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About 107,153 results

'Call to Action' for DPYD Testing Before Fluorouracil Chemo
https://www.medscape.com/viewarticle/984799

Dec 1st, 2022 - The debate over whether or not to test for DPYD gene variants before administering fluoropyrimidine (FP) chemotherapy has erupted again among experts in the United States, where such testing is not recommended at present, unlike in Europe. Testing for DPYD variants and subsequent dose adjustment should be offered to US patients who are due to receive fluoropyrimidine chemotherapy, says Daniel L...

Latinx and Melanoma: Barriers and Opportunities
https://www.medscape.com/viewarticle/984769

Nov 30th, 2022 - Latinx individuals have a lower overall risk of melanoma than non-Latinx Whites (NLW), but they are more likely to be diagnosed with advanced disease, and experience greater mortality. A new qualitative study of Latinx and low-income NLW individuals in California has revealed some of the socioeconomic and community factors that may play a role in preventing early access to care. Thicker melanom...

Racial Disparities in Lung Cancer Start With Research
https://www.medscape.com/viewarticle/984774

Nov 30th, 2022 - During a routine visit to the Good Samaritan Clinic in Morganton, North Carolina, in 2018, Herbert Buff casually mentioned that he sometimes had trouble breathing. He was 55 years old and a decades-long smoker. So the doctor recommended that Buff schedule time on a 35-foot-long bus operated by the Levine Cancer Institute that would roll through town later that week offering free lung-cancer scr...

Move Faster, Live Longer? A Little More Effort Goes a Long Way
https://www.medscape.com/viewarticle/984778

Nov 30th, 2022 - If there's one public health message Americans have heard loud and clear, it's this one: Move more. Take more steps. Spend more time doing physical activity — at least 150 minutes a week, according to the latest guidelines. But hearing the message doesn't mean we act on it. A whopping 25% of Americans don't get any physical activity beyond what they do in their job, according to a CDC survey. A...

Ultra-Long Stroke Transfers; Isotopes Return; Back-to-Back CPR During Half Marathon
https://www.medpagetoday.com/cardiology/prevention/101958

Nov 29th, 2022 - Persistent asthma was linked to higher carotid plaque burden and inflammation in the MESA cohort. (Journal of the American Heart Association) Hospitals can still make endovascular therapy work for stroke patients transferred from over 300 miles away, suggested a retrospective study from New Zealand and Australia. (Stroke) Good news during the medical radioisotope shortage: the global supply of ...

Will a One-Dose Drug Mean the End of Sleeping Sickness?
https://www.medscape.com/viewarticle/984736

Nov 29th, 2022 - A single dose of oral acoziborole resulted in a greater than 95% cure or probable cure rate for human African trypanosomiasis (HAT), also known as sleeping sickness, according to results from a clinical trial testing a one-dose experimental drug. The drug has "the potential to revolutionize treatment" for the disease, which remains endemic in sub-Saharan Africa, said Antoine Tarral, MD, head of...

Don't Skip Exercise in Lifestyle Interventions for Kids With Obesity
https://www.medpagetoday.com/pediatrics/obesity/101939

Nov 28th, 2022 - Exercise is a key component of a family-based lifestyle intervention program aimed at helping kids lose fat, according to a secondary analysis of a nonrandomized controlled trial. Over the 22-week program, kids with overweight or obesity whose families participated in a lifestyle intervention program with supervised exercise training saw an 18.1% reduction in visceral adipose tissue (VAT) versu...

WHO Issues New Name for Monkeypox
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/101940

Nov 28th, 2022 - Monkeypox has been renamed mpox in order reduce stigmatization and racism associated with the name, the World Health Organization (WHO) announced. While the process of changing the name of a virus would normally take a couple of years, the process was accelerated in this case. Mpox will enter ICD-10 online within days as a synonym for monkeypox and become official in the 2023 release of ICD-11,...

Wide Variance Described in Monitoring of Conventional DMARDs
https://www.medscape.com/viewarticle/984656

Nov 28th, 2022 - Rheumatologists tend to order the same types of tests to monitor their patients’ responses to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), but they vary widely in how often they order tests and how they respond to abnormal results, responses to a survey suggest. “The study found that, although guidelines exist, people didn’t follow them consistently. They also respon...

Mood Stabilizers, Particularly Lithium, Potential Lifesavers in Bipolar Disorder
https://www.medscape.com/viewarticle/984663

Nov 28th, 2022 - Mood stabilizers protect against suicide and all-cause mortality in patients with bipolar disorder (BD), including natural mortality, with lithium emerging as the most protective agent, new research suggests. Investigators led by Pao-Huan Chen, MD, of the Department of Psychiatry, Taipei Medical University Hospital, Taiwan, evaluated the association between the use of mood stabilizers and the r...

EU Regulator Warns of 'Disappointing' Vaccine Booster Uptake
https://www.medscape.com/viewarticle/984585

Nov 28th, 2022 - (Reuters) - Recent uptake of COVID-19 vaccine booster doses in the European Union has been "rather disappointing," an official said on Thursday, amid concerns that protection against severe cases of the disease could weaken during the winter. The European average rate of re-vaccination, or receiving booster doses, was only 29% in the groups of people considered to be at highest risk, such as th...

Hormonal Management of Gender-Diverse Patients: SOC8 Updates
https://www.medscape.com/viewarticle/984653

Nov 28th, 2022 - In September, the World Professional Association for Transgender Health released its much-anticipated standards of care (SOC8). While this update has unfortunately received intense scrutiny for its guidance about gender-diverse adolescents and youth, the SOC8 is their most evidence-based version to date. Recommendations were developed based on data from independent systematic literature reviews...

Elevated Lp(a) Tied to More Early CV Events Than FH
https://www.medscape.com/viewarticle/984693

Nov 28th, 2022 - Many more people are at risk for early cardiovascular events because of raised Lp(a) levels than from having familial hypercholesterolemia (FH), a new study suggests. The Danish study set out to try and establish a level of Lp(a) that would be associated with a cardiovascular risk similar to that seen with FH. As there are many different definitions of FH, results showed a large range of Lp(a) ...

Does Lipoprotein(a) Play a Causal Role in Atherosclerotic Cardiovascular Disease?
https://www.medscape.com/viewarticle/983641

Nov 28th, 2022 - This transcript has been edited for clarity. Michelle L. O'Donoghue, MD, MPH: Hi. I'm Dr Michelle O'Donoghue. I'm a cardiologist at Brigham and Women's Hospital, and I'm reporting for Medscape. Joining me today is Dr Stephen Nicholls. He's a professor of cardiology at Monash University in Australia. Welcome. Stephen J. Nicholls, MBBS, PhD: Thanks. O'Donoghue: He's really a world expert on the f...

Forging a New Field
https://www.onclive.com/view/forging-a-new-field

Nov 24th, 2022 - Jennifer Temel, MD, has a calming demeanor and an easy laugh. It is easy to see how patients feel comforted in her presence, although she shared that she feels most at ease when with small groups of people. A truly gentle spirit, she is a lifelong vegetarian, something she now shares with her older son, and despite her nearly career-defining blood phobia, she is an avid fan of Buffy the Vampire...

Updates from Melanoma Trials Demonstrate New Roles for Adjuvant/Neoadjuvant Treatment
https://www.onclive.com/view/updates-from-melanoma-trials-demonstrate-new-roles-for-adjuvant-neoadjuvant-treatment

Nov 23rd, 2022 - Varying therapies for the neoadjuvant and adjuvant treatment of melanoma based on staging continue to be explored with pembrolizumab (Keytruda) a common agent in both settings, according to Sapna Patel, MD. Patel’s presentation at the 40th Annual CFS® meeting, Neoadjuvant and Adjuvant Therapeutic Approaches for Melanoma highlighted clinical trials such as phase 2 S1801 (NCT03698019) and discus...

Meta-Analysis Finds ADHD Drugs Not Linked to Risk of Cardiovascular Disease
https://www.medpagetoday.com/psychiatry/adhd-add/101914

Nov 23rd, 2022 - Use of medications for attention deficit-hyperactivity disorder (ADHD) was not associated with increased cardiovascular disease (CVD) risk, a systematic review and meta-analysis of 19 studies showed, although the researchers cautioned that a modest risk increase could not be completely ruled out. Among over 3 million people, there were no statistically significant associations between ADHD medi...

Combo Treatment Could Delay Kidney Failure for Years in Nondiabetic CKD
https://www.medpagetoday.com/nephrology/esrd/101909

Nov 23rd, 2022 - Combining the powers of SGLT2 and renin-angiotensin-aldosterone system (RAAS) inhibitor therapy could substantially reduce the risk of kidney failure or death for patients with albuminuric, nondiabetic chronic kidney disease (CKD), researchers predicted. In an analysis calculated using trial-level estimates, adding an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker...

Rhinitis Patients Report Symptomatic Medication Use in Mobile App
https://www.medscape.com/viewarticle/984571

Nov 23rd, 2022 - Patients with rhinitis treat their condition as symptoms arise, rather than by guidelines on how to keep their disease under control, suggests a longitudinal study that confirms cross-sectional analyses. Investigators captured data from patients in 25 countries via a mobile application called MASK-air. The app provides real-world data on patient experiences with their allergic rhinitis and how ...

Paxlovid Vindicated for Younger COVID Patients
https://www.medpagetoday.com/infectiousdisease/covid19/101874

Nov 22nd, 2022 - Nirmatrelvir-ritonavir (Paxlovid) halved hospitalizations for COVID-19 patients, including triply vaccinated individuals and younger adults, a CDC study showed. People prescribed the antiviral combination within 5 days of diagnosis had a 51% lower hospitalization rate within 30 days after diagnosis than those who did not receive the drug (0.47% vs 0.86%, adjusted HR 0.49, 95% CI 0.46-0.53), rep...