About 36,770 results

Elacestrant Improves PFS Over SOC in ER+ Advanced or Metastatic Breast Cancer

Oct 20th, 2021 - Elacestrant (RAD1901) monotherapy improved progression-free survival over standard-of-care (SOC) treatment in patients with estrogen receptor (ER)–positive, HER2-negative breast cancer, including those whose tumors harbored ESR1 mutations, meeting the primary end points of the phase 3 EMERALD trial (NCT03778931).1 Topline results from the trial also showed that the toxicity profile of the sele...

Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

Oct 19th, 2021 - A multisystem inflammatory syndrome in children (MIS-C) and adults (MIS-A) occurring after coronavirus disease (COVID-19) has been identified; onset is ≈4–6 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1–3). A case definition for MIS-A has been developed by the Centers for Disease Control and Prevention (CDC) (4); MIS-A after vaccination is rare and remain...

Highly Pathogenic Avian Influenza A(H5N1) Virus in Wild Red Foxes, the Netherlands, 2021

Oct 19th, 2021 - Figure Figure. Salivating red fox (Vulpes vulpes) cub 1 during a fit, the Netherlands, 2021. Seizure started with retracting lips at 0 sec (A), followed by facial wrinkling with opening... Video Video. Salivating red fox (Vulpes vulpes) cub 1 during a fit, the Netherlands, May 10, 2021. On May 10, a red fox Vulpes vulpes cub (cub 1) displaying abnormal behavior was found in Bellingwolde, the Ne...

The Brain and Heart Want Different Blood Pressure Goals

Oct 18th, 2021 - The optimal systolic and diastolic blood pressure (BP) target for each person may depend on his or her individual risk profile, an observational study suggested. Based on the 33,357-patient ALLHAT trial, there appeared to be a U- or J-shaped association between risk of several cardiovascular events and BP, such that going too low in systolic or diastolic BP was not good for the patient. The nad...

Half-Dose DOACs Cut Bleeding, Thrombus Risk Post-Watchman LAA Closure

Oct 15th, 2021 - In a potential case of "less is more," an antithrombotic regimen with only short-term antiplatelets and long-term reliance on direct oral anticoagulants (DOACs) — but at half the standard dosages — led to an almost 90% drop in risk of thromboembolic and major bleeding events after transcatheter left-atrial appendage (LAA) closure, in an observational study. Meanwhile, the long-term half-dose DO...

WHO Says It May Be 'Last Chance' to Find COVID Origins

Oct 14th, 2021 - GENEVA (Reuters) - The World Health Organization (WHO) said on Wednesday its newly formed advisory group on dangerous pathogens may be "our last chance" to determine the origins of the SARS-CoV-2 virus and and urged China to provide data from early cases. The first human cases of COVID-19 were reported in the central Chinese city of Wuhan in December 2019. China has repeatedly dismissed theorie...

New York Surgeon Dies in Hit-and-Run Car Crash

Oct 14th, 2021 - Vascular surgeon John Chambers Hordines, Jr, 54, has died in a hit-and-run car crash in Cornwall, New York. Having practiced medicine for nearly 30 years, he is remembered by family, friends, and colleagues as someone who went above and beyond for his patients. "I don't think I've ever known anyone who fought for the patients more," John Powell, MD, who worked closely with Hordines at Crystal R...

Shorter Pregnancies Mean Higher Lifelong Hypertension Risk

Oct 13th, 2021 - Delivering a child preterm carried lifelong risk for hypertension, a large population-based study showed. Among more than 2 million women in Sweden, delivery before 37 weeks' gestation was independently associated with a 1.67-fold increased risk (95% CI 1.61-1.74) of developing hypertension in the following 10 years, reported Casey Crump, MD, PhD, of Icahn School of Medicine at Mount Sinai in N...

New FDA Guidance Aims to Cut Sodium in Processed Foods

Oct 13th, 2021 - The US Food and Drug Administration (FDA) has issued voluntary, short-term sodium reduction targets for food manufacturers, chain restaurants, and food service operators for processed, packaged, and prepared foods, with an eye toward reducing diet-related conditions such as heart disease and obesity. According to the FDA, more than 70% of total sodium intake is from sodium added during food man...

Key Takeaways From the Latest Stroke Guidelines

Oct 13th, 2021 - This transcript has been edited for clarity. Dear colleagues, I am Christoph Diener from the faculty of medicine at the University of Duisburg-Essen in Germany. This month I would like to report on several new publications from the European Stroke Organisation on the management and prevention of stroke. Managing Blood Pressure in the First 24 Hours The first study deals with the management of b...

Rivaroxaban's Single Daily Dose May Lead to Higher Bleeding Risk Than Other DOACs

Oct 12th, 2021 - A study that compared three types of direct oral anticoagulants (DOACs) found that rivaroxaban was associated with a much higher risk of overall and major gastrointestinal bleeding than apixaban or dabigatran. The results, which were published in the Annals of Internal Medicine, could help guide DOAC selection for high-risk groups with a prior history of peptic ulcer disease or major GI bleedin...

USPSTF Rules Out Aspirin for Over 60s in Primary CVD Prevention

Oct 12th, 2021 - New draft recommendations from the US Preventive Services Task Force (USPSTF) on the use of aspirin for the primary prevention of cardiovascular disease (CVD) have been released and appear to limit the population in which it should be considered.   "The USPSTF concludes with moderate certainty that aspirin use for the primary prevention of CVD events in adults ages 40 to 59 years who have a 10%...

Rivaroxaban’s single daily dose may lead to higher bleeding risk than other DOACs
Jennifer Lubell

Oct 11th, 2021 - A study that compared three types of direct oral anticoagulants (DOACs) found that rivaroxaban was associated with a much higher risk of overall and major gastrointestinal bleeding than apixaban or dabigatran. The results, which were published in the Annals of Internal Medicine, could help guide DOAC selection for high-risk groups with a prior history of peptic ulcer disease or major GI bleedin.

Little Benefit From Adding Aspiration to Thrombectomy for Stroke

Oct 11th, 2021 - A first-line thrombectomy approach that combines contact aspiration and stent retrieval techniques does not significantly improve the reperfusion rate compared to stent retrieval alone in patients with acute ischemic stroke and large-vessel occlusion, a newly published study shows. Dr Bertrand Lapergue However, the trial was likely underpowered, so the question of whether the combined approach ...

NICE: Inclisiran for Treating Primary Hypercholesterolaemia or Mixed Dyslipidaemia

Oct 11th, 2021 - National Institute for Health and Care Excellence (NICE) has issued new guidance which recommends inclisiran as an option for treating primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet in adults. The treatment is recommended only if: There is a history of any of the following cardiovascular events: Acute coronary syndrome (such a...

The Long-term Effects of Underdiagnosed Conditions in Sleep Disorders
Jessie Wrobel, BSN, MSN, FNP-C

Oct 8th, 2021 - Jessie Wrobel is a board-certified Family Nurse Practitioner. She earned a Bachelor of Science in Nursing from Southern Connecticut State University, concurrently graduating from their Honor’s College in 2009 and spent 9 years at the bedside focusing on heart failure and stroke populations.

Saccular Aneurysm No Bar to Thrombolysis in Ischemic Stroke

Oct 8th, 2021 - Intravenous thrombolysis (IVT) seems to be relatively safe for acute ischemic stroke patients who have even larger-sized saccular unruptured intracranial aneurysms (UIAs), a Finnish study suggests. "I think there is now sufficient evidence that saccular aneurysms should not be considered a contraindication for thrombolysis," Jyri Virta, MD, PhD, with the Department of Neurosurgery and Neurology...

Immunotherapy, Second-Generation AR Antagonists Provide Expansive Utility Throughout Prostate Cancer

Oct 7th, 2021 - The second-generation androgen receptor (AR) antagonists, darolutamide (Nubeqa), enzalutamide (Xtandi), and apalutamide (Erleada) and immune-oncology (IO) agents, such as checkpoint inhibitors and bispecific antibodies, are generating excitement in prostate cancer, according to Sumit K. Subudhi, MD, PhD. Current drivers of treatment decisions are the adverse effects (AEs) and central nervous s...

The Stroke–obesity Paradox Becomes Evident in yet Another Study

Oct 7th, 2021 - Takeaway Overweight or obesity may be linked to a more favourable prognosis for subsequent major adverse cardiovascular events (MACE), peripheral vascular disease (PVD) and mortality in stroke survivors, regardless of confounding variables at the time of stroke. The authors warn that the stroke–obesity paradox is strictly an association and should not be considered causal. Why this matters Ther...

Optimum A1c to Prevent Events in Stroke Patients With Diabetes?

Oct 7th, 2021 - For patients with diabetes who have had a stroke, glycated hemoglobin (A1c) level at the time of admission to the hospital was significantly associated with the risk for future vascular events in a new study. The optimum range of admission A1c associated with a minimum risk for vascular events and stroke recurrence was estimated to be between 6.8% and 7.0%. The risk significantly increased abov...