 randomized controlled trial has shown that a 5-mg dose is effective at controlling CINV but does not have sedation as a side effect. The results could change clinical guidelines from ...

'Major Impact': Olanzapine for CINV at 5 mg, Not 10 mg
https://www.medscape.com/viewarticle/923291

Jan 1st, 2020 - For years, the antipsychotic olanzapine (Zyprexa, Lilly) has been used off label for chemotherapy-induced nausea and vomiting (CINV), but the currently recommended 10-mg dose causes daytime sedation. Now a phase 3 randomized controlled trial has shown that a 5-mg dose is effective at controlling CINV but does not have sedation as a side effect. The results could change clinical guidelines from ...

Most Drug Treatments Fail to Control Long-term OA Pain
https://www.staging.medscape.com/viewarticle/907032

Dec 26th, 2018 - The first meta-analysis of long-term pharmacologic treatments for knee osteoarthritis (OA) found little evidence that most currently prescribed medications improve pain control or preserve joint structure after 12 months of treatment. There was a small but statistically and clinically significant benefit from prescription-grade glucosamine sulfate. The study, by Dario Gregori, PhD, from the Uni...

Most Drug Treatments Fail to Control Long-term OA Pain
https://www.medscape.com/viewarticle/907032

Dec 26th, 2018 - The first meta-analysis of long-term pharmacologic treatments for knee osteoarthritis (OA) found little evidence that most currently prescribed medications improve pain control or preserve joint structure after 12 months of treatment. There was a small but statistically and clinically significant benefit from prescription-grade glucosamine sulfate. The study, by Dario Gregori, PhD, from the Uni...

Pediatric Multiple Sclerosis: A Game-Changing New Therapy
https://www.medscape.com/viewarticle/901407

Sep 13th, 2018 - Good morning. My name's Brenda Banwell. I'm the chief of neurology at the Children's Hospital of Philadelphia. I serve as the director of the Pediatric Multiple Sclerosis Clinic at CHOP. I recently served as one of the co–principal investigators of the first-ever pediatric multiple sclerosis (MS) clinical trial, a trial that compared fingolimod, or Gilenya®, to interferon beta-1a by a subcutane...

IBM Watson Oncology: Not Living Up to Expectations
https://www.medscape.com/viewarticle/900746

Aug 14th, 2018 - If it sounds too good to be true, then maybe it is. Such seems to be the case with IBM Watson, which has been aggressively marketed as a tool to assist oncologists in selecting the optimal treatment regimen for their patients. However, some of its recommendations for cancer treatment have been questionable, according to a new investigative report by STAT, which suggests it is not yet ready for ...

Time to Abandon the Digital Rectal Exam?
https://www.medscape.com/viewarticle/868843

Sep 14th, 2016 - In men with a normal prostate specific antigen (PSA) level, the digital rectal examination (DRE) rarely assists in diagnosing clinically significant prostate cancer, yet it is an invasive, uncomfortable examination with very little gain, according to a new study. In an analysis of data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), DRE screening in the setting o...

How Guidelines Happen
https://www.ashclinicalnews.org/features/how-guidelines-happen/

Aug 1st, 2015

Oral Antibacterial Therapy for Acne Vulgaris
https://emedicine.medscape.com/viewarticle/883885

Time to Abandon the Digital Rectal Exam?
https://emedicine.medscape.com/viewarticle/868843

In men with a normal prostate specific antigen (PSA) level, the digital rectal examination (DRE) rarely assists in diagnosing clinically significant prostate cancer, yet it is an invasive, uncomfortable examination with very little gain, according to a new study. In an analysis of data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), DRE screening in the setting o...

IBM Watson Oncology: Not Living Up to Expectations
https://emedicine.medscape.com/viewarticle/900746

If it sounds too good to be true, then maybe it is. Such seems to be the case with IBM Watson, which has been aggressively marketed as a tool to assist oncologists in selecting the optimal treatment regimen for their patients. However, some of its recommendations for cancer treatment have been questionable, according to a new investigative report by STAT, which suggests it is not yet ready for ...

Most Drug Treatments Fail to Control Long-term OA Pain
https://emedicine.medscape.com/viewarticle/907032

The first meta-analysis of long-term pharmacologic treatments for knee osteoarthritis (OA) found little evidence that most currently prescribed medications improve pain control or preserve joint structure after 12 months of treatment. There was a small but statistically and clinically significant benefit from prescription-grade glucosamine sulfate. The study, by Dario Gregori, PhD, from the Uni...

'Major Impact': Olanzapine for CINV at 5 mg, Not 10 mg
https://emedicine.medscape.com/viewarticle/923291

For years, the antipsychotic olanzapine (Zyprexa, Lilly) has been used off label for chemotherapy-induced nausea and vomiting (CINV), but the currently recommended 10-mg dose causes daytime sedation. Now a phase 3 randomized controlled trial has shown that a 5-mg dose is effective at controlling CINV but does not have sedation as a side effect. The results could change clinical guidelines from ...

Fast Five Quiz: Chronic Spontaneous Urticaria
https://emedicine.medscape.com/viewarticle/920709

Chronic spontaneous urticaria (CSU) (also referred to as "chronic idiopathic urticaria") represents the majority of cases of chronic urticaria. CSU is defined as chronic urticaria of known or unknown etiology lasting for ≥ 6 weeks. In a subset of patients with CSU, there is an identifiable underlying autoimmune etiology (chronic autoimmune urticaria). CSU can be challenging to manage and often ...