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About 235,878 results

Unique Nationwide Screening Program Fails to Move the Needle on CVD Risk Factors
https://www.medpagetoday.com/primarycare/preventivecare/102002

Dec 1st, 2022 - Japan's mass screening and counseling intervention resulted in only modest population-wide improvements in obesity and cardiovascular disease (CVD) risk factors, a study showed. Among over 3.4 million men and 2.3 million women, those who met the threshold for high waist circumference with high blood pressure, impaired glucose tolerance, or dyslipidemia and received lifestyle guidance and counse...

Year in Review: Diffuse Large B-Cell Lymphoma
https://www.medpagetoday.com/hematologyoncology/lymphoma/101996

Dec 1st, 2022 - Second-line treatment for diffuse large B-cell lymphoma (DLBCL) got a big boost in 2022 with new indications for a pair of chimeric antigen receptor (CAR) T-cell therapies, while an antibody-drug conjugate moved one step closer to shaking up treatment in the first-line setting. CAR-T Products Move to Second-Line In April, axicabtagene ciloleucel (axi-cel; Yescarta) became the first CAR T-cell t...

TikTok Creates Ozempic Shortage; New MS Framework Proposed; and AI May Cut Bias in Drug Trials
https://www.medscape.com/viewarticle/984741

Dec 1st, 2022 - TikTok Creates Ozempic Shortage TikTok is fueling demand for Ozempic, creating shortages of the diabetes drug now used for weight loss. Videos on TikTok hashtagged #ozempic have amassed more than 275 million views, and #ozempicweightloss has more than 110 million. The trend follows social media posts by celebrities such as Kim Kardashian and Elon Musk touting their own use of the drug or weight...

Eisai, Biogen Alzheimer's drug slows cognitive decline, safety for some becomes focus
https://www.reuters.com/article/eisai-biogen-alzheimers/eisai-biogen-alzheimers-drug-slows-cognitive-decline-safety-for-some-becomes-focus-idUSL1N32O1QW

Nov 30th, 2022 - SAN FRANCISCO, Nov 29 (Reuters) - An experimental Alzheimer’s disease drug from Eisai and Biogen slowed cognitive decline in a closely-watched trial but may carry a risk of dangerous side effects for certain patients, according to new data presented on Tuesday. The drug, lecanemab, was associated with a type of brain swelling in 12.6% of trial patients, a side effect previously seen with simila...

Is It Time to Write a Prescription for Meditation Instead of Medication in Type 2 Diabetes?
https://www.medscape.com/viewarticle/984551

Nov 30th, 2022 - A recently published meta-analysis suggested that the utilization of mind-body practices in people living with type 2 diabetes can help significantly improve glycemic control. Multiple media outlets extolled the findings that these techniques could lead to a mean A1c reduction of 0.84%, which is similar to or better than what is achieved with many pharmacotherapies developed for the management ...

The 'Too Many Toes Sign' and the Thompson Squeeze
https://www.medscape.com/viewarticle/984256

Nov 30th, 2022 - This transcript has been edited for clarity. Matthew F. Watto, MD: Welcome back to The Curbsiders. I'm Dr Matthew Watto, here with my great friend Dr Paul Nelson Williams. Today we're going to be talking about foot and ankle pain. We had a great podcast episode on this, The Thrill of Victory and the Agony of the Feet, with Dr Joan Ritter. Paul, let's start with ankle sprains. Give me a pearl. P...

New Genetic Variant Linked to Maturity-Onset Diabetes of the Young
https://www.medscape.com/viewarticle/984757

Nov 30th, 2022 - A newly discovered genetic variant that is associated with type 2 diabetes (T2D) is responsible for almost 7% of all diabetes cases in Greenland, according to a whole-genome sequencing analysis of 448 Greenlandic Inuit individuals. The variant, identified as c.1108G>T, "has the largest population impact of any previously reported variant" within the HNF1A gene – a gene that can cause maturity-o...

With Type 1 Diabetes Delay Possible, Focus Now on Screening
https://www.medscape.com/viewarticle/984748

Nov 30th, 2022 - The recent approval of teplizumab-mzwv (Tzield, Provention Bio) for the delay of type 1 diabetes by the US Food and Drug Administration is expected to advance efforts to increase screening to cost-effectively identify those at risk for the condition who would be eligible to receive the new treatment. The anti-CD3 monoclonal antibody was approved November 17 as the first disease-modifying therap...

The TikTok Trend That Triggered a Diabetes Drug Shortage
https://www.medscape.com/viewarticle/984758

Nov 30th, 2022 - Weight loss advice is everywhere you look on social media, but one trend sweeping TikTok has led to shortages of an important diabetes drug.  Ozempic, a weekly injection that helps boost insulin sensitivity in people with type 2 diabetes, also suppresses appetite, which leads to weight loss. Stories of celebrities using the drug off-label to lose a few pounds have led to an explosion of interes...

One Dose of Acoziborole Led to Cure of 'Sleeping Sickness' Across Disease Stages
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/101970

Nov 29th, 2022 - A single dose of oral acoziborole proved to be efficacious and safe for adults and adolescents with gambiense human African trypanosomiasis (HAT), also known as "sleeping sickness," suggesting its promise in interrupting transmission, a single-arm phase II/III trial showed. Over 18 months of follow-up, the treatment success rate was 95.2% in those with late-stage disease and 98.1% in the evalua...

Metastasis-Directed Therapy May Delay ADT in Advanced Prostate Cancer
https://www.medpagetoday.com/hematologyoncology/prostatecancer/101967

Nov 29th, 2022 - Metastasis-directed therapy (MDT) in selected patients with recurrent oligometastatic prostate cancer led to PSA responses in a majority of patients and delayed initiation of hormonal therapy by 18 months, a retrospective study showed. Overall, 77 of 124 patients had PSA declines of more than 50% with surgery or stereotactic body radiation therapy (SBRT). In particular, surgery led to PSA respo...

Ultra-Long Stroke Transfers; Isotopes Return; Back-to-Back CPR During Half Marathon
https://www.medpagetoday.com/cardiology/prevention/101958

Nov 29th, 2022 - Persistent asthma was linked to higher carotid plaque burden and inflammation in the MESA cohort. (Journal of the American Heart Association) Hospitals can still make endovascular therapy work for stroke patients transferred from over 300 miles away, suggested a retrospective study from New Zealand and Australia. (Stroke) Good news during the medical radioisotope shortage: the global supply of ...

Albuminuria Remission With Meds; Tzield's High Cost; Osteoporosis Prevention Lags
https://www.medpagetoday.com/endocrinology/generalendocrinology/101956

Nov 29th, 2022 - "Best" medical treatment with drugs such as SGLT2 inhibitors and GLP-1 receptor agonists was just as effective as Roux-en-Y gastric bypass at achieving albuminuria remission in patients with diabetic kidney disease and class I obesity. (eClinicalMedicine) Men with metabolic syndrome, and particularly those with obesity and high triglycerides, had a higher risk for developing gout in a study of ...

Lupus Linked With Greater Risk of Cardiovascular Complications of Childbirth
https://www.medpagetoday.com/rheumatology/lupus/101954

Nov 29th, 2022 - Pregnant women with systemic lupus erythematosus (SLE) were more prone to cardiovascular complications during delivery, and their risk seems to have increased over the past 15 years, according to national administrative data. The cross-sectional study supports the role that the underlying inflammatory activity of SLE may play in these cardiovascular complications, since even after adjustment fo...

AFib Risk Rises as A1c Increases
https://www.medscape.com/viewarticle/984714

Nov 29th, 2022 - Researchers published the study covered in this summary on Research Square as a preprint that has not yet been peer reviewed. Key Takeaways Adults not receiving glucose-lowering drugs showed a stepwise, increasing risk of developing atrial fibrillation (AFib) that tracked with increasing levels of A1c from 5.8% to 7.6% (40 to 60 mmol/mol). Patients with new-onset diabetes had a similar risk of ...

Stool Transplants May Boost Immunotherapy Success in Melanoma
https://www.medscape.com/viewarticle/984710

Nov 29th, 2022 - In advanced and metastatic melanoma patients, fecal microbiota transplant (FMT) from healthy donors in advance of anti–PD-1 immunotherapy led to a 75% clinical benefit rate, defined as complete response, partial response, or stable disease that lasted 6 months or longer. The results come from a small, single arm phase 1 study whose primary endpoint was safety. "We know that the gut microbiome h...

'Just Some Eccentric Guy in Australia': The Story of a Non-retraction for Plagiarism
https://www.medscape.com/viewarticle/984719

Nov 29th, 2022 - After reading a paper published in The Annals of the Royal College of Surgeons of England last March, Andrew Thomas, an orthopedic surgeon in the UK, noticed that it was very similar to an article published the previous December in another journal. He wrote a letter to the editor of Annals, notifying the journal of the similarity between its paper, "The possible effect of different types of ven...

Medical Masks, N95s May Offer Similar Prevention vs COVID: Study
https://www.medscape.com/viewarticle/984734

Nov 29th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Regular medical masks might provide protection similar to that of N95 respirators in preventing SARS-CoV-2 infection among healthcare workers, according to the first randomized trial that tested the two types of masks head to head in the COVID-19 era. Owing to limitations in the study, however, ...

We Have an Amputation Epidemic
https://www.medscape.com/viewarticle/984461

Nov 29th, 2022 - Every three minutes in America, a person loses all or part of a limb due to their diabetes. Every. Three. Minutes. Robert A. Gabbay, MD, PhD Five-year mortality numbers for individuals undergoing a diabetes-related amputation rival those of many forms of cancer. Tragically, your odds of suffering from limb loss can come down to the color of your skin, your gender, your educational level, where ...

Don't Skip Exercise in Lifestyle Interventions for Kids With Obesity
https://www.medpagetoday.com/pediatrics/obesity/101939

Nov 28th, 2022 - Exercise is a key component of a family-based lifestyle intervention program aimed at helping kids lose fat, according to a secondary analysis of a nonrandomized controlled trial. Over the 22-week program, kids with overweight or obesity whose families participated in a lifestyle intervention program with supervised exercise training saw an 18.1% reduction in visceral adipose tissue (VAT) versu...