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About 108 results

Variants Spur New FDA Guidance on COVID Vaccines, Tests, Drugs
https://www.medscape.com/viewarticle/946266

Feb 21st, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. The US Food and Drug Administration (FDA) on Monday updated its October guidance for manufacturers developing COVID-19 vaccines, diagnostics, and treatments in the wake of circulating SARS-CoV-2 variants. The United States is currently facing three main variant threats, according to the Centers...

Visual Interpretation of Tau PET Predicts Cognitive Decline
https://www.medscape.com/viewarticle/946249

Feb 21st, 2021 - A relatively simple and accessible Food and Drug Administration (FDA) approved method of visually classifying flortaucipir PET accurately predicts cognitive deterioration, new research shows. The results from two independent studies consistently showed that patients with a flortaucipir advanced tau pattern had greater mean deterioration across several clinical endpoints within 18 months. Dr Min...

Surgery Equals Drug Treatment for Bleeding in Diabetic Retinopathy
https://www.medscape.com/viewarticle/943374

Dec 29th, 2020 - In the treatment of vitreous hemorrhage from proliferative diabetic retinopathy, intraocular injection with anti–vascular endothelial growth factor (VEGF) shows similar efficacy to that of vitrectomy with photocoagulation; however, patients commonly require both treatments, new research shows. "For patients who are experiencing visual loss from bleeding due to proliferative diabetic retinopathy...

Study: Doctors Underreport Side Effects of Breast Irradiation
https://www.medscape.com/viewarticle/943289

Dec 28th, 2020 - There is a substantial mismatch between patient and physician reports of toxicity during radiotherapy for breast cancer, according to an analysis of nearly 10,000 U.S. patients. Researchers assessed physician underrecognition of four key symptoms – pain, pruritus, edema, and fatigue – during radiotherapy. Physicians underrecognized one of these four symptoms at least once in 53.2% of patients w...

NFL Sets Higher Bar for Dementia Compensation in Black Former Players
https://www.medscape.com/viewarticle/943097

Dec 22nd, 2020 - (Reuters Health) - The National Football League (NFL) has been unfairly depriving cognitively impaired Black players of monetary awards they would normally receive from a landmark 2013 settlement by insisting that test scores be "race-normed," according to clinical psychologists who are taking the league to task. In a Viewpoint piece published in JAMA Neurology, Katherine Possin and her colleag...

SLN Biopsy for Oral Cancer? French Surgeons Say 'Oui'
https://www.medscape.com/viewarticle/940134

Nov 1st, 2020 - French investigators are suggesting that sentinel lymph node (SLN) biopsy should replace neck lymph node dissection as the new standard for detecting occult metastases in patients with T1-T2N0 oral and oropharyngeal squamous cell carcinoma. In a randomized trial involving 279 patents, oncologic outcomes at 5 years were similar with both techniques, but there was substantially less morbidity wit...

Batten Down the Hatches for Thyroid Storm
https://www.staging.medscape.com/viewarticle/937168

Sep 9th, 2020 - Thyroid storm is a life-threatening endocrine emergency for which, remarkably, there are no definitive diagnostic tests, and the management of which is supported by a startlingly weak evidence base. "What's tricky is there really are no specific biochemical level cutoffs for thyroid storm, and also no unique laboratory abnormalities. So in the end, it's a clinical diagnosis and a clinical judgm...

Vitamin D Tied to Lower Risk for Immunotherapy-Induced Colitis
https://www.medscape.com/viewarticle/933301

Jul 1st, 2020 - Taking vitamin D before starting immune checkpoint inhibitor (ICI) therapy may decrease the risk for treatment-related colitis, say researchers in an article published online on June 22 in the journal Cancer. The study is the first to find a link between pretreatment vitamin D use and decreased risk for ICI colitis, they comment. They caution that the results are preliminary and require confirm...

Women Have Steeper, Earlier BP Increases Over Lifetime
https://www.medscape.com/viewarticle/923981

Jan 19th, 2020 - New findings from an analysis of sex-specific blood pressure trajectories show that starting at an early age and continuing throughout life, women experience steeper increases in blood pressure than men. "In contrast with the notion that important vascular diseases in women lag behind men by 10 to 20 years, our findings indicate that certain vascular changes not only develop earlier but also pr...

'Major Impact': Olanzapine for CINV at 5 mg, Not 10 mg
https://www.staging.medscape.com/viewarticle/923291

Jan 1st, 2020 - For years, the antipsychotic olanzapine (Zyprexa, Lilly) has been used off label for chemotherapy-induced nausea and vomiting (CINV), but the currently recommended 10-mg dose causes daytime sedation. Now a phase 3 randomized controlled trial has shown that a 5-mg dose is effective at controlling CINV but does not have sedation as a side effect. The results could change clinical guidelines from ...

'Major Impact': Olanzapine for CINV at 5 mg, Not 10 mg
https://www.medscape.com/viewarticle/923291

Jan 1st, 2020 - For years, the antipsychotic olanzapine (Zyprexa, Lilly) has been used off label for chemotherapy-induced nausea and vomiting (CINV), but the currently recommended 10-mg dose causes daytime sedation. Now a phase 3 randomized controlled trial has shown that a 5-mg dose is effective at controlling CINV but does not have sedation as a side effect. The results could change clinical guidelines from ...

'An Emotional Slap in the Face': The Language of Cancer
https://www.staging.medscape.com/viewarticle/914359

Jun 16th, 2019 - This transcript has been edited for clarity. Don S. Dizon: Hi. I'm Don Dizon, professor of medicine at Brown University and director of women's cancers at Lifespan Cancer Institute in Providence, Rhode Island. With me is Tatiana Prowell, associate professor in the breast cancer program at Johns Hopkins Kimmel Cancer Center in Baltimore, Maryland. She is also the breast cancer scientific liaison...

'An Emotional Slap in the Face': The Language of Cancer
https://www.medscape.com/viewarticle/914359

Jun 16th, 2019 - This transcript has been edited for clarity. Don S. Dizon: Hi. I'm Don Dizon, professor of medicine at Brown University and director of women's cancers at Lifespan Cancer Institute in Providence, Rhode Island. With me is Tatiana Prowell, associate professor in the breast cancer program at Johns Hopkins Kimmel Cancer Center in Baltimore, Maryland. She is also the breast cancer scientific liaison...

Improved Cancer Drugs Access Needs 'Radical Action'
https://www.staging.medscape.com/viewarticle/912216

Apr 24th, 2019 - A new approach by the pharmaceutical industry and regulators is needed to ensure that people with cancer have faster access to innovative treatments, specialists have said. A 10-point manifesto published by the Institute of Cancer Research (ICR) set out "radical action" needed to make drugs more affordable, prioritise genuinely innovative treatments, and overhaul the clinical trials process. It...

Improved Cancer Drugs Access Needs 'Radical Action'
https://www.medscape.com/viewarticle/912216

Apr 24th, 2019 - A new approach by the pharmaceutical industry and regulators is needed to ensure that people with cancer have faster access to innovative treatments, specialists have said. A 10-point manifesto published by the Institute of Cancer Research (ICR) set out "radical action" needed to make drugs more affordable, prioritise genuinely innovative treatments, and overhaul the clinical trials process. "I...

New Findings on Polypharmacy in Depression
https://www.medscape.com/viewarticle/909371

Mar 10th, 2019 - This transcript has been edited for clarity. This is the Medscape Psychiatry Minute. I'm Dr Peter Yellowlees. In routine clinical practice, antidepressants are increasingly being combined. However, there are few clinical trials investigating the effectiveness of this practice. Now, a team from Bristol Medical School in England has investigated the effectiveness of combining mirtazapine with a s...

Longer Survival in Black Men on Newer Prostate Cancer Drugs
https://www.medscape.com/viewarticle/909031

Feb 12th, 2019 - Population-based studies have suggested that, compared with white men, black men are at higher risk of dying from prostate cancer. However, recent findings show that that isn't necessarily the case. In the latest study, survival was longer for African American patients who were treated with the newer hormonal therapies. The findings come from an analysis of chemotherapy-naive patients with meta...

Longer Survival in Black Men on Newer Prostate Cancer Drugs
https://www.staging.medscape.com/viewarticle/909031

Feb 12th, 2019 - Population-based studies have suggested that, compared with white men, black men are at higher risk of dying from prostate cancer. However, recent findings show that that isn't necessarily the case. In the latest study, survival was longer for African American patients who were treated with the newer hormonal therapies. The findings come from an analysis of chemotherapy-naive patients with meta...

Antiphospholipid Syndrome: Insights Into a Life-Threatening Autoimmune Disease With Limited Awareness
https://www.medscape.com/viewarticle/908091

Jan 28th, 2019 - Antiphospholipid syndrome (APS) is a systemic autoimmune disease in which antiphospholipid antibodies (aPL) increase the risk for thrombosis, pregnancy morbidity, and other nonthrombotic complications such as thrombocytopenia. Doruk Erkan, MD, MPH Thanks to the concerted efforts of a small but active community of researchers, our understanding of this rare disease has expanded, and there is inc...

Most Drug Treatments Fail to Control Long-term OA Pain
https://www.staging.medscape.com/viewarticle/907032

Dec 26th, 2018 - The first meta-analysis of long-term pharmacologic treatments for knee osteoarthritis (OA) found little evidence that most currently prescribed medications improve pain control or preserve joint structure after 12 months of treatment. There was a small but statistically and clinically significant benefit from prescription-grade glucosamine sulfate. The study, by Dario Gregori, PhD, from the Uni...