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Fauci in the Doghouse; SCOTUS to Review Texas Abortion Law; Public Health's Downfall
https://www.medpagetoday.com/infectiousdisease/covid19/95235

Oct 25th, 2021 - Note that some links may require registration or subscription. NIH officials admitted that they funded research to the Wuhan Institute of Virology that enhanced bat coronaviruses, but insisted there were too many genetic differences for one of those viruses to have led to the origin of the COVID pandemic. (Vanity Fair) Meanwhile, 24 legislators sent a letter to NIAID Director Anthony Fauci, MD,...

Gustavo Fonseca, MD, FACP, Manish Patel, MD, and James Reeves, MD, Co-Author Integrated Safety Analysis of Umbralisib in Lymphoid Malignancies
https://www.onclive.com/view/gustavo-fonseca-md-facp-manish-patel-md-and-james-reeves-md-co-author-integrated-safety-analysis-of-umbralisib-in-lymphoid-malignancies

Oct 22nd, 2021 - Three medical oncologists at Florida Cancer Specialists & Research Institute (FCS) are co-authors on a new integrated safety analysis of umbralisib, used to treat lymphoid malignancies. FCS Director of Clinical Research Gustavo Fonseca, MD, FACP, Director of Drug Development Manish Patel, MD and James Reeves, MD, a member of the FCS clinical research team, participated in the study entitled Int...

Agenus Withdraws BLA for Balstilimab in Metastatic Cervical Cancer
https://www.onclive.com/view/agenus-withdraws-bla-for-balstilimab-in-metastatic-cervical-cancer

Oct 22nd, 2021 - The immuno-oncology company Agenus has made the decision to withdraw its biologic license application (BLA) for the use of the PD-1 inhibitor balstilimab in patients with recurrent or metastatic cervical cancer who experienced disease progression on, or after, chemotherapy.1 The decision follows the full approval of pembrolizumab (Keytruda) on October 13, 2021, for use as a single agent in pat...

Children With Cancer At Higher Risk for Severe Illness from COVID-19
https://www.onclive.com/view/children-with-cancer-at-higher-risk-for-severe-illness-from-covid-19

Oct 22nd, 2021 - Approximately 20% of pediatric patients with cancer infected with COVID-19 experienced severe illness, according to data published in The Lancet Oncology. Furthermore, deaths due to the infection were proportionally higher in this patient population compared with the general pediatric population, providing evidence that children with cancer are at higher risk of developing severe illness from C...

Oncopeptides Withdraws Melphalan Flufenamide Myeloma Indication in the United States
https://www.onclive.com/view/oncopeptides-withdraws-melphalan-flufenamide-myeloma-indication-in-the-united-states

Oct 22nd, 2021 - Oncopeptides AB (publ) has made the decision to withdraw the indication of melphalan flufenamide (Pepaxto; melflufen) in combination with dexamethasone in select adult patients with relapsed or refractory multiple myeloma from the US market.1 In February 2021, the FDA approved melflufen plus dexamethasone for use in adult patients with relapsed/refractory multiple myeloma who have received at ...

Low androgen in kidney recipients tied to diabetes
https://www.mdedge.com/endocrinology/article/247792/diabetes/low-androgen-kidney-recipients-tied-diabetes
Miriam E. Tucker

Oct 22nd, 2021 - Low androgen levels appear to be linked to the development of posttransplantation diabetes mellitus (PTDM) in male kidney transplant recipients, new research suggests. London_England/Thinkstock Among 243 men who did not have diabetes prior to undergoing kidney transplantation, levels of both dihydrotestosterone (DHT) and testosterone were inversely related to the risk for developing diabetes th.

Explainer-Americans wonder: Which COVID-19 booster is best?
https://www.reuters.com/article/us-health-coronavirus-boosters-explainer/explainer-americans-wonder-which-covid-19-booster-is-best-idUSKBN2HC243

Oct 22nd, 2021 - CHICAGO (Reuters) - Americans this week were handed a big decision when it comes to getting a COVID-19 vaccine booster. The U.S. Centers for Disease Control and Prevention (CDC) on Thursday said individuals who qualify could choose a different vaccine from the one they received for their initial inoculation. For Americans asking how to choose, the following is what some experts advise: The CDC ...

TAS-102 Plus Bevacizumab Misses PFS End Point in Frontline Unresectable Metastatic CRC
https://www.onclive.com/view/tas-102-plus-bevacizumab-misses-pfs-end-point-in-frontline-unresectable-metastatic-crc

Oct 22nd, 2021 - The frontline combination of trifluridine/tipiracil (TAS-102; Lonsurf) and bevacizumab (Avastin) was not found to result in a significant improvement in progression-free survival (PFS) over capecitabine and bevacizumab in patients with unresectable metastatic colorectal cancer (mCRC) who are not eligible to receive intensive therapy, missing the primary end point of the phase 3 SOLSTICE trial (...

Walmart, Walgreens U.S. stores roll out Moderna, J&J COVID-19 booster shots
https://www.reuters.com/article/health-coronavirus-boosters/update-4-walmart-walgreens-u-s-stores-roll-out-moderna-jj-covid-19-booster-shots-idUSL4N2RI3BC

Oct 22nd, 2021 - (Reuters) -Walgreens Boots Alliance Inc and Walmart Inc said on Friday their U.S. pharmacies started administering COVID-19 booster shots from Moderna Inc and Johnson & Johnson, in addition to previously authorized Pfizer-BioNTech booster. The Centers for Disease Control and Prevention (CDC) on Thursday recommended J&J and Moderna’s booster shots and said Americans can choose a different shot f...

Pembrolizumab/Chemo Approved in Europe for Select Locally Recurrent Unresectable or Metastatic TNBC
https://www.onclive.com/view/pembrolizumab-chemo-approved-in-europe-for-select-locally-recurrent-unresectable-or-metastatic-tnbc

Oct 22nd, 2021 - The European Commission has approved pembrolizumab (Keytruda) plus chemotherapy for the frontline treatment of patients with locally recurrent unresectable or metastatic triple-negative breast cancer (TNBC) whose tumors have a PD-L1 expression combined positive score (CPS) of 10 or higher and who have not previously received chemotherapy for metastatic disease.1 The regulatory decision is ba...

HCA Healthcare's labor pains cast shadow on upbeat quarter
https://www.reuters.com/article/hca-healthcare-results/update-4-hca-healthcares-labor-pains-cast-shadow-on-upbeat-quarter-idUSL4N2RI2TL

Oct 22nd, 2021 - (Reuters) -HCA Healthcare Inc on Friday cautioned higher labor costs that tarnished strong third quarter profits could linger for longer as the hospital operator battles a staff crunch, sending the company’s shares down. A nationwide shortage of healthcare workers amid fatigue from a prolonged COVID-19 pandemic has forced hospitals to shell out more to hire and retain nurses and other staff ami...

A Wealth of Therapeutic Advances in Lung Cancer Stress a Need for Early NGS Testing
https://www.onclive.com/view/a-wealth-of-therapeutic-advances-in-lung-cancer-stress-a-need-for-early-ngs-testing

Oct 22nd, 2021 - The overwhelming number of options for the treatment of patients with lung cancer underscores the importance of broad molecular testing up front to ensure patients receive optimal care, said Stephen V. Liu, MD. Our strategies [for managing lung cancer] are becoming more sophisticated and precise, but the first step of broad next-generation sequencing [NGS] is really the key. NGS is essential t...

FDA Approves Companion Diagnostic for Adjuvant Atezolizumab in Stage II to IIIA NSCLC
https://www.onclive.com/view/fda-approves-companion-diagnostic-for-adjuvant-atezolizumab-in-stage-ii-to-iiia-nsclc

Oct 22nd, 2021 - The FDA has approved the VENTANA PD-L1 (SP263) assay to assist in identifying which adult patients with stage II to IIIA non–small cell lung cancer (NSCLC) whose tumors have PD-L1 expression on 1% or more of tumor cells are eligible to receive adjuvant atezolizumab (Tecentriq) following surgery and platinum-based chemotherapy.1 Adjuvant atezolizumab was approved for use in this indication on O...

Tissue Mapping Center for Cellular Senescence Launched at Yale Cancer Center to Study Human Lymphoid Organs
https://www.onclive.com/view/tissue-mapping-center-for-cellular-senescence-launched-at-yale-cancer-center-to-study-human-lymphoid-organs

Oct 22nd, 2021 - The National Institutes of Health (NIH) has awarded a grant to fund cellular senescence research in lymphoid organs at Yale Cancer Center. The five-year, $6.5 million grant will help generate multiscale molecular and cellular maps of cellular senescence in primary and secondary human lymphoid organs to improve our understanding of cellular senescence in development, aging, and disease, includin...

U.S. 2021 fiscal year shrinks from prior year's record, Treasury says
https://www.reuters.com/article/usa-economy-budget/u-s-2021-fiscal-year-shrinks-from-prior-years-record-treasury-says-idUSW1N2PU055

Oct 22nd, 2021 - Oct 22 (Reuters) - The U.S. budget deficit totaled $2.772 trillion during fiscal 2021, below the prior year’s record shortfall but still reflecting a second straight year of massive spending to support households and businesses through the coronavirus pandemic, the Treasury Department said on Friday. The United States posted a deficit of $3.132 trillion in fiscal 2020, when the federal governme...

Factbox-Latest on the worldwide spread of the coronavirus
https://www.reuters.com/article/us-health-coronavirus-latest/factbox-latest-on-the-worldwide-spread-of-the-coronavirus-idUSKBN2HC0J2

Oct 22nd, 2021 - (Reuters) - Russia reported a fourth straight daily record of COVID-19 deaths with a week to go before the start of a workplace shutdown ordered by President Vladimir Putin, while Germany’s seven-day incidence rate rose sharply over the past week. * The UK Health Security Agency designated a Delta subvariant called AY.4.2 as a “Variant Under Investigation”, saying on Friday there was some evide...

Washington subway to continue reduced service through at least Oct. 31
https://www.reuters.com/article/usa-washington-subway/washington-subway-to-continue-reduced-service-through-at-least-oct-31-idUSL1N2RI1DP

Oct 22nd, 2021 - WASHINGTON, Oct 22 (Reuters) - The Washington-area subway system said Friday it will continue sharply reduced subway service through at least Oct. 31 as it works to finalize plans to return most of its railcars to service after an Oct. 12 derailment. The Washington Metropolitan Area Transit Authority (WMATA) on Sunday was ordered to indefinitely remove about 60% of the subway system’s railcars ...

CANADA STOCKS-TSX flat as weakness in tech, healthcare offset commodity-linked gains
https://www.reuters.com/article/canada-stocks/canada-stocks-tsx-flat-as-weakness-in-tech-healthcare-offset-commodity-linked-gains-idUSL4N2RI3BH

Oct 22nd, 2021 - (Updates prices, adds analyst comment) Oct 22 (Reuters) - Canada’s main stock index was little changed on Friday, as weakness in technology and healthcare stocks offset commodity-linked gains, however the benchmark index was on course for its third straight week of gains. At 9:42 a.m. ET (13:42 GMT), the Toronto Stock Exchange’s S&P/TSX composite index was down 5.76 points, or 0.03%, at 21,206....

Will Slow and Steady Progress in Treating SCLC Win the Race?
https://www.onclive.com/view/will-slow-and-steady-progress-in-treating-sclc-win-the-race-

Oct 22nd, 2021 - Clinical advances in the treatment of small cell lung cancer (SCLC) have lagged behind those of other tumor types, but the delay is not for lack of effort. In recent years, however, improved understanding of disease biology has identified some novel targets that may make these tumors more vulnerable to treatment. One such approach in the frontline setting has been the integration of various imm...

Walgreens to administer Moderna, J&J COVID-19 booster shots at U.S. stores
https://www.reuters.com/article/health-coronavirus-boosters/walgreens-to-administer-moderna-jj-covid-19-booster-shots-at-u-s-stores-idUSL4N2RI3AO

Oct 22nd, 2021 - Oct 22 (Reuters) - Walgreens Boots Alliance Inc said on Friday customers can start receiving booster COVID-19 shots from Moderna Inc and Johnson & Johnson at its U.S. stores. The move comes after the Centers for Disease Control and Prevention (CDC) on Thursday recommended the additional doses and said Americans can choose a different shot from their original inoculation as a booster.