About 320,088 results

Alternative birthing practices tied to neonatal infection risk
Diana Swift

Jan 24th, 2022 - Increasingly popular alternative peripartum practices such as water immersion and nonseverance of the umbilical cord may increase the risk of infections in newborns, a new clinical report from the American Academy of Pediatrics found. Another perinatal measure potentially raising infection risk was placentophagy, according to a review led by Dawn Nolt, MD, MPH, a professor of pediatric infectio.

Gene Therapy Shows Clinical Benefit in Metachromatic Leukodystrophy

Jan 24th, 2022 - An investigational gene therapy showed benefit in pediatric patients with early-onset metachromatic leukodystrophy (MLD), a small study showed. Treatment with atidarsagene autotemcel (arsa-cel) preserved motor development and cognitive function in MLD patients enrolled in a prospective phase I/II trial or treated through expanded access programs, reported Alessandro Aiuti, MD, of the San Raffae...

Abraxane still in short supply for cancer patients
Jim Kling

Jan 24th, 2022 - Abraxane, a chemotherapy treatment for advanced pancreatic cancer, advanced non–small cell lung cancer and metastatic breast cancer, is on allocation through early March because of manufacturing delays, forcing physicians to find alternatives for a drug once lauded for being easier to tolerate. Abraxane (Bristol-Myers Squibb) is a paclitaxel albumin-bound injectable.

Infectious and Back at Work; FDA May Limit Some Monoclonals; 'Done With COVID'?

Jan 24th, 2022 - Note that some links may require registration or subscription. Strained hospitals are calling potentially infectious healthcare workers back to their posts, citing the CDC's latest guidance. (Washington Post) NIAID Director Anthony Fauci, MD, said he's "as confident as you can be" that most U.S. states will see Omicron infections peak over the next several weeks, during an appearance on ABC's "...

Burden of Tick-Borne Encephalitis, Sweden

Jan 24th, 2022 - Figure 1 Figure 1. Reported tick-borne encephalitis cases per year, Sweden, 1956–2021. Tick-borne encephalitis became a notifiable disease in Sweden in July 2004; thus, the number of reported cases before 2005 is less certain... Tick-borne encephalitis virus (TBEV) is the cause of tick-borne encephalitis (TBE), an infectious disease of growing public health concern (1,2). In Sweden, the disease...

Genetic Relatedness of Infectious Hypodermal and Hematopoietic Necrosis Virus Isolates, United States, 2019

Jan 24th, 2022 - The Penstylhamaparvovirus species Decapod penstylhamaparvovirus 1, commonly known as infectious hypodermal and hematopoietic necrosis virus (IHHNV), is the smallest of known shrimp viruses belonging to the family Parvoviridae, subfamily Hamaparvovirinae (1,2). The virions are icosahedral, nonenveloped, measure 22–23 nm in size, and contain a single-stranded DNA genome ≈4.1 kb in length (3,4). I...

Semglee Pen Recall; Prader-Willi Syndrome Drug Rejected; Resilience Good for Sex

Jan 23rd, 2022 - The FDA announced that Mylan Pharmaceuticals is voluntarily recalling a batch of its non-interchangeable insulin glargine injection (Semglee) prefilled pens for possible missing labels. In other FDA news, the agency turned down Levo Therapeutics' investigational intranasal form of carbetocin (LV-101), which was developed as a treatment for hyperphagia, anxiety, and distress associated with Prad...

TST001 Under Evaluation in Locally Advanced or Metastatic Solid Tumors

Jan 23rd, 2022 - The safety and tolerability of TST001, a high affinity humanized IgG1 monoclonal antibody to CLDN18.2, is under investigation as a potential treatment option for patients with gastric/gastroesophageal junction (GEJ) cancer and other locally advanced or metastatic solid tumors as part of a phase 1 trial (NCT04396821).1,2 CLDN18.2 expression showcases a unique tissue distribution pattern than ot...

SARS-CoV-2 Circulation, Guinea, March 2020–July 2021

Jan 23rd, 2022 - In Guinea, the index coronavirus disease (COVID-19) case-patient identified on March 12, 2020, was an expatriate traveling back from Europe. Immediately, a COVID-19 task force was established by the Agence Nationale de Sécurité Sanitaire; 6 national laboratories were involved in the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. As of July 16, 2021, a tota...

Postvaccination Multisystem Inflammatory Syndrome in Adult with No Evidence of Prior SARS-CoV-2 Infection

Jan 23rd, 2022 - Multisystem inflammatory syndrome (MIS) is a serious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that affects multiple body systems (cardiovascular, gastrointestinal, skin). It occurs predominantly in children (MIS-C) (1) and only rarely in adults (MIS-A) (2). The Brighton Collaboration Network (https://brightoncollaboration.us) includes MIS-C and MIS-...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, November 2021

Jan 23rd, 2022 - A new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), B.1.1.529, was identified in Botswana and South Africa in early November 2021 and was designated as variant of concern (VOC) Omicron by the World Health Organization on November 26, 2021 (1). As of December 1, 2021, ≈220 sequences were available on GISAID (https://www.gisaid.org), and this variant has been detected i...

Dirofilaria immitis Pulmonary Dirofilariasis, Slovakia

Jan 23rd, 2022 - Dirofilaria immitis is a filarioid nematode that infects numerous mammalian species. Dogs are the main reservoir and various mosquito species (e.g., genera Culex, Anopheles, Aedes, and Ochlerotatus) the infection vectors. The parasite is related to the pulmonary form of dirofilariasis, manifested by the formation of coin lesions or nodules in lung parenchyma in humans, an accidental parasite ho...

The Color Puce (Pyüs)

Jan 23rd, 2022 - Puce [pyoos] Figure Figure. A) Digitally colored scanning electron microscopic image of a flea. Puce is a particularly difficult color to describe. Numerous shades of puce exist, some of which are associated with different... For those with synesthesia, in whom stimulating 1 sensory pathway gives rise to a subjective sensation of a different character, the word plague may chromatically resonate...

Olaparib Plus Pembrolizumab Demonstrates Manageable AEs in Advanced Cholangiocarcinoma

Jan 22nd, 2022 - The combination of olaparib (Lynparza) and pembrolizumab (Keytruda) demonstrated acceptable safety and an manageable adverse effect (AE) profile in patients with advanced cholangiocarcinoma who had received prior gemcitabine-based therapy, according to findings from a phase 2 trial (NCT04306367) that were presented at the 2022 Gastrointestinal Cancers Symposium. In the interim update of the ...

West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States

Jan 22nd, 2022 - West Nile virus (WNV) is the leading cause of mosquitoborne disease in the contiguous United States and is spread to humans primarily by Culex species mosquitoes (1). Transmission through solid organ transplantation (SOT) and blood transfusion was recognized during 2002 (2,3). Patients infected by SOT are at increased risk for severe disease and death, probably related to immunosuppression (2,4...

Clinical Features and Neurodevelopmental Outcomes for Infants with Perinatal Vertical Transmission of Zika Virus, Colombia

Jan 22nd, 2022 - The emergence of Zika virus (ZIKV) in the Americas has coincided with an abnormal increase in prenatal and neonatal documented cases of microcephaly and other anomalies of the central nervous system (1) These alterations of the brain, along with animal models of vertical transmission of ZIKV, a single-stranded RNA flavivirus, are evidence of the neurotropic nature of the virus (2–4). Vertical t...

Serial Interval and Transmission Dynamics during SARS-CoV-2 Delta Variant Predominance, South Korea

Jan 22nd, 2022 - As of August 2021, South Korea is in the middle of a fourth community epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, which is now predominated by the B.1.617.2 lineage (Delta variant) (1,2). The epidemic size largely depends on such epidemiologic characteristics as serial interval distribution and transmissibility (3,4). For the Delta variant of SARS-CoV-...

Invasive Burkholderia cepacia Complex Infections among Persons Who Inject Drugs, Hong Kong, China, 2016–2019

Jan 22nd, 2022 - Burkholderia cepacia complex (BCC) is a ubiquitous aerobic gram-negative bacillus composed of >20 phylogenetically closely related species (1). BCC is commonly found in water, soil, and plants and was the cause of onion rot in the 1950s, when it was first described (2). It is a rapidly growing bacterium that can survive for a long time in harsh environments. Studies have demonstrated that it is...

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

Jan 22nd, 2022 - Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii. The main vector of this bacterium is the Rhipicephalus sanguineus tick (1); the main hosts of these ticks are domestic dogs, and humans are incidental hosts (2). MSF is endemic to the Mediterranean, Europe, Africa, western Asia, and India. The case-fatality rate is 3%–7% in hospitalized patients (3,4). In 2017...

Neisseria gonorrhoeae FC428 Subclone, Vietnam, 2019–2020

Jan 22nd, 2022 - Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae; global incidence is ≈80 million cases/year (1,2). To treat uncomplicated gonorrhea, the World Health Organization recommends dual therapy with a single-dose extended-spectrum cephalosporin (ESC) (intramuscular ceftriaxone or oral cefixime) and oral azithromycin (3). However, N. gonorrhoeae resistance to ESCs and azit...