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ASL Video Series: COVID-19 Vaccines Work

Research studies show that the COVID-19 vaccines currently authorized and recommended for use in the United States work well at preventing COVID-19. More COVID-19 information in ASL: https://www.youtube.com/playlist?list=PLvrp9iOILTQatwnqm61jqFrsfUB4RKh6J More COVID-19 information in English text: https://www.cdc.gov/coronavirus/ Development of these materials was supported by a grant ...

Benefits of Post-Op Penile Traction Therapy Hold Up Over Time

Oct 23rd, 2021 - SCOTTSDALE, Ariz. -- A penile traction therapy (PTT) device produced lasting improvements in men after prostatectomy, a researcher reported. The current data builds on an August 2021 study of 6-month data from 55 men (average age 58.6) who were randomly assigned to control (n=25) or treatment with PTT (n=30) after prostatectomy. The interventions began 1 month post-surgery, and those in the PTT...

Gustavo Fonseca, MD, FACP, Manish Patel, MD, and James Reeves, MD, Co-Author Integrated Safety Analysis of Umbralisib in Lymphoid Malignancies

Oct 22nd, 2021 - Three medical oncologists at Florida Cancer Specialists & Research Institute (FCS) are co-authors on a new integrated safety analysis of umbralisib, used to treat lymphoid malignancies. FCS Director of Clinical Research Gustavo Fonseca, MD, FACP, Director of Drug Development Manish Patel, MD and James Reeves, MD, a member of the FCS clinical research team, participated in the study entitled Int...

Children With Cancer At Higher Risk for Severe Illness from COVID-19

Oct 22nd, 2021 - Approximately 20% of pediatric patients with cancer infected with COVID-19 experienced severe illness, according to data published in The Lancet Oncology. Furthermore, deaths due to the infection were proportionally higher in this patient population compared with the general pediatric population, providing evidence that children with cancer are at higher risk of developing severe illness from C...

Oncopeptides Withdraws Melphalan Flufenamide Myeloma Indication in the United States

Oct 22nd, 2021 - Oncopeptides AB (publ) has made the decision to withdraw the indication of melphalan flufenamide (Pepaxto; melflufen) in combination with dexamethasone in select adult patients with relapsed or refractory multiple myeloma from the US market.1 In February 2021, the FDA approved melflufen plus dexamethasone for use in adult patients with relapsed/refractory multiple myeloma who have received at ...

Exercise may help stall MS disability and progression
Jim Kling

Oct 22nd, 2021 - Though once regarded with suspicion, exercise as a therapy for multiple sclerosis (MS) has gained traction in recent years, and has the potential to counter the physical effects often seen among patients, as well as reduce risk of progression. Dr.

NSCLC Incidence Declining, Except in Stage I Disease

Oct 22nd, 2021 - The overall incidence of non-small cell lung cancer (NSCLC) decreased from 2010 to 2017, with the incidence of stage IV disease falling, and stage I disease rising, researchers determined. A cross-sectional epidemiological analysis showed that NSCLC incidence per 100,000 population declined from 46.4 to 40.9 during the study period. While the incidence of stage II, IIIA, and IIIB disease was st...

Burnout a Risk Factor for Suicidal Thoughts in Nurses

Oct 22nd, 2021 - Nurses experiencing burnout were twice as likely to have thoughts of suicide, and those with symptoms of depression were 11 times as likely to experience suicidal thoughts, a survey study found. Among more than 7,000 nurses surveyed from November to December 2017, a total of 5.5% experienced suicidal ideation, which is higher than rates of suicidal thoughts in the general population (4.3%), rep...

A Wealth of Therapeutic Advances in Lung Cancer Stress a Need for Early NGS Testing

Oct 22nd, 2021 - The overwhelming number of options for the treatment of patients with lung cancer underscores the importance of broad molecular testing up front to ensure patients receive optimal care, said Stephen V. Liu, MD. Our strategies [for managing lung cancer] are becoming more sophisticated and precise, but the first step of broad next-generation sequencing [NGS] is really the key. NGS is essential t...

Arterial Chemo Tops Chemoembolization for Large Liver Tumors

Oct 22nd, 2021 - Patients with unresectable large-volume liver cancer lived significantly longer when treated with hepatic-artery infusion chemotherapy (HAIC) than with transarterial chemoembolization (TACE), a randomized trial from China showed. Median overall survival (OS) increased from 16.1 months with TACE to 23.1 months with FOLFOX (leucovorin, fluorouracil, and oxaliplatin)-HAIC. Progression-free surviva...

Will Slow and Steady Progress in Treating SCLC Win the Race?

Oct 22nd, 2021 - Clinical advances in the treatment of small cell lung cancer (SCLC) have lagged behind those of other tumor types, but the delay is not for lack of effort. In recent years, however, improved understanding of disease biology has identified some novel targets that may make these tumors more vulnerable to treatment. One such approach in the frontline setting has been the integration of various imm...

Brain Fog After COVID-19 May Last Longer Than We Think

Oct 22nd, 2021 - Relatively young people -- ranging from 38 to 59 years old -- showed cognitive dysfunction or "brain fog" months after being diagnosed with COVID-19, a cross-sectional study found. More than 7 months after acute infection, a substantial proportion of COVID-19 patients exhibited deficits in processing speed, executive functioning, category fluency, memory encoding, and recall, reported Jacquelin...

Analysis-Vaccinated Singapore shows zero-COVID countries cost of reopening

Oct 22nd, 2021 - SINGAPORE (Reuters) -Few are left to inoculate in wealthy Singapore after a vigorous campaign achieved a level of coverage envied by many nations battling the coronavirus pandemic, but a record surge in deaths and infections gives warning of risks that may still lie ahead. Despite mask mandates, strict social curbs and COVID-19 booster doses available for over a month, infections in the Asian c...

Cabozantinib Shows Activity Against RCC Brain Metastases

Oct 22nd, 2021 - The tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx) showed promising activity against brain metastases from renal cell carcinoma (RCC), researchers reported. In a retrospective cohort study of 88 patients with RCC brain metastases, the intracranial response rate with cabozantinib was 55% (95% CI 36-73%) in those with progressing brain metastases without concomitant brain-directed local...

'Deep learning' AI shows benefit in colonoscopy in U.S. population
Heidi Splete

Oct 21st, 2021 - Adenoma miss rates were significantly lower with the use of an artificial intelligence (AI)–based computer-aided detection (CADe) system than with high-definition white light (HDWL), according to a new prospective, multicenter, single-blind randomized study based on data from more than 200 colonoscopies. Missed adenomas can be generally categorized as adenomas fully obscured from the visual fie.

CDC Panel Champions 'Mix and Match' Booster Strategy

Oct 21st, 2021 - The CDC's Advisory Committee on Immunization Practices (ACIP) came out strongly in favor of heterologous, or "mix and match," boosters in two unanimous votes on Thursday. ACIP voted 15-0 that certain populations authorized to receive a booster dose of COVID-19 vaccine who received a Pfizer or Moderna primary series receive a booster at least 6 months later, including adults ages 65 and up, adul...

Is exercise therapy effective treatment for low back pain?
MDedge Family Medicine; Christine Broszko, MD, FAAFP, Krystyna Golden, MD et. al.

Oct 21st, 2021 - EVIDENCE SUMMARY General exercise offers benefit …at least for chronic LBP A 2017 systematic review of 4 systematic reviews and 50 RCTs (122 total trials) evaluated general exercise vs usual care for acute (< 4 weeks), subacute (4 to 12 weeks), or chronic (≥ 12 weeks) LBP with or without radiculopathy in adults. 1 Exercise was not consistently associated with decreased pain in acute or subacute.

Rapid Readouts: Phase 1 Cohort of TRANSCEND-CLL-004 Study

Oct 21st, 2021 - William G. Wierda, MD, discusses data from the following presentation: TRANSCEND-CLL-004 phase 1 cohort of lisocabtagene maraleucel combined with ibrutinib for patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic leukemia (R/R CLL/SLL). (Wierda EG, et al. iwCLL 2021; September 17-20, 2021) Recent studies in patients with R/R CLL suggest that CD19-directed CAR (chim...

New Class of Radiopharmaceutical Therapy Makes Headway in Prostate Cancer

Oct 21st, 2021 - Investigators have made great strides in the development of radiopharmaceuticals for prostate cancer diagnostics, culminating in recent FDA approvals for the first prostate-specific membrane antigen (PSMA)–targeted radioligands, gallium 68 (68Ga)–PSMA-11 and piflufolastat F 18 (Pylarify), for the detection of disease recurrence and metastatic lesions.1,2 Meanwhile, the use of PSMA-targeted rad...

Oral Abx Cut Surgical Site Infections in Colorectal Surgeries

Oct 21st, 2021 - Adding oral antibiotics to intravenous antibiotics with or without enema came out on top for reducing surgical site infections (SSIs) in patients undergoing elective colorectal surgeries, a network meta-analysis suggested. In the analysis of 35 randomized trials involving over 8,000 patients, this combination had the best probability of ranking first (86% chance) in reducing incisional SSIs, wh...