About 456,868 results

Lung Screening Saves Lives; Clues to Hyperprogression; Bacteria Foil Immunotherapy

Nov 25th, 2022 - Diagnosis of early-stage lung cancer with low-dose CT screening was associated with significant improvement in long-term survival. (Mount Sinai, Radiological Society of North America) Researchers have discovered how cancer immunotherapy sometimes causes paradoxical tumor hyperprogression and identified a potential mechanism to prevent it. (Science Translational Medicine) Continuing its expansio...

Fire Hazard Alert About Omnipod 5 'Artificial Pancreas' Charger

Nov 25th, 2022 - Insulet has alerted users of the Omnipod 5 Automated Insulin Delivery (AID) System about a potential fire hazard with the controller device's battery charger. The Medical Device Correction notice issued November 14 is not a recall; rather, users are advised to check the charging port on the controller to see if it is "melted, deformed, or discolored," or if the device overheats or emits an odor...

Managing T-DXd Adverse Events in the Real World

Nov 25th, 2022 - With recent expansions in its breast cancer indications, there has been an increase in the use of trastuzumab deruxtecan (T-DXd; Enhertu). "A lot of us are using this more frequently now than we were in the past," explained Sid Yadav, MD, a breast and gynecologic cancer specialist at the Mayo Clinic in Rochester, Minnesota. However, he added that managing its adverse events has been a "bit of a...

FDA Rejects Piziotinib for Certain Types of NSCLC

Nov 25th, 2022 - The US Food and Drug Administration (FDA) has announced that it will not approve poziotinib (Spectrum Pharmaceuticals) for the treatment of certain patients with nonsmall-cell lung cancer (NSCLC). The clinical data that the company had submitted was deemed insufficient for approval, and additional data including a randomized clinical trial would be needed, the agency said. The move is not a sur...

Heart Disease Deaths Spiked During COVID After 10-Year Decline

Nov 25th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Yearly deaths from heart disease in the United States increased in 2020 during the COVID pandemic, after a steady decline during the previous decade, a new study shows. The rate of death from heart disease in the overall population rebounded in 2020 to what it had been in 2015 — essentially wipi...

Vax Conspiracy Film Hits Twitter; More Apnea Device Deaths; GSK Pulls Cancer Drug

Nov 23rd, 2022 - Note that some links may require subscriptions. Also note that Morning Break will be taking its own break Thursday and Friday for the Thanksgiving holiday. Look for it again on Monday, November 28. The anti-vax film "Died Suddenly," which claims COVID vaccines were designed to depopulate the world, premiered on Twitter. (Forbes) Pediatric hospitalizations spiked up to 60% on Long Island as resp...

Risk of Cardiovascular Diseases Associated With Medications Used in Attention-Deficit/Hyperactivity Disorder
JAMA Network Open; Zhang L, Yao H et. al.

Nov 23rd, 2022 - Attention-deficit/hyperactivity disorder (ADHD), one of the most common neurodevelopmental disorders, is characterized by developmentally inappropriate inattention and/or hyperactivity-impulsivity symptoms starting in childhood.1 The symptoms often persist into adulthood,2,3 and even into older age for a substantial number of patients.4 ADHD medications, including both stimulants and nonstimula...

Paying Attention to Attention-Deficit/Hyperactivity Disorder Medications and Cardiovascular Risk
JAMA Network Open; Ziegelstein RC.

Nov 23rd, 2022 - Zhang, et al1 performed a meta-analysis of 19 observational studies with more than 3.9 million participants followed from 3 months to 9.5 years (median follow-up, 1.5 years) and found no association between use of medications to treat attention-deficit/hyperactivity disorder (ADHD) and any cardiovascular disease (CVD) outcome. This is an important study for many reasons.

Don't Call Me 'Dr', Say Some Physicians -- but Most Prefer the Title
Medscape Loudin A.

Nov 23rd, 2022 - When Mark Cucuzzella, MD, meets a new patient at the West Virginia Medical School clinic, he introduces himself as "Mark." For one thing, says Cucuzzella, his last name is a mouthful. For another, the 56-year-old general practitioner asserts that getting on a first-name basis with his patients is integral to delivering the best care.

There's an App for That: Let Technology Do the Work for You

Nov 23rd, 2022 - The array of online and digital resources aimed at emergency physicians continues to grow, and sorting through them can take more time and effort than most clinicians want to spare to get the best information, education, and communication, according to Christian Rose, MD, of Stanford University, Stanford, California. In a presentation at the American College of Emergency Physicians (ACEP) 2022 ...

New Guidance on Talking to Patients With MS About Brain Atrophy

Nov 23rd, 2022 - New expert guidance on discussing the sensitive topic of brain atrophy in multiple sclerosis (MS) has been released. Robert Zivadinov, MD, PhD On the basis of data from surveys, workshops, and other sources, a team of providers, patients and researchers has developed 13 recommendations to help improve treatment adherence and underline the importance of a healthy lifestyle, guideline author Robe...

Dopamine Dysregulation a Causative Culprit in Schizophrenia?

Nov 23rd, 2022 - A genetic postmortem analysis of the brains of patients with schizophrenia suggests dysfunction of dopamine receptors in the caudate nucleus may cause the disorder. Investigators identified a mechanism on the dopamine receptor, known as the autoreceptor, which regulates how much dopamine is released from the presynaptic neuron. Impairment of this autoreceptor leads to poorly controlled dopamine...

'New Kid on the Block' May Help Relieve PTSD, Panic Disorder

Nov 23rd, 2022 - A digital intervention may offer a new and effective treatment option for panic disorder (PD) and posttraumatic stress disorder (PTSD), new research suggests. The 28-day home-based treatment, known as the Capnometry Guided Respiratory Intervention (CGRI), uses an app-based feedback protocol to normalize respiration and increase patients' ability to cope with symptoms of stress, anxiety, and pan...

Cardiovascular Societies Less Apt to Recognize Women, Minorities

Nov 23rd, 2022 - Major cardiovascular societies are more apt to give out awards to men and White individuals than to women and minorities, according to a look at two decades' worth of data. Martha Gulati, MD "Women received significantly fewer awards than men in all societies, countries, and award categories," author Martha Gulati, MD, director of preventive cardiology at Smidt Heart Institute at Cedars-Sinai, ...

PrEP Education During STI Testing Could Boost HIV Protection

Nov 23rd, 2022 - TAMPA, Florida — Screening and recommending preexposure prophylaxis (PrEP) to people at risk for HIV exposure could be more successful if education and access to the preventive protocol is offered during testing for sexually transmitted infections (STIs). It comes down to numbers, said Gabriela Brito, MSN, RN, ACRN, a researcher at nonprofit CAN Community Health, headquartered in Sarasota, Flor...

Endemic Mycoses: Better Diagnosis and Reporting Needed

Nov 23rd, 2022 - Blastomycosis, coccidioidomycosis (Valley fever), and histoplasmosis are the most prevalent endemic fungal diseases (mycoses) in North America. Authors of an opinion piece in Annals of Internal Medicine argue that we need to improve the diagnosis and reporting of these infections to better serve patients and understand the scope of the problem. Traditionally, these infections have had known reg...

People Living With HIV Are a Model Population for Vaccination

Nov 23rd, 2022 - TAMPA, Florida — People living with HIV (PLWH) were more likely than other populations to get vaccinated for flu and COVID-19, to seek reputable sources of information, and to be connected through essential community organizations that share essential health and wellness information, according to the results of a large survey. PLWH, therefore, would have been an ideal model population for creat...

FDA approves CSL's gene therapy for hemophilia

Nov 22nd, 2022 - Nov 22 (Reuters) - The U.S. health regulator on Tuesday approved Australian drugmaker CSL Ltd and partner Uniqure NV’s gene therapy for hemophilia B, potentially offering a long-term solution for patients with the blood clotting disorder. The approval from the Food and Drug Administration makes the treatment, which will be branded Hemgenix, the first gene therapy for the rare inherited disorder...

US STOCKS-Retailer, energy boost helps Wall Street rally

Nov 22nd, 2022 - (For a Reuters live blog on U.S., UK and European stock markets, click or type LIVE/ in a news window.) Best Buy up, sees smaller annual sales drop Dollar Tree drops on lower FY profit forecast Manchester United surges on sale report (Updates to market close) NEW YORK, Nov 22 (Reuters) - U.S. stocks rallied on Tuesday in light trading volume as a sales forecast by Best Buy dampened concerns hig...

Updated COVID vaccines offer better protection than original -U.S. study

Nov 22nd, 2022 - Nov 22 (Reuters) - Updated COVID-19 boosters offer increased protection against new variants in people who have previously received up to four doses of the older vaccine, a real-world study in the United States showed. The study of over 360,000 people, published in Morbidity and Mortality Weekly Report, offers the first evidence that the new vaccines by Pfizer-BioNTech and Moderna provide bette...