About 46,718 results

Widespread rash in toddler
MDedge Family Medicine;

Jun 30th, 2022 - This patient was given a diagnosis of Gianotti Crosti syndrome (GCS; also called infantile acrodermatitis of childhood), which is a self-resolving (often dramatic) dermatosis triggered by a viral infection or immunization. Patients with this syndrome develop papules, vesicles, and plaques on their face, hands, feet, and extremities a week (or more) after having a viral illness or receiving an i.

ASCO 2022: A Reflection on Data to Build On in Bladder Cancer

Jun 30th, 2022 - Cheryl Lee, MD, considers the updates on several studies presented at ASCO 2022, which, though not immediately practice-changing, offer encouraging glimpses of prospective bladder cancer treatments. Starting with a look at a report on the BAYOU study, Dr Lee notes how results of this trial, though not indicating significant therapeutic differences between the involved regimens, point to potenti...

'Important' New Data on Second-Line HIV Treatment Regimens: The NADIA Study

Jun 30th, 2022 - NEW YORK (Reuters Health) - For second-line HIV therapy, both dolutegravir and ritonavir-boosted darunavir regimens, plus two nucleoside reverse-transcriptase inhibitors (NRTIs), maintained good viral suppression during 96 weeks follow-up in the NADIA trial. Dolutegravir was non-inferior to darunavir but had a greater risk of resistance in second-line therapy, according to the results published...

Pfizer, Moderna to Be Ready With BA.1-Specific COVID Boosters

Jun 29th, 2022 - (Reuters) - Pfizer Inc and Moderna Inc said on Tuesday they will be ready with COVID-19 vaccines designed to combat the BA.1 Omicron variant that was dominant last winter earlier than those designed to target currently dominant versions of Omicron. Moderna said it would be ready with a "couple of hundred million" bivalent vaccines designed to combat BA.1 by September, but it would be late Octob...

Nodules on the Anterior Neck Following Poly-L-lactic Acid Injection
Austin Dunn, DO, Tyler Long, DO et. al.

Jun 28th, 2022 - Poly-L-lactic acid (PLLA) is a synthetic biologic polymer that is suspended in solution and can be injected for soft-tissue augmentation. The stimulatory molecule functions to increase collagen synthesis as a by-product of its degradation.

Highly effective memory B cells localized in the lungs

Jun 28th, 2022 - How can we increase the efficacy of vaccines used to protect against viral respiratory diseases such as influenza and COVID-19? Scientists from Inserm, CNRS and Aix-Marseille Université at the Center of Immunology Marseille-Luminy are opening up new prospects in the field, with the triggering of memory B cells directly in the lungs looking to be a promising avenue. At present, the vaccines are ...

Update noise regulations to protect seals, porpoises

Jun 28th, 2022 - WASHINGTON, June 28, 2022 – Noise produced by pile drivers building offshore wind turbines can damage the hearing of porpoises, seals, and other marine life. Regulations are in place, but guidance on this difficult topic requires regular revisits to incorporate results from new experiments. Current guidance is based on extensive literature reviews by the U.S. National Marine Fisheries Service, ...

Dynamic cells linked to brain tumor growth and recurrence

Jun 28th, 2022 - Tumors are made up of many types of cells, both cancerous and benign. The specific complexity of the cells inside brain tumors has been a trademark of the disease, one that makes treatment extremely difficult. While scientists have long known about the variety of cells within a brain tumor, the ways these tumors grow has relied on the understanding that the cells are static, unmoving and relati...

US Supreme Court Sides With Doctors Challenging Opioid Convictions

Jun 28th, 2022 - (Reuters) - The U.S. Supreme Court on Monday made it harder for prosecutors to win convictions of doctors accused of running "pill mills" and excessively prescribing opioids and other addictive drugs by requiring the government to prove that defendants knew their prescriptions had no legitimate medical purpose. The 9-0 ruling, authored by liberal Justice Stephen Breyer, sided with Xiulu Ruan an...

Novel Liver-Targeting Drug Offers Hope for AAT Deficiency

Jun 28th, 2022 - LONDON — The novel liver-targeting agent fazirsiran has fared well in a small, but significant, study looking at its ability to improve liver histology in adults with alpha-1 antitrypsin (AAT) deficiency. Not only were serum and liver levels of the aberrant Z-AAT protein decreased, but also reductions in key liver enzymes were observed. Dr Pavel Strnad AAT is “a greatly understudied disease,” s...

Stroke risk rises for women with history of infertility, miscarriage, stillbirth
Heidi Splete

Jun 27th, 2022 - Infertility, pregnancy loss, and stillbirth increased women’s later risk of both nonfatal and fatal stroke, based on data from more than 600,000 women. “To date, multiple studies have generated an expanding body of evidence on the association between pregnancy complications (e.

Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find

Jun 27th, 2022 - BOSTON – More than 40 percent of American adults have obesity, a complex condition that can increase the risk of diabetes, cardiovascular disease and certain cancers. One mechanism by which obesity can lead to other health problems is by causing low-grade chronic inflammation, the accumulation of immune cells in insulin-sensitive tissues. Scientists hypothesize that reversing – known as resolvi...

Brooke Emerling awarded $2.3 million to demystify breast cancer metabolism

Jun 27th, 2022 - Brooke Emerling from Sanford Burnham Prebys has been awarded a new grant from the National Institutes of Health (NIH) to continue her work on cellular signaling in cancer. The four-year, $2.3 million project could accelerate the development of new therapies for a range of cancers, particularly metastatic breast cancer. It also offers an answer to a longstanding mystery in cancer metabolism. “We...

Moffitt researchers determine 1st crystal structure of LAG3

Jun 27th, 2022 - TAMPA, Fla. — Immune checkpoint inhibitors have revolutionized cancer care. The therapy works by preventing tumors from shutting down the immune response, which in turn allows T cells to kill cancer cells. Established checkpoint inhibitors target the proteins PD-1 and CTLA-4 and are used to treat a variety of solid tumor types, including melanoma and lung cancer. However, the U.S. Food and Drug...

Chemically modified plant compounds work against hepatitis E virus

Jun 27th, 2022 - The team around Dimas F. Praditya, Mara Klöhn and Professor Eike Steinmann reports in the journal Antiviral Research from 18. Juni 2022. Plant compounds inhibit proliferation of cancer cells and viruses Rocaglates are a group of plant substances produced by various mahogany plants. They are known to have an inhibitory effect on the proliferation of some cancer cells. It was not until 2008 that ...

Doc Releases Song About Racist Attack in Buffalo, NY

Jun 27th, 2022 - Physician-musician Cleveland Francis responded to the recent mass shooting in Buffalo, New York, which left 10 dead, in the only way he knew how. He wrote and recorded a song to honor the victims as "a plea to the other side to recognize us as people," the Black cardiologist told Medscape. He couldn't sleep after the shooting, and "this song was just in my head." In the 1990s, Francis took a 3-...

Stroke Risk Rises for Women With History of Infertility, Miscarriage, Stillbirth

Jun 27th, 2022 - Infertility, pregnancy loss, and stillbirth increased women's later risk of both nonfatal and fatal stroke, based on data from more than 600,000 women. "To date, multiple studies have generated an expanding body of evidence on the association between pregnancy complications (e.g., gestational diabetes and preeclampsia) and the long-term risk of stroke, but studies on associations with infertili...

The Sussex researchers who used international collaboration and 3D printing to stem PPE shortages in Nigeria

Jun 26th, 2022 - Researchers at the University of Sussex and their partners in Nigeria used open-source designs and 3D printing to reduce personal protective equipment (PPE) shortages for a community in Nigeria during the Covid-19 pandemic – tells a recently published academic paper. In their paper in PLOS Biology, Dr Andre Maia Chagas from the University of Sussex, and Dr. Royhaan Folarin from the Olabisi Onab...

Glucagon Analog Stops Hypoglycemia Faster Than Carbs

Jun 24th, 2022 - Dasiglucagon, a glucagon analog approved for treating severe hypoglycemia, also appeared to be effective and highly acceptable for patients with type 1 diabetes with nonsevere hypoglycemia in a controlled, crossover study of 24 patients. In the head-to-head comparison with the main nonpharmacologic option for treating nonsevere hypoglycemia — ingestion of fast-acting carbohydrates — dasiglucago...

Retained Motor Skills Linked to Single-Neuron Activity

Jun 24th, 2022 - The study covered in this summary was published bioRxiv.org as a preprint and has not yet been peer reviewed. Key Takeaways Analysis of stereotyped behavior patterns with recordings of single-neuron activity in the motor cortex and dorsolateral striatum reveal that neural circuit dynamics are highly stable at the level of single neurons. Stable single-unit activity in motor circuits is involved...