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Clinical Edge Journal Scan Commentary: Multiple Sclerosis June 2022
https://www.mdedge.com/neurology/msresourcecenter/article/255056/multiple-sclerosis/clinical-edge-journal-scan-commentary
Mark Gudesblatt, MD

May 27th, 2022 - Mark Gudesblatt, MD Multiple sclerosis (MS) remains a complex disease with varied effects, some visible and clinically symptomatic and others invisible (eg, effects on cognition). However much we focus on the visible and uncovering the currently invisible effects, we must be aware of the effects of prior infection with SARS-CoV-2 (ie, post-acute COVID-19 syndrome, aka long COVID) in people with.

KRAS p.G12C mutations may have prognostic implications in mCRC
https://www.mdedge.com/hematology-oncology/article/255019/gastrointestinal-cancer/kras-pg12c-mutations-may-have-prognostic

May 27th, 2022 - Key clinical point: Patients with KRAS p. G12C-mutant metastatic colorectal cancer (mCRC) show poor treatment outcomes, which are numerically worse than those in patients without this mutation or with KRAS non-p.

Breakthrough Infections May Be Less Contagious
https://www.medscape.com/viewarticle/974700

May 27th, 2022 - (Reuters) - Fully vaccinated individuals who get infected with the coronavirus spread the infection to fewer people and are contagious for less time compared to people who are partially vaccinated or unvaccinated, a small study from South Korea suggests. In 173 hospital workers with COVID-19, including 50 who had breakthrough infections, researchers found that the virus had been transmitted to ...

MRI Technique May Yield Clues to Long COVID Breathlessness
https://www.medscape.com/viewarticle/974705

May 27th, 2022 - (Reuters) - In people with lasting breathlessness after COVID-19, a special type of magnetic resonance imaging (MRI) reveals lung abnormalities that traditional imaging techniques do not detect, a small study shows. In 23 patients with shortness of breath lasting for months after COVID-19, including 11 who had not required hospitalization, the researchers performed hyperpolarized xenon 129MRI, ...

Is Subfertility Linked With Postpartum Mental Illness?
https://www.medscape.com/viewarticle/974741

May 27th, 2022 - Mothers with previous subfertility have increased risk for postpartum mental illness, compared with mothers who conceived spontaneously, according to a new study. In a population-based cohort study that examined almost 800,000 births, the adjusted relative risk (RR) for postpartum mental illness was 1.14 in women with subfertility, compared with women without reproductive assistance. The magnit...

'It's an Amazing Time to Be a Hemophilia Provider'
https://www.medscape.com/viewarticle/974738

May 27th, 2022 - New medications such as emicizumab (Hemlibra) are transforming the lives of patients with hemophilia A, and more treatments are in the pipeline. "It's an amazing time to be a hemophilia provider," Alice D. Ma, MD, University of North Carolina at Chapel Hill hematologist and bleeding disorder specialist, said in an interview. "There are real options, and it's very exciting." But the drugs come w...

ESG's Cardiometabolic Benefits Last 5 Years
https://www.medscape.com/viewarticle/974768

May 27th, 2022 - SAN DIEGO – Endoscopic sleeve gastroplasty (ESG) led to sustained weight loss and a reduction of cardiometabolic syndrome comorbidities at 5 years, according to a new retrospective analysis of prospectively collected data. Dr Donevan Westerveld Improved cardiometabolic outcomes following bariatric surgery have been well documented, but ESG is relatively new, so its outcomes haven't been as well...

'Unlimited' Cancer Costs: The Medicare Part D Dilemma
https://www.medscape.com/viewarticle/974754

May 27th, 2022 - Learning that a family member has cancer can be devastating enough. Waiting to find out whether a loved one can afford their treatment takes the concern to another level. That was the case for health policy expert Stacie B. Dusetzina, PhD, when her mother was diagnosed with metastatic breast cancer. "There is this period where you are waiting to learn more about the cancer type and treatment op...

H pylori Antibiotics Briefly Disrupt Gut Microbiome
https://www.medscape.com/viewarticle/974767

May 27th, 2022 - SAN DIEGO – Treatments to eradicate Helicobacter pylori (H. pylori) infections do increase the antibiotic resistance of the gut microbiota, but for only a few months, researchers reported at Digestive Disease Week® (DDW). The finding applies similarly to levofloxacin quadruple therapy and bismuth quadruple therapy, both of which are equally efficacious as second-line treatments, said Jyh-Ming L...

Eosinophilic Diseases Often Overlap, Raising Costs
https://www.medscape.com/viewarticle/974781

May 27th, 2022 - Eosinophilic GI diseases (EGIDs) often overlap with other eosinophil-associated diseases (EADs), which leads to greater health care costs, according to an analysis of the U.S. Optum Clinformatics claims database. EADs have gained increased attention in recent years. They include eosinophilic esophagitis (EoE), eosinophilic asthma, bullous pemphigoid, eosinophilic granulomatosis with polyangiiti...

Early Liver Transplant Outcomes Not Impacted by New US Allocation System
https://www.medscape.com/viewarticle/974702

May 27th, 2022 - NEW YORK (Reuters Health) - A new system for allocating liver allografts in the United States, implemented in 2020, has been associated with procurement-related delays but has had no adverse impact on early transplant outcomes, a new study shows. To assess the effect of Liver Acuity Circle Allocation (AC), researchers compared data from the Organ Procurement and Transplantation Network (OPTN) o...

Disparities Exist in Diabetes-Related ED Visits
https://www.medscape.com/viewarticle/974720

May 27th, 2022 - Wide disparities exist in diabetes-related emergency department (ED) use between racial and ethnic groups, rural and urban patients, and Medicare and Medicaid-insured adults versus those who were privately insured between 2008 and 2017, a serial cross-sectional study indicates. All-cause ED visits increased by over 50% during the same period even though substantial health reforms were made duri...

Gout App Improves Treat to Target, Reduces Flares
https://www.medscape.com/viewarticle/974721

May 27th, 2022 - Self-management of gout using a smartphone app to record self-test urate levels and flares, and communicate those results to clinicians, could see more patients reaching target urate levels and even reducing flare frequency, a study has found. Writing in The Lancet Rheumatology, Philip Riches, PhD, of the rheumatic disease unit at Western General Hospital in Edinburgh, and coauthors presented t...

Screening Finds Albuminuria in 3% of Community Adults
https://www.medscape.com/viewarticle/974739

May 27th, 2022 - Roughly 3% of adults in the general population of The Netherlands have microalbuminuria or macroalbuminuria, and in nearly two thirds of this subgroup — roughly 2% of the general population — kidney disease had previously gone unidentified, based on screening results in a study of about 15,000 adults. "This is the first study to prospectively investigate population screening for albuminuria," s...

COVID-19 Vaccines Work Better and for Longer Than Expected Across Populations, Including Immunocompromised Individuals
https://www.medscape.com/viewarticle/974363

May 27th, 2022 - The mRNA vaccines are powerful in terms of preventing severe disease with COVID-19 across populations because of the multifaceted immune response they generate, a redundancy that can help among patients on agents which cause immunocompromise. Although antibodies from the vaccines will wane over time, or these antibodies can be less effective against new variants like Omicron, the vaccines do no...

Social media data show language related to depression didn’t spike after initial pandemic wave
https://www.eurekalert.org/news-releases/954190

May 27th, 2022 - Researchers who analyzed language related to depression on social media during the pandemic say the data suggest people learned to cope as the waves wore on. University of Alberta researcher Alona Fyshe and her collaborators at the University of Western Ontario hypothesized that depression-related language would spike during each wave of COVID-19. But their study shows that wasn’t the case. “Th...

MSK scientists identify new — and very common — subtype of prostate cancer
https://www.eurekalert.org/news-releases/954169

May 27th, 2022 - A previously unknown subtype of hormone-resistant prostate cancer accounts for about 30% of all cases, according to a new study from a team of scientists at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine, published May 27, 2022, in the journal Science. The results could pave the way for targeted therapies for people with this subtype of prostate cancer. Prior to this re...

Previous COVID-19 or MIS-C does not protect kids from Omicron
https://www.eurekalert.org/news-releases/954167

May 27th, 2022 - Research drawing on the national Overcoming COVID-19 study, led by Boston Children’s Hospital, and the hospital’s own Taking On COVID-19 Together Group provides evidence that children who previously had COVID-19 (or the inflammatory condition MIS-C) are not protected against the newer Omicron variant. Vaccination, however, does afford protection, the study found. The findings, published in Natu...

Chung-Ang University researchers unravel role of cohesins in embryonic stem cell division
https://www.eurekalert.org/news-releases/954143

May 27th, 2022 - Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division. These changes occur at a high level of accuracy to prevent genome instability. Genome instability resulting from broken, missing, or rearranged chromosomes has been found to be the root cause of cell death, carcinogenesis, and congenital disorders. Studying genomic instability helps...

Study reveals potential target for treatment of diseases associated with mitochondrial DNA mutations
https://www.eurekalert.org/news-releases/954172

May 27th, 2022 - A study by Brazilian scientists points to the probable biological mechanism that modulates the accumulation of mutant mitochondrial DNA in cells during aging, especially in the liver. The mechanism is called autophagy, a process of cellular cleansing that destroys organelles, including mitochondria, and recycles their components. The findings resolve a paradigm in the field and raise a hypothes...