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Commentary: Menstruation, sleep, and visual disturbances in migraine, October 2022
https://www.mdedge.com/migraine-icymi/article/258412/headache-migraine/commentary-menstruation-sleep-and-visual
Thomas Berk, MD

Oct 4th, 2022 - Women experience three times more migraine than men, and menstrual migraine specifically is a common subtype of migraine in women. Even women who do not have exclusively menstrual-related attacks can still have significant hormonal triggers of their migraine.

Infections Reported After Single Dose of Monkeypox Vaccine
https://www.clinicaladvisor.com/home/topics/infectious-diseases-information-center/infections-reported-after-single-dose-monkeypox-vaccine/
Clinical Advisor

Oct 4th, 2022 - HealthDay News — Most cases of monkeypox that occur after vaccination with the modified Vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN) occur within 14 days of receipt of the first dose, according to a research letter published online in the Journal of the American Medical Association. Aniruddha Hazra, MD, from Howard Brown Health in Chicago, and colleagues describe monkeypox infections after ...

Pulmonary Rehabilitation for COPD Has Greater Effect Coupled With Triple Therapy
https://www.pulmonologyadvisor.com/home/topics/copd/pulmonary-rehabilitation-for-copd-has-greater-effect-coupled-with-triple-therapy/
Pulmonology Advisor

Oct 4th, 2022 - Pulmonary rehabilitation (PR) significantly benefits patients with chronic obstructive pulmonary disease (COPD). Moreover, those receiving inhaled triple therapy (TT) experienced greater benefits in exercise tolerance with pulmonary rehabilitation than those not using TT. These are among study findings published in Respiratory Medicine. Investigators assessed the effects of inpatient PR in pati...

Metformin, Ivermectin, and Fluvoxamine Do Not Prevent Severe COVID-19 Outcomes
https://www.rheumatologyadvisor.com/general-medicine/metformin-ivermectin-flucoxamine-prevent-severe-covid-19-outcomes/
Rheumatology Advisor

Oct 4th, 2022 - Treatment with metformin, ivermectin, or fluvoxamine for COVID-19 among nonhospitalized adults did not lead to any observed benefits compared with placebo, according to study findings published in The New England Journal of Medicine. As protection from vaccination against SARS-CoV-2 wanes among the general population, effective outpatient therapies to decrease risk for severe disease are needed...

Few Patients With Alopecia Areata Are Willing to Undergo Treatment
https://www.dermatologyadvisor.com/home/topics/general-dermatology/few-patients-with-alopecia-areata-willing-to-undergo-treatment/
Dermatology Advisor

Oct 4th, 2022 - Most patients with alopecia areata (AA) reported that severe health risks are not acceptable when undergoing treatment, and stinging/burning is the only risk that most would tolerate, according to findings from a study published in the Archives of Dermatological Research. Investigators sought to characterize the willingness of patients with AA to undergo treatment via a secondary data analysis ...

Tralokinumab Promising for Long-Term Treatment of Atopic Dermatitis
https://www.dermatologyadvisor.com/home/topics/dermatitis/tralokinumab-promising-for-long-term-treatment-of-atopic-dermatitis/
Dermatology Advisor

Oct 4th, 2022 - Tralokinumab, a monoclonal antibody which inhibits interleukin (IL)-13, was well-tolerated and effective for atopic dermatitis (AD), controlling signs and symptoms during 2 years in adults with moderate to severe AD, according to data from a post hoc interim analysis from the ongoing, open-label, 5-year extension trial ECZTEND published in the Journal of the American Academy of Dermatology. Pat...

High Rate of Undiagnosed axSpA Among Patients With Inflammatory Bowel Disease
https://www.dermatologyadvisor.com/home/topics/general-medicine/high-prevalence-of-chronic-back-pain-and-axial-spondyloarthritis-in-inflammatory-bowel-disease/
Dermatology Advisor

Oct 4th, 2022 - A high prevalence of chronic back pain and a substantial hidden burden of axial spondyloarthritis (axSpA) were identified among patients with inflammatory bowel disease (IBD), according to the results of a study published in Rheumatology. Investigators from Norfolk and Norwich University Hospitals NHS Foundation Trust in the United Kingdom performed this observational, cross-sectional study bet...

The hunt for N-acetylcysteine: Medicine or dietary supplement?
https://www.mdedge.com/psychiatry/article/258393/obsessive-compulsive-disorder/hunt-n-acetylcysteine-medicine-or-dietary
Dinah Miller, MD

Oct 4th, 2022 - Medicine or dietary supplement? N-acetylcysteine (NAC) is marketed as both and in 2021, the supplement abruptly became difficult to find, causing distress to people who had been using it for a variety of conditions. The story behind its disappearance is one of a cat-and-mouse chase between manufacturers, advocacy agencies, and the Food and Drug Administration.

Nodular Liver a Marker for Worse Outcomes in Cystic Fibrosis Liver Disease
https://www.pulmonologyadvisor.com/home/topics/obstructive-lung-disease/nodular-liver-a-marker-for-worse-outcomes-in-cystic-fibrosis-liver-disease/
Pulmonology Advisor

Oct 4th, 2022 - Among children with cystic fibrosis (CF) liver disease (CFLD), those with nodular liver (NOD) have more liver-related complications than those without, according to study findings published in the Journal of Cystic Fibrosis. The Prediction by Ultrasound of the Risk of Hepatic Cirrhosis (PUSH) study enrolled children (N=166) aged 3 to 12 years with CF between 2010 and 2013. In this 9-year longit...

Atrial Fibrillation and Cardio-Embolic Stroke Affect Post-Stroke Delirium Risk
https://www.thecardiologyadvisor.com/home/topics/arrhythmia/atrial-fibrillation-and-cardio-embolic-stroke-affect-post-stroke-delirium-risk/
Cardiology Advisor

Oct 4th, 2022 - Atrial fibrillation (AF) and cardio-embolic stroke may contribute to an increased risk for post-stroke delirium, according to study findings published in World Neurosurgery. Investigators in China sought to determine if an association exists between AF and cardio-embolic stroke and post-stroke delirium. They conducted a systematic review and meta-analysis that included 18 observational studies ...

Myocardial Perfusion Does Not Differ Between Patients With Untreated RA and Healthy Individuals
https://www.thecardiologyadvisor.com/general-cardiology/myocardial-perfusion-does-not-differ-between-patients-with-untreated-ra-and-healthy-individuals/
Cardiology Advisor

Oct 4th, 2022 - Myocardial perfusion values did not differ between treatment-naive patients with early rheumatoid arthritis (RA) and healthy control participants, according to study findings published in Arthritis & Rheumatology. Patients with RA demonstrate an increased risk of developing coronary artery disease, secondary to inflammation, resulting in myocardial microvascular dysfunction. Researchers at Biom...

Chlorhexidine in Alcohol, Olanexidine Favored for Preventing Surgical Site Infections
https://www.thecardiologyadvisor.com/home/topics/prevention/chlorhexidine-in-alcohol-olanexidine-favored-for-preventing-surgical-site-infections/
Cardiology Advisor

Oct 4th, 2022 - Preoperative skin preparation with either chlorhexidine in alcohol or olanexidine is the most effective for preventing surgical site infections (SSIs), according to results of a systematic review and meta-analysis published in The Lancet Microbe. Researchers from Amsterdam University Medical Center in the Netherlands searched publication databases through November 2021 for studies of that asses...

Cutaneous Eruption in an Immunocompromised Patient
https://www.mdedge.com/dermatology/article/258385/infectious-diseases/cutaneous-eruption-immunocompromised-patient
Hesham Alshaikh, MD, Ahmad Aleisa, MD et. al.

Oct 4th, 2022 - The Diagnosis: Secondary Syphilis Histopathology revealed a lichenoid interface dermatitis with psoriasiform hyperplasia (Figure 1A). A single spirochete was identified using immunohistochemical staining (Figure 1B).

PSMA PET/CT Lymph Node Staging Can Predict Prostate Cancer Surgery Outcomes
https://www.endocrinologyadvisor.com/home/topics/general-endocrinology/psma-pet-ct-lymph-node-staging-can-predict-prostate-cancer-surgery-outcomes/
Endocrinology Advisor

Oct 4th, 2022 - Patients with prostate cancer who have pelvic lymph node metastases visualized on preoperative PSMA PET/CT staging (prostate-specific membrane antigen positron emission tomography/computed tomography) have a significantly higher risk for biochemical disease progression after robot-assisted radical prostatectomy (RARP) compared with those without pelvic lymph node metastases on imaging, recent s...

Nodular Liver a Marker for Worse Outcomes in Cystic Fibrosis Liver Disease
https://www.endocrinologyadvisor.com/home/topics/general-endocrinology/nodular-liver-a-marker-for-worse-outcomes-in-cystic-fibrosis-liver-disease/
Endocrinology Advisor

Oct 4th, 2022 - Among children with cystic fibrosis (CF) liver disease (CFLD), those with nodular liver (NOD) have more liver-related complications than those without, according to study findings published in the Journal of Cystic Fibrosis. The Prediction by Ultrasound of the Risk of Hepatic Cirrhosis (PUSH) study enrolled children (N=166) aged 3 to 12 years with CF between 2010 and 2013. In this 9-year longit...

Benefits of Dapagliflozin in HFmrEF/HFpEF Not Modified by AF at Baseline
https://www.endocrinologyadvisor.com/home/topics/cardiovascular-and-metabolic-disorders/benefits-of-dapagliflozin-in-hfmref-hfpef-not-modified-by-af-at-baseline/
Endocrinology Advisor

Oct 4th, 2022 - The beneficial effects of treatment with dapagliflozin, compared with placebo, on clinical events and symptoms in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or heart failure with preserved ejection fraction (HFpEF) is not modified by the presence of atrial fibrillation (AF). These findings were published in the Journal of the American College of Cardiology. A sec...

How Anthem Gets Away With Nonpayment and Denials
https://www.medscape.com/viewarticle/980278

Oct 4th, 2022 - This discussion was recorded on August 31, 2022. This transcript has been edited for clarity. Editor's Note: All views expressed are those of the authors and do not represent the opinions of any affiliates. Medscape reached out to Anthem with an opportunity to respond to claims made regarding payment denials mentioned in this interview. Since the alleged claims are currently the subject of liti...

Physician Bias Against Disabilities; Cannabis Substitutes for Opioids; Don't Thumb Your Nose at Nasal Vaccines
https://www.medscape.com/viewarticle/981743

Oct 4th, 2022 - Physician Bias Against Disabilities Some clinicians are refusing to take people with disabilities on as patients, according to a new study. Though small, the research sheds an alarming light on why people with disabilities have worse outcomes, including undetected cancer, obesity, and cardiovascular disease. Many simply cannot get a doctor to see them. Broken system: There is physician bias at ...

AstraZeneca Pays 660% Premium for Gene Therapy Firm LogicBio
https://www.medscape.com/viewarticle/981755

Oct 4th, 2022 - (Reuters) - Shares of LogicBio Therapeutics skyrocketed on Monday after Britain's AstraZeneca's said it would buy the U.S.-based gene therapy developer at a rare 660% premium for $68 million. LoigBio's shares, which have traded below $1 since February, were up 637% at $2 before the bell, close to AstraZeneca's offer price of $2.07 per share. LogicBio is developing gene editing therapies to trea...

Breakthrough COVID Studies Lend Support to Use of New Boosters in Immunosuppressed Patients
https://www.medscape.com/viewarticle/981835

Oct 4th, 2022 - People with immune-mediated inflammatory diseases who are taking immunosuppressants don't mount as strong of an immune defense against the Omicron variant as they did against the original SARS-CoV-2 wild-type virus, according to two studies published in Annals of the Rheumatic Diseases. One of the studies further showed that vaccinated individuals taking immunosuppressants have poorer cross-neu...