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About 21,225 results

Study: Follow-Up Articles Helpful in Depression Care Research
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/361367

Information on external validity enables public health practitioners to generalize conclusions about an intervention, which is critical to moving research into practice. Prior reviews examining external validity focused on efficacy publications only. The objective of this study was to determine the extent to which secondary articles could enhance information about external validity presented in...

Psychedelic Succeeds as Quick Depression Fix in Early Trial
https://www.medpagetoday.com/psychiatry/depression/102807

Jan 25th, 2023 - An investigational N,N-dimethyltryptamine treatment -- commonly known as the hallucinogen DMT -- achieved the primary endpoint in a phase IIa trial for major depressive disorder (MDD), developer Small Pharma announced. Paired with supportive therapy, a 21.5-mg infusion of the agent, dubbed SPL026, significantly reduced depressive symptoms by 7.4 points more than placebo (P=0.02) at 2 weeks afte...

Emotional Blunting Explained; 8% of Adults on Sleep Meds; Long Waits for Psych Care
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102801

Jan 25th, 2023 - Emotional "blunting," often seen with use of antidepressants, may stem from the drugs' effects on reinforcement learning, according to a placebo-controlled semi-randomized trial. (Neuropsychopharmacology) Attention deficit-hyperactivity disorder was an even bigger predictor of internalizing problems than autism spectrum disorder, a study of over 500 people found. (Scientific Reports) About 8% o...

ACP Guideline Backs Newer Antidepressants, CBT for Acute Phase of Major Depression
https://www.medpagetoday.com/psychiatry/depression/102762

Jan 23rd, 2023 - Cognitive behavioral therapy (CBT), second-generation antidepressants, or a combination of the two approaches are recommended for the initial treatment of adults in the acute phase of moderate-to-severe major depressive disorder (MDD), according to updated clinical recommendations from the American College of Physicians (ACP). The decision on which treatment to start first should be based on a ...

Gender-Affirming Hormones Boost Mental Health for Transgender Youth
https://www.medpagetoday.com/endocrinology/generalendocrinology/102687

Jan 18th, 2023 - Use of gender-affirming hormones (GAH) in transgender and nonbinary youth helped improve psychosocial functioning in a four-site prospective, observational study. In the study of 315 participants in the U.S., taking GAH was linked with a 0.48-point annual increase (on a 5-point scale) in scores for appearance congruence -- defined as alignment between gender identity and physical appearance -- ...

Genetic Links Found Between Endometriosis and Psychiatric Disorders
https://www.medpagetoday.com/psychiatry/depression/102682

Jan 18th, 2023 - Endometriosis was associated with several psychiatric disorders through genetic and phenotypic mechanisms, even after accounting for several comorbidities including chronic pain, according to a genetic association study. A multivariate regression analysis of more than 200,000 women found that endometriosis was associated with depression, anxiety, and eating disorders through a pleiotropic mecha...

FDA OKs Long-Acting Risperidone; TMS for Anxious Depression; CBT Bests Pharma
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102680

Jan 18th, 2023 - The FDA approved the biweekly long-acting injectable (LAI) risperidone (Rykindo) for the treatment of schizophrenia and bipolar I disorder, Luye Pharma Group announced. A phase IIa study showed a significantly greater improvement in Montgomery-Åsberg Depression Rating Scale score with the potential first-in-class investigational treatment ALTO-100 among a group of patients with biomarker-define...

What Happens When Patients Learn About Their Alzheimer's Status?
https://www.medpagetoday.com/neurology/alzheimersdisease/102642

Jan 13th, 2023 - Learning about a positive amyloid-PET result was associated with psychological changes among people with subjective cognitive decline, but those changes did not reach a threshold for clinical concern. In the prospective AMYPAD consortium study, people who received news about a positive amyloid scan showed small increases in distress, anxiety, or depression scores compared with peers who learned...

Experiencing Racism Tied to Doubled Odds of Depression During Pregnancy
https://www.clinicaladvisor.com/home/topics/psychiatry-information-center/experiencing-racism-tied-doubled-odds-depression-during-pregnancy/
Clinical Advisor

Jan 12th, 2023 - HealthDay News — Women who have been upset due to experiencing racism in the year prior to delivery have significantly higher odds of depression during pregnancy, according to a study published online in the Journal of Advanced Nursing. Kelly M. Bower, PhD, MPH, RN, from the Johns Hopkins School of Nursing in Baltimore, and colleagues used data from phase 8 (2018) of the Pregnancy Risk Assessme...

Cancer Surgery Linked to Higher Suicide Risk
https://www.medpagetoday.com/hematologyoncology/othercancers/102611

Jan 12th, 2023 - The incidence of suicide was significantly higher in patients undergoing cancer surgery compared with the general U.S. population, a retrospective population-based cohort study showed. Among patients undergoing surgery for the 15 deadliest cancers in the U.S. from 2000 to 2016, the suicide rate was 14.5 per 100,000 person-years -- a rate that was significantly higher compared with the general p...

Religious Leaders May Help Address Mental Health Needs, Study Suggests
https://www.medpagetoday.com/psychiatry/depression/102590

Jan 11th, 2023 - Most religious leaders endorse views about depression that are in line with medical experts, a cross-sectional study showed, suggesting that collaboration between the two groups could address mental health needs in their shared communities. Among nearly 900 church leaders surveyed, 79% said that depression was caused by chemical imbalance, while 59% endorsed genetics, reported Anna Holleman, Ph...

R-Ketamine Phase II Flop; More Antipsychotics for Kids; Horse Tranq-Laced Opioids
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102589

Jan 11th, 2023 - Investigational R-ketamine agent PCN-101 missed the primary endpoint of a phase IIa clinical trial in people with treatment-resistant depression, failing to lower depression scores 24 hours after dosing, Atai Life Sciences announced. During the first year of the COVID-19 pandemic, the weekly rate of in-person mental health service utilization dropped by over 50%, though this was quickly followe...

Women With ADHD at Increased Risk for Depression With Hormonal Contraceptive Use
https://www.clinicaladvisor.com/home/topics/adhd-information-center/women-adhd-increased-risk-depression-hormonal-contraceptive-use/
Clinical Advisor

Jan 10th, 2023 - Women or girls who were using hormonal contraceptives (HCs) and had attention-deficit/hyperactivity disorder (ADHD) were associated with increased risk for depression compared with HC users who did not have ADHD. These findings were published in the Journal of the American Academy of Child & Adolescent Psychiatry. Data for this study were sourced from national databases in Sweden. Swedish-born ...

Second Year of Pandemic Took a Heavy Mental Health Toll on Young Adults
https://www.medpagetoday.com/psychiatry/anxietystress/102519

Jan 5th, 2023 - Nearly half of 18- to 25-year-olds experienced any mental illness or a substance use disorder in 2021, according to the National Survey on Drug Use and Health's latest report. While the national rate of mental illness was 22.8% for adults overall in the second year of the pandemic, that proportion reached 33% among young adults, according to a survey by the U.S. Department of Health and Human S...

Watch for New Psych Disorders in the Spouses of Cancer Patients
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102510

Jan 5th, 2023 - The heightened stress of having a spouse battling cancer may manifest in a clinical diagnosis of a new psychiatric disorder, a population-based cohort study found. Looking at over 3 million people living in Denmark and Sweden, there was a higher incidence of first-onset psychiatric disorders among spouses of patients with cancer when compared with the spouses of patients without cancer (6.9% vs...

1 Psilocybin Dose for Depression; Add-On Schizophrenia Success; Genetic Suicidality
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102500

Jan 4th, 2023 - Just one moderate dose of psilocybin (0.215 mg/kg body weight) -- commonly known as magic mushrooms -- was associated with a 13-point drop in depressive symptom severity versus placebo, lasting at least 2 weeks. (eClinicalMedicine) Parental leave from work for postpartum mothers, especially paid leave for a minimum of 2 to 3 months, was protective against poor mental health. (Lancet Public Heal...

Anxiety and Depression Association in Patients With Pediatric Psoriasis
https://www.clinicaladvisor.com/home/topics/psoriasis-information-center/anxiety-depression-in-patients-with-pediatric-psoriasis/
Clinical Advisor

Jan 3rd, 2023 - A positive relationship may exist between pediatric psoriasis and the onset of depression and anxiety, and evidence suggests the causal relationship may go both ways. It is unknown how early comorbid psychiatric trends begin in patients with pediatric psoriasis. These are among the review findings published in Pediatric Dermatology. An association between psoriasis and the onset of mood disorde...

Regular Exercise Can Reduce Depressive Symptoms in Teens
https://www.medpagetoday.com/psychiatry/depression/102471

Jan 3rd, 2023 - Physical activity can help alleviate depressive symptoms in teens, according to a systematic review and meta-analysis of clinical trials. Engaging in physical activity significantly helped to reduce depressive symptoms, with a modest corrected effect size compared with controls (g= -0.29, 95% CI -0.47 to -0.10, P=0.004), found Parco M. Siu, PhD, of the University of Hong Kong, and colleagues. A...

Mental Health ED Visits Up for Kids; FDA Turns Down Roluperidone; Facebook Addiction
https://www.medpagetoday.com/psychiatry/generalpsychiatry/102413

Dec 28th, 2022 - Rates of emergency department visits among kids with mental health problems increased by 8% annually from 2015 to 2020 and 13% of patients revisited within 6 months. (JAMA Pediatrics) Mothers with diabetes during pregnancy -- including type 1, type 2, and gestational diabetes -- had a higher risk of having a child with a neurodevelopmental conditions like ADHD and autism. (Developmental Medicin...

5-ARIs Not Linked to Risk of Dementia Over the Long Term
https://www.medpagetoday.com/urology/urology/102369

Dec 22nd, 2022 - Men taking 5α-reductase inhibitors (5-ARIs), commonly used for androgenic alopecia and benign prostatic hyperplasia (BPH), should be aware of possible adverse psychological effects, researchers warned. In a register-based cohort study of over 2.2 million Swedish men, an increased risk for depression was seen in those taking finasteride (Proscar, Propecia; HR 1.61, 95% CI 1.48-1.75) or dutasteri...