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About 515,145 results

Type 1 Diabetes Diagnoses Spiked During the Pandemic
https://www.medpagetoday.com/endocrinology/type1diabetes/96835

Jan 24th, 2022 - Significantly more children were diagnosed with type 1 diabetes (T1D) during the COVID-19 pandemic compared with previous years, a single-institution study suggested. From March 2020 to March 2021, a total of 187 children were admitted for new onset T1D at a San Diego children's hospital, a 57% increase over the 119 children in the prior year, according to Jane Kim, MD, of the University of Cal...

Dementia Risk Rises With Stroke Recurrence, Severity
https://www.medpagetoday.com/neurology/dementia/96832

Jan 24th, 2022 - Stroke recurrence and severity raised the risk of dementia, data from the prospective Atherosclerosis Risk in Communities (ARIC) study showed. Incident dementia rates were especially elevated in people with multiple strokes over time and with more severe strokes, suggesting a dose-response relationship between stroke severity and recurrence and risk of dementia, reported Silvia Koton, PhD, RN, ...

Black Men's Outsized Heart Failure Risk Persists to Old Age
https://www.medpagetoday.com/cardiology/chf/96830

Jan 24th, 2022 - Race and gender differences in cardiac structure and systolic function persisted to late life even after accounting for established cardiovascular risk factors, according to an analysis of the aging Atherosclerosis Risk in Communities (ARIC) cohort. Men and Black people tended to show worse left ventricular (LV) systolic function in a cohort of more than 5,000 study participants without baselin...

Do Cash Gifts for Mothers in Poverty Help Kids' Early Brain Activity?
https://www.medpagetoday.com/pediatrics/generalpediatrics/96831

Jan 24th, 2022 - Unconditional income assistance for mothers living in poverty may have a positive effect on babies' brain activity, early results of a randomized study suggested. In a subsample of the Baby's First Years trial, babies born to mothers who received a monthly $333 cash gift had higher absolute power in electrical brain activity in the mid- to high-frequency range at 1 year compared to babies born ...

Cost Study Backs PT Over Steroid Shots in Knee Osteoarthritis
https://www.medpagetoday.com/rheumatology/arthritis/96824

Jan 24th, 2022 - Although physical therapy for osteoarthritis of the knee costs more than an intra-articular steroid injection, it's cost-effective when clinical outcomes a year later are taken into account, researchers said. A secondary analysis of data from 156 participants in the SMART trial indicated that total 1-year medical costs averaged $2,113 for patients receiving steroid shots versus $2,131 for a gro...

Burden of Tick-Borne Encephalitis, Sweden
https://wwwnc.cdc.gov/eid/article/28/2/20-4324_article

Jan 24th, 2022 - Figure 1 Figure 1. Reported tick-borne encephalitis cases per year, Sweden, 1956–2021. Tick-borne encephalitis became a notifiable disease in Sweden in July 2004; thus, the number of reported cases before 2005 is less certain... Tick-borne encephalitis virus (TBEV) is the cause of tick-borne encephalitis (TBE), an infectious disease of growing public health concern (1,2). In Sweden, the disease...

Genetic Relatedness of Infectious Hypodermal and Hematopoietic Necrosis Virus Isolates, United States, 2019
https://wwwnc.cdc.gov/eid/article/28/2/21-1874_article

Jan 24th, 2022 - The Penstylhamaparvovirus species Decapod penstylhamaparvovirus 1, commonly known as infectious hypodermal and hematopoietic necrosis virus (IHHNV), is the smallest of known shrimp viruses belonging to the family Parvoviridae, subfamily Hamaparvovirinae (1,2). The virions are icosahedral, nonenveloped, measure 22–23 nm in size, and contain a single-stranded DNA genome ≈4.1 kb in length (3,4). I...

Melflufen Improves PFS, Not OS in Relapsed/Refractory Multiple Myeloma
https://www.cancertherapyadvisor.com/home/cancer-topics/multiple-myeloma/multiple-myeloma-melflufen-improves-survival-treatment-risk/

Jan 24th, 2022 - Melflufen plus dexamethasone improved progression-free survival (PFS), compared with pomalidomide plus dexamethasone, in patients with relapsed or refractory multiple myeloma (MM), according to phase 3 results published in The Lancet Haematology. The phase 3 OCEAN trial (ClinicalTrials.gov Identifier: NCT03151811) enrolled 495 patients with MM who had received 2 to 4 previous lines of therapy a...

Semglee Pen Recall; Prader-Willi Syndrome Drug Rejected; Resilience Good for Sex
https://www.medpagetoday.com/endocrinology/generalendocrinology/96800

Jan 23rd, 2022 - The FDA announced that Mylan Pharmaceuticals is voluntarily recalling a batch of its non-interchangeable insulin glargine injection (Semglee) prefilled pens for possible missing labels. In other FDA news, the agency turned down Levo Therapeutics' investigational intranasal form of carbetocin (LV-101), which was developed as a treatment for hyperphagia, anxiety, and distress associated with Prad...

TST001 Under Evaluation in Locally Advanced or Metastatic Solid Tumors
https://www.onclive.com/view/tst001-under-evaluation-in-locally-advanced-or-metastatic-solid-tumors

Jan 23rd, 2022 - The safety and tolerability of TST001, a high affinity humanized IgG1 monoclonal antibody to CLDN18.2, is under investigation as a potential treatment option for patients with gastric/gastroesophageal junction (GEJ) cancer and other locally advanced or metastatic solid tumors as part of a phase 1 trial (NCT04396821).1,2 CLDN18.2 expression showcases a unique tissue distribution pattern than ot...

Nivolumab Plus mFOLFOX6 and Bevacizumab Misses PFS End Point in mCRC
https://www.onclive.com/view/nivolumab-plus-mfolfox6-and-bevacizumab-misses-pfs-end-point-in-mcrc

Jan 23rd, 2022 - The addition of nivolumab (Opdivo) to 5-fluorouracil/leucovorin/oxaliplatin (mFOLFOX6)/bevacizumab (Avastin; BEV) (standard of care [SOC]) failed to demonstrate a statistically significant improvement in progression-free survival (PFS) vs SOC alone in previously untreated patients with metastatic colorectal cancer (mCRC), according to findings from the phase 2/3 CheckMate 9X8 trial (NCT03414983...

SARS-CoV-2 Circulation, Guinea, March 2020–July 2021
https://wwwnc.cdc.gov/eid/article/28/2/21-2182_article

Jan 23rd, 2022 - In Guinea, the index coronavirus disease (COVID-19) case-patient identified on March 12, 2020, was an expatriate traveling back from Europe. Immediately, a COVID-19 task force was established by the Agence Nationale de Sécurité Sanitaire; 6 national laboratories were involved in the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. As of July 16, 2021, a tota...

Postvaccination Multisystem Inflammatory Syndrome in Adult with No Evidence of Prior SARS-CoV-2 Infection
https://wwwnc.cdc.gov/eid/article/28/2/21-1938_article

Jan 23rd, 2022 - Multisystem inflammatory syndrome (MIS) is a serious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that affects multiple body systems (cardiovascular, gastrointestinal, skin). It occurs predominantly in children (MIS-C) (1) and only rarely in adults (MIS-A) (2). The Brighton Collaboration Network (https://brightoncollaboration.us) includes MIS-C and MIS-...

Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, November 2021
https://wwwnc.cdc.gov/eid/article/28/2/21-2422_article

Jan 23rd, 2022 - A new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), B.1.1.529, was identified in Botswana and South Africa in early November 2021 and was designated as variant of concern (VOC) Omicron by the World Health Organization on November 26, 2021 (1). As of December 1, 2021, ≈220 sequences were available on GISAID (https://www.gisaid.org), and this variant has been detected i...

Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017–2019
https://wwwnc.cdc.gov/eid/article/28/2/21-1849_article

Jan 23rd, 2022 - The recent introductions of chikungunya virus (CHIKV) and Zika virus (ZIKV) in the Americas led to widespread epidemics with substantial health and economic effects. Small island developing states in the Caribbean are particularly affected by emerging mosquitoborne disease, primarily because of year-round climatic conditions favorable for mosquito breeding, high levels of poverty, and extensive...

Dirofilaria immitis Pulmonary Dirofilariasis, Slovakia
https://wwwnc.cdc.gov/eid/article/28/2/21-1963_article

Jan 23rd, 2022 - Dirofilaria immitis is a filarioid nematode that infects numerous mammalian species. Dogs are the main reservoir and various mosquito species (e.g., genera Culex, Anopheles, Aedes, and Ochlerotatus) the infection vectors. The parasite is related to the pulmonary form of dirofilariasis, manifested by the formation of coin lesions or nodules in lung parenchyma in humans, an accidental parasite ho...

The Color Puce (Pyüs)
https://wwwnc.cdc.gov/eid/article/28/2/21-2274_article

Jan 23rd, 2022 - Puce [pyoos] Figure Figure. A) Digitally colored scanning electron microscopic image of a flea. Puce is a particularly difficult color to describe. Numerous shades of puce exist, some of which are associated with different... For those with synesthesia, in whom stimulating 1 sensory pathway gives rise to a subjective sensation of a different character, the word plague may chromatically resonate...

High Infection Attack Rate after SARS-CoV-2 Delta Surge, Chattogram, Bangladesh
https://wwwnc.cdc.gov/eid/article/28/2/21-2417_article

Jan 23rd, 2022 - To the Editor: After an initial serosurvey (1) to understand the prevalence of total antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in residents of the Sitakunda subdistrict was completed, a large epidemic wave hit the area, and nearly all publicly available samples genotyped via GISAID (https://www.gisaid.org) were the SARS-CoV-2 Delta variant (2,3). Of the total co...

Trastuzumab Deruxtecan Demonstrates Sustained Efficacy in HER2+ mCRC
https://www.onclive.com/view/trastuzumab-deruxtecan-demonstrates-sustained-efficacy-in-her2-mcrc

Jan 22nd, 2022 - Fam-trastuzumab deruxtecan-nxki (Enhertu; T-DXd) demonstrated durable responses and a safety profile that was consistent with findings from the primary analysis of the phase 2 DESTINY-CRC01 trial (NCT03384940) in pretreated patients with HER2-expressing metastatic colorectal cancer (mCRC), according to updated results of the study that were presented at the 2022 Gastrointestinal Cancers Symposi...

Nivolumab/Encorafenib/Cetuximab Triplet Elicits High Response Rate in MSS, BRAF V600E-Mutant mCRC
https://www.onclive.com/view/nivolumab-encorafenib-cetuximab-triplet-elicits-high-response-rate-in-mss-braf-v600e-mutant-mcrc

Jan 22nd, 2022 - The addition of nivolumab (Opdivo) to encorafenib (Braftovi) and cetuximab (Erbitux) elicited a high response rate and an acceptable safety profile in patients with refractory microsatellite stable (MSS), BRAF V600E–mutant metastatic colorectal cancer (CRC), according to findings from a phase 1/2 trial (NCT04017650) that were presented during the 2022 Gastrointestinal Cancers Symposium. The ...