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About 648,040 results

ECG Challenge: Irregular Pulse During Cardiology Visit
https://www.medscape.com/viewarticle/984169

Nov 28th, 2022 - A 58-year-old man with a history of hypertension (treated with amlodipine and hydrochlorothiazide) and coronary artery disease (treated with a beta-blocker and isosorbide mononitrate) visits his cardiologist for a routine physical examination. His pulse is noted to be irregular, and a 12-lead ECG is obtained. Figure 1.

Vitamin D Fails to Stave Off Statin-Related Muscle Symptoms
https://www.medscape.com/viewarticle/984622

Nov 28th, 2022 - Vitamin D supplements do not prevent muscle symptoms in new statin users or affect the likelihood of discontinuing a statin due to muscle pain and discomfort, a substudy of the VITAL trial indicates. Among more than 2000 randomized participants, statin-associated muscle symptoms (SAMS) were reported by 31% assigned to vitamin D and 31% assigned to placebo. The two groups were also equally likel...

Symptoms Worsen Before Dialysis, Ease After, in Older Patients With CKD
https://www.medscape.com/viewarticle/984628

Nov 28th, 2022 - Among older patients with advanced kidney disease, the mean number of kidney failure–related symptoms and symptom burden worsened considerably in the year before they started dialysis but generally stabilized in the following year, researchers report. The findings are from close to 500 patients aged 65 and older with kidney failure in six European countries who took part in the European Quality...

More Vaccinated People Dying of COVID as Fewer Get Booster Shots
https://www.medscape.com/viewarticle/984633

Nov 28th, 2022 - For the first time, the majority of people dying from COVID-19 in America have been vaccinated. "We can no longer say this is a pandemic of the unvaccinated," Kaiser Family Foundation Vice President Cynthia Cox, who conducted the analysis, told The Washington Post . People who had been vaccinated or boosted made up 58% of COVID-19 deaths in August, the analysis showed. The rate has been on the ...

Preop TT3 Predicts HPA Axis Recovery After Cushing Surgery
https://www.medscape.com/viewarticle/984629

Nov 28th, 2022 - The study covered in this summary was published on researchsquare.com as a preprint and has not yet been peer reviewed. Key Takeaways The hypothalamic-pituitary-adrenal (HPA) axis recovered in nearly three quarters of patients with Cushing disease (CD) within 2 years after successful trans-sphenoidal surgery (TSS), with a median recovery time of 12 months. Preoperative total triiodothyronine (T...

Transgender Patients on Hormone Therapy Require Monitoring
https://www.medscape.com/viewarticle/984631

Nov 28th, 2022 - PAU, France — Transgender patients on hormone therapy have a greater risk for death than the general population and so must be closely monitored, especially in terms of cardiovascular health and oncology, reported Marie D'Assigny, MD, of the Department of Endocrinology, Diabetes and Dietetics at Poitiers University Hospital, Poitiers, France at the Infogyn 2022 conference. Since transgender wom...

Should Older Seniors Risk Major Surgery? New Research Offers Guidance
https://www.medscape.com/viewarticle/984658

Nov 28th, 2022 - Nearly 1 in 7 older adults die within a year of undergoing major surgery, according to an important new study that sheds much-needed light on the risks seniors face when having invasive procedures. Especially vulnerable are older patients with probable dementia (33% die within a year) and frailty (28%), as well as those having emergency surgeries (22%). Advanced age also amplifies risk: Patient...

More Evidence Flavanols in Tea, Fruit, and Veg Preserve Memory, Cognition
https://www.medscape.com/viewarticle/984651

Nov 28th, 2022 - Consumption of flavonols may preserve memory and cognition over time, new research suggests. Three specific components of flavonols in particular — kaempferol, myricetin, and quercetin — were associated with slower global cognitive decline. Dr Thomas Holland "It is never too early, or too late, to start making healthy lifestyle changes, especially when it comes to diet," lead investigator Thoma...

The Green Mediterranean diet reduces twice as much visceral fat as the Mediterranean diet and 10% more than a healthy diet
https://www.eurekalert.org/news-releases/972470
EurekAlert!

Nov 28th, 2022 - BEER-SHEVA, Israel, November 28, 2022 – The green Mediterranean diet (MED) significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra "tire" around your waist. The green Mediterranean diet was pitted against the Mediterranean diet and a healthy diet in a large-scale clinical interventional trial- the DIRECT PLUS. Subsequent ana...

Effects of COVID Vaccine on Menstruation
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/101908

Nov 27th, 2022 - In this video, Victoria Male, PhD, of Imperial College London's Department of Metabolism, Digestion and Reproduction, highlights recent research on the effects of COVID-19 vaccination on menstruation. The following is a transcript of her remarks: We first started to think that there might be an impact of COVID vaccination on menstrual periods back in the spring of 2021. Particularly in the U.K....

COVID-19 Mask Guidance Based on Community Level
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/678059

ASL Information on COVID-19 Mask Guidance Based on Community Level Transcript: https://www.cdc.gov/coronavirus/2019-ncov/videos/asl/cdc-mask-guidance/Transcript-COVID-19-Mask-Guidance-Based-on-Community-Level.pdf This video can also be viewed at http://www.cdc.gov/coronavirus/2019-ncov/videos/asl/cdc-mask-guidance/cdc-mask-guidance-english-FINAL.mp4

Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03770-4
Journal of Translational Medicine; Kong, K. et. al.

Nov 26th, 2022 - The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patients with COVID-19, including Paxlovid, which block the synthesis of virus-related proteins and replication of viral RNA, respectively.

HIV
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/285311

Too many people don't know they have HIV (human immunodeficiency virus). More than 1 million people are living with HIV in the United States, but 1 in 8 don't know they are infected.

Fire Hazard Alert About Omnipod 5 'Artificial Pancreas' Charger
https://www.medscape.com/viewarticle/984602

Nov 25th, 2022 - Insulet has alerted users of the Omnipod 5 Automated Insulin Delivery (AID) System about a potential fire hazard with the controller device's battery charger. The Medical Device Correction notice issued November 14 is not a recall; rather, users are advised to check the charging port on the controller to see if it is "melted, deformed, or discolored," or if the device overheats or emits an odor...

Managing T-DXd Adverse Events in the Real World
https://www.medscape.com/viewarticle/984603

Nov 25th, 2022 - With recent expansions in its breast cancer indications, there has been an increase in the use of trastuzumab deruxtecan (T-DXd; Enhertu). "A lot of us are using this more frequently now than we were in the past," explained Sid Yadav, MD, a breast and gynecologic cancer specialist at the Mayo Clinic in Rochester, Minnesota. However, he added that managing its adverse events has been a "bit of a...

Perceived Discrimination Tied to Worse Recovery After MI in Young
https://www.medscape.com/viewarticle/984607

Nov 25th, 2022 - Perceived discrimination — unfair treatment due to their race, gender, ethnicity, socioeconomic status, or other factors — in day-to-day life was common in young myocardial infarction (MI) survivors and was associated with worse recovery, new research suggests. In this study, patients completed three questionnaires assessing perceived discrimination, general mental and physical health, and angi...

Halmos Highlights Immunotherapy Treatment Decisions, Emerging ADCs in NSCLC
https://www.onclive.com/view/halmos-highlights-immunotherapy-treatment-decisions-emerging-adcs-in-nsclc

Nov 23rd, 2022 - For patients with non–small cell lung cancer (NSCLC) without driver mutations such as EGFR or ALK, immunotherapy-based regimens have become standard of care in the frontline setting. New data have continued to help shape treatment decisions based on PD-L1 expression, either with immunotherapy alone or in combination with chemotherapy, according to Balazs Halmos, MD. Halmos also noted that addi...

PDS0101 Plus Chemoradiation Elicits 100% ORR in High-Risk Locally Advanced Cervical Cancer
https://www.onclive.com/view/pds0101-plus-chemoradiation-elicits-100-orr-in-high-risk-locally-advanced-cervical-cancer

Nov 23rd, 2022 - PDS0101 given in conjunction with chemoradiation elicited an 100% overall response rate (ORR), along with tumor shrinkage greater than 60%, in 9 patients with high-risk, locally advanced cervical cancer, according to results of the phase 2 IMMUNOCERV trial (NCT04580771) that were presented during the 2022 SITC Annual Meeting.1,2 Specifically, the ORR was comprised of 8 complete responses and 1...

Innovative Trajectory Built From Tradition
https://www.onclive.com/view/innovative-trajectory-built-from-tradition

Nov 23rd, 2022 - From a young age, Roy S. Herbst, MD, PhD, was fascinated by physiology. He was an avid learner and successful student in many academic subjects, but he had a singular passion for science that grew stronger throughout his childhood and young adult life. Discovering the intricacies of the human body shaped his educational trajectory. As a high school student in New Rochelle, New York, he was sel...

Afamitresgene Autoleucel Induces Durable Clinical Response in Advanced Synovial Sarcoma Or Myxoid/Round Cell Liposarcoma
https://www.onclive.com/view/afamitresgene-autoleucel-induces-durable-clinical-response-in-advanced-synovial-sarcoma-or-myxoid-round-cell-liposarcoma

Nov 23rd, 2022 - Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), a novel T-cell therapy, produced good clinical response lasting more than 4 years in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS), according to findings from cohort 1 of the ongoing phase 2 SPEARHEAD-1 trial (NCT04044768).1 An independent review showed that afami-cel induced an overall response rate ...